Cited by 159Berberine and alkaloids researchSirtuins and Resveratrol in MedicineMetabolism, Diabetes, and Cancer

The DOI matches its Crossref record; 60 of the 61 references it cites were found in a registry or an index.

Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis

Open access

Gomes, Ana P., Duarte, Filipe V., Nunes, Patricia, Hubbard, Basil P., Teodoro, João S., Varela, Ana T., Jones, John G., Sinclair, David A., Palmeira, Carlos M., Rolo, Anabela P.·2012·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI 10.1016/j.bbadis.2011.10.008PMC PMC3366688

Open this paper in CoChat — free account Open PDF

Abstract

Berberine (BBR) has recently been shown to improve insulin sensitivity in rodent models of insulin resistance. Although this effect was explained partly through an observed activation of AMP-activated protein kinase (AMPK), the upstream and downstream mediators of this phenotype were not explored. Here, we show that BBR supplementation reverts mitochondrial dysfunction induced by High Fat Diet (HFD) and hyperglycemia in skeletal muscle, in part due to an increase in mitochondrial biogenesis. Furthermore, we observe that the prevention of mitochondrial dysfunction by BBR, the increase in mitochondrial biogenesis, as well as BBR-induced AMPK activation, are blocked in cells in which SIRT1 has been knocked-down. Taken together, these data reveal an important role for SIRT1 and mitochondrial biogenesis in the preventive effects of BBR on diet-induced insulin resistance.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.bbadis.2011.10.008

Cites

60 of 60 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED: Redox Regulation of the AMP-Activated Protein Kinase
Han, Y., Wang, Q., Song, P., Zhu, Y., & Zou, M.-H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015420 · Cited by 71
Retracted
PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197
Obesity as a medical problem
Kopelman, P. G. (2000) · Nature · doi:10.1038/35007508 · Cited by 4,795
Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
Self-citation
Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057
Obesity
Haslam, D. W., & James, W. P. T. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67483-1 · Cited by 3,757
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160
Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes
Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2944 · Cited by 2,321
Mammalian Sirtuins: Biological Insights and Disease Relevance
Haigis, M. C., & Sinclair, D. A. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092250 · Cited by 2,085
Self-citation

Flagged first, then by citations

Show all 61 references

1 of the 61 references couldn’t be matched to a known paper.

Sorted by citations

SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function
Price, N. L., Gomes, A. P., Ling, A. J. Y., Duarte, F. V., Martin-Montalvo, A., North, B. J., Agarwal, B., Ye, L., Ramadori, G., Teodoro, J. S., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.003 · Cited by 1,602
Self-citation
Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging
Gomes, A. P., Price, N. L., Ling, A. J. Y., Moslehi, J. J., Montgomery, M. K., Rajman, L., White, J. P., Teodoro, J. S., Wrann, C. D., Hubbard, B. P., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.037 · Cited by 1,482
Self-citation
Biological properties and clinical applications of berberine
Song, D., Hao, J., & Fan, D. (2020) · Frontiers of Medicine · doi:10.1007/s11684-019-0724-6 · Cited by 514
AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: implications for obesity.
O’Neill, H. M., Holloway, G. P., & Steinberg, G. R. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.06.019 · Cited by 364
Skeletal muscle insulin resistance: role of mitochondria and other ROS sources
Di Meo, S., Iossa, S., & Venditti, P. (2017) · Journal of Endocrinology · doi:10.1530/joe-16-0598 · Cited by 282
Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders
Jęśko, H. M., Wencel, P. L., Strosznajder, R. P., & Strosznajder, J. B. (2016) · Neurochemical Research · doi:10.1007/s11064-016-2110-y · Cited by 264
Mechanisms underlying the effect of polysaccharides in the treatment of type 2 diabetes: A review
Wu, J., Shi, S., Wang, H., & Wang, S. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2016.02.040 · Cited by 244
Dietary Regulation of Oxidative Stress in Chronic Metabolic Diseases
Jiang, S., Liu, H., & Li, C. (2021) · Foods · doi:10.3390/foods10081854 · Cited by 241
Berberine as a therapy for type 2 diabetes and its complications: From mechanism of action to clinical studies
Chang, W., Chen, L., & Hatch, G. M. (2014) · Biochemistry and Cell Biology · doi:10.1139/bcb-2014-0107 · Cited by 159
Insulin Resistance and Mitochondrial Dysfunction
González-Franquesa, A., & Patti, M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-55330-6_25 · Cited by 160
Pre-diabetes alters testicular PGC1-α/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress
Rato, L., Duarte, A. I., Tomás, G. D., Santos, M. S., Moreira, P. I., Socorro, S., Cavaco, J. E. B., Alves, M. G., & Oliveira, P. F. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2013.12.008 · Cited by 157
Berberine attenuates hepatic steatosis and enhances energy expenditure in mice by inducing autophagy and fibroblast growth factor 21
Sun, Y., Xia, M., Yan, H., Han, Y., Zhang, F., Hu, Z., Cui, A., Ma, F., Liu, Z., Gong, Q., et al. (2017) · British Journal of Pharmacology · doi:10.1111/bph.14079 · Cited by 152
The Role of microRNAs in Mitochondria: Small Players Acting Wide
Duarte, F. V., Palmeira, C. M., & Rolo, A. P. (2014) · Genes · doi:10.3390/genes5040865 · Cited by 150
Self-citation
Berberine alleviates cardiac ischemia/reperfusion injury by inhibiting excessive autophagy in cardiomyocytes
Huang, Z., Han, Z., Ye, B., Dai, Z., Shan, P., Lu, Z., Dai, K., Wang, C., & Huang, W. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.05.028 · Cited by 152
Melatonin Improves Mitochondrial Function by Promoting MT1/SIRT1/PGC-1 Alpha-Dependent Mitochondrial Biogenesis in Cadmium-Induced Hepatotoxicity In Vitro
Guo, P., Pi, H., Xu, S., Zhang, L., Li, Y., Li, M., Cao, Z., Li, T. X., Xie, J., Li, R., et al. (2014) · Toxicological Sciences · doi:10.1093/toxsci/kfu164 · Cited by 134
Dietary Polyphenols Protect Against Oleic Acid-Induced Steatosis in an in Vitro Model of NAFLD by Modulating Lipid Metabolism and Improving Mitochondrial Function
Rafiei, H., Omidian, K., & Bandy, B. (2019) · Nutrients · doi:10.3390/nu11030541 · Cited by 132
Berberine Attenuates Myocardial Ischemia/Reperfusion Injury by Reducing Oxidative Stress and Inflammation Response: Role of Silent Information Regulator 1
Yu, L., Li, Q., Yu, B., Yang, Y., Jin, Z., Duan, W., Zhao, G., Zhai, M., Liu, L., Yi, D., et al. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/1689602 · Cited by 122
Berberine Ameliorates Doxorubicin-Induced Cardiotoxicity via a SIRT1/p66Shc-Mediated Pathway
Wu, Y., Zhang, L., Wu, Z., Shan, T.-T., & Xiong, C. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/2150394 · Cited by 122
Berberine modulates deacetylation of PPARγ to promote adipose tissue remodeling and thermogenesis via AMPK/SIRT1 pathway
Xu, Y., Yu, T., Ma, G., Zheng, L., Jiang, X., Yang, F., Wang, Z., Li, N., He, Z., Song, X., et al. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.62556 · Cited by 110
Phytopharmacology and Clinical Updates of Berberis Species Against Diabetes and Other Metabolic Diseases
Belwal, T., Bisht, A., Devkota, H. P., Ullah, H., Khan, H. Z., Pandey, A., BHATT, I. D., & Echeverría, J. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00041 · Cited by 119
Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: A possible role for SirT3 activation
Teodoro, J. S., Duarte, F. V., Gomes, A. P., Varela, A. T. I. F., Peixoto, F., Rolo, A. P., & Palmeira, C. M. (2013) · Mitochondrion · doi:10.1016/j.mito.2013.09.002 · Cited by 112
Self-citation
Berberine Improves Cognitive Deficiency and Muscular Dysfunction via Activation of the AMPK/SIRT1/PGC-1a Pathway in Skeletal Muscle from Naturally Aging Rats
Yu, Y., Zhao, Y., Teng, F., Li, J., Guan, Y., Xu, J., Lv, X., Guan, F., Zhang, M., & Chen, L. (2018) · The journal of nutrition health & aging · doi:10.1007/s12603-018-1015-7 · Cited by 111
Berberine Promotes Cardiac Function by Upregulating PINK1/Parkin-Mediated Mitophagy in Heart Failure
Abudureyimu, M., Yu, W., Cao, R. Y., Zhang, Y., Liu, H., & Zheng, H. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.565751 · Cited by 109
Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity
Jeong, J., Moon, M., Lee, Y.-J., Seol, J., & Park, S. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.04.002 · Cited by 105
HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders
Fields, J. A., Serger, E., Campos, S., Divakaruni, A. S., Kim, C., Smith, K., Trejo, M., Adame, A., Spencer, B. J., Rockenstein, E. M., et al. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.11.015 · Cited by 102
Berberine alleviates nonalcoholic fatty liver induced by a high‐fat diet in mice by activating SIRT3
Xu, X., Zhu, X., Bai, J., Xia, P., Li, Y., Lü, Y., Li, X.-Y., & Gao, X. (2019) · The FASEB Journal · doi:10.1096/fj.201802316r · Cited by 86
Berberine protects against diet-induced obesity through regulating metabolic endotoxemia and gut hormone levels
Xu, J. H., Liu, X., Pan, W., & Zou, D. J. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6321 · Cited by 86
The Emerging Role of MitomiRs in the Pathophysiology of Human Disease
Duarte, F. V., Palmeira, C. M., & Rolo, A. P. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-22671-2_8 · Cited by 81
Self-citation
Berberine attenuates hepatic oxidative stress in rats with non‑alcoholic fatty liver disease via the Nrf2/ARE signalling pathway
Deng, Y., Tang, K., Chen, R., Nie, H., Shu, L., Zhang, J., Zhang, Y., & Yang, Q. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.7208 · Cited by 79
Berberine-induced cardioprotection and Sirt3 modulation in doxorubicin-treated H9c2 cardiomyoblasts
Coelho, A. R., Martins, T. R., Couto, R., Deus, C. M., Pereira, C. V., Simões, R. F., Rizvanov, A. A., Silva, F. S. G., Cunha‐Oliveira, T., Oliveira, P. J., et al. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.07.030 · Cited by 78
Role of nutraceutical SIRT1 modulators in AMPK and mTOR pathway: Evidence of a synergistic effect
Giovannini, L., & Bianchi, S. E. (2016) · Nutrition · doi:10.1016/j.nut.2016.09.008 · Cited by 79
Berberine Ameliorates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation of SIRT3/AMPK/ACC Pathway
Zhang, Y., Deng, Y., Tang, K., Chen, R.-S., Shu, L., Liang, Y., Li, H., Jin, L., Liang, Z., Chen, Y., et al. (2019) · Current Medical Science · doi:10.1007/s11596-019-1997-3 · Cited by 76
EGCG-mediated autophagy flux has a neuroprotection effect via a class III histone deacetylase in primary neuron cells
Lee, J., Moon, J.-H., Kim, S.-W., Jeong, J., Nazim, U. M., Lee, Y.-J., Seol, J., & Park, S. (2015) · Oncotarget · doi:10.18632/oncotarget.3832 · Cited by 77
MicroRNA-194 Modulates Glucose Metabolism and Its Skeletal Muscle Expression Is Reduced in Diabetes
Latouche, C., Natoli, A., Reddy-Luthmoodoo, M., Heywood, S. E., Armitage, J. A., & Kingwell, B. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0155108 · Cited by 73
Using mitochondrial sirtuins as drug targets: disease implications and available compounds
Gertz, M., & Steegborn, C. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2180-7 · Cited by 73
miR-378a: a new emerging microRNA in metabolism
Machado, I. F., Teodoro, J. S., Palmeira, C. M., & Rolo, A. P. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03375-z · Cited by 72
Self-citation
Research progress on the pharmacological effects of berberine targeting mitochondria
Fang, X., Wu, H., Wei, J., Miao, R., Zhang, Y., & Tian, J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.982145 · Cited by 75
Berberine improves mesenteric artery insulin sensitivity through up‐regulating insulin receptor‐mediated signalling in diabetic rats
Geng, F., Li, G., Zhang, X., Zhang, P., Dong, M., Zhao, Z., Zhang, Y., Dong, L., & Gao, F. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13466 · Cited by 68
Berberine Improves Diabetic Encephalopathy Through the SIRT1/ER Stress Pathway in db/db Mice
Li, H., Wang, X.-C., Xu, Y., Luo, N., Luo, S., Hao, X.-Y., Cheng, S., Fang, J., Wang, Q., Zhang, S., et al. (2017) · Rejuvenation Research · doi:10.1089/rej.2017.1972 · Cited by 68
Nutraceutical Activation of Sirt1: A Review
DiNicolantonio, J. J., McCarty, M. F., & O'Keefe, J. H. (2022) · Open Heart · doi:10.1136/openhrt-2022-002171 · Cited by 65
The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review
Nie, Q., Li, M., Huang, C., Yongwei, Y., Liang, Q., Ma, X., Qiu, T., & Li, J. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05011-2 · Cited by 65
Protective role of mitoquinone against impaired mitochondrial homeostasis in metabolic syndrome
Yang, J., Suo, H., & Song, J. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1809344 · Cited by 65
Mechanisms Underlying Muscle-Related Diseases and Aging: Insights into Pathophysiology and Therapeutic Strategies
Fan, J., Fan, J., & Khanzada, Z. (2025) · Muscles · doi:10.3390/muscles4030026 · Cited by 65
The Potential Mechanisms of Berberine in the Treatment of Nonalcoholic Fatty Liver Disease
Zhu, X., Bian, H., & Gao, X. (2016) · Molecules · doi:10.3390/molecules21101336 · Cited by 63
Metformin attenuates osteoarthritis by targeting chondrocytes, synovial macrophages and adipocytes
Li, D., Ruan, G., Zhang, Y., Zhao, Y., Zhu, Z., Ou, Q., Huang, H., Chen, J., Han, W., Tang, S., et al. (2022) · Rheumatology · doi:10.1093/rheumatology/keac467 · Cited by 62
SIRT1/PGC-1α signaling protects hepatocytes against mitochondrial oxidative stress induced by bile acids
Tan, M., Tang, C., Zhang, Y., Cheng, Y., Cai, L., Chen, X., Gao, Y., Deng, Y., & Pan, M. (2015) · Free Radical Research · doi:10.3109/10715762.2015.1016020 · Cited by 61
Disease‐specific phenotypes in iPSC‐derived neural stem cells with POLG mutations
Liang, K. X., Kristiansen, C. K., Mostafavi, S., Vatne, G. H., Zantingh, G. A., Kianian, A., Tzoulis, C., Høyland, L. E., Ziegler, M., Pérez, R., et al. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.202012146 · Cited by 62
Cell-specific pattern of berberine pleiotropic effects on different human cell lines
Agnarelli, A., Natali, M., Garcia‐Gil, M., Pesi, R., Tozzi, M. G., Ippolito, C., Bernardini, N., Vignali, R., Batistoni, R., Bianucci, A. M., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-28952-3 · Cited by 57
Berberine protects against ischemia/reperfusion injury after orthotopic liver transplantation via activating Sirt1/FoxO3α induced autophagy
Lin, Y., Sheng, M., Weng, Y., Xu, R., Lü, N., Du, H., & Yu, W. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.01.028 · Cited by 57
Berberine protects liver from ethanol-induced oxidative stress and steatosis in mice
Zhang, P., Ma, D., Wang, Y., Zhang, M., Qiang, X., Liao, M., Xie, L., Wu, H., & Zhang, Y. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.10.005 · Cited by 56
Mitochondrial microRNA (MitomiRs) in cancer and complex mitochondrial diseases: current status and future perspectives
Purohit, P., & Saini, N. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03670-0 · Cited by 40
Binding of plant alkaloids berberine and palmatine to serum albumins: a thermodynamic investigation
Khan, A. Y., Hossain, M., & Kumar, G. S. (2012) · Molecular Biology Reports · doi:10.1007/s11033-012-2092-z · Cited by 53
Celastrol attenuates inflammatory responses in adipose tissues and improves skeletal muscle mitochondrial functions in high fat diet-induced obese rats via upregulation of AMPK/SIRT1 signaling pathways
Abu Bakar, M. H., Shariff, K. A., Tan, J. S., & Lee, L. K. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173371 · Cited by 51
Retracted: Insulin receptor A and Sirtuin 1 synergistically improve learning and spatial memory following chronic salidroside treatment during hypoxia
Barhwal, K. K., Das, S. K., Kumar, A., Hota, S. K., & Srivastava, R. B. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13225 · Cited by 50
Retracted
Comparison of dietary polyphenols for protection against molecular mechanisms underlying nonalcoholic fatty liver disease in a cell model of steatosis
Rafiei, H., Omidian, K., & Bandy, B. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600781 · Cited by 51
Adipose Tissue SIRT1 Regulates Insulin Sensitizing and Anti-Inflammatory Effects of Berberine
Shan, Y., Zhang, S., Gao, B., Liang, S., Zhang, H., Yu, X., Zhao, J., Ye, L., Yang, Q., & Shang, W. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.591227 · Cited by 49
Berberine prevents NAFLD and HCC by modulating metabolic disorders
Lin, X., Zhang, J., Chu, Y., Nie, Q., & Zhang, J. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108593 · Cited by 56
Natural products: Potential therapeutic agents to prevent skeletal muscle atrophy
Yadav, A., Yadav, S. S., Singh, S., & Dabur, R. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.174995 · Cited by 54
Berberine Alleviates Oxidative Stress in Islets of Diabetic Mice by Inhibiting miR‐106b Expression and Up‐Regulating SIRT1
Chen, D., & Yang, K. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26089 · Cited by 45
High-fat and obesogenic diets: current and future strategies to fight obesity and diabetes
Teodoro, J. S., Varela, A. T. I. F., Rolo, A. P., & Palmeira, C. M. (2014) · Genes & Nutrition · doi:10.1007/s12263-014-0406-6 · Cited by 45
Self-citation
Combination of Berberine with Resveratrol Improves the Lipid-Lowering Efficacy
Zhu, X., Yang, J., Zhu, W., Yin, X., Yang, B., Wei, Y., & Guo, X. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123903 · Cited by 47
Preservation of Mitochondrial Health in Liver Ischemia/Reperfusion Injury
Machado, I. F., Palmeira, C. M., & Rolo, A. P. (2023) · Biomedicines · doi:10.3390/biomedicines11030948 · Cited by 41
Self-citation
Berberine Protects Human Retinal Pigment Epithelial Cells from Hydrogen Peroxide-Induced Oxidative Damage through Activation of AMPK
Li, S., Gaur, U., Chong, C., Lin, S., Fang, J., Zeng, Z., Wang, H., & Zheng, W. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061736 · Cited by 41
Berberine and/or zinc protect against methotrexate-induced intestinal damage: Role of GSK-3β/NRF2 and JAK1/STAT-3 signaling pathways
Hassanein, E. H. M., Kamel, E. O., Ali, F. E. M., & Ahmed, M. A. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119754 · Cited by 39
New natural amino acid-bearing prodrugs boost pterostilbene’s oral pharmacokinetic and distribution profile
Azzolini, M., Mattarei, A., Spina, M. L., Fanin, M., Chiodarelli, G., Romio, M., Zoratti, M., Paradisi, C., & Biasutto, L. (2017) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2017.02.017 · Cited by 38
The anti-hyperglycemia effects of Rhizoma Coptidis alkaloids: A systematic review of modern pharmacological studies of the traditional herbal medicine
Ma, H., He, K., Zhu, J., Li, X., & Ye, X. (2019) · Fitoterapia · doi:10.1016/j.fitote.2019.03.003 · Cited by 37
The AMPK activator R419 improves exercise capacity and skeletal muscle insulin sensitivity in obese mice
Marcinko, K., Bujak, A. L., Lally, J., Ford, R. J., Wong, T. H., Smith, B. K., Kemp, B. E., Jenkins, Y., Li, W., Kinsella, T. M., et al. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.06.002 · Cited by 35
The multifaceted roles of natural products in mitochondrial dysfunction
Chen, Q., Ruan, D., Shi, J., Du, D., & Bian, C. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1093038 · Cited by 39
Exploiting Common Aspects of Obesity and Alzheimer’s Disease
Tabassum, S., Misrani, A., & Yang, L. (2020) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2020.602360 · Cited by 36
SIRT1 activation attenuates palmitate induced apoptosis in C2C12 muscle cells
Taheripak, G., Sabeti, N., Najar, N., Razavi, Z., Saharkhiz, S., & Alipourfard, I. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09250-w · Cited by 33
Pharmacological properties and therapeutic potential of berberine: a comprehensive review
Fan, K.-Q., Zhang, L., Song, F., Zhang, Y., Chen, T., Cheng, X., Su, N., Zou, Y., Yu, T., Tan, F., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1604071 · Cited by 33
Berberine protects renal tubular cells against hypoxia/reoxygenation injury via the Sirt1/p53 pathway
Lin, Y., Sheng, M., Ding, Y., Zhang, N., Song, Y., Du, H., Lü, N., & Yu, W. (2018) · Journal of Natural Medicines · doi:10.1007/s11418-018-1210-1 · Cited by 33
Metformin in contrast to berberine reversed arsenic‐induced oxidative stress in mitochondria from rat pancreas probably via Sirt3‐dependent pathway
Javadipour, M., Rezaei, M., Keshtzar, E., & Khodayar, M. J. (2019) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22368 · Cited by 32
Resveratrol improves left ventricular remodeling in chronic kidney disease via Sirt1‐mediated regulation of FoxO1 activity and MnSOD expression
Li, P., Song, X., Zhang, D., Guo, N., Wu, C., Chen, K., Liu, Y., Yuan, L., Chen, X., & Huang, X. (2019) · BioFactors · doi:10.1002/biof.1584 · Cited by 33
Uncoupling proteins as a therapeutic target to protect the diabetic heart
Dludla, P. V., Nkambule, B. B., Tiano, L., Louw, J., Jastroch, M., & Mazibuko-Mbeje, S. E. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.09.013 · Cited by 32
Berberine Ameliorates Hepatic Insulin Resistance by Regulating microRNA-146b/SIRT1 Pathway
Sui, M., Jiang, X., Sun, H., Liu, C., & Fan, Y. (2021) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s313068 · Cited by 32
Licochalcone Suppresses LXRα-Induced Hepatic Lipogenic Gene Expression through AMPK/Sirt1 Pathway Activation
Han, J. Y., Park, S. H., Yang, J. H., Kim, M. G., Cho, S., Yoon, G., Cheon, S. H., & Ki, S. H. (2014) · Toxicological Research · doi:10.5487/tr.2014.30.1.019 · Cited by 31
SirT3 regulates diabetogenic effects caused by arsenic: An implication for mitochondrial complex II modification
Rezaei, M., Keshtzar, E., Khodayar, M. J., & Javadipour, M. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.10.025 · Cited by 31
Coumestrol Induces Mitochondrial Biogenesis by Activating Sirt1 in Cultured Skeletal Muscle Cells
Seo, D.-B., Jeong, H. W., Lee, S.-J., & Lee, S. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf404882w · Cited by 30
Emerging Roles of NDUFS8 Located in Mitochondrial Complex I in Different Diseases
Wang, S., Kang, Y., Wang, R., Deng, J., Yu, Y., Yu, J. J., & Wang, J. (2022) · Molecules · doi:10.3390/molecules27248754 · Cited by 28
Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds
Jun, L., Tao, Y.-X., Geetha, T., & Babu, J. R. (2024) · Current Nutrition Reports · doi:10.1007/s13668-024-00555-7 · Cited by 27
Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine
Chappell, W. H., Abrams, S. L., Franklin, R. A., LaHair, M. M., Montalto, G., Cervello, M., Martelli, A. M., Nicoletti, F., Candido, S., Libra, M., et al. (2012) · Cell Cycle · doi:10.4161/cc.22786 · Cited by 27
Berberine-induced glucagon-like peptide-1 and its mechanism for controlling type 2 diabetes mellitus: a comprehensive pathway review
Araj‐Khodaei, M., Ayati, M. H., Azizi-Zeinalhajlou, A., Novinbahador, T., Yousefi, M., Shiri, M., Mahmoodpoor, A., Shamekh, A., Namazi, N., & Sanaie, S. (2023) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2023.2258559 · Cited by 30
Alteration in iron efflux affects male sex hormone testosterone biosynthesis in a diet-induced obese rat model
Kurniawan, A. L., Lee, Y., Shih, C., Hsieh, R., Chen, S., & Chang, J. (2019) · Food & Function · doi:10.1039/c8fo01870g · Cited by 26
Berberine Improves Inflammatory Responses of Diabetes Mellitus in Zucker Diabetic Fatty Rats and Insulin‐Resistant HepG2 Cells through the PPM1B Pathway
Wu, Y. S., Li, Z. M., Chen, Y. T., Dai, S. J., Zhou, X. J., Yang, Y. X., Lou, J. S., Ji, L. T., Bao, Y. T., Xuan, L., et al. (2020) · Journal of Immunology Research · doi:10.1155/2020/2141508 · Cited by 25
Huang Lian Jie Du Tang attenuates paraquat-induced mitophagy in human SH-SY5Y cells: A traditional decoction with a novel therapeutic potential in treating Parkinson’s disease
Lee, I., Chao, C., Yang, Y.-C., Cheng, J., Huang, C., Chiou, C., Huang, H., Kuo, Y., & Huang, N. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111170 · Cited by 27
Modulatory effect of berberine on adipose tissue PPARγ, adipocytokines and oxidative stress in high fat diet/ streptozotocin-induced diabetic rats
Mahmoud, A. M., Abdel-Rahman, M. M., Bastawy, N., & Eissa, H. (2017) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2017.70401 · Cited by 25
An autophagic process is activated in HepG2 cells to mediate BDE-100-induced toxicity
Pereira, L. C., Duarte, F. V., Varela, A. T. I. F., Rolo, A. P., Palmeira, C. M., & Dorta, D. J. (2016) · Toxicology · doi:10.1016/j.tox.2016.05.022 · Cited by 24
Self-citation
Berberine Protects against NEFA-Induced Impairment of Mitochondrial Respiratory Chain Function and Insulin Signaling in Bovine Hepatocytes
Shi, Z., Li, X., Peng, Z.-C., Peng, Z., Zhao, C.-X., Du, X.-L., Fang, Z.-Y., Fang, Z., Liu, G.-W., & Liu, G. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061691 · Cited by 24
Cost-effectiveness of immunization in The Gambia.
Robertson, R. L., Foster, S. O., Hull, H. F., & Williams, P. J. (1985) · PubMed · Cited by 24
Berberine regulates neurite outgrowth through AMPK-dependent pathways by lowering energy status
Lu, J., Cao, Y., Cheng, K., Xu, B., Wang, T., Yang, Q., Yang, Q., Feng, X., & Xia, Q. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.04.006 · Cited by 24
Protective Effects of Myricetin on Acute Hypoxia-Induced Exercise Intolerance and Mitochondrial Impairments in Rats
Zou, D., Liu, P., Chen, K., Xie, Q., Liang, X., Bai, Q., Zhou, Q., Liu, K., Zhang, T., Zhu, J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124727 · Cited by 23
Berberine improves intralipid-induced insulin resistance in murine
Dong, Z.-H., Lin, H., Chen, F., Che, X.-Q., Bi, W., Shi, S., Wang, J., Gao, L., He, Z., & Zhao, J. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-0493-4 · Cited by 23
Berberine in fish nutrition: Impact on hepatoenteric health, antioxidative and immune status
Wang, L., Sagada, G., Wang, C., Gao, C. Y., Wang, B., Shao, Q., & Yan, Y. (2022) · Frontiers in Marine Science · doi:10.3389/fmars.2022.967748 · Cited by 21
G-quadruplex-mediated reduction of a pathogenic mitochondrial heteroplasmy
Naeem, M. M., Maheshan, R., Costford, S. R., Wahedi, A., Trajkovski, M., Plavec, J., Yatsunyk, L. A., Ciesielski, G. L., Kaufman, B. A., & Sondheimer, N. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz153 · Cited by 21
Tibetan Medicine for Diabetes Mellitus: Overview of Pharmacological Perspectives
Yan, L.-S., Cheng, B. C., Zhang, S., Luo, G., Zhang, C., Wang, Q.-G., Fu, X., Wang, Y., & Zhang, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.748500 · Cited by 23
Resveratrol attenuates against high-fat-diet-promoted non-alcoholic fatty liver disease in rats mainly by targeting the miR-34a/SIRT1 axis
BinMowyna, M. N., AlFaris, N. A., AL-SANEA, E. A., ALTAMIMI, J. Z., & Aldayel, T. S. (2022) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2022.2046106 · Cited by 24
Methionine-chelated Zn promotes anabolism by integrating mTOR signal and autophagy pathway in juvenile yellow catfish
Wu, K., Chen, G., Högstrand, C., Ling, S.-C., Wu, L., & Luo, Z. (2021) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2021.126732 · Cited by 21
Inhibition of mTOR/S6K1/4E-BP1 Signaling by Nutraceutical SIRT1 Modulators
Bianchi, S. E., & Giovannini, L. (2018) · Nutrition and Cancer · doi:10.1080/01635581.2018.1446093 · Cited by 20
Berberine mitigates hepatic insulin resistance by enhancing mitochondrial architecture via the SIRT1/Opa1 signalling pathway
Xu, J. F., Zhang, Y., Yu, Z., Guan, Y., Lv, Y., Zhang, M., Zhang, M., Chen, L., Lv, X., & Guan, F. (2022) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2022146 · Cited by 20

Authors: Gomes, A. P., Duarte, F. V., Nunes, P., Hubbard, B. P., Teodoro, J. S., Varela, A. T., Jones, J. G., Sinclair, D. A., Palmeira, C. M., & Rolo, A. P.
Affiliations: Harvard University (US)
Centro de Neurociências e Biologia Celular (PT)
Corresponding author: Palmeira, Carlos M.
Rolo, Anabela P.
ORCID: Gomes, Ana P.
Duarte, Filipe V.
Hubbard, Basil P.
Teodoro, João S.
Varela, Ana T.
Jones, John G.
Sinclair, David A.
Palmeira, Carlos M.
Rolo, Anabela P.
Venue: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Publisher: Elsevier BV
Published: 2012-02
Volume: 1822
Issue: 2
Pages: 185-195
ISSN: 0925-4439 (ISSN-L)
DOI: 10.1016/j.bbadis.2011.10.008
PMC: PMC3366688
OpenAlex: W2016281492
Cited by: 159
References: 61
Citations by year: 2026: 5 · 2025: 10 · 2024: 9 · 2023: 8 · 2022: 10 · 2021: 14 · 2020: 17 · 2019: 18 · 2018: 12 · 2017: 12 · 2016: 12 · 2015: 11 · 2014: 9 · 2013: 6 · 2012: 5
FWCI: 4.68
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 533 d)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Radboud Repository (Radboud University) (submittedVersion)
Funders: Portuguese Foundation for Science and Technology
NIH/NIA
Topics: Health Sciences › Medicine › Pharmacology (medical) › Berberine and alkaloids research
Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: berberine, SIRT1, mitochondrial biogenesis, skeletal muscle mitochondria, mitochondrial dysfunction, high-fat diet, insulin resistance, AMPK, hyperglycemia, SIRT1 knockdown
MeSH terms: Animals, Berberine, Organelle Biogenesis, Cell Line, Glucose, Hormones, Hyperglycemia, Insulin Resistance, Male, Mitochondria, Mitochondria, Muscle, NAD, Obesity, Phosphorylation, Rats, Sprague-Dawley, Muscle, Skeletal, Myoblasts, Mice, Rats, AMP-Activated Protein Kinases, Sirtuin 1, Diet, High-Fat

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks