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The molecular targets of resveratrol
Open accessAbstract
Resveratrol has emerged in recent years as a compound conferring strong protection against metabolic, cardiovascular and other age-related complications, including neurodegeneration and cancer. This has generated the notion that resveratrol treatment acts as a calorie-restriction mimetic, based on the many overlapping health benefits observed upon both interventions in diverse organisms, including yeast, worms, flies and rodents. Though studied for over a decade, the molecular mechanisms governing the therapeutic properties of resveratrol still remain elusive. Elucidating how resveratrol exerts its effects would provide not only new insights in its fundamental biological actions but also new avenues for the design and development of more potent drugs to efficiently manage metabolic disorders. In this review we will cover the most recent advances in the field, with special focus on the metabolic actions of resveratrol and the potential role of SIRT1 and AMPK. This article is part of a Special Issue entitled: Resveratrol: Challenges in translating pre-clinical findings to improved patient outcomes.
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“Moreover, RSV is a well-known activator of SIRT1 and our previous study also found that RSV improved hepatic steatosis partially by inducing autophagy via the SIRT1 signaling pathway in vitro and in vivo (36–38).”
In the citing paper
“Moreover, RSV is a well-known activator of SIRT1 and our previous study also found that RSV improved hepatic steatosis partially by inducing autophagy via the SIRT1 signaling pathway in vitro and in vivo (36–38).”
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“However, despite producing an ex vivo increase in mitochondrial respiration that may be dependent of its ability to increase AMPK activity (Kulkarni and Cantó, 2015)”
From Mitochondrial (Dys)function and Insulin Resistance: From Pathophysiological Molecular Mechanisms to the Impact of Diet (2019) · cites this paper as Kulkarni and Cantó, 2015
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1 retracted
Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats
Braidy, N., Guillemin, G. J., Mansour, H., Chan-Ling, T., Poljak, A., & Grant, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019194 · Cited by 594 · cited 1×
“tent declines to the levels thatmight compromise SIRT1 activity [37,38].”
BackgroundRetractedAMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227 · cited 1×
“subsequent induction of autophagy [128,129].”
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935
AMPK: a nutrient and energy sensor that maintains energy homeostasis
Hardie, D. G., Ross, F. A., & Hawley, S. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3311 · Cited by 4,602 · cited 2×
“Upon activation, AMPK diminishes the rates ofmost energy consumingmetabolic programs such as lipid and protein biosynthesis, and triggers energy producing biochemical processes such as lipid oxidation and glycolysis to counter energy depletion [65].”
BackgroundResveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057 · cited 9×
“Accordingly, Rsv treatment led to large increases in mitochondrial content in key metabolic tissues, such as skeletal muscle or brown adipose tissue [44].”
BackgroundInfluentialTherapeutic potential of resveratrol: the in vivo evidence
Baur, J. A., & Sinclair, D. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2060 · Cited by 3,958
AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A., Vasquez, D. S., Turk, B. E., & Shaw, R. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.003 · Cited by 3,849 · cited 1×
“AMPK activation can trigger the phosphorylation of Raptor, a component of the mTORC1 complex, thereby repressing mTORC1 activity [124].”
BackgroundSmall molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796 · cited 3×
“its associated health benefits, the Sinclair lab used an in vitro screening strategy with a fluorescent labeled substrate aimed to identify small molecule activators of SIRT1 [26].”
BackgroundWine, alcohol, platelets, and the French paradox for coronary heart disease
Renaud, S., & de Lorgeril, M. (1992) · The Lancet · doi:10.1016/0140-6736(92)91277-f · Cited by 3,700
Cited by
Sorted by citations
The therapeutic potential of resveratrol: a review of clinical trials
Berman, A. Y., Motechin, R. A., Wiesenfeld, M. Y., & Holz, M. K. (2017) · npj Precision Oncology · doi:10.1038/s41698-017-0038-6 · Cited by 931
Chen, M.-L., Yi, L., Zhang, Y., Zhou, X., Ran, L., Yang, J., Zhu, J.-D., Zhang, Q.-Y., & Mi, M.-T. (2016) · mBio · doi:10.1128/mbio.02210-15 · Cited by 754
A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease
Turner, R. S., Thomas, R. G., Craft, S., van Dyck, C. H., Mintzer, J. E., Reynolds, B., Brewer, J. B., Rissman, R. A., Raman, R., Aisen, P. S. S., et al. (2015) · Neurology · doi:10.1212/wnl.0000000000002035 · Cited by 769
“Resveratrol has many targets, with some engaged at uM concentrations.(4) These findings suggest that a central molecular target may be engaged at nM concentrations.”
InfluentialTargeting cellular senescence with senotherapeutics: senolytics and senomorphics
Zhang, L. J., Pitcher, L. E., Prahalad, V., Niedernhofer, L. J., & Robbins, P. D. (2022) · FEBS Journal · doi:10.1111/febs.16350 · Cited by 674
Resveratrol (RV): A pharmacological review and call for further research
Zhang, L., Li, C., Kakar, M. U., Khan, M. S., Wu, P.-F., Amir, R. M., Dai, D., Naveed, M., Li, Q., Saeed, M., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112164 · Cited by 580
Health benefits of resveratrol: Evidence from clinical studies
Singh, A. P., Singh, R., Verma, S. S., Rai, V., Kaschula, C. H., Maiti, P., & Gupta, S. C. (2019) · Medicinal Research Reviews · doi:10.1002/med.21565 · Cited by 523
“Both clinical and preclinical data has shown that resveratrol has many targets and that it can modulate numerous signaling molecules including Wnt, nuclear factor‐κB (NF‐κB), cytokines, caspases, Notch, matrix metalloproteinases (MMPs), 5′‐AMP‐activated protein kinase (AMPK), intercellular adhesion molecule (ICAM), va…”
BackgroundIschemia/Reperfusion Injury Revisited: An Overview of the Latest Pharmacological Strategies
Soares, R. O. D. S., Losada, D. M., Jordani, M. C., Évora, P. R. B., & Castro-e-Silva, O. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205034 · Cited by 427
Sergi, D., Naumovski, N., Heilbronn, L. K., Abeywardena, M., O’Callaghan, N., Lionetti, L., & Luscombe-Marsh, N. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00532 · Cited by 347
Targeting mitochondrial metabolism for precision medicine in cancer
Sainero‐Alcolado, L., Liaño-Pons, J., Ruiz-Pérez, M. V., & Arsenian‐Henriksson, M. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-01022-y · Cited by 338
“Complex III Resveratrol Lack of specificity [141]”
Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity
Seals, D. R., Justice, J. N., & LaRocca, T. J. (2015) · The Journal of Physiology · doi:10.1113/jphysiol.2014.282665 · Cited by 334
“…through a variety of SIRT-1-dependent or -independent mechanisms, including antioxidant, anti-inflammatory and/or nitric oxide-enhancing actions, as well as cytoprotective effects mediated via stimulation of cellular stress resistance pathways (Knutson & Leeuwenburgh, 2008; Kulkarni & Canto, 2014).”
BackgroundResveratrol and Its Human Metabolites—Effects on Metabolic Health and Obesity
Springer, M., & Moco, S. (2019) · Nutrients · doi:10.3390/nu11010143 · Cited by 293
“Activation of Akt reduces the activity of AMPK through direct phosphorylation [79].”
BackgroundInfluentialTreatment Options for Motor and Non-Motor Symptoms of Parkinson’s Disease
Church, F. (2021) · Biomolecules · doi:10.3390/biom11040612 · Cited by 325
“Trans-resveratrol is a potent antioxidant capable of reducing free radicals in the environment of the brain [141,142].”
BackgroundResveratrol for Alzheimer's disease
Sawda, C. N., Moussa, C., & Turner, R. S. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13431 · Cited by 287
Role of AMPK mediated pathways in autophagy and aging
Ge, Y., Zhou, M., Chen, C., Wu, X., & Wang, X. (2021) · Biochimie · doi:10.1016/j.biochi.2021.11.008 · Cited by 262
Zheng, Z., Bian, Y., Zhang, Y., Ren, G., & Li, G. (2020) · Cell Cycle · doi:10.1080/15384101.2020.1743911 · Cited by 248
Resveratrol supplementation: Where are we now and where should we go?
Novelle, M. G., Wahl, D., Diéguez, C., Bernier, M., & de Cabo, R. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.01.002 · Cited by 254
“The identification and validation of the cellular targets of RSV is key for understanding its health benefits (for a recent review about this topic see (Kulkarni and Canto, 2014)).”
Long non-coding RNAs are emerging targets of phytochemicals for cancer and other chronic diseases
Mishra, S., Verma, S. S., Rai, V., Awasthee, N., Chava, S. P., Hui, K. M., Kumar, A. P., Challagundla, K. B., Sethi, G., & Gupta, S. C. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03053-0 · Cited by 226
Redox Signaling and Advanced Glycation Endproducts (AGEs) in Diet-Related Diseases
Cepas, V., Collino, M., Mayo, J. C., & Sainz, R. M. (2020) · Antioxidants · doi:10.3390/antiox9020142 · Cited by 216
de Oliveira, M. R., Nabavi, S. F., Manayi, A., Daglia, M., Hajheydari, Z., & Nabavi, S. M. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.01.017 · Cited by 192
Therapeutic Versatility of Resveratrol Derivatives
Nawaz, W., Zhou, Z.-Q., Deng, S., Ma, X., Ma, X., Li, C., & Shu, X. H. (2017) · Nutrients · doi:10.3390/nu9111188 · Cited by 180
“The chemical structure of resveratrol is composed of two aromatic rings allied by a methylene bridge, and presents in both trans- and cis-isomeric forms naturally (Figure 1), however, the majority of the recorded medical advantages are attributed to trans-resveratrol but not its cis-form, so the structure activity rel…”
BackgroundUnravelling the mechanisms regulating muscle mitochondrial biogenesis
Hood, D. A., Tryon, L. D., Carter, H. N., Kim, Y., & Chen, C. C. W. (2016) · Biochemical Journal · doi:10.1042/bcj20160009 · Cited by 159
Epigenetic Regulatory Mechanisms Induced by Resveratrol
Fernandes, G., Silva, G., Pavan, A. R., Chiba, D. E., Chin, C. M., & dos Santos, J. L. (2017) · Nutrients · doi:10.3390/nu9111201 · Cited by 166
Kerkhofs, M., Bittremieux, M., Morciano, G., Giorgi, C., Pinton, P., Parys, J. B., & Bultynck, G. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0179-0 · Cited by 165
Buhrmann, C., Shayan, P., Kraehe, P., Popper, B., Goel, A., & Shakibaei, M. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.08.105 · Cited by 149
“Ultrathin sections were contrasted with 2% uranyl acetate/lead citrate and examined under FEI Tecnai12 transmission electron microscope operated at 120 kV. Digital images were taken with an OSIS Megaview III CCD camera or Carl Zeiss Microscopy TEM 902, operated at 80kV, images were digitized using a slow-scan charge-c…”
InfluentialRole of Hedgehog Signaling in Breast Cancer: Pathogenesis and Therapeutics
Galdo, N. A. R., Montero, Á. L., & Wertheimer, E. V. (2019) · Cells · doi:10.3390/cells8040375 · Cited by 145
An instrumented phantom system for analog computation of treatment plans.
Alderson, S. W., Lanzl, L. H., ROLLINS, M., & SPIRA, J. (1962) · PubMed · Cited by 144
Strategies to Improve Resveratrol Systemic and Topical Bioavailability: An Update
Intagliata, S., Modica, M. N., Santagati, L. M., & Montenegro, L. (2019) · Antioxidants · doi:10.3390/antiox8080244 · Cited by 144
“Conversely, RSV activates various biochemical factors such as adenosine monophosphate (AMP)-activated protein kinase (AMPK) [29–33] and the tumor suppressor p53 [34,35], and also induces nitric oxide synthase (NOS) [36].”
BackgroundEffects of Resveratrol against Lung Cancer: In Vitro and In Vivo Studies
Yousef, M., Vlachogiannis, I. A., & Tsiani, E. (2017) · Nutrients · doi:10.3390/nu9111231 · Cited by 138
“Furthermore, RSV has been established as an activator of SIRT1, a histone deacetylase that plays important role in many fundamental cellular processes [64,65].”
BackgroundThe Effects of Resveratrol in the Treatment of Metabolic Syndrome
Hou, C., Tain, Y., Yu, H., & Huang, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030535 · Cited by 149
“AMPK has emerged as a key nutrient sensor, with the ability to regulate whole-body metabolism [24], coordinating many metabolic reactions [25] to maintain metabolic homeostasis and induce the inflammatory response [26].”
BackgroundInhibition of NF-κB Signaling Pathway by Resveratrol Improves Spinal Cord Injury
Xu, L. K., Botchway, B. O. A., Zhang, S., Zhou, J., & Liu, X. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00690 · Cited by 139
“…(Lai et al., 2017), antiapoptosis (Huang et al., 2014), anti-nociception (Pan et al., 2016), anti-depression (Finnell et al., 2016), anti-cancer activities (Chin et al., 2015; Kumar et al., 2015), neuronal protection (Nalagoni and Karnati, 2016) and regulation of metabolism (Luo et al., 2017).”
The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials
Izzo, C., Annunziata, M., Melara, G., Sciorio, R., Dallio, M., Masarone, M., Federico, A., & Persico, M. (2021) · Nutrients · doi:10.3390/nu13030933 · Cited by 138
“500 mg od for six months AMPK/SIRT1/Nrf2, ERK/p38, MAPK and PTEN/Akt signaling pathways, inducing autophagy through an mTOR-dependent or TFEB-dependent pathway Synthesis of antioxidant molecules and the expression of related genes involved in the biogenesis of mitochondrial energy [36,37]”
BackgroundSirtuins and FoxOs in osteoporosis and osteoarthritis
Almeida, M., & Porter, R. M. (2019) · Bone · doi:10.1016/j.bone.2019.01.018 · Cited by 131
Valenti, D., Lidia de, B. A. R. I., Rasmo, D. D., Signorile, A., Henrion‐Caude, A., Contestabile, A., & Vacca, R. A. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.03.003 · Cited by 133
Natural Compounds as Regulators of NLRP3 Inflammasome-Mediated IL-1 β Production
Tőzsér, J., & Benkő, S. (2016) · Mediators of Inflammation · doi:10.1155/2016/5460302 · Cited by 129
“At high doses, resveratrol has been shown to activate AMPK; which is involved in the negative regulation of the NLRP3-inflammasome [113].”
BackgroundInfluentialTargeting senescent cells: approaches, opportunities, challenges
von Kobbe, C. (2019) · Aging · doi:10.18632/aging.102557 · Cited by 132
Patra, S., Mishra, S. R., Behera, B. P., Mahapatra, K. K., Panigrahi, D. P., Bhol, C. S., Praharaj, P. P., Sethi, G., Patra, S. K., & Bhutia, S. K. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.05.008 · Cited by 129
Zhu, C. W., Grossman, H. T., Neugroschl, J. A., Parker, S., Burden, A. R., Luo, X., & Sano, M. C. (2018) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2018.09.009 · Cited by 125
“Finally, neuroprotection has been proposed based on reducing cell death via activation of sirtuins (including SIRT1), resulting in protection against peptide aggregate [9].”
BackgroundZhang, E., Guo, Q., Gao, H., Xu, R., Teng, S., & Wu, Y. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143814 · Cited by 125
Wan, D., Zhou, Y., Wang, K., Hou, Y., Hou, R., & Ye, X. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.02.011 · Cited by 128
Vega-García, C. C., Reyes‐Castro, L. A., Rodríguez-González, G. L., Bautista, C. J., Vázquez‐Martínez, M., Larrea, F., Chamorro‐Cevallos, G. A., Nathanielsz, P. W., & Zambrano, E. (2015) · The Journal of Physiology · doi:10.1113/jp271543 · Cited by 123
“Using transgenic mouse models, it was shown that AMPK and SIRT1 are key mediators of the metabolic health actions driven by resveratrol (Kulkarni & Canto, 2015).”
BackgroundSaunier, E. F., Antonio, S., Regazzetti, A., Auzeil, N., Laprévôte, O., Shay, J. W., Coumoul, X., Barouki, R., Benelli, C., Laurence Therese, H. U. C., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-07006-0 · Cited by 121
Lysosomes: Signaling Hubs for Metabolic Sensing and Longevity
Savini, M., Zhao, Q., & Wang, M. C. (2019) · Trends in Cell Biology · doi:10.1016/j.tcb.2019.08.008 · Cited by 116
“and mice [91,113,114], which is at least partially attributed to lysosomal activation of AMPK [115,116].”
BackgroundThe road ahead for health and lifespan interventions
Gonzalez-Freire, M., Diaz-Ruiz, A., Hauser, D., Martinez-Romero, J., Ferrucci, L., Bernier, M., & de Cabo, R. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101037 · Cited by 118
“The molecular mechanisms of action of resveratrol remain elusive; however, AMPK and the NAD-dependent deacetylase SIRT1 have been proposed to mediate the anti-aging response and disease protection of resveratrol, reminiscent of CR signaling (Baur et al., 2006; Park et al., 2012; Kulkarni and Canto, 2015).”
BackgroundDemaré, S., Kothari, A., Calcutt, N. A., & Fernyhough, P. (2020) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2021.1847645 · Cited by 117
Resveratrol promotes hUC-MSCs engraftment and neural repair in a mouse model of Alzheimer’s disease
Wang, X., Ma, S., Yang, B., Huang, T., Meng, N., Xu, L., Xing, Q., Zhang, Y.-T. Y., Zhang, K., Li, Q., et al. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.10.032 · Cited by 116
“Studies have shown that resveratrol can mimic certain aspects of caloric restriction and it exerts a wide range of biological effects that can protect against age-related diseases including cardiovascular and neurodegenerative diseases [6].”
Early-Life Origins of Metabolic Syndrome: Mechanisms and Preventive Aspects
Hsu, C., Hou, C., Hsu, W.-H., & Tain, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111872 · Cited by 116
Lejri, I., Agapouda, A., Grimm, A., & Eckert, A. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/9695412 · Cited by 109
“In fact, the essential neuroprotective effect of resveratrol is based on the action of SIRT1 and AMPK and on the phosphorylation/acetylation status of PGC-1α that consequently activates the mitochondrial biogenesis leading to the improvement of the mitochondrial activity [103] (Figure 3).”
BackgroundSirtuins, resveratrol and the intertwining cellular pathways connecting them
Ungurianu, A., Zanfirescu, A., & Margina, D. M. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101936 · Cited by 114
The “Yin and Yang” of Natural Compounds in Anticancer Therapy of Triple-Negative Breast Cancers
Varghese, E., Samuel, S. M., Abotaleb, M., Cheema, S., Mamtani, R., & Büsselberg, D. (2018) · Cancers · doi:10.3390/cancers10100346 · Cited by 114
“Resveratrol exerts its anticancer effects in different cancers by reducing ROS, COX, and cytokine expression (antioxidant and anti-inflammatory effect); by decreasing the activity of transcription factors such as NF-κB and AP-1 (anti-proliferative and anti-survival effect); by decreasing cyclins and CDKs (anti-prolife…”
BackgroundResveratrol in Cancer Patients: From Bench to Bedside
Berretta, M., Bignucolo, A., Francia, R. D., Comello, F., Facchini, G., Ceccarelli, M., Iaffaioli, R. V., Quagliariello, V., & Maurea, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082945 · Cited by 107
Iakovou, E., & Kourti, M. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.827900 · Cited by 119
Polyphenol compounds and PKC signaling
Das, J., Ramani, R., & Suraju, M. O. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.06.022 · Cited by 109
Significance of Resveratrol in Clinical Management of Chronic Diseases
Wahab, A., Gao, K., Jia, C., Zhang, F., Tian, G., Murtaza, G., & Chen, J. (2017) · Molecules · doi:10.3390/molecules22081329 · Cited by 113
“Health outcomes of RSV could be better understood if its cellular targets were identified and validated [135].”
BackgroundAntidiabetic Effects of Resveratrol: The Way Forward in Its Clinical Utility
Oyenihi, O. R., Oyenihi, A. B., Adeyanju, A. A., & Oguntibeju, O. O. (2016) · Journal of Diabetes Research · doi:10.1155/2016/9737483 · Cited by 109
“The alleviation of diabetic complications upon the activation of AMPK by RSV has been confirmed in animal models [15, 19, 59, 89].”
BackgroundInfluentialAnti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions
Kuršvietienė, L., Kopustinskienė, D. M., Stanevičienė, I., Mongirdienė, A., Kubová, K., Masteiková, R., & Bernatonienė, J. (2023) · Antioxidants · doi:10.3390/antiox12122056 · Cited by 102
“Resveratrol exerts anti-cancer activity through various molecular mechanisms, including the PI3K/Akt, STAT3/5, MAPK, AMPK/mTOR, SIRT1/NF-κ B, and PGC-1 α signaling pathways [46–48].”
BackgroundCHUNG, S. S., Dutta, P., Austin, D., Wang, P., Awad, A., & Vadgama, J. V. (2018) · Oncotarget · doi:10.18632/oncotarget.25993 · Cited by 102
“Resveratrol interacts with various molecular targets associated with inflammation and immunity [13].”
BackgroundLi, W., Ma, X., Li, N., Liu, H., Dong, Q., Zhang, J., Yang, C., Liu, Y., Liang, Q., Zhang, S., et al. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2016.11.002 · Cited by 98
Hühn, S., Beyer, F., Zhang, R., Lampe, L., Grothe, J., Kratzsch, J., Willenberg, A., Breitfeld, J., Kovacs, P. L., Stümvoll, M., et al. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.03.023 · Cited by 99
“In vitro as well as in vivo rodent and primate studies provided evidence for antioxidative, anti-inflammatory and calorie-restriction mimicking characteristics of resveratrol (Baur, 2010; Bastianetto et al., 2015; Kulkarni and Canto, 2015).”
BackgroundSUGIYAMA, M., Kawahara‐Miki, R., KAWANA, H., Shirasuna, K., Kuwayama, T., & Iwata, H. (2015) · Journal of Reproduction and Development · doi:10.1262/jrd.2015-001 · Cited by 94
Neuroprotective effects of plant polysaccharides: A review of the mechanisms
Gao, Q., Fu, X., Zhang, R., Wang, Z., & Guo, M. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.08.075 · Cited by 93
“By enhancing the degradation of IκB, NF-κB can then migrate into the nuclear compartment, where these transcription factors act as heterodimers that bind the DNA promoters of many inflammatory and immune response genes [28,29].”
BackgroundCurrent nutritional and pharmacological anti-aging interventions
Ros, M., & Carrascosa, J. M. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.165612 · Cited by 86
Research Progress on Alzheimer's Disease and Resveratrol
Yan, Y., Yang, H., Xie, Y., Ding, Y., Kong, D., & Yu, H. (2020) · Neurochemical Research · doi:10.1007/s11064-020-03007-0 · Cited by 93
Ramakrishnan, P., Loh, W. M., Gopinath, S. C. B., Bonam, S. R., Fareez, I. M., Guad, R. M., Sim, M. S., & Wu, Y. S. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.11.008 · Cited by 90
Moderate Wine Consumption and Health: A Narrative Review
Hrelia, S., Renzo, L. D., Bavaresco, L., Bernardi, E., Malaguti, M., & Giacosa, A. (2022) · Nutrients · doi:10.3390/nu15010175 · Cited by 106
Resveratrol regulates muscle fiber type conversion via miR-22-3p and AMPK/SIRT1/PGC-1α pathway
Wen, W., Chen, X., Huang, Z., Chen, D., Chen, H., Luo, Y., He, J., Zheng, P., Yu, J., & Yu, B. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.108297 · Cited by 88
Gupta, P., Bala, M., Gupta, S. K., Dua, A., Dabur, R., Injeti, E. R., & Mittal, A. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.09.029 · Cited by 92
Nutrition and longevity—From mechanisms to uncertainties
Ekmekcioglu, C. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1676698 · Cited by 87
Resveratrol distinctively modulates the inflammatory profiles of immune and endothelial cells
Schwager, J., Richard, N., Widmer, F., & Raederstorff, D. (2017) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-017-1823-z · Cited by 90
“Not unexpectedly, many controversies have grown [6], since the effects of RES were pleiotropic and relied on diverse mode of actions in different cells, tissue, metabolic states and species [21].”
BackgroundResveratrol’s Anti-Cancer Effects through the Modulation of Tumor Glucose Metabolism
Brockmueller, A., Sameri, S., Líšková, A., Zhai, K., Varghese, E., Samuel, S. M., Büsselberg, D., Kubatka, P., & Shakibaei, M. (2021) · Cancers · doi:10.3390/cancers13020188 · Cited by 89
Resveratrol As A Natural Regulator Of Autophagy For Prevention And Treatment Of Cancer
Tian, Y., Song, W., Li, D., Cai, L., & Zhao, Y. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s213043 · Cited by 88
“eral cancers by targeting some molecules that play important roles in tumourigenesis.(3,4) Studies have shown that resveratrol can induce autophagy in cancer cells.”
BackgroundResveratrol and Other Natural Oligomeric Stilbenoid Compounds and Their Therapeutic Applications
Duta-Bratu, C.-G., Nițulescu, G. M., Mihai, D. P., & Olaru, O. T. (2023) · Plants · doi:10.3390/plants12162935 · Cited by 85
“association domain family 1 isoform A (RASSF-1α), pAkt, vascular endothelial growth factor (VEGF), cyclooxygenase 2 (COX-2), nuclear factor erythroid 2-like 2 (Nrf 2), and Kelch-like ECH-associated protein 1 [57,58].”
BackgroundFeng, Y., Liu, T., Dong, S., Guo, Y., Jankovic, J. J., Xu, H., & Wu, Y. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13172 · Cited by 85
Zhang, D., Yan, Y., Tian, H., Jiang, G., Li, X., & Liu, W. (2017) · Fish Physiology and Biochemistry · doi:10.1007/s10695-017-0421-9 · Cited by 85
Thongchot, S., Ferraresi, A., Vidoni, C., Loilome, W., Yongvanit, P., Namwat, N., & Isidoro, C. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.05.031 · Cited by 84
de Oliveira, M. T. P., Coutinho, D. D. S., de Souza, É. T., Guterres, S. S., Pohlmann, A. R., Silva, P., Martins, M. A., & Bernardi, A. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s200666 · Cited by 86
“RSV effects have been related to the PI3K/Akt and mitogen-activated protein kinase (MAPK) pathways, among others, including the extracellular signal regulated kinases 1 and 2 (ERK1/2).(77) Both the PI3K/Akt and MAPK intracellular cascades can be initiated by LPSTRL4 receptor activation,(78) leading to gene transcripti…”
BackgroundWen, W., Chen, X., Huang, Z., Chen, D., Yu, B., He, J., Luo, Y., Yan, H., Chen, H., Zheng, P., et al. (2021) · Animal nutrition · doi:10.1016/j.aninu.2021.06.012 · Cited by 83
“Sirt1 and PGC-1a, downstream regulators of AMPK are directly activated by AMPK and drive the transformation of fast glycolytic fiber to slow oxidative fiber (Kulkarni and Cant o, 2015; Li et al., 2002).”
BackgroundImplications of Resveratrol in Obesity and Insulin Resistance: A State-of-the-Art Review
Barber, T. M., Kabisch, S., Randeva, H. S., Pfeiffer, A. F. H., & Weickert, M. O. (2022) · Nutrients · doi:10.3390/nu14142870 · Cited by 83
“Other potential mechanisms of resveratrol action include the inhibition of ATP production through the activation of 5′ Adenosine Monophosphate-activated Protein Kinase (AMPK, a key regulator of energy homeostasis), that in turn inhibits mammalian Target of Rapamycin (mTOR) signaling, with possible anti-ageing effects…”
BackgroundResveratrol Regulates Colorectal Cancer Cell Invasion by Modulation of Focal Adhesion Molecules
Buhrmann, C., Shayan, P., Goel, A., & Shakibaei, M. (2017) · Nutrients · doi:10.3390/nu9101073 · Cited by 84
Song, Z., Shi, Y., Han, Q., & Dai, G. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.05.095 · Cited by 82
de Ligt, M., Bruls, Y. M. H., Hansen, J., Habets, M.-F., Havekes, B., Nascimento, E. B. M., Moonen-Kornips, E., Schaart, G., Schrauwen-Hinderling, V. B., van Marken Lichtenbelt, W., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.04.004 · Cited by 79
“Abbreviations: AMPK, AMP-activated protein kinase; BAT, brown adipose tissue; DHR glucose; FDR, first-degree relatives; IHL, intrahepatic lipid; IMCL, intramyocellular lipid malate þ octanoyl-carnitine; MOG, malate þ octanoyl-carnitine þ glutamate; MOG, spectroscopy; NE, norepinephrine; OGTT, oral glucose tolerance te…”
BackgroundInfluentialChatterjee, B., Ghosh, K. K., & Kanade, S. R. (2019) · BioFactors · doi:10.1002/biof.1544 · Cited by 79
The Role of Antioxidants in the Therapy of Cardiovascular Diseases—A Literature Review
Młynarska, E., Hajdys, J., Czarnik, W., Fularski, P., Leszto, K., Majchrowicz, G., Lisińska, W., Rysz, J., & Franczyk, B. (2024) · Nutrients · doi:10.3390/nu16162587 · Cited by 89
“Furthermore, resveratrol enhances vasculoprotective nitric oxide (NO) synthesis through eNOS activation, which is mediated by estrogen receptors, MAPK signaling, and SIRT1 activation.”
BackgroundGuthrie, A. R., Chow, H. ‐. S., & Martinez, J. A. (2017) · Pharmacology Research & Perspectives · doi:10.1002/prp2.294 · Cited by 78
Epigenetic regulation of bone remodeling by natural compounds
Raut, N. A., Wicks, S. M., Lawal, T. O., & Mahady, G. B. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104350 · Cited by 73
Resveratrol suppresses human hepatocellular carcinoma via targeting HGF-c-Met signaling pathway
Gao, F., Deng, G., Liu, W., Zhou, K., & Li, M. (2017) · Oncology Reports · doi:10.3892/or.2017.5347 · Cited by 76
“Previous studies have demonstrated that resveratrol displayed potent antitumor effect in various types of tumors, including lung, breast, prostate and colon cancer (23,26).”
BackgroundSharma, B., Satija, G., Madan, A., Garg, M., Alam, M. M., Shaquiquzzaman, M., Khanna, S., Tiwari, P., Parvez, S., Iqubal, A., et al. (2022) · Inflammation · doi:10.1007/s10753-022-01730-0 · Cited by 77
Yang, A. J. T., Bagit, A., & MacPherson, R. E. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094628 · Cited by 77
Peñalver, P., Belmonte‐Reche, E., Adán, N., Caro, M., Mateos‐Martín, M. L., Delgado, M., González‐Rey, E., & Morales, J. C. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.01.037 · Cited by 72
“Its bioactivity com es from direct interactions of resveratrol with multip e molecular targets involved on inflammation, cell cycle arrest, cell signaling, metabolism and posttranslat ion l modification [18, 19].”
BackgroundLeyton, L., Hott, M., Acuña, F., Caroca, J., Nuñez, M., Martín, C., Zambrano, Á., Concha, M. I., & Carola Otth, L. (2015) · Virus Research · doi:10.1016/j.virusres.2015.05.015 · Cited by 72
Gellan Gum/Pectin Beads Are Safe and Efficient for the Targeted Colonic Delivery of Resveratrol
Prezotti, F. G., Boni, F. I., Ferreira, N. N., Silva, D., Filho, S. P. C., Almeida, A., Vasconcelos, T., Gremião, M. P. D., Cury, B. S. F., & Sarmento, B. F. C. C. (2018) · Polymers · doi:10.3390/polym10010050 · Cited by 69
“Resveratrol (RES), a class II in the Biopharmaceutical Classification System, is a natural polyphenol with recognized antioxidant properties found in grapes, red wine, peanuts, mulberries, and some medicinal plants [26], and is potentially useful as a dietary supplement or for use in natural medicine [22,23].”
BackgroundHedayati, N., Safari, M. H., Milasi, Y. E., Kahkesh, S., Farahani, N., Khoshnazar, S. M., Dorostgou, Z., Alaei, E., Alimohammadi, M., Rahimzadeh, P., et al. (2025) · Discover Oncology · doi:10.1007/s12672-025-02471-w · Cited by 75
“These findings emphasize the need for advanced formulations, such as resveratrol analogs or nano-delivery systems, to maximize therapeutic benefits in ongoing trials targeting breast, colon, and prostate cancers [206].”
Plant polyphenols as natural drugs for the management of Down syndrome and related disorders
Vacca, R. A., Valenti, D., Caccamese, S., Daglia, M., Braidy, N., & Nabavi, S. M. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.10.023 · Cited by 69
Teplova, V. V., Isakova, E. P., Klein, O. I., Dergachova, D. I., Гесслер, Н. Н., & Deryabina, Y. I. (2018) · Applied Biochemistry and Microbiology · doi:10.1134/s0003683818030146 · Cited by 69
Resveratrol promotes oxidative stress to drive DLC1 mediated cellular senescence in cancer cells
Ji, S., Zheng, Z., Liu, S., Ren, G., Gao, J., Zhang, Y., & Li, G. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.06.031 · Cited by 70
Kang, H., Park, Y., & Lee, J. (2021) · Laboratory Investigation · doi:10.1038/s41374-021-00599-1 · Cited by 70
Duan, J., Zhan, J., Wang, G., Zhao, X., Huang, W., & Zhou, G. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13899 · Cited by 66
“Resveratrol exhibits chemopreventive(5) and therapeutic effects against several cancers(6) by targeting some molecules that play important roles in tumourigenesis.(7) Indeed, other red”
BackgroundRubio-Ruiz, M. E., Guarner‐Lans, V., Cano-Martı́nez, A., Díaz‐Díaz, E., Manzano-Pech, L., Gamas-Magaña, A., Castrejón-Téllez, V., Tapia-Cortina, C., & Pérez-Torres, I. (2019) · Molecules · doi:10.3390/molecules24071297 · Cited by 65
“It then dissociates from keap1 and translocates to the cell nucleus, causing the acetylation of DNA, binding to the elements of the antioxidant response in the promoter region of the genes that are involved in the transcription of the already mentioned antioxidant enzymes [58].”
BackgroundMa, S., Motevalli, S. M., Chen, J., Xu, M., Wang, Y., Feng, J. H., Qiu, Y. F., Han, D., Fan, M., Ding, M., et al. (2018) · Theranostics · doi:10.7150/thno.24364 · Cited by 63
Li, Y. H., Choi, D. H., Lee, E. H., Seo, S. R., Lee, S., & Cho, E.-H. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.692244 · Cited by 62
“Resveratrol also inhibits phosphodiesterases and the NF- B family of transcription factors (45).”
BackgroundLi, P., Wang, X., Zhao, M., Song, R., & Zhao, K. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1054806 · Cited by 59
“Recently, it was reported that SIRT1 activation by Res could deacetylate and activate downstream substrates such as FOXOs or peroxisome proliferator-activated receptor gamma coactivator-1 a (PGC-1 a) under oxidative stress, thereby inducing SOD2 expression, leading to suppression of oxidant-induced cell death [37-39].”
Background
Metadata
- Authors
- Kulkarni, S. S., & Cantó, C.
- Corresponding author
- Cantó, Carles
- ORCID
- Cantó, Carles
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 1852
- Issue
- 6
- Pages
- 1114-1123
- ISSN
- 0925-4439 (ISSN-L)
- OpenAlex
- W2053510668
- Cited by
- 477
- References
- 135
- Citations by year
- 2026: 15 · 2025: 27 · 2024: 32 · 2023: 23 · 2022: 50 · 2021: 40 · 2020: 56 · 2019: 63 · 2018: 55 · 2017: 39 · 2016: 38 · 2015: 37
- FWCI
- 3.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- resveratrol, molecular targets, caloric restriction mimetics, SIRT1, AMPK, metabolic disorders, neuroprotection, cancer, cardioprotection, aging, drug development
- MeSH terms
- Resveratrol, Animals, Humans, Mitochondria, Stilbenes, Signal Transduction, Transcriptional Activation, NF-kappa B, Sirtuins, AMP-Activated Protein Kinases
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