Changes in glutathione-dependent redox status and mitochondrial energetic strategies are part of the adaptive response during the filamentation process in Candida albicans

Guedouari, H.; Gergondey, R.; Bourdais, A.; Vanparis, O.; Bulteau, A.L.; Camadro, J.M.; Auchère, F.

doi:10.1016/j.bbadis.2014.07.006

Cited by 45Fungal and yeast genetics researchRedox biology and oxidative stressAntifungal resistance and susceptibility

Changes in glutathione-dependent redox status and mitochondrial energetic strategies are part of the adaptive response during the filamentation process in Candida albicans

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Guedouari, H., Gergondey, R., Bourdais, A., Vanparis, O., Bulteau, A.L., Camadro, J.M., Auchère, F.·2014·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI 10.1016/j.bbadis.2014.07.006

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Abstract

Candida albicans is an opportunist pathogen responsible for a large spectrum of infections, from superficial mycosis to systemic diseases called candidiasis. Its ability to grow in various morphological forms, such as unicellular budding yeast, filamentous pseudohyphae and hyphae, contributes to its survival in the diverse microenvironments it encounters in the host. During infection in vivo, C. albicans is faced with high levels of reactive oxygen species (ROS) generated by phagocytes, and the thiol-dependent redox status of the cells reflects their levels of oxidative stress. We investigated the role of glutathione during the transition between the yeast and hyphal forms of the pathogen, in relation to possible changes in mitochondrial bioenergetic pathways. Using various growth media and selective mutations affecting the filamentation process, we showed that C. albicans filamentation was always associated with a depletion of intracellular glutathione levels. Moreover, the induction of hypha formation resulted in general changes in thiol metabolism, including the oxidation of cell surface -SH groups and glutathione excretion. Metabolic adaptation involved tricarboxylic acid (TCA) cycle activation, acceleration of mitochondrial respiration and a redistribution of electron transfer pathways, with an increase in the contribution of the alternative oxidase and rotenone-insensitive dehydrogenase. Changes in redox status and apparent oxidative stress may be necessary to the shift to adaptive metabolic pathways, ensuring normal mitochondrial function and adenosine triphosphate (ATP) levels. The consumption of intracellular glutathione levels during the filamentation process may thus be the price paid by C. albicans for survival in the conditions encountered in the host.

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Isolated mitochondria from C. albicans are more active at 37°C compared to 30°C.
“Indeed, isolated mitochondria from C. albicans were shown to be more active at 37°C compared to 30°C [34].”
From Mitochondrial Activity and Cyr1 Are Key Regulators of Ras1 Activation of C. albicans Virulence Pathways (2015) · cites this paper as [34]
Section 3.8 (page unavailable) reports greater oxygen consumption by isolated mitochondria from filamentous cells measured at 37°C when pyruvate/malate was the electron donor. It also reports decreased consumption with NADH, so the finding does not support a general claim that the mitochondria were more active at 37°C. The comparison also changes cell form and growth conditions, not temperature alone. (LLM, conf=0.88)
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The adaptive metabolic response involves specific protein glutathionylation during the filamentation process in the pathogen Candida albicans
Gergondey, R., Garcia, C., Serre, V., Camadro, J., & Auchère, F. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.04.004 · Cited by 12 · see citing works
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The adaptive response to alternative carbon sources in the pathogen Candida albicans involves a remodeling of thiol- and glutathione-dependent redox status
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An analysis of respiratory function and mitochondrial morphology in Candida albicansPreprint
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Authors: Guedouari, H., Gergondey, R., Bourdais, A., Vanparis, O., Bulteau, A. L., Camadro, J. M., & Auchère, F.
Affiliations: Centre National de la Recherche Scientifique (FR)
Université de Pau et des Pays de l'Adour (FR)
Corresponding author: Auchère, F.
ORCID: Guedouari, H.
Bulteau, A.L.
Camadro, J.M.
Auchère, F.
Venue: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Publisher: Elsevier BV
Published: 2014-09
Volume: 1842
Issue: 9
Pages: 1855-1869
ISSN: 0925-4439 (ISSN-L)
DOI: 10.1016/j.bbadis.2014.07.006
OpenAlex: W2018502270
Cited by: 45
References: 83
Citations by year: 2026: 2 · 2025: 4 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 7 · 2017: 3 · 2016: 7 · 2015: 4 · 2014: 1
FWCI: 2.05
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 365 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: Agence Nationale de la Recherche
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Keywords: Candida albicans, filamentation, hyphal morphogenesis, glutathione depletion, thiol metabolism, oxidative stress, reactive oxygen species, mitochondrial respiration, TCA cycle, alternative oxidase, electron transfer pathway, ATP production, yeast-to-hypha transition
MeSH terms: Adaptation, Physiological, Candida albicans, Candidiasis, Electron Transport, Energy Metabolism, Fungal Proteins, Glutathione, Mitochondria, Mutation, Oxidation-Reduction, Reactive Oxygen Species, Hyphae, Metabolic Networks and Pathways

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Changes in glutathione-dependent redox status and mitochondrial energetic strategies are part of the adaptive response during the filamentation process in Candida albicans

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