Cited by 384Cellular Mechanics and InteractionsCardiac Fibrosis and RemodelingElasticity and Material Modeling

The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.

Tissue mechanics and fibrosis

Open access

Wells, Rebecca G.·2013·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI 10.1016/j.bbadis.2013.02.007PMC PMC3641165

Open this paper in CoChat — free account Open PDF

Abstract

Mechanical forces are essential to the development and progression of fibrosis, and are likely to be as important as soluble factors. These forces regulate the phenotype and proliferation of myofibroblasts and other cells in damaged tissues, the activation of growth factors, the structure and mechanics of the matrix, and, potentially, tissue patterning. Better understanding of the variety and magnitude of forces, the characteristics of those forces in biological tissues, and their impact on fibrosis in multiple tissues is needed and may lead to identification of important new therapeutic targets. This article is part of a Special Issue entitled: Fibrosis: Translation of basic research to human disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.bbadis.2013.02.007

Cites

110 of 110 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Biomechanics. Mechanical Properties of Living Tissues
Fung, Y. C., & Skalak, R. (1982) · Journal of Applied Mechanics · doi:10.1115/1.3162171 · Cited by 6,040
Role of YAP/TAZ in mechanotransduction
Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., Zanconato, F., Le Digabel, J., Forcato, M., Bicciato, S., et al. (2011) · Nature · doi:10.1038/nature10137 · Cited by 5,979
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
Levental, K. R., Yu, H., Kass, L., Lakins, J. N., Egeblad, M., Erler, J. T., Fong, S. F. T., Csiszar, K., Giaccia, A., Weninger, W., et al. (2009) · Cell · doi:10.1016/j.cell.2009.10.027 · Cited by 4,101
Biomechanics: Mechanical Properties of Living Tissues
Fung, Y. C., & Skalak, R. (1981) · Journal of Biomechanical Engineering · doi:10.1115/1.3138285 · Cited by 2,784
Nonlinear elasticity in biological gels
Storm, C., Pastore, J. J., MacKintosh, F. C., Lubensky, T. C., & Janmey, P. A. (2005) · Nature · doi:10.1038/nature03521 · Cited by 1,707
Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix
Wipff, P.-J., Rifkin, D. B., Meister, J.-J., & Hinz, B. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704042 · Cited by 1,346
NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma
Luedde, T., & Schwabe, R. F. (2011) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.213 · Cited by 1,345
Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma
Conklin, M. W., Eickhoff, J. C., Riching, K. M., Pehlke, C. A., Eliceiri, K. W., Provenzano, P. P., Friedl, A., & Keely, P. J. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2010.11.076 · Cited by 1,321
Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology
Davies, P. F. (2008) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio1397 · Cited by 1,216
Interactions between extracellular matrix and growth factors in wound healing
Schultz, G. S., & Wysocki, A. (2009) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2009.00466.x · Cited by 1,126
Fibroblast traction as a mechanism for collagen morphogenesis
Harris, A. K., Stopak, D., & Wild, P. (1981) · Nature · doi:10.1038/290249a0 · Cited by 871
Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment
Barry-Hamilton, V., Spangler, R., Marshall, D., McCauley, S., Rodriguez, H. M., Oyasu, M., Mikels, A., Vaysberg, M., Ghermazien, H., Wai, C., et al. (2010) · Nature Medicine · doi:10.1038/nm.2208 · Cited by 870
Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression
Liu, F., Mih, J. D., Shea, B. S., Kho, A. T., Sharif, A. S., Tager, A. M., & Tschumperlin, D. J. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201004082 · Cited by 828
Lumican regulates collagen fibril assembly: skin fragility and corneal opacity in the absence of lumican
Chakravarti, S., Magnuson, T., Lass, J. H., Jepsen, K. J., LaMantia, C., & Carroll, H. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.5.1277 · Cited by 731
Acellular Normal and Fibrotic Human Lung Matrices as a Culture System for In Vitro Investigation
Booth, A. J., Hadley, R., Cornett, A. M., Dreffs, A. A., Matthes, S. A., Tsui, J. L., Weiss, K., Horowitz, J. C., Fiore, V. F., Barker, T. H., et al. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0754oc · Cited by 665
Mechanical Tension Controls Granulation Tissue Contractile Activity and Myofibroblast Differentiation
Hinz, B., Mastrangelo, D., Iselin, C. E., Chaponnier, C., & Gabbiani, G. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61776-2 · Cited by 638
Extracellular matrix 4: The elastic fiber
Rosenbloom, J., Abrams, W. R., & Mecham, R. P. (1993) · The FASEB Journal · doi:10.1096/fasebj.7.13.8405806 · Cited by 625
Interstitial Flow and Its Effects in Soft Tissues
Swartz, M. A., & Fleury, M. E. (2007) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.9.060906.151850 · Cited by 606
Rho-mediated Contractility Exposes a Cryptic Site in Fibronectin and Induces Fibronectin Matrix Assembly
Zhong, C., Chrzanowska‐Wodnicka, M., Brown, J. A., Maddox, A. S., Belkin, A. M., & Burridge, K. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.2.539 · Cited by 605
Connective tissue morphogenesis by fibroblast traction
Stopak, D., & Harris, A. K. (1982) · Developmental Biology · doi:10.1016/0012-1606(82)90388-8 · Cited by 596
Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis
Georges, P. C., Hui, J.-J., Gombos, Z., McCormick, M. E., Wang, A. Y., Uemura, M., Mick, R., Janmey, P. A., Furth, E. E., & Wells, R. G. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00032.2007 · Cited by 577
Self-citation
A mechanosensitive transcriptional mechanism that controls angiogenesis
Mammoto, A., Connor, K. M., Mammoto, T., Yung, C. W., Huh, D., Aderman, C. M., Mostoslavsky, G., Smith, L. E. H., & Ingber, D. E. (2009) · Nature · doi:10.1038/nature07765 · Cited by 548
Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction
Huang, X., Yang, N., Fiore, V. F., Barker, T. H., Sun, Y., Morris, S. W., Ding, Q., Thannickal, V. J., & Zhou, Y. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0050oc · Cited by 530
Mechanotransduction – a field pulling together?
Chen, C. S. (2008) · Journal of Cell Science · doi:10.1242/jcs.023507 · Cited by 520
The Compliance of Collagen Gels Regulates Transforming Growth Factor-β Induction of α-Smooth Muscle Actin in Fibroblasts
Arora, P. D., Narani, N., & McCulloch, C. A. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65334-5 · Cited by 474
Mechanisms of mechanical signaling in development and disease
Janmey, P. A., & Miller, R. T. (2010) · Journal of Cell Science · doi:10.1242/jcs.071001 · Cited by 462
Spontaneous recovery from micronodular cirrhosis: Evidence for incomplete resolution associated with matrix cross-linking☆
Issa, R., Zhou, X., Constandinou, C. M., Fallowfield, J. A., Millward‐Sadler, H., Gaça, M. D. A., Sands, E., Suliman, I., Trim, N., & Knorr, A. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.03.009 · Cited by 454
Matrix rigidity regulates a switch between TGF-β1–induced apoptosis and epithelial–mesenchymal transition
Leight, J. L., Wozniak, M. A., Chen, S., Lynch, M. L., & Chen, C. S. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-06-0537 · Cited by 440
The influence of substrate creep on mesenchymal stem cell behaviour and phenotype
Cameron, A. R., Frith, J. E., & Cooper-White, J. J. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.04.003 · Cited by 437
Decorin regulates assembly of collagen fibrils and acquisition of biomechanical properties during tendon development
Zhang, G., Ezura, Y., Chervoneva, I., Robinson, P. S., Beason, D. P., Carine, E. T., Soslowsky, L. J., Iozzo, R. V., & Birk, D. E. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20776 · Cited by 430
Diagnostic accuracy of FibroScan and comparison to liver fibrosis biomarkers in chronic viral hepatitis: A multicenter prospective study (the FIBROSTIC study)
Degos, F., Perez, P., Roche, B., Mahmoudi, A., Asselineau, J., Voitot, H., & Bédossa, P. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.05.035 · Cited by 429
The mechanical memory of lung myofibroblasts
Balestrini, J. L., Chaudhry, S., Sarrazy, V., Koehler, A., & Hinz, B. (2012) · Integrative Biology · doi:10.1039/c2ib00149g · Cited by 414
Age-Related Intimal Stiffening Enhances Endothelial Permeability and Leukocyte Transmigration
Huynh, J., Nishimura, N., Rana, K., Peloquin, J. M., Califano, J. P., Montague, C. R., King, M. R., Schaffer, C. B., & Reinhart‐King, C. A. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002761 · Cited by 412
Nuclear factor‐κB and the hepatic inflammation‐fibrosis‐cancer axis†
Elsharkawy, A. M., & Mann, D. A. (2007) · Hepatology · doi:10.1002/hep.21802 · Cited by 400
Strain-Induced Alignment in Collagen Gels
Vader, D., Kabla, A., Weitz, D. A., & Mahadevan, L. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005902 · Cited by 390
Non-Linear Elasticity of Extracellular Matrices Enables Contractile Cells to Communicate Local Position and Orientation
Winer-Jones, J. P., Oake, S. A., & Janmey, P. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006382 · Cited by 368
Interstitial fluid flow induces myofibroblast differentiation and collagen alignment in vitro
Ng, C. P., Hinz, B., & Swartz, M. A. (2005) · Journal of Cell Science · doi:10.1242/jcs.02605 · Cited by 360
Hepatic stellate cells require a stiff environment for myofibroblastic differentiation
Olsen, A. L., Bloomer, S. A., Chan, E. P., Gaça, M. D. A., Georges, P. C., Sackey, B., Uemura, M., Janmey, P. A., & Wells, R. G. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00412.2010 · Cited by 355
Self-citation
Transforming growth factor-β and substrate stiffness regulate portal fibroblast activation in culture
Li, Z., Dranoff, J. A., Chan, E. P., Uemura, M., Sévigny, J., & Wells, R. G. (2007) · Hepatology · doi:10.1002/hep.21792 · Cited by 338
Self-citation
New insights into form and function of fibronectin splice variants
White, E. S., Baralle, F. E., & Muro, A. F. (2008) · The Journal of Pathology · doi:10.1002/path.2388 · Cited by 335
The relative magnitudes of endothelial force generation and matrix stiffness modulate capillary morphogenesis in vitro
Sieminski, A. L., Hebbel, R. P., & Gooch, K. J. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.03.035 · Cited by 281
Cell Elasticity Determines Macrophage Function
Patel, N. R., Bole, M., Chen, C., Hardin, C. C., Kho, A. T., Mih, J., Deng, L., Butler, J., Tschumperlin, D., Fredberg, J. J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041024 · Cited by 275
Finding the weakest link – exploring integrin-mediated mechanical molecular pathways
Roca‐Cusachs, P., Iskratsch, T., & Sheetz, M. P. (2012) · Journal of Cell Science · doi:10.1242/jcs.095794 · Cited by 269
The Single-Molecule Mechanics of the Latent TGF-β1 Complex
Buscemi, L., Ramonet, D., Klingberg, F., Formey, A., Smith-Clerc, J., Meister, J.-J., & Hinz, B. (2011) · Current Biology · doi:10.1016/j.cub.2011.11.037 · Cited by 266
Fibronectin forms the most extensible biological fibers displaying switchable force-exposed cryptic binding sites
Klotzsch, E., Smith, M. L., Kubow, K. E., Muntwyler, S., Little, W. C., Beyeler, F., Gourdon, D., Nelson, B. J., & Viola Vogel, B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907518106 · Cited by 264
Mechanical interactions between collagen and proteoglycans: implications for the stability of lung tissue
Cavalcante, F. S. Á., Ito, S., Brewer, K. K., Sakai, H., Alencar, A. M., de Almeida, M. P., Andrade, J. S., Majumdar, A., Ingenito, E. P., & Suki, B. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00619.2004 · Cited by 262
Role of lysyl oxidase in myocardial fibrosis: from basic science to clinical aspects
López, B., González, A., Hermida, N., Valencia, F., de Teresa, E., & Dı́ez, J. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00335.2010 · Cited by 256
Functions of lumican and fibromodulin: Lessons from knockout mice
Chakravarti, S. (2002) · Glycoconjugate Journal · doi:10.1023/a:1025348417078 · Cited by 248
Fluid Flow Mechanotransduction in Vascular Smooth Muscle Cells and Fibroblasts
Shi, Z., & Tarbell, J. M. (2011) · Annals of Biomedical Engineering · doi:10.1007/s10439-011-0309-2 · Cited by 245
A Syndrome of Joint Laxity and Impaired Tendon Integrity in Lumican- and Fibromodulin-deficient Mice* 210
Jepsen, K., Wu, F., Peragallo, J., Paul, J., Roberts, L., Ezura, Y., Oldberg, Å., Birk, D., & Chakravarti, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205398200 · Cited by 237
Substrate stiffening promotes endothelial monolayer disruption through enhanced physical forces
Krishnan, R., Klumpers, D. D., Park, C. Y., Rajendran, K., Trepat, X., van Bezu, J. S. M., van Hinsbergh, V. W. M., Carman, C. V., Brain, J. D., Fredberg, J. J., et al. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00195.2010 · Cited by 229
Endothelial cell substrate stiffness influences neutrophil transmigration via myosin light chain kinase-dependent cell contraction
Stroka, K. M., & Aranda‐Espinoza, H. (2011) · Blood · doi:10.1182/blood-2010-11-321125 · Cited by 214
Fibroblast Foci Are Not Discrete Sites of Lung Injury or Repair
Cool, C. D., Groshong, S. D., Pradeep, R., Henson, P. M., Stewart, J., & Brown, K. K. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200602-205oc · Cited by 196
Endothelial cell traction and ECM density influence both capillary morphogenesis and maintenance in 3-D
Kniazeva, E., & Putnam, A. J. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00018.2009 · Cited by 193
Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis
Pellicoro, A., Aucott, R. L., Ramachandran, P., Robson, A. J., Fallowfield, J. A., Snowdon, V., Hartland, S. N., Vernon, M. A., Duffield, J. S., Benyon, C. R., et al. (2011) · Hepatology · doi:10.1002/hep.25567 · Cited by 191
On the viscoelastic character of liver tissue: experiments and modelling of the linear behaviour
Liu, Z., & Bilston, L. E. (2000) · Biorheology · doi:10.1177/0006355x2000037003002 · Cited by 188
β-Catenin Mediates Mechanically Regulated, Transforming Growth Factor-β1–Induced Myofibroblast Differentiation of Aortic Valve Interstitial Cells
Chen, J., Chen, W. L. K., Sider, K. L., Yip, C. Y. Y., & Simmons, C. A. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.220061 · Cited by 188
Cardiovascular Protection by ApoE and ApoE-HDL Linked to Suppression of ECM Gene Expression and Arterial Stiffening
Kothapalli, D., Liu, S., Bae, Y., Monslow, J., Xu, T., Hawthorne, E. A., Byfield, F. J., Castagnino, P. A., Rao, S. J., Rader, D. J., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.09.018 · Cited by 187
Hepatic stellate cells and portal fibroblasts are the major cellular sources of collagens and lysyl oxidases in normal liver and early after injury
Perepelyuk, M., Terajima, M., Wang, A. Y., Georges, P. C., Janmey, P. A., Yamauchi, M., & Wells, R. G. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00222.2012 · Cited by 184
Self-citation
Matrix Elasticity, Cytoskeletal Tension, and TGF-β: The Insoluble and Soluble Meet
Wells, R. G., & Discher, D. E. (2008) · Science Signaling · doi:10.1126/stke.110pe13 · Cited by 183
Self-citation
Force-dependent cell signaling in stem cell differentiation
Yim, E. K. F., & Sheetz, M. P. (2012) · Stem Cell Research & Therapy · doi:10.1186/scrt132 · Cited by 170
Enhancing mechanical properties of tissue‐engineered constructs via lysyl oxidase crosslinking activity
Elbjeirami, W. M., Yonter, E. O., STARCHER, B. C., & West, J. L. (2003) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.10021 · Cited by 167
Mechanotransduction in the renal tubule
Weinbaum, S., Duan, Y., Satlin, L. M., Wang, T., & Weinstein, A. M. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00453.2010 · Cited by 164
Matrices of Physiologic Stiffness Potently Inactivate Idiopathic Pulmonary Fibrosis Fibroblasts
Marinković, A., Liu, F., & Tschumperlin, D. J. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0335oc · Cited by 162
Changes in Extracellular Matrix and Tissue Viscoelasticity in Bleomycin–induced Lung Fibrosis
Ebihara, T., Venkatesan, N., Tanaka, R., & Ludwig, M. S. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.4.9912011 · Cited by 158
Physical and chemical microenvironmental cues orthogonally control the degree and duration of fibrosis‐associated epithelial‐to‐mesenchymal transitions
Brown, A. C., Fiore, V. F., Sulchek, T., & Barker, T. H. (2012) · The Journal of Pathology · doi:10.1002/path.4114 · Cited by 154
Mechanical Regulation of Nuclear Structure and Function
Martins, R. P., Finan, J. D., Guilak, F., & Lee, D. A. (2012) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071910-124638 · Cited by 151
Podocytes are sensitive to fluid shear stress in vitro
Friedrich, C., Endlich, N., Kriz, W., & Endlich, K. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00196.2005 · Cited by 150
Mechanical Stretch Induces Epithelial-Mesenchymal Transition in Alveolar Epithelia via Hyaluronan Activation of Innate Immunity
Heise, R. L., Stober, V. P., Cheluvaraju, C., Hollingsworth, J. W., & Garantziotis, S. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.137273 · Cited by 149
Improved throughput traction microscopy reveals pivotal role for matrix stiffness in fibroblast contractility and TGF-β responsiveness
Marinković, А., Mih, J. D., Park, J., Liu, F., & Tschumperlin, D. J. (2012) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00108.2012 · Cited by 148
Linking Parenchymal Disease Progression to Changes in Lung Mechanical Function by Percolation
Bates, J. H. T., Davis, G. S., Majumdar, A., Butnor, K. J., & Suki, B. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200611-1739oc · Cited by 145
Basement membrane-like matrix inhibits proliferation and collagen synthesis by activated rat hepatic stellate cells: evidence for matrix-dependent deactivation of stellate cells
Gaça, M., Zhou, X., Issa, R., Kiriella, K., Iredale, J. P., & Benyon, R. C. (2003) · Matrix Biology · doi:10.1016/s0945-053x(03)00017-9 · Cited by 144
Tissue Transglutaminase Does Not Affect Fibrotic Matrix Stability or Regression of Liver Fibrosis in Mice
Popov, Y. V., Sverdlov, D., Sharma, A. K., Bhaskar, K. R., Li, S., Freitag, T. L., Lee, J. D., Dieterich, W., Melino, G., & Schuppan, D. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.01.040 · Cited by 137
Lumican, an extracellular matrix proteoglycan, is a novel requisite for hepatic fibrosis
Krishnan, A., Li, X., Kao, W.-Y., Viker, K., Butters, K. A., Masuoka, H. C., Knudsen, B. E., Gores, G. J., & Charlton, M. (2012) · Laboratory Investigation · doi:10.1038/labinvest.2012.121 · Cited by 132
Integrin α9β1 Directly Binds to Vascular Endothelial Growth Factor (VEGF)-A and Contributes to VEGF-A-induced Angiogenesis
Vlahakis, N. E., Young, B. A., Atakilit, A., Hawkridge, A. E., Issaka, R. B., Boudreau, N. J., & Sheppard, D. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609323200 · Cited by 130
Combining Dynamic Stretch and Tunable Stiffness to Probe Cell Mechanobiology In Vitro
Throm, A. M., Sierad, L. N., Capulli, A. K., Firstenberg, L. E., & Billiar, K. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023272 · Cited by 125
A simple indentation device for measuring micrometer-scale tissue stiffness
Levental, I., Levental, K. R., Klein, E. A., Assoian, R. K., Miller, R. T., Wells, R. G., & Janmey, P. A. (2010) · Journal of Physics Condensed Matter · doi:10.1088/0953-8984/22/19/194120 · Cited by 120
Self-citation
Hemodynamic alterations in cirrhosis and portal hypertension
Kim, M. Y., Baik, S. K., & Lee, S. S. (2010) · The Korean Journal of Hepatology · doi:10.3350/kjhep.2010.16.4.347 · Cited by 112
Interstitial flow promotes vascular fibroblast, myofibroblast, and smooth muscle cell motility in 3-D collagen I via upregulation of MMP-1
Shi, Z., Ji, X., Qazi, H., & Tarbell, J. M. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00369.2009 · Cited by 98
Mechanosignaling pathways in cutaneous scarring
Huang, C., Akaishi, S., & Ogawa, R. (2012) · Archives of Dermatological Research · doi:10.1007/s00403-012-1278-5 · Cited by 97
Cyclic mechanical stretch reduces myofibroblast differentiation of primary lung fibroblasts
Blaauboer, M. E., Smit, T. H., Hanemaaijer, R., Stoop, R., & Everts, V. E. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.11.033 · Cited by 94
The role of stem cells in liver repair and fibrosis
Greenbaum, L. E., & Wells, R. G. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.11.006 · Cited by 83
Self-citation
Collagen Fibril Flow and Tissue Translocation Coupled to Fibroblast Migration in 3D Collagen Matrices
Miron-Mendoza, M., Seemann, J., & Grinnell, F. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-09-0930 · Cited by 83
Dynamic viscoelastic nonlinearity of lung parenchymal tissue
Navajas, D., Maksym, G. N., & Bates, J. H. T. (1995) · Journal of Applied Physiology · doi:10.1152/jappl.1995.79.1.348 · Cited by 81
Transcription factor regulation by mechanical stress
Mendez, M. G., & Janmey, P. A. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.02.003 · Cited by 78
Fibromodulin, an Oxidative Stress-Sensitive Proteoglycan, Regulates the Fibrogenic Response to Liver Injury in Mice
Mormone, E., Lu, Y., Ge, X., Fiel, M. I., & Nieto, N. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.11.029 · Cited by 73
Fibrillin-1 expression in normal and fibrotic rat liver and in cultured hepatic fibroblastic cells: modulation by mechanical stress and role in cell adhesion
Lorena, D., Darby, I. A., Reinhardt, D. P., Sapin, V., Rosenbaum, J., & Desmoulière, A. (2004) · Laboratory Investigation · doi:10.1038/labinvest.3700023 · Cited by 72
Biomechanical regulation of mesenchymal cell function
Tschumperlin, D. J., Liu, F., & Tager, A. M. (2012) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e32835b13cd · Cited by 72
Extracellular matrix rigidity controls podosome induction in microvascular endothelial cells
Juin, A., Planus, E., Guillemot, F., Horakova, P., Albigès‐Rizo, C., Genot, E. M., Rosenbaum, J., Moreau, V., & Saltel, F. (2012) · Biology of the Cell · doi:10.1111/boc.201200037 · Cited by 72
Reduced serum content and increased matrix stiffness promote the cardiac myofibroblast transition in 3D collagen matrices
Galie, P. A., Westfall, M. V., & Stegemann, J. P. (2011) · Cardiovascular Pathology · doi:10.1016/j.carpath.2010.10.001 · Cited by 71
Recent advances and new opportunities in lung mechanobiology
Tschumperlin, D. J., Boudreault, F., & Liu, F. (2009) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2009.09.015 · Cited by 70
Role of glomerular mechanical strain in the pathogenesis of diabetic nephropathy
Cortés, P., Zhao, X., Riser, B. L., & Narins, R. G. (1997) · Kidney International · doi:10.1038/ki.1997.8 · Cited by 69
Crosslinking of cell-derived 3D scaffolds up-regulates the stretching and unfolding of new extracellular matrix assembled by reseeded cells
Kubow, K. E., Klotzsch, E., Smith, M. L., Gourdon, D., Little, W. C., & Viola Vogel, B. (2009) · Integrative Biology · doi:10.1039/b914996a · Cited by 66
The effect of stretching on formation of myofibroblasts in mouse skin
Squier, C. A. (1981) · Cell and Tissue Research · doi:10.1007/bf00210512 · Cited by 65
Mechanical stretch induces TGF‐β synthesis in hepatic stellate cells
Sakata, R., Ueno, T., Nakamura, T., Ueno, H., & Sata, M. (2004) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2004.01302.x · Cited by 64
Hydrostatic pressure sensation in cells: integration into the tensegrity model
Myers, K. A., Rattner, J. B., Shrive, N. G., & Hart, D. A. (2007) · Biochemistry and Cell Biology · doi:10.1139/o07-108 · Cited by 62
Mechanoregulation of cytoskeletal dynamics by TRP channels
Kuipers, A. J., Middelbeek, J., & van Leeuwen, F. N. (2012) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2012.05.006 · Cited by 61
Intratubular hydrodynamic forces influence tubulointerstitial fibrosis in the kidney
Rohatgi, R., & Flores, D. (2009) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e32833327f3 · Cited by 56
Pressure activates rat pancreatic stellate cells
Watanabe, S., Nagashio, Y., Asaumi, H., Nomiyama, Y., Taguchi, M., Tashiro, M., Kihara, Y., Nakamura, H., & Otsuki, M. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00339.2004 · Cited by 56
Mechanism of Stretch-Induced Activation of the Mechanotransducer Zyxin in Vascular Cells
Babu, S. S., Wojtowicz, A., Freichel, M., Birnbaumer, L., Hecker, M., & Cattaruzza, M. (2012) · Science Signaling · doi:10.1126/scisignal.2003173 · Cited by 53
Elastin Gene Expression is Upregulated During Pulmonary Fibrosis
Hoff, C. R., Perkins, D., & Davidson, J. M. (1999) · Connective Tissue Research · doi:10.3109/03008209909029110 · Cited by 46
Stem Cells and Pulmonary Fibrosis: Cause or Cure?
McNulty, K., & Janes, S. M. (2012) · Proceedings of the American Thoracic Society · doi:10.1513/pats.201201-010aw · Cited by 44
Inhibition of Experimental Cirrhosis by Carbon Tetrachloride following Treatment with Aminoacetonitrile
FIUME, L., & Favilli, G. (1961) · Nature · doi:10.1038/189071a0 · Cited by 39
HIV infection changes glomerular podocyte cytoskeletal composition and results in distinct cellular mechanical properties
Tandon, R., Levental, I., Huang, C., Byfield, F. J., Ziembicki, J. A., Schelling, J. R., Bruggeman, L. A., Sedor, J. R., Janmey, P. A., & Miller, R. T. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00246.2006 · Cited by 38
Mechanical Properties of β-Catenin Revealed by Single-Molecule Experiments
Valbuena, A., Vera, A. M., Oroz, J., Menéndez, M., & Carrión‐Vázquez, M. (2012) · Biophysical Journal · doi:10.1016/j.bpj.2012.07.051 · Cited by 31
The rigidity in fibrin gels as a contributing factor to the dynamics of in vitro vascular cord formation
Stéphanou, A., Meskaoui, G., Vailhé, B., & Tracqui, P. (2006) · Microvascular Research · doi:10.1016/j.mvr.2006.12.002 · Cited by 31
In silico modeling of interstitial lung mechanics: implications for disease development and repair
Suki, B., Majumdar, A., Nugent, M. A., & Bates, J. H. T. (2007) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2007.10.002 · Cited by 30
Renal tubular fluid shear stress facilitates monocyte activation toward inflammatory macrophages
Miravète, M., Dissard, R., Klein, J., Gonzalez, J., Caubet, C., Pécher, C., Pipy, B., Bascands, J., Mercier‐Bonin, M., Schanstra, J. P., et al. (2012) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00409.2011 · Cited by 25
The common bile duct ligation in rat: a relevant in vivo model to study the role of mechanical stress on cell and matrix behaviour
Guyot, C., Combe, C., & Desmoulière, A. (2006) · Histochemistry and Cell Biology · doi:10.1007/s00418-006-0185-2 · Cited by 24
Pressure loading and ethanol exposure differentially modulate rat hepatic stellate cell activation
Okada, Y., Tsuzuki, Y., Hokari, R., Miyazaki, J., Matsuzaki, K., Mataki, N., Komoto, S., Watanabe, C., Kawaguchi, A., Nagao, S., et al. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21329 · Cited by 17

Flagged first, then by citations

Research works printed but not linked: 1

A. Marinkovic, F. Liu, D.J. Tschumperlin, Matrices of physiologic stiffness potently inactivate IPF fibroblasts, Am. J. Respir. Cell Mol. Biol. (in press).

Sorted by citations

Shared and distinct mechanisms of fibrosis
Distler, J. H. W., Györfi, A., Ramanujam, M., Whitfield, M. L., Königshoff, M., & Lafyatis, R. (2019) · Nature Reviews Rheumatology · doi:10.1038/s41584-019-0322-7 · Cited by 674
The extracellular matrix and transforming growth factor-β1: Tale of a strained relationship
Hinz, B. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.05.006 · Cited by 637
Targeting metabolic dysregulation for fibrosis therapy
Zhao, X. L., Kwan, J. Y. Y., Yip, K. W., Liu, P. P., & Liu, F. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0040-5 · Cited by 537
YAP/TAZ Are Mechanoregulators of TGF-β-Smad Signaling and Renal Fibrogenesis
Szeto, S. G., Narimatsu, M., Lu, M., He, X., Sidiqi, A. M., Tolosa, M. F., Chan, L., Freitas, K. D., Bialik, J. F., Majumder, S., et al. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015050499 · Cited by 478
Tuning immunity through tissue mechanotransduction
Du, H., Bartleson, J. M., Butenko, S., Alonso, V., Liu, W. F., Winer, D. A., & Butte, M. J. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00761-w · Cited by 451

See all 384

Authors: Wells, R. G.
Affiliations: University of Pennsylvania (US)
Corresponding author: Wells, Rebecca G.
ORCID: Wells, Rebecca G.
Venue: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Publisher: Elsevier BV
Published: 2013-07
Volume: 1832
Issue: 7
Pages: 884-890
ISSN: 0925-4439 (ISSN-L)
DOI: 10.1016/j.bbadis.2013.02.007
PMC: PMC3641165
OpenAlex: W2063208689
Cited by: 384
References: 110
Citations by year: 2026: 18 · 2025: 33 · 2024: 42 · 2023: 35 · 2022: 45 · 2021: 54 · 2020: 41 · 2019: 30 · 2018: 33 · 2017: 16 · 2016: 18 · 2015: 12 · 2014: 4 · 2013: 3
FWCI: 7.16
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 365 d)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (R01-DK-058123)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
Keywords: tissue mechanics, fibrosis, mechanical forces, myofibroblasts, myofibroblast proliferation, growth factor activation, tissue patterning, therapeutic target
MeSH terms: Fibrosis, Humans, Disease Progression, Myofibroblasts

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Tissue mechanics and fibrosis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks