Cited by 478Sirtuins and Resveratrol in MedicineMetabolism, Diabetes, and CancerAdipose Tissue and Metabolism

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The molecular targets of resveratrol

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Kulkarni, Sameer S., Cantó, Carles·2015·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI 10.1016/j.bbadis.2014.10.005

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Abstract

Resveratrol has emerged in recent years as a compound conferring strong protection against metabolic, cardiovascular and other age-related complications, including neurodegeneration and cancer. This has generated the notion that resveratrol treatment acts as a calorie-restriction mimetic, based on the many overlapping health benefits observed upon both interventions in diverse organisms, including yeast, worms, flies and rodents. Though studied for over a decade, the molecular mechanisms governing the therapeutic properties of resveratrol still remain elusive. Elucidating how resveratrol exerts its effects would provide not only new insights in its fundamental biological actions but also new avenues for the design and development of more potent drugs to efficiently manage metabolic disorders. In this review we will cover the most recent advances in the field, with special focus on the metabolic actions of resveratrol and the potential role of SIRT1 and AMPK. This article is part of a Special Issue entitled: Resveratrol: Challenges in translating pre-clinical findings to improved patient outcomes.

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1 retracted

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Background
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Items 201–300 of 478

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Background
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Background
Anticancer effects of novel resveratrol analogues on human ovarian cancer cells
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Background
Resveratrol restores the level of key inflammatory cytokines and RANKL/OPG ratio in the femur of rat osteoporosis model
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Background
The Cardiac Lipidome in Models of Cardiovascular Disease
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Background
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Background
Resveratrol Mitigates Oxygen and Glucose Deprivation-Induced Inflammation, NLRP3 Inflammasome, and Oxidative Stress in 3D Neuronal Culture
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Background
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“Additionally, SIRT1 overexpression is reported to attenuate oncogeneinduced replicative senescence via p53 deacetylation (Langley et al., 2002).”
Background
Pinosylvin Inhibits TRPA 1‐Induced Calcium Influx In Vitro and TRPA 1‐Mediated Acute Paw Inflammation In Vivo
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Resveratrol and Myopathy
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BackgroundResultInfluential
Telmisartan Protects a Microglia Cell Line from LPS Injury Beyond AT1 Receptor Blockade or PPARγ Activation
ELKAHLOUN, A. G., Rodríguez, Y., Alaiyed, S., Wenzel, E. D., & Saavedra, J. M. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1300-9 · Cited by 31
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Method
Cellular and Molecular Targets of Resveratrol on Lymphoma and Leukemia Cells
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“It is clear from the literature that the effects of Resveratrol on EGR1 gene transcription are concentration dependent [51], with some reports stating that lower ( 20 μM) concentrations of Resveratrol increase, while higher ( 50 μM) concentrations decrease, EGR1 gene expression [33, 52–54].”
Background
Maternal Resveratrol Treatment Re-Programs and Maternal High-Fat Diet-Induced Retroperitoneal Adiposity in Male Offspring
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Lotocki, V., Yazdani, H., Zhang, Q., Gran, E. R., Nyrko, A., Maysinger, D., & Kakkar, A. K. (2020) · Macromolecular Bioscience · doi:10.1002/mabi.202000305 · Cited by 29
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Ammonia impairs glutamatergic communication in astroglial cells: protective role of resveratrol
Bobermin, L. D., Hansel, G., Scherer, E. B. S., Wyse, Â. T. D. S., Souza, D. O., Quincozes‐Santos, A., & Gonçalves, C. (2015) · Toxicology in Vitro · doi:10.1016/j.tiv.2015.08.008 · Cited by 29
“Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a natural polyphenol found in a variety of dietary sources such as grapes and red wine (Kulkarni and Cantó, 2014; Park and Pezzuto, 2015; Pervaiz, 2003).”
Resveratrol and derivatives for the treatment of atrial fibrillation
Baczkó, I., & Light, P. E. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12843 · Cited by 30
Resveratrol significantly inhibits the occurrence and development of cervical cancer by regulating phospholipid scramblase 1
Zhao, Y., Yuan, X., Li, X., & Zhang, Y. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27335 · Cited by 28
“It is shown to have immunomodulatory, anticancerogenic, and cardioprotective effects.(3) It has been increasingly recognized that resveratrol possesses cancer‐preventive and suppressive activities.”
Background
Critical evaluation of current Alzheimer’s drug discovery (2018–19) & futuristic Alzheimer drug model approach
Dorababu, A. (2019) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2019.103299 · Cited by 28
“Resveratrol, a polyphenol analog has been used in the treatment of AD [223] and it could interfere with the formation of Aβ and improve antioxidant activity [224].”
Background
Resveratrol delay the cataract formation against naphthalene‐induced experimental cataract in the albino rats
Singh, A., & Bodakhe, S. H. (2019) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22420 · Cited by 28
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“AMPK has emerged as amajor regulator linking inflammation, activation of AMPK enhances the phagocytic activity of neutrophils and macrophages [37,38], which is also recognized to have potential beneficial effects on preventing lung dysfunction [39,40].”
Background
Chronic Resveratrol Treatment Reduces the Pro-angiogenic Effect of Human Fibroblast “Senescent-Associated Secretory Phenotype” on Endothelial Colony-Forming Cells: The Role of IL8
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“SIRT1 is involved in energy metabolism, circadian rhythm, and aging and regulates cell physiology during conditions of low energy availability (Nakahata et al., 2008; Kulkarni and Cant ´ o, 2015).”
Potential of resveratrol in mitigating metabolic disturbances induced by ethanol
Szkudelski, T., & Szkudelska, K. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.02.063 · Cited by 26
Targeted cancer treatment using a combination of siRNA-liposomes and resveratrol-electrospun fibers in co-cultures
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miR-22-3p regulates muscle fiber-type conversion through inhibiting AMPK/SIRT1/PGC-1α pathway
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“involved in promoting skeletal muscle fiber-type switching from fast-twitch to slow-twitch.(14,17,26) Besides, PGC-1A also drives the conversion of muscle fiber type from fast-twitch to slow-twitch.”
BackgroundInfluential
Resveratrol and SRT1720 Elicit Differential Effects in Metabolic Organs and Modulate Systemic Parameters Independently of Skeletal Muscle Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α)
Svensson, K., Schnyder, S., Albert, V., Cardel, B., Quagliata, L., Terracciano, L., & Handschin, C. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.590653 · Cited by 26
“Moreover, the main molecular target for RSV in vivo is not well established (44), and recent studies in particular have questioned the effects of RSV in skeletal muscle (45).”
Background
Correction of oxidative stress enhances enzyme replacement therapy in Pompe disease
Tarallo, A., Damiano, C., Strollo, S., Minopoli, N., Indrieri, A., Polishchuk, E., Zappa, F., Nusco, E., Fecarotta, S., Porto, C., et al. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202114434 · Cited by 27
The resveratrol analogue, HS‑1793, enhances the effects of radiation therapy through the induction of anti‑tumor immunity in mammary tumor growth
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“Resveratrol is found in red wine and is contained in various food components that have known biological activities (19).”
Background
Food bioactives, micronutrients, immune function and COVID-19
Lange, K. W., & Nakamura, Y. (2020) · Journal of Food Bioactives · doi:10.31665/jfb.2020.10222 · Cited by 27
“Resveratrol administered at high doses has been found to activate adenosine monophosphate kinase, which is involved in the negative regulation of the NLRP3-inflammasome (Kulkarni and Cantó, 2015).”
Innate immunity and immunotherapy for hemorrhagic shock
Huang, Q., Gao, S., Yao, Y., Wang, Y., Li, J., Chen, J., Chen, G., Zhao, D., & Li, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.918380 · Cited by 26
“Increasing research has confirmed the role of resveratrol, a natural polyphenol widely found in plants and fruits, in improving survival and prolonging lifespan following HS by improving immune function and reducing inflammation (129, 130).”
Background
In Search of Panacea—Review of Recent Studies Concerning Nature-Derived Anticancer Agents
Przystupski, D., Niemczura, M. J., Górska, A., Supplitt, S., Kotowski, K. W., Wawryka, P., Rozborska, P., Woźniak, K., Michel, O., Kiełbik, A., et al. (2019) · Nutrients · doi:10.3390/nu11061426 · Cited by 25
“However resveratrol might be an overall health booster by activating the MPK/SIRT1/PGC-1α pathway and, similarly to serum starvation, downstream activating key stress signaling pathways connected to TyrRS–PARP1–NAD1, which promotes metabolic health and longevity [218,219].”
Background
Resveratrol in Cancer Treatment with a Focus on Breast Cancer
Gilasi, H. R., Hamblin, M. R., Mirzaei, H., Kowsari, H., Davoodvandi, A., Dashti, F., Mirazimi, S. M. A., Bahabadi, Z. R., Aschner, M., & Sahebkar, A. (2022) · Current Molecular Pharmacology · doi:10.2174/1874467215666220616145216 · Cited by 24
Resveratrol, Rapamycin and Metformin as Modulators of Antiviral Pathways
Benedetti, F., Sorrenti, V., Buriani, A., Fortinguerra, S., Scapagnini, G., & Zella, D. (2020) · Viruses · doi:10.3390/v12121458 · Cited by 26
“A large body of literature emphasizes the effect of resveratrol on enzyme activities or its binding to receptors, activating cellular pathways involved in apoptosis [76,77].”
Background
Targeting Cellular Senescence with Senotherapeutics: Development of New Approaches for Skin Care
Thompson, E. L., Pitcher, L. E., Niedernhofer, L. J., & Robbins, P. D. (2021) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000009668 · Cited by 26
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“Resveratrol (RSV, 3,4′,5-trans-trihydroxy-stilbene), a phenolic ompound, has been investigated to explore several types of bioogical activity and is currently used for its antioxidant, anti-cancer nd anti-inflammatory properties [1,2].”
Background
Suppression of Syk activation by resveratrol inhibits MSU crystal-induced inflammation in human monocytes
Chung, Y., Kim, H. Y., Yoon, B. R., Kang, Y. J., & Lee, W. (2019) · Journal of Molecular Medicine · doi:10.1007/s00109-018-01736-y · Cited by 24
Effect of bovine oocyte vitrification with EGTA and post-warming recovery with resveratrol on meiotic spindle, mitochondrial function, reactive oxygen species, and developmental competence
Gutierrez, E. J., Diaz, F., Talbot, S. A., & Bondioli, K. R. (2022) · Theriogenology · doi:10.1016/j.theriogenology.2022.11.006 · Cited by 23
Hydroxystilbenes and methoxystilbenes activate human aryl hydrocarbon receptor and induce CYP1A genes in human hepatoma cells and human hepatocytes
Pastorková, B., Vrzalová, A., Bachleda, P., & Dvořák, Z. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.03.008 · Cited by 24
Usefulness of resveratrol supplementation in decreasing cardiometabolic risk factors comparing subjects with metabolic syndrome and healthy subjects with or without obesity: meta-analysis using multinational, randomised, controlled trials
Sergi, C. M., Chiu, B., Feulefack, J., Shen, F., & Chiu, B. (2020) · Archives of Medical Science - Atherosclerotic Diseases · doi:10.5114/amsad.2020.95884 · Cited by 23
“The molecular mechanisms of protective effects of RES may include the activations of SIRT-1 and AMPK, and inhibitions of cyclooxygenases and NF-kB in the downregulation of pro-inflammatory stimuli, as observed in Met-S and liver tumours [32, 35].”
Background
Resveratrol inhibits Erk1/2‐mediated adhesion of cancer cells via activating PP2A–PTEN signaling network
Chen, X., Hu, X., Li, Y., Zhu, C., Dong, X., Zhang, R., Ma, J., Huang, S., & Chen, L. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27100 · Cited by 22
“Additionally, it has been reported that resveratrol regulates Erk1/2 activity in cancer cells (Kato et al., 2015; Kulkarni & Canto, 2015).”
Background
Resveratrol prevents steroid‐induced osteonecrosis of the femoral head via miR‐146a modulation
Nan, K., Pei, J., Fan, L., Zhang, Y., Zhang, X., Liu, K., Shi, Z., Dang, X., & Wang, K. (2021) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14555 · Cited by 23
Melanoidins, extracted from Chinese traditional vinegar powder, inhibit alcohol-induced inflammation and oxidative stress in macrophages via activation of SIRT1 and SIRT3
Li, Y., Jia, X. T., Tang, N., Huiyuan, T., Xia, R. M., & Cheng, Y. (2021) · Food & Function · doi:10.1039/d1fo00978h · Cited by 24
Effects of fluctuating temperature and food availability on reproduction and lifespan
Schwartz, T. S., Pearson, P. R., Dawson, J. A., Allison, D. B., & Gohlke, J. M. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.06.010 · Cited by 21
“Based on gene expression studies in mammals, genes and molecular pathways that link resveratrol’s effect on circadian rhythm includes CLOCK genes, Sirt1, and Pparα (Kulkarni and Canto 2015; Park and others 2014).”
Background
Influence of controlled release of resveratrol from electrospun fibers in combination with siRNA on leukemia cells
Al-Attar, T., & Madihally, S. V. (2018) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2018.07.043 · Cited by 22
FGF19 alleviates palmitate-induced atrophy in C2C12 cells by inhibiting mitochondrial overload and insulin resistance
Sun, Y., Yang, Z.-X., Ren, F., & Fang, B. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.04.186 · Cited by 22
Chronic arsenic intoxication diagnostic score (CAsIDS)
Dani, S. U., & Walter, G. F. (2017) · Journal of Applied Toxicology · doi:10.1002/jat.3512 · Cited by 25
“The use of exogenous and endogenous antioxidants (Chan & Chan, 2015; Kulkarni & Cantó, 2015) is also a concept that deserves experimental and clinical verification.”
Background
Sirt1 enhances tau exon 10 inclusion and improves spatial memory of Htau mice
Qian, S., Gu, J., Dai, W., Jin, N., Chu, D., Huang, Q., Liu, F., & Qian, W. (2018) · Aging · doi:10.18632/aging.101564 · Cited by 22
“Since Sirt1 is the core effector of resveratrol [26], we analyzed the expression of Sirt1 in resveratrol treated and control mice by western blot developed with anti-Sirt1.”
Background
Resveratrol and related stilbene derivatives induce stress granules with distinct clearance kinetics
Amen, T., Guihur, A., Zelent, C., Ursache, R., Wilting, J., & Kaganovich, D. (2021) · Molecular Biology of the Cell · doi:10.1091/mbc.e21-02-0066 · Cited by 23
“On the other hand, resveratrol is known to have many molecular targets, including those regulating SG formation (e.g., mTOR and PKC; Slater et al., 2003; Pirola and Frojdo, 2008; Kulkarni and Canto, 2015; Park et al., 2016).”
Background
Insights into inflammasome regulation: cellular, molecular, and pathogenic control of inflammasome activation
Challagundla, N., Saha, B., & Agrawal-Rajput, R. (2022) · Immunologic Research · doi:10.1007/s12026-022-09286-9 · Cited by 22
Insights into the Therapeutic and Pharmacological Properties of Resveratrol as a Nutraceutical Antioxidant Polyphenol in Health Promotion and Disease Prevention
Mohammadi, S., Moghadam, M. D., Nasiriasl, M., Akhzari, M., & Barazesh, M. (2024) · Current Clinical Pharmacology · doi:10.2174/0127724328268507231218051058 · Cited by 22
Alteration of cytokine profile following hemorrhagic shock
Lu, S., Aguilar, A., Subramani, K., Poulose, N., Ayub, A., & Raju, R. P. (2016) · Cytokine · doi:10.1016/j.cyto.2016.01.022 · Cited by 21
“Studies have shown that resveratrol activates SIRT1, a sirtuin family of proteins, which deacetylates a number of critical proteins including NF-κb [9, 10].”
Background
Biorelevant physicochemical profiling of (E)- and (Z)-resveratrol determined from isomeric mixtures
Orgován, G., Gonda, I., & Noszál, B. (2016) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2016.09.019 · Cited by 20
Resveratrol and other Stilbenes: Effects on Dysregulated Gene Expression in Cancers and Novel Delivery Systems
Poltronieri, P., Xu, B., & Giovinazzo, G. (2020) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520620666200705220722 · Cited by 21
Roles of AMPK and Its Downstream Signals in Pain Regulation
Wang, S., & Dai, Y. (2021) · Life · doi:10.3390/life11080836 · Cited by 21
“, 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) [6], A769662 [7], resveratrol [8]) and metformin [9]).”
Effect of resveratrol supplementation on biomarkers associated with atherosclerosis in humans
Santana, T. M., Ogawa, L. Y., Rogero, M. M., Barroso, L. P., & de Castro, I. A. (2021) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2021.101491 · Cited by 20
Oxidative stress in rat brain during experimental status epilepticus: effect of antioxidants
Fuchs, M., Viel, C., Lehto, A., Lau, H., & Klein, J. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1233184 · Cited by 20
“Resveratrol is a much-studied compound with anti-in ﬂ ammatory and antioxidative properties (Kulkarni and Cantó, 2015).”
Background
New resveratrol analogs as improved biologically active structures: Design, synthesis and computational modeling
Mlakić, M., Odak, I., Barić, D., Talić, S., Šagud, I., Štefanić, Z., Molčanov, K., Lasić, Z., Kovačević, B., & Škorić, I. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.106965 · Cited by 20
Effect of dietary polyunsaturated fatty acid and antioxidant supplementation on the transcriptional level of genes involved in lipid and energy metabolism in swine
Vitali, M., Dimauro, C., Sirri, R., Zappaterra, M., Zambonelli, P., Manca, E., Sami, D., Fiego, D. P. L., & Davoli, R. (2018) · PLoS ONE · doi:10.1371/journal.pone.0204869 · Cited by 20
Label-free discrimination and quantitative analysis of oxidative stress induced cytotoxicity and potential protection of antioxidants using Raman micro-spectroscopy and machine learning
Zhang, W., Rhodes, J. S., Garg, A., Takemoto, J. Y., Qi, X., Harihar, S., Chang, C. T., Moon, K. R., & Zhou, A. (2020) · Analytica Chimica Acta · doi:10.1016/j.aca.2020.06.074 · Cited by 21
Resveratrol Reduces COMPopathy in Mice Through Activation of Autophagy
Hecht, J. T., Coustry, F., Veerisetty, A. C., Hossain, M. G., & Posey, K. L. (2020) · JBMR Plus · doi:10.1002/jbm4.10456 · Cited by 20
“Resveratrol: Resveratrol (Reserveages Organics liquid resveratrol super berry extract), with known antioxidant/anti-inflammatory properties(20-22), was administered in a dose of 0.”
Method
TRPA1 channels as targets for resveratrol and related stilbenoids
Nalli, M., Ortar, G., Moriello, A. S., Morera, E., Marzo, V. D., & PETROCELLIS, L. D. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.12.065 · Cited by 20
Screening Health-Promoting Compounds for Their Capacity to Induce the Activity of FOXO3
Jiménez, L., da Silva, A. M., Calissi, G., Grenho, I., Monteiro, A. R., Mayoral-Varo, V., Blanco‐Aparicio, C., Pastor, J., Bustos, V., Bracher, F., et al. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab265 · Cited by 19
“Though a variety of molecular targets of resveratrol have been studied, the molecular mechanisms underlying its therapeutic properties still remain elusive (32).”
Background
The Impact of Phytochemicals in Obesity-Related Metabolic Diseases: Focus on Ceramide Metabolism
Kim, E., & Jeon, S. (2023) · Nutrients · doi:10.3390/nu15030703 · Cited by 21
“Evidence shows that resveratrol can exhibit various metabolic benefits by modulating molecular targets such as sirtuin 1 (SIRT1) and AMP-activated protein kinase (AMPK) [93].”
Background
Resveratrol: A Multifaceted Guardian against Anxiety and Stress Disorders—An Overview of Experimental Evidence
Цейликман, В. Э., Tseilikman, O. B., Yegorov, O. N., Brichagina, A. A., Karpenko, M. N., Tseilikman, D., Shatilov, V. A., Zhukov, M. S., & Novak, J. (2024) · Nutrients · doi:10.3390/nu16172856 · Cited by 19
“…activate other mitochondrial-related autophagic pathways, such as the MEK/ERK signaling pathway and the Jun N -terminal kinases-associated B-cell lymphoma-2 (JNK/Bcl-2) pathway, contributing to its neuroprotective effects by increasing autophagy and reducing oxidative stress and apoptosis [71].”
Background
Maternal Polyphenols and Offspring Cardiovascular–Kidney–Metabolic Health
Tain, Y., & Hsu, C. (2024) · Nutrients · doi:10.3390/nu16183168 · Cited by 24
“Several protective actions of polyphenols in hypertension have been revealed, including enhancement of endothelial function, inhibition of oxidative stress, improvement of NO availability, and inhibition of the renin–angiotensin system (RAS) [74,75].”
Background
Cytoprotective Effects of Natural Highly Bio-Available Vegetable Derivatives on Human-Derived Retinal Cells
Munia, I., Gafray, L., Bringer, M.-A., Goldschmidt, P. L., Proukhnitzky, L., Jacquemot, N., Cercy, C., Othman, K. R. B., Errera, M. H., & Ranchon‐Cole, I. (2020) · Nutrients · doi:10.3390/nu12030879 · Cited by 19
“Protective effects have been reported for several ocular diseases, such as light/oxygen-induced retinopathy [23,24], endotoxin-induced uveitis [20], and diabetic retinopathy [24,25].”
The role and current research status of resveratrol in the treatment of osteoarthritis and its mechanisms: a narrative review
Zou, X., Xu, H., & Qian, W. (2024) · Drug Metabolism Reviews · doi:10.1080/03602532.2024.2402751 · Cited by 18
“…is tasteless, poorly soluble in water, readily soluble in organic solvents, and has a melting point between 253 °c and 255 °c (Francioso et al. 2014; Kulkarni and cantó 2015). when exposed to 365 nm ultraviolet light, resveratrol exhibits fluorescence. it also undergoes color reactions with…”
Elucidating the Inhibitory Effect of Resveratrol and Its Structural Analogs on Selected Nucleotide-Related Enzymes
Wu, Y., Hsieh, T., WU, J. M., Wang, X., Christopher, J. S., Pham, A. H., Swaby, J. D.-L., Lou, L., & Xie, Z. (2020) · Biomolecules · doi:10.3390/biom10091223 · Cited by 18
“The distinct functions of resveratrol are in part attributed to its regulatory activity on signaling pathways and its impacts on molecular targets [10].”
Background
Next generation sequencing of RNA reveals novel targets of resveratrol with possible implications for Canavan disease
Dembić, M., Andersen, H. S., Bastin, J., Doktor, T. K., Corydon, T. J., Sass, J. O., Costa, A. L., Djouadi, F., & Andresen, B. S. (2018) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2018.10.004 · Cited by 18
“Many of the effects of RSV on the metabolism are thus mediated through the stimulation of the AMPK/SIRT1/PGC-1α axis, resulting in the transcriptional activation of genetic programs involved in mitochondrial biogenesis and oxidative metabolism [9, 34, 35, 40].”
BackgroundInfluential
Clofarabine‑phytochemical combination exposures in CML cells inhibit DNA methylation machinery, upregulate tumor suppressor genes and promote caspase‑dependent apoptosis
Kaufman‐Szymczyk, A., Majda, K., Szuławska‐Mroczek, A., Fabianowska‐Majewska, K., & Lubecka, K. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10619 · Cited by 17
“other possible molecular targets of RSV are AMPK and SIRT1, mToR, NF‐kB, PI3K/AKT, MAPK signaling pathways (23).”
Background
COVID-19: A Challenge to Physiology of Aging
Golubev, A. G. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.584248 · Cited by 18
Novel Insights on Dietary Polyphenols for Prevention in Early-Life Origins of Hypertension: A Review Focusing on Preclinical Animal Models
Tain, Y., & Hsu, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126620 · Cited by 18
“Conversely, inhibition of the classic RAAS or activation of the nonclassic RAAS can prevent the development of hypertension [112].”
BackgroundInfluential
N-Monosubstituted Methoxy-oligo(ethylene glycol) Carbamate Ester Prodrugs of Resveratrol
Mattarei, A., Azzolini, M., Zoratti, M., Biasutto, L., & Paradisi, C. (2015) · Molecules · doi:10.3390/molecules200916085 · Cited by 17
“, [25–30]).”
Advanced iron-overload cardiomyopathy in a genetic murine model is rescued by resveratrol therapy
Das, S. K., Zhabyeyev, P., Basu, R., Patel, V. B., Dyck, J. R. B., Kassiri, Z., & Oudit, G. Y. (2017) · Bioscience Reports · doi:10.1042/bsr20171302 · Cited by 18
Maternal Supplementation of Probiotics, Prebiotics or Postbiotics to Prevent Offspring Metabolic Syndrome: The Gap between Preclinical Results and Clinical Translation
Huang, Y.-H., Tain, Y., & Hsu, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231710173 · Cited by 18
Resveratrol–Maltol and Resveratrol–Thiophene Hybrids as Cholinesterase Inhibitors and Antioxidants: Synthesis, Biometal Chelating Capability and Crystal Structure
Mlakić, M., Fodor, L., Odak, I., Horváth, O., Štefiček, M. J. L., Barić, D., Milašinović, V., Molčanov, K., Marinić, Ž., Lasić, Z., et al. (2022) · Molecules · doi:10.3390/molecules27196379 · Cited by 15
“The same configurational effect was also observed for cis- and trans-resveratrol [29,30], indicating that the structure–activity relationship must be considered in the determination of biological activity.”
Background
Resveratrol promotes liver cell survival in mice liver-induced ischemia-reperfusion through unfolded protein response: a possible approach in liver transplantation
Totonchi, H., Mokarram, P., Karima, S., Rezaei, R., Dastghaib, S., Koohpeyma, F., Noori, S., & Azarpira, N. (2022) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-022-00611-4 · Cited by 16
Hot-Water Extracts from Roots of Vitis thunbergii var. taiwaniana and Identified ε-Viniferin Improve Obesity in High-Fat Diet-Induced Mice
Lu, Y., Lin, S.-Y., Fang, S.-U., Hsieh, Y.-Y., Chen, C., Wen, C.-L., Chang, C., & Hou, W. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b00327 · Cited by 16
Resveratrol as an inductor of autophagy: is there a unique pathway of activation?
Aguilera, P., & Pineda-Ramírez, N. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.286959 · Cited by 16
“Important ly, autophagy regulat ion is responsible for some of the beneficial effects of RSV in different pathologies (Kulkarni and Cantó, 2015; Pineda-Ramirez et al., 2018).”
BackgroundInfluential
Natural Antioxidant Application on Fat Accumulation: Preclinical Evidence
Roy, P., Tomassoni, D., Traini, E., Martinelli, I., Bonaventura, M. V. M. D., Cifani, C., Amenta, F., & Tayebati, S. K. (2021) · Antioxidants · doi:10.3390/antiox10060858 · Cited by 18
“Resveratrol (trans-3, 4′, 5-trihydroxystilbene, RSV, Figure 3) is a small polyphenol that has been largely studied for decades in a wide spectrum of therapeutic research areas [60,61].”
Background
Resveratrol binding to human complement fragment 5a (hC5a) may modulate the C5aR signaling axes
Mishra, R., Das, A., & Rana, S. (2020) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2020.1738958 · Cited by 16
Resveratrol impacts on aquatic animals: a review
Kari, Z. A., Téllez‐Isaías, G., Khoo, M. I., Wee, W., Kabir, M. A., Cheadoloh, R., & Wei, L. S. (2024) · Fish Physiology and Biochemistry · doi:10.1007/s10695-024-01319-4 · Cited by 15
“Resveratrol can also be found in red wine (Bhat et al. 2001) and sold commercially as white powder derived from methanol extraction (Kulkarni and Cantó 2015).”
Synthesis of new heterocyclic resveratrol analogues in milli- and microreactors: intensification of the Wittig reaction
Mlakić, M., Rajič, L., Ljubić, A., Vušak, V., Zelić, B., Gojun, M., Odak, I., Čule, I., Šagud, I., Šalić, A., et al. (2022) · Journal of Flow Chemistry · doi:10.1007/s41981-022-00239-9 · Cited by 15
Embryoid body test with morphological and molecular endpoints implicates potential developmental toxicity of trans-resveratrol
Kim, I. Q., & Marikawa, Y. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.07.006 · Cited by 16
“The molecular targets of resveratrol that are responsible for its various beneficial effects are still elusive, although several candidate molecules have been proposed (Kulkarni and Cantó, 2015).”
Influential
Resveratrol inhibited LPS induced transcription of immune genes and secretion of eicosanoids in Atlantic salmon (Salmo salar), comparing mono-, co- and a novel triple cell culture model of head kidney leukocytes, liver cells and visceral adipocyte tissue
Holen, E., Araujo, P. W., Xie, S., Søfteland, L., & Espe, M. (2019) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2019.108560 · Cited by 15
Unexpected beta-amyloid production by middle doses of resveratrol through stabilization of APP protein and AMPK-mediated inhibition of trypsin-like proteasome activity in a cell model of Alzheimer's disease
Jang, B.-G., Lee, J., Choi, B., Koh, Y. H., & Kim, M.-J. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112185 · Cited by 15

Authors: Kulkarni, S. S., & Cantó, C.
Corresponding author: Cantó, Carles
ORCID: Cantó, Carles
Venue: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Publisher: Elsevier BV
Published: 2015-06
Volume: 1852
Issue: 6
Pages: 1114-1123
ISSN: 0925-4439 (ISSN-L)
DOI: 10.1016/j.bbadis.2014.10.005
OpenAlex: W2053510668
Cited by: 477
References: 135
Citations by year: 2026: 15 · 2025: 27 · 2024: 32 · 2023: 23 · 2022: 50 · 2021: 40 · 2020: 56 · 2019: 63 · 2018: 55 · 2017: 39 · 2016: 38 · 2015: 37
FWCI: 3.20
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 366 d)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: resveratrol, molecular targets, caloric restriction mimetics, SIRT1, AMPK, metabolic disorders, neuroprotection, cancer, cardioprotection, aging, drug development
MeSH terms: Resveratrol, Animals, Humans, Mitochondria, Stilbenes, Signal Transduction, Transcriptional Activation, NF-kappa B, Sirtuins, AMP-Activated Protein Kinases

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The molecular targets of resveratrol

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