The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
microRNA-7 Inhibits the Epidermal Growth Factor Receptor and the Akt Pathway and Is Down-regulated in Glioblastoma
Abstract
microRNAs are noncoding RNAs inhibiting expression of numerous target genes, and a few have been shown to act as oncogenes or tumor suppressors. We show that microRNA-7 (miR-7) is a potential tumor suppressor in glioblastoma targeting critical cancer pathways. miR-7 potently suppressed epidermal growth factor receptor expression, and furthermore it independently inhibited the Akt pathway via targeting upstream regulators. miR-7 expression was down-regulated in glioblastoma versus surrounding brain, with a mechanism involving impaired processing. Importantly, transfection with miR-7 decreased viability and invasiveness of primary glioblastoma lines. This study establishes miR-7 as a regulator of major cancer pathways and suggests that it has therapeutic potential for glioblastoma. [Cancer Res 2008;68(10):3566–71]
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miR-7 can directly repress expression of EGFR, which is often amplified and/or over-expressed in gliomas.
“Of note, miR-7 can directly repress expression of EGFR, which is often amplified at the genetic level and/or over-expressed at the protein level in gliomas [19].”
From Reduced Expression of Brain-Enriched microRNAs in Glioblastomas Permits Targeted Regulation of a Cell Death Gene (2011) · cites this paper as [19]
miR-7, miR-124, and miR-128 impair cell growth and proliferation when over-expressed in glioma-derived stem cells.
“miR-7, miR-124, and miR-128 have been reported to impair cell growth and proliferation when over-expressed in glioma-derived stem cells [14], [15], [19], [41].”
From Reduced Expression of Brain-Enriched microRNAs in Glioblastomas Permits Targeted Regulation of a Cell Death Gene (2011) · cites this paper as [19]
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Circular RNA: a new star of noncoding RNAs
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Repression of α-synuclein expression and toxicity by microRNA-7
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miR-195 and miR-483-5p Identified as Predictors of Poor Prognosis in Adrenocortical Cancer
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Metadata
- Authors
- Kefas, B., Godlewski, J., Comeau, L., Li, Y., Abounader, R., Hawkinson, M., Lee, J., Fine, H., Chiocca, E. A., Lawler, S., & Purow, B.
- Affiliations
- 1Division of Neuro-Oncology, Neurology Department, University of Virginia Health System, Charlottesville, Virginia;
- 2Dardinger Laboratory for Neuro-Oncology and Neurosciences, Department of Neurological Surgery, Ohio State University Medical Center, Columbus, Ohio; and
- 3Neuro-Oncology Branch, National Cancer Institute, NIH, Bethesda, Maryland
- Venue
- Cancer Research
- Published
- 2008-05-15
- Volume
- 68
- Issue
- 10
- Pages
- 3566-3572
- ISSN
- 0008-5472
- 1538-7445
- Cited by
- 647
- References
- 1
- Language
- en
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