The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
Tissue mechanics and fibrosis
Open accessAbstract
Mechanical forces are essential to the development and progression of fibrosis, and are likely to be as important as soluble factors. These forces regulate the phenotype and proliferation of myofibroblasts and other cells in damaged tissues, the activation of growth factors, the structure and mechanics of the matrix, and, potentially, tissue patterning. Better understanding of the variety and magnitude of forces, the characteristics of those forces in biological tissues, and their impact on fibrosis in multiple tissues is needed and may lead to identification of important new therapeutic targets. This article is part of a Special Issue entitled: Fibrosis: Translation of basic research to human disease.
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“The change in concentration could alter the stiffness of the GelMA hydrogel, which varied from an elastic modulus of 0.1 to 5 kPa (fig. S3), a range consistent with healthy liver tissue to fibrotic liver tissue (0.1 to 1.8 kPa) (Fig. 2A) (24).”
From Matrix mechanical remodeled carrier-free nanosystem for programmable closed-loop reversal of liver fibrosis via STING alkylation (2025) · cites this paper as [24]
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Cites
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Role of YAP/TAZ in mechanotransduction
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Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
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Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix
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NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma
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Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma
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Research works printed but not linked: 1
- A. Marinkovic, F. Liu, D.J. Tschumperlin, Matrices of physiologic stiffness potently inactivate IPF fibroblasts, Am. J. Respir. Cell Mol. Biol. (in press).
Cited by
Sorted by citations
Shared and distinct mechanisms of fibrosis
Distler, J. H. W., Györfi, A., Ramanujam, M., Whitfield, M. L., Königshoff, M., & Lafyatis, R. (2019) · Nature Reviews Rheumatology · doi:10.1038/s41584-019-0322-7 · Cited by 674
The extracellular matrix and transforming growth factor-β1: Tale of a strained relationship
Hinz, B. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.05.006 · Cited by 637
Targeting metabolic dysregulation for fibrosis therapy
Zhao, X. L., Kwan, J. Y. Y., Yip, K. W., Liu, P. P., & Liu, F. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0040-5 · Cited by 537
YAP/TAZ Are Mechanoregulators of TGF-β-Smad Signaling and Renal Fibrogenesis
Szeto, S. G., Narimatsu, M., Lu, M., He, X., Sidiqi, A. M., Tolosa, M. F., Chan, L., Freitas, K. D., Bialik, J. F., Majumder, S., et al. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015050499 · Cited by 478
Tuning immunity through tissue mechanotransduction
Du, H., Bartleson, J. M., Butenko, S., Alonso, V., Liu, W. F., Winer, D. A., & Butte, M. J. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00761-w · Cited by 451
Metadata
- Authors
- Wells, R. G.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Wells, Rebecca G.
- ORCID
- Wells, Rebecca G.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 1832
- Issue
- 7
- Pages
- 884-890
- ISSN
- 0925-4439 (ISSN-L)
- PMC
- PMC3641165
- OpenAlex
- W2063208689
- Cited by
- 384
- References
- 110
- Citations by year
- 2026: 18 · 2025: 33 · 2024: 42 · 2023: 35 · 2022: 45 · 2021: 54 · 2020: 41 · 2019: 30 · 2018: 33 · 2017: 16 · 2016: 18 · 2015: 12 · 2014: 4 · 2013: 3
- FWCI
- 7.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01-DK-058123)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
- Keywords
- tissue mechanics, fibrosis, mechanical forces, myofibroblasts, myofibroblast proliferation, growth factor activation, tissue patterning, therapeutic target
- MeSH terms
- Fibrosis, Humans, Disease Progression, Myofibroblasts
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