Tissue mechanics and fibrosis

Biomechanics. Mechanical Properties of Living Tissues

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Role of YAP/TAZ in mechanotransduction

Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., Zanconato, F., Le Digabel, J., Forcato, M., Bicciato, S., et al. (2011) · Nature · doi:10.1038/nature10137 · Cited by 5,979

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

Levental, K. R., Yu, H., Kass, L., Lakins, J. N., Egeblad, M., Erler, J. T., Fong, S. F. T., Csiszar, K., Giaccia, A., Weninger, W., et al. (2009) · Cell · doi:10.1016/j.cell.2009.10.027 · Cited by 4,101

Biomechanics: Mechanical Properties of Living Tissues

Fung, Y. C., & Skalak, R. (1981) · Journal of Biomechanical Engineering · doi:10.1115/1.3138285 · Cited by 2,784

Nonlinear elasticity in biological gels

Storm, C., Pastore, J. J., MacKintosh, F. C., Lubensky, T. C., & Janmey, P. A. (2005) · Nature · doi:10.1038/nature03521 · Cited by 1,707

Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix

Wipff, P.-J., Rifkin, D. B., Meister, J.-J., & Hinz, B. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704042 · Cited by 1,346

NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma

Luedde, T., & Schwabe, R. F. (2011) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.213 · Cited by 1,345

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma

Conklin, M. W., Eickhoff, J. C., Riching, K. M., Pehlke, C. A., Eliceiri, K. W., Provenzano, P. P., Friedl, A., & Keely, P. J. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2010.11.076 · Cited by 1,321

Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology

Davies, P. F. (2008) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio1397 · Cited by 1,216

Interactions between extracellular matrix and growth factors in wound healing

Schultz, G. S., & Wysocki, A. (2009) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2009.00466.x · Cited by 1,126

Shared and distinct mechanisms of fibrosis

Distler, J. H. W., Györfi, A., Ramanujam, M., Whitfield, M. L., Königshoff, M., & Lafyatis, R. (2019) · Nature Reviews Rheumatology · doi:10.1038/s41584-019-0322-7 · Cited by 674

The extracellular matrix and transforming growth factor-β1: Tale of a strained relationship

Hinz, B. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.05.006 · Cited by 637

Targeting metabolic dysregulation for fibrosis therapy

Zhao, X. L., Kwan, J. Y. Y., Yip, K. W., Liu, P. P., & Liu, F. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0040-5 · Cited by 537

YAP/TAZ Are Mechanoregulators of TGF-β-Smad Signaling and Renal Fibrogenesis

Szeto, S. G., Narimatsu, M., Lu, M., He, X., Sidiqi, A. M., Tolosa, M. F., Chan, L., Freitas, K. D., Bialik, J. F., Majumder, S., et al. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015050499 · Cited by 478

Tuning immunity through tissue mechanotransduction

Du, H., Bartleson, J. M., Butenko, S., Alonso, V., Liu, W. F., Winer, D. A., & Butte, M. J. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00761-w · Cited by 451

Cell Adhesion by Integrins

Bachmann, M., Kukkurainen, S., Hytönen, V. P., & Wehrle‐Haller, B. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2018 · Cited by 416

Mechanosensing and fibrosis

Tschumperlin, D. J., Ligresti, G., Hilscher, M. B., & Shah, V. H. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93561 · Cited by 359

Organ-on-a-chip platforms: a convergence of advanced materials, cells, and microscale technologies

Ahadian, S., Civitarese, R., Bannerman, D., Mohammadi, M. H., Lu, R., Wang, E., Davenport‐Huyer, L., Lai, B., Zhang, B., Zhao, Y., et al. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201700506 · Cited by 315

TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice

Rahaman, S. O., Grove, L. M., Paruchuri, S., Southern, B. D., Abraham, S., Niese, K. A., Scheraga, R. G., Ghosh, S., Thodeti, C. K., Zhang, D. X., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci75331 · Cited by 310

TGF ‐β as a driver of fibrosis: physiological roles and therapeutic opportunities

Budi, E. H., Schaub, J. R., Decaris, M. L., Turner, S., & Derynck, R. (2021) · The Journal of Pathology · doi:10.1002/path.5680 · Cited by 310

Stem Cell Differentiation is Regulated by Extracellular Matrix Mechanics

Smith, L., Cho, S., & Discher, D. E. (2017) · Physiology · doi:10.1152/physiol.00026.2017 · Cited by 295

Mechanical stiffness controls dendritic cell metabolism and function

Chakraborty, M., Chu, K., Shrestha, A., Revelo, X. S., Zhang, X., Gold, M. J., Khan, S., Lee, M., Huang, C., Akbari, M., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108609 · Cited by 258

Hemicellulose-reinforced nanocellulose hydrogels for wound healing application

Liu, J., Chinga‐Carrasco, G., Cheng, F., Xu, W., Willför, S. M., Syverud, K., & Xu, C. (2016) · Cellulose · doi:10.1007/s10570-016-1038-3 · Cited by 214

Vimentin Enhances Cell Elastic Behavior and Protects against Compressive Stress

Mendez, M. G., Restle, D. J., & Janmey, P. A. (2014) · Biophysical Journal · doi:10.1016/j.bpj.2014.04.050 · Cited by 200

Human cardiac fibrosis-on-a-chip model recapitulates disease hallmarks and can serve as a platform for drug testing

Mastikhina, O., Moon, B., Williams, K., Hatkar, R., Gustafson, D., Mourad, O., Sun, X., Koo, M., Lam, A. Y. L., Sun, Y., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119741 · Cited by 192

Drug targeting to myofibroblasts: Implications for fibrosis and cancer

Yazdani, S., Bansal, R., & Prakash, J. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.07.010 · Cited by 191

Glycemic control by the SGLT2 inhibitor empagliflozin decreases aortic stiffness, renal resistivity index and kidney injury

Aroor, A. R., Das, N. A., Carpenter, A. J., Habibi, J., Jia, G., Ramirez‐Perez, F. I., Martinez‐Lemus, L. A., Manrique‐Acevedo, C., Hayden, M. R., Duta, C., et al. (2018) · Cardiovascular Diabetology · doi:10.1186/s12933-018-0750-8 · Cited by 182

Extracellular Matrix Remodeling in Chronic Liver Disease

Ortiz, C., Schierwagen, R., Schaefer, L., Klein, S., Trepat, X., & Trebicka, J. (2021) · Current Tissue Microenvironment Reports · doi:10.1007/s43152-021-00030-3 · Cited by 197

Matrix Stiffness: the Conductor of Organ Fibrosis

Santos, A., & Lagares, D. (2018) · Current Rheumatology Reports · doi:10.1007/s11926-018-0710-z · Cited by 183

Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts

Walker, C. J., Crocini, C., Ramirez, D. M. C., Killaars, A. R., Grim, J. C., Aguado, B. A., Clark, K., Allen, M. A., Dowell, R. D., Leinwand, L. A., et al. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00709-w · Cited by 178

Mechanotransduction in Wound Healing and Fibrosis

Kuehlmann, B. A., Bonham, C. A., Zucal, I., Prantl, L., & Gurtner, G. C. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051423 · Cited by 182

Compressive force induces reversible chromatin condensation and cell geometry–dependent transcriptional response

Damodaran, K., Venkatachalapathy, S., Alisafaei, F., Radhakrishnan, A., Jokhun, D. S., Shenoy, V. B., & Shivashankar, G. V. (2018) · Molecular Biology of the Cell · doi:10.1091/mbc.e18-04-0256 · Cited by 168

Integrins and integrin-related proteins in cardiac fibrosis

Chen, C., Li, R., Ross, R. S., & Manso, A. M. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.11.010 · Cited by 165

AFM assessing of nanomechanical fingerprints for cancer early diagnosis and classification: from single cell to tissue level

Stylianou, A., Lekka, M., & Stylianopoulos, T. (2018) · Nanoscale · doi:10.1039/c8nr06146g · Cited by 155

Matrix stiffness modulates the activity of MMP-9 and TIMP-1 in hepatic stellate cells to perpetuate fibrosis

Lachowski, D., Cortés, E., Rice, A. J., Pinato, D. J., Rombouts, K., & Hernández, A. E. D. R. (2019) · Scientific Reports · doi:10.1038/s41598-019-43759-6 · Cited by 151

Extracellular Matrix Cues Regulate Mechanosensing and Mechanotransduction of Cancer Cells

Mierke, C. T. (2024) · Cells · doi:10.3390/cells13010096 · Cited by 146

Chemically Modified Gellan Gum Hydrogels with Tunable Properties for Use as Tissue Engineering Scaffolds

Xu, Z., Li, Z., Jiang, S., & Bratlie, K. M. (2018) · ACS Omega · doi:10.1021/acsomega.8b00683 · Cited by 151

Development of a biomimetic liver tumor-on-a-chip model based on decellularized liver matrix for toxicity testing

Lu, S., Cuzzucoli, F., Jiang, J., Liang, L.-G., Wang, Y., Kong, M., Zhao, X., Cui, W., Li, J., & Wang, S. (2018) · Lab on a Chip · doi:10.1039/c8lc00852c · Cited by 144

Regulation of fibrosis in muscular dystrophy

Smith, L., & Barton, E. R. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.01.014 · Cited by 138

Biomechanics of TGFβ‐induced epithelial‐mesenchymal transition: implications for fibrosis and cancer

O’Connor, J. W., & Gomez, E. W. (2014) · Clinical and Translational Medicine · doi:10.1186/2001-1326-3-23 · Cited by 136

Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases

Blokland, K. E. C., Pouwels, S. D., Schuliga, M. J., Knight, D. A., & Burgess, J. K. (2020) · Clinical Science · doi:10.1042/cs20190893 · Cited by 132

Generation of functionally distinct T-cell populations by altering the viscoelasticity of their extracellular matrix

Adu‐Berchie, K., Liu, Y., Zhang, D. K. Y., Freedman, B. R., Brockman, J. M., Vining, K. H., Nerger, B. A., Garmilla, A., & Mooney, D. J. (2023) · Nature Biomedical Engineering · doi:10.1038/s41551-023-01052-y · Cited by 130

Intestinal fibrosis

Lenti, M. V., & Sabatino, A. D. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.10.003 · Cited by 128

Spatiotemporal Control of Viscoelasticity in Phototunable Hyaluronic Acid Hydrogels

Hui, E., Gimeno, K. I., Guan, G., & Caliari, S. R. (2019) · Biomacromolecules · doi:10.1021/acs.biomac.9b00965 · Cited by 120

Mechanosensing regulates tissue repair program in macrophages

Meizlish, M. L., Kimura, Y., Pope, S. D., Matta, R., Kim, C., Philip, N. H., Meyaard, L., Gonzalez, A., & Medzhitov, R. (2024) · Science Advances · doi:10.1126/sciadv.adk6906 · Cited by 114

Radiation-Induced Lung Fibrosis: Preclinical Animal Models and Therapeutic Strategies

Jin, H. K., Yoo, Y., Kim, Y.-H., Kim, Y., Cho, J., & Lee, Y. (2020) · Cancers · doi:10.3390/cancers12061561 · Cited by 115

The vital role for nitric oxide in intraocular pressure homeostasis

Reina‐Torres, E., Ieso, M. L. D., Pasquale, L. R., Madekurozwa, M., Sherwood, J. M., Overby, D. R., & Stamer, W. D. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100922 · Cited by 109

Matrix Mechanosensing: From Scaling Concepts in ’Omics Data to Mechanisms in the Nucleus, Regeneration, and Cancer

Discher, D. E., Smith, L., Cho, S., Colasurdo, M., García, A. J., & Safran, S. A. (2017) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-062215-011206 · Cited by 111

Discoidin Domain Receptor 1 Mediates Myosin-Dependent Collagen Contraction

Coelho, N. M., Arora, P. D., van Putten, S., Boo, S., Petrovic, P., Lin, A. X., Hinz, B., & McCulloch, C. A. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.01.061 · Cited by 109

Sensing the mechano-chemical properties of the extracellular matrix

Ringer, P., Coló, G. P., Fässler, R., & Grashoff, C. (2017) · Matrix Biology · doi:10.1016/j.matbio.2017.03.004 · Cited by 107

Piezo1 Channels Contribute to the Regulation of Human Atrial Fibroblast Mechanical Properties and Matrix Stiffness Sensing

Emig, R., Knodt, W., Krussig, M. J., Zgierski-Johnston, C. M., Gorka, O., Groß, O., Kohl, P. K., Ravens, U., & Peyronnet, R. (2021) · Cells · doi:10.3390/cells10030663 · Cited by 107

Nanoscale Surface Topography Reduces Focal Adhesions and Cell Stiffness by Enhancing Integrin Endocytosis

Li, X., Klausen, L. H., Zhang, W., Jahed, Z., Tsai, C., Li, T. L., & Cui, B. (2021) · Nano Letters · doi:10.1021/acs.nanolett.1c01934 · Cited by 103

The diverse roles of hydrogel mechanics in injectable stem cell transplantation

Foster, A. A., Marquardt, L. M., & Heilshorn, S. C. (2016) · Current Opinion in Chemical Engineering · doi:10.1016/j.coche.2016.11.003 · Cited by 99

Incorporating mechanical strain in organs-on-a-chip: Lung and skin

Guenat, O. T., & Francois Berthiaume, B. (2018) · Biomicrofluidics · doi:10.1063/1.5024895 · Cited by 101

Quantitative assessment of intestinal stiffness and associations with fibrosis in human inflammatory bowel disease

Stewart, D. C., Berrie, D., Li, J., Liu, X., Rickerson, C., Mkoji, D., Iqbal, A., Tan, S., Doty, A. L., Glover, S. C., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200377 · Cited by 99

Metastasis-on-a-chip mimicking the progression of kidney cancer in the liver for predicting treatment efficacy

Wang, Y., Wu, D., Wu, G., Wu, J., Lu, S., Lo, J., He, Y., Zhao, C., Zhao, X., Zhang, H., et al. (2020) · Theranostics · doi:10.7150/thno.38736 · Cited by 93

Mechanotransduction-induced glycolysis epigenetically regulates a CXCL1-dominant angiocrine signaling program in liver sinusoidal endothelial cells in vitro and in vivo

Greuter, T., Yaqoob, U., Gan, C., Jalan-Sakrikar, N., Kostallari, E., Lu, J., Gao, J., Sun, L., Liu, M., Sehrawat, T. S., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.03.029 · Cited by 92

In wound repair vimentin mediates the transition of mesenchymal leader cells to a myofibroblast phenotype

Walker, J. L., Bleaken, B. M., Romisher, A., Alnwibit, A. A., & Menko, A. S. (2018) · Molecular Biology of the Cell · doi:10.1091/mbc.e17-06-0364 · Cited by 97

Noninvasive assessment of renal fibrosis by magnetic resonance imaging and ultrasound techniques

Jiang, K., Ferguson, C. M., & Lerman, L. O. (2019) · Translational research · doi:10.1016/j.trsl.2019.02.009 · Cited by 94

Bioengineered 3D Models to Recapitulate Tissue Fibrosis

Sacchi, M., Bansal, R., & Rouwkema, J. (2020) · Trends in biotechnology · doi:10.1016/j.tibtech.2019.12.010 · Cited by 93

The sulfilimine cross-link of collagen IV contributes to kidney tubular basement membrane stiffness

Bhave, G. B., Colon, S., & Ferrell, N. J. (2017) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00096.2017 · Cited by 91

Engineered Biomaterial Platforms to Study Fibrosis

Davidson, M. D., Burdick, J. A., & Wells, R. G. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.201901682 · Cited by 95

Microimpedance tomography system to monitor cell activity and membrane movements in a breathing lung-on-chip

Mermoud, Y., Felder, M., Stucki, J. D., Stucki, A., & Guenat, O. T. (2017) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2017.09.192 · Cited by 88

Adhesion G protein-coupled receptors: opportunities for drug discovery

Bassilana, F., Nash, M., & Ludwig, M. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0039-y · Cited by 88

Does pressure cause liver cirrhosis? The sinusoidal pressure hypothesis

Mueller, S. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i48.10482 · Cited by 89

Dynamic control of hydrogel crosslinking via sortase-mediated reversible transpeptidation

Arkenberg, M. R., Moore, D. M., & Lin, C. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.11.011 · Cited by 82

Fighting the Fiber: Targeting Collagen in Lung Fibrosis

Staab-Weijnitz, C. A. (2021) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2021-0342tr · Cited by 86

Passive stiffness of fibrotic skeletal muscle in mdx mice relates to collagen architecture

Brashear, S. E., Wohlgemuth, R. P., Gonzalez, G., & Smith, L. (2020) · The Journal of Physiology · doi:10.1113/jp280656 · Cited by 78

Mechanotransduction in the pathogenesis of non-alcoholic fatty liver disease

Mitten, E. K., & Baffy, G. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.08.028 · Cited by 85

Nano-mechanical mapping of interdependent cell and ECM mechanics by AFM force spectroscopy

Babu, P. K. V., Rianna, C., Mirastschijski, U., & Radmacher, M. (2019) · Scientific Reports · doi:10.1038/s41598-019-48566-7 · Cited by 77

Biomaterial Properties Modulating Bone Regeneration

Zhu, Y. X., Goh, C. M., & Shrestha, A. (2021) · Macromolecular Bioscience · doi:10.1002/mabi.202000365 · Cited by 83

Alveolar cells under mechanical stressed niche: critical contributors to pulmonary fibrosis

Yang, J., Pan, X., Wang, L., & Yu, G. (2020) · Molecular Medicine · doi:10.1186/s10020-020-00223-w · Cited by 79

Mechanoregulation of cardiac myofibroblast differentiation: implications for cardiac fibrosis and therapy

Yong, K. W., Li, Y., Huang, G., Lu, T. J., Zaman, W. S. W. K., Pingguan‐Murphy, B., & Xu, F. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00299.2015 · Cited by 76

Mechanical homeostasis imbalance in hepatic stellate cells activation and hepatic fibrosis

Zhao, Y.-Q., Deng, X.-W., Xu, G.-Q., Lin, J., Lu, H.-Z., & Chen, J. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1183808 · Cited by 71

Matrix Mechanics as Regulatory Factors and Therapeutic Targets in Hepatic Fibrosis

Chen, G., Xia, B., Fu, Q., Xiang, H., Wang, F., Chen, Z., & Lv, Y. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.37500 · Cited by 75

Injury- and inflammation-driven skin fibrosis: The paradigm of epidermolysis bullosa

Nyström, A., & Bruckner‐Tuderman, L. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.01.016 · Cited by 74

Natural killer cell immune synapse formation and cytotoxicity are controlled by tension of the target interface

Friedman, D., Simmonds, P., Hale, A. J., Bere, L. D., Hodson, N. W., White, M., & Davis, D. M. (2021) · Journal of Cell Science · doi:10.1242/jcs.258570 · Cited by 69

New Amniotic Membrane Based Biocomposite for Future Application in Reconstructive Urology

Adamowicz, J., Pokrywczyńska, M., Tworkiewicz, J., Kowalczyk, T., van Breda, S. V., Tyloch, D. J., Kloskowski, T., Bodnar, M., Skopińska-Wiśniewska, J., Marszałek, A., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146012 · Cited by 70

Overlooked subclinical portal hypertension in non-cirrhotic NAFLD: Is it real and how to measure it?

Baffy, G., & Bosch, J. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.09.029 · Cited by 69

Magnetic Resonance Elastography to Assess Fibrosis in Kidney Allografts

Kirpalani, A., Hashim, E., Leung, G., Kim, J. K., Krizova, A., Jothy, S., Deeb, M., Jiang, N., Glick, L. A., Mnatzakanian, G. N., et al. (2017) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.01830217 · Cited by 69

Macrophage–stroma interactions in fibrosis: biochemical, biophysical, and cellular perspectives

Vasse, G. F., Nizamoglu, M., Heijink, I. H., Schlepütz, M., van Rijn, P., Thomas, M. J., Burgess, J. K., & Melgert, B. N. (2021) · The Journal of Pathology · doi:10.1002/path.5632 · Cited by 70

Liver Injury and the Activation of the Hepatic Myofibroblasts

Jiang, J. X., & Torok, N. J. (2013) · Current Pathobiology Reports · doi:10.1007/s40139-013-0019-6 · Cited by 70

Sensitivity of the fasciae to sex hormone levels: Modulation of collagen-I, collagen-III and fibrillin production

Fede, C., Pirri, C., Fan, C., Albertin, G., Porzionato, A., Macchi, V., De, R., & Stecco, C. (2019) · PLoS ONE · doi:10.1371/journal.pone.0223195 · Cited by 66

The Balance between Actomyosin Contractility and Microtubule Polymerization Regulates Hierarchical Protrusions That Govern Efficient Fibroblast–Collagen Interactions

Shakiba, D., Alisafaei, F., Savadipour, A., Rowe, R. A., Liu, Z., Pryse, K. M., Shenoy, V. B., Elson, E. L., & Genin, G. M. (2020) · ACS Nano · doi:10.1021/acsnano.9b09941 · Cited by 61

Effect of Adhesion and Substrate Elasticity on Neutrophil Extracellular Trap Formation

Erpenbeck, L., Gruhn, A. L., Kudryasheva, G., Günay, G., Meyer, D., Neubert, E., Grandke, J., Schön, M. P., Rehfeldt, F., & Kruss, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02320 · Cited by 63

Biosynthetic, biomimetic, and self-assembled vascularized Organ-on-a-Chip systems

Fritschen, A., & Blaeser, A. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120556 · Cited by 61

Cell Shape and Matrix Stiffness Impact Schwann Cell Plasticity via YAP/TAZ and Rho GTPases

Xu, Z., Orkwis, J. A., & Harris, G. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094821 · Cited by 61

Tension-tuned receptors for synthetic mechanotransduction and intercellular force detection

Sloas, D. C., Tran, J. C., Marzilli, A. M., & Ngo, J. T. (2023) · Nature Biotechnology · doi:10.1038/s41587-022-01638-y · Cited by 61

An Improved Method of Maintaining Primary Murine Cardiac Fibroblasts in Two-Dimensional Cell Culture

Landry, N. M., Rattan, S. G., & Dixon, I. (2019) · Scientific Reports · doi:10.1038/s41598-019-49285-9 · Cited by 66

Spatial mapping of the collagen distribution in human and mouse tissues by force volume atomic force microscopy

Calò, A., Romin, Y., Srouji, R. M., Zambirinis, C. P., Fan, N., Santella, A., Feng, E., Fujisawa, S., Turkekul, M., Huang, S., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-72564-9 · Cited by 59

Modelling and targeting mechanical forces in organ fibrosis

Mascharak, S., L. Guo, J., Griffin, M., E. Berry, C., C. Wan, D., & T. Longaker, M. (2024) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00144-3 · Cited by 59

Mechano-Responsive Piezoelectric Nanofiber as an On-Demand Drug Delivery Vehicle

Jariwala, T., Ico, G., Tai, Y., Park, H., Myung, N. V., & Nam, J. (2021) · ACS Applied Bio Materials · doi:10.1021/acsabm.1c00232 · Cited by 58

Matrix stiffness and architecture drive fibro-adipogenic progenitors’ activation into myofibroblasts

Loomis, T., Hu, L.-Y., Wohlgemuth, R. P., Chellakudam, R. R., Muralidharan, P. D., & Smith, L. (2022) · Scientific Reports · doi:10.1038/s41598-022-17852-2 · Cited by 61

Paracrine Effects of Adipose-Derived Stem Cells on Matrix Stiffness-Induced Cardiac Myofibroblast Differentiation via Angiotensin II Type 1 Receptor and Smad7

Yong, K. W., Li, Y., Liu, F., Gao, B., Lu, T. J., Abas, W. A. B. W., Zaman, W. S. W. K., Pingguan‐Murphy, B., Ma, Y., Xu, F., et al. (2016) · Scientific Reports · doi:10.1038/srep33067 · Cited by 60

Mechanical signaling through the discoidin domain receptor 1 plays a central role in tissue fibrosis

Coelho, N. M., & McCulloch, C. A. (2018) · Cell Adhesion & Migration · doi:10.1080/19336918.2018.1448353 · Cited by 59

Three-dimensional bioprinting of stem-cell derived tissues for human regenerative medicine

Skeldon, G., Lucendo‐Villarin, B., & Shu, W. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2017.0224 · Cited by 59

Towards a unified approach in the modeling of fibrosis: A review with research perspectives

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