Resveratrol as a calorie restriction mimetic: therapeutic implications

Chung, Jay H.; Manganiello, Vincent; Dyck, Jason R.B.

doi:10.1016/j.tcb.2012.07.004

Cited by 192Sirtuins and Resveratrol in MedicineMetabolism, Diabetes, and CancerPhytochemicals and Antioxidant Activities

Resveratrol as a calorie restriction mimetic: therapeutic implications

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Chung, Jay H., Manganiello, Vincent, Dyck, Jason R.B.·2012·Trends in Cell Biology

DOI 10.1016/j.tcb.2012.07.004PMC PMC3462230

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Abstract

It is widely believed that calorie restriction (CR) can extend the lifespan of model organisms and protect against aging-related diseases. A potential CR mimetic is resveratrol, which may have beneficial effects against numerous diseases such as type 2 diabetes, cardiovascular diseases, and cancer in tissue culture and animal models. However, resveratrol in its current form is not ideal as therapy, because even at very high doses it has modest efficacy and many downstream effects. Identifying the cellular targets responsible for the effects of resveratrol and developing target-specific therapies will be helpful in increasing the efficacy of this drug without increasing its potential adverse effects. A recent discovery suggests that the metabolic effects of resveratrol may be mediated by inhibiting cAMP phosphodiesterases (PDEs), particularly PDE4. Here, we review the current literature on the metabolic and cardiovascular effects of resveratrol and attempt to shed light on the controversies surrounding its action.

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Resveratrol is a natural polyphenol that is beneficial for treatment of many metabolic diseases, including atherosclerosis.
“Resveratrol (RSV) is a natural polyphenol that mainly occurs in grapes, berries, and other dietary constituents and is beneficial for treatment of many metabolic diseases, including AS (13).”
From Resveratrol Attenuates Trimethylamine- N -Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota (2016) · cites this paper as [13]

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[29]Kaeberlein M Substrate-specific activation of sirtuins by resveratrol J. Biol. Chem 2005 280 17038 17045 15684413
[65]Timmers S Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans Cell Metab 2011 14 612 622 22055504 PMC3880862

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Authors: Chung, J. H., Manganiello, V., & Dyck, J. R. B.
Affiliations: National Institutes of Health (US)
University of Alberta (CA)
Corresponding author: Chung, Jay H.
ORCID: Chung, Jay H.
Dyck, Jason R.B.
Venue: Trends in Cell Biology
Publisher: Elsevier BV
Published: 2012-10
Volume: 22
Issue: 10
Pages: 546-554
ISSN: 0962-8924 (ISSN-L)
DOI: 10.1016/j.tcb.2012.07.004
PMC: PMC3462230
OpenAlex: W2008532131
Cited by: 192
References: 105
Citations by year: 2026: 7 · 2025: 6 · 2024: 7 · 2023: 10 · 2022: 8 · 2021: 16 · 2020: 17 · 2019: 12 · 2018: 16 · 2017: 13 · 2016: 14 · 2015: 24 · 2014: 23 · 2013: 16 · 2012: 3
FWCI: 1.78
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Cell Biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
Canadian Institutes of Health Research
National Heart, Lung, and Blood Institute (ZIAHL006118)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords: resveratrol, caloric restriction mimetics, lifespan extension, aging, type 2 diabetes, cardiovascular disease, cancer, cAMP phosphodiesterase, PDE4 inhibition, cellular targets, drug efficacy, adverse effects
MeSH terms: Resveratrol, Aging, Animals, Humans, Stilbenes, Signal Transduction, Caloric Restriction, Biomimetic Materials, Sirtuin 1

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Resveratrol as a calorie restriction mimetic: therapeutic implications

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