The pharmacology of resveratrol in animals and humans

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Cancer chemopreventive activity of resveratrol, a natural product derived from grapes

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SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function

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Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

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Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

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Concentration of the Phytoalexin Resveratrol in Wine

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Exploring the Comparative Efficacy of Metformin and Resveratrol in the Management of Diabetes-Associated Complications: A Systematic Review of Preclinical Studies

Dludla, P. V., Silvestri, S., Orlando, P., Gabuza, K., Mazibuko-Mbeje, S. E., Nyambuya, T. M., Mxinwa, V., Mokgalaboni, K., Johnson, R., Muller, C. J. F., et al. (2020) · Nutrients · doi:10.3390/nu12030739 · Cited by 37

Resveratrol loaded self-nanoemulsifying drug delivery system (SNEDDS) for pancreatic cancer: Formulation design, optimization and in vitro evaluation

Md, S., Alhakamy, N. A., Aldawsari, H. M., Ahmad, J., Alharbi, W. S., & Asfour, H. Z. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102555 · Cited by 35

Genetics and Pharmacology of Longevity

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Resveratrol suppresses NTHi-induced inflammation via up-regulation of the negative regulator MyD88 short

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Resveratrol mediates cell cycle arrest and cell death in human esophageal squamous cell carcinoma by directly targeting the EGFR signaling pathway

Jin, Z., Feng, W., Ji, Y., & Jin, L. (2016) · Oncology Letters · doi:10.3892/ol.2016.5391 · Cited by 34

Resveratrol Reactivates Latent HIV through Increasing Histone Acetylation and Activating Heat Shock Factor 1

Zeng, X., Pan, X., Xu, X., Lin, J., Que, F.-C., Tian, Y., Li, L., & Liu, S. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b00418 · Cited by 37

Resveratrol Induces Apoptosis-Like Death and Prevents In Vitro and In Vivo Virulence of Entamoeba histolytica

Pais-Morales, J., Betanzos, A., García‐Rivera, G., Chávez‐Munguía, B., Shibayama, M., & Orozco, E. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146287 · Cited by 33

A Meta-Analysis of the Impact of Resveratrol Supplementation on Markers of Renal Function and Blood Pressure in Type 2 Diabetic Patients on Hypoglycemic Therapy

Nyambuya, T. M., Nkambule, B. B., Mazibuko-Mbeje, S. E., Mxinwa, V., Mokgalaboni, K., Orlando, P., Silvestri, S., Louw, J., Tiano, L., & Dludla, P. V. (2020) · Molecules · doi:10.3390/molecules25235645 · Cited by 34

During yeast chronological aging resveratrol supplementation results in a short-lived phenotype Sir2-dependent

Orlandi, I., Stamerra, G., Strippoli, M., & Vai, M. (2017) · Redox Biology · doi:10.1016/j.redox.2017.04.015 · Cited by 32

Evaluation of novel conjugated resveratrol polymeric nanoparticles in reduction of plasma degradation, hepatic metabolism and its augmentation of anticancer activity in vitro and in vivo

Yee, Y. J., Benson, H. A., Dass, C. R., & Chen, Y. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.121499 · Cited by 32

Formation, characterization and properties of resveratrol-dietary fiber composites: Release behavior, bioaccessibility and long-term storage stability

Ji, S., Jia, C., Cao, D., Muhoza, B., & Zhang, X. (2020) · LWT · doi:10.1016/j.lwt.2020.109556 · Cited by 31

Immobilized Lipase Based on Hollow Mesoporous Silicon Spheres for Efficient Enzymatic Synthesis of Resveratrol Ester Derivatives

Xu, L., Yang, T., Wang, J., Huang, F., & Zheng, M. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c07501 · Cited by 31

Vitamin C intake potentially lowers total cholesterol to improve endothelial function in diabetic patients at increased risk of cardiovascular disease: A systematic review of randomized controlled trials

Dludla, P. V., Nkambule, B. B., Nyambuya, T. M., Ziqubu, K., Mabhida, S. E., Mxinwa, V., Mokgalaboni, K., Ndevahoma, F., Hanser, S., Mazibuko-Mbeje, S. E., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1011002 · Cited by 34

Resveratrol and Myopathy

Bastin, J., & Djouadi, F. (2016) · Nutrients · doi:10.3390/nu8050254 · Cited by 31

Increased expression of tripartite motif (TRIM) like 2 promotes tumoral growth in human oral cancer

Hayashi, F., Kasamatsu, A., Endo‐Sakamoto, Y., Eizuka, K., Hiroshima, K., Kita, A., Saito, T., Koike, K., Tanzawa, H., & Uzawa, K. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.12.060 · Cited by 30

An Innovative Strategy for Oral Biofilm Control in Early Childhood Based on a Resveratrol-Cyclodextrin Nanotechnology Approach

Berta, G. N., Romano, F., Vallone, R., Abbadessa, G., Scipio, F. D., & Defabianis, P. (2021) · Materials · doi:10.3390/ma14143801 · Cited by 29

Ammonia impairs glutamatergic communication in astroglial cells: protective role of resveratrol

Bobermin, L. D., Hansel, G., Scherer, E. B. S., Wyse, Â. T. D. S., Souza, D. O., Quincozes‐Santos, A., & Gonçalves, C. (2015) · Toxicology in Vitro · doi:10.1016/j.tiv.2015.08.008 · Cited by 29

Preparation of resveratrol dry suspension and its immunomodulatory and anti-inflammatory activity in mice

Chen, M., Fu, Q., Song, X., Abaidullah, M., Jia, R., Zou, Y., Yin, L., Li, L., He, C., Ye, G., et al. (2019) · Pharmaceutical Biology · doi:10.1080/13880209.2019.1699123 · Cited by 29

Resveratrol and derivatives for the treatment of atrial fibrillation

Baczkó, I., & Light, P. E. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12843 · Cited by 30

Potential application of resveratrol in nanocarriers against cancer: Overview and future trends

Moshawih, S., Mydin, R. B. S. M. N., Shanker, K., & Jarrar, Q. (2019) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2019.101187 · Cited by 28

Pathogenesis of NASH and Promising Natural Products

Leng, Y., Zhang, M., Luo, J., & Zhang, H. (2021) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(21)60002-x · Cited by 29

Influence of Resveratrol on the Cardiovascular Health Effects of Chronic Kidney Disease

Song, J.-Y., Shen, T.-C., Hou, Y., Chang, J., Lu, C., Liu, W.-C., Chen, P.-J., Chen, B.-H., Zheng, C., & Lu, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176294 · Cited by 28

Synergistic effects of brain injury and aging: common mechanisms of proteostatic dysfunction

Saikumar, J., & Bonini, N. M. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.06.003 · Cited by 28

Endophytic Fungi Accelerate Leaf Physiological Activity and Resveratrol Accumulation in Polygonum cuspidatum by Up-Regulating Expression of Associated Genes

Sun, R.-T., Zhang, Z.-Z., Feng, X.-C., Zhou, N., Feng, H.-D., Liu, Y., Harsonowati, W., Hashem, A., Allah, E. F. A., & Wu, Q. (2022) · Agronomy · doi:10.3390/agronomy12051220 · Cited by 27

Female germline stem cells: aging and anti-aging

Hong, W., Wang, B., Zhu, Y., Wu, J., Li, Q., Ling, S., Zhou, Z., Dai, Y., Zhong, Z., & Zheng, Y. (2022) · Journal of Ovarian Research · doi:10.1186/s13048-022-01011-2 · Cited by 27

Consumption of Grapes Modulates Gene Expression, Reduces Non-Alcoholic Fatty Liver Disease, and Extends Longevity in Female C57BL/6J Mice Provided with a High-Fat Western-Pattern Diet

Dave, A., Park, E., Kumar, A., Parande, F., Beyoğlu, D., Idle, J. R., & Pezzuto, J. M. (2022) · Foods · doi:10.3390/foods11131984 · Cited by 27

Therapeutic potential of stilbenes in neuropsychiatric and neurological disorders: A comprehensive review of preclinical and clinical evidence

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Highly regioselective hydroxylation of polydatin, a resveratrol glucoside, for one-step synthesis of astringin, a piceatannol glucoside, by P450 BM3

Le, T., Jang, H., Nguyen, H. T. H., Doan, T. T. M., Lee, G., Park, K. D., Ahn, T., Joung, Y. H., Kang, H., & Yun, C. (2016) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2016.11.003 · Cited by 26

Effect of Resveratrol on periodontal pathogens during experimental periodontitis in rats

Cirano, F. R., Casarin, R. C. V., Ribeiro, F. V., Casati, M. Z., Pimentel, S. P., Taiete, T., & Bernardi, M. M. (2016) · Brazilian Oral Research · doi:10.1590/1807-3107bor-2016.vol30.0128 · Cited by 26

Natural Products for Cancer Chemoprevention

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The activation of SIRT1 by resveratrol reduces breast cancer metastasis to lung through inhibiting neutrophil extracellular traps

Yu, W., Wang, Z., Dai, P., Sun, J., Li, J., Han, W., & Li, K. (2023) · Journal of drug targeting · doi:10.1080/1061186x.2023.2265585 · Cited by 25

The Role of Therapeutic Drugs on Acquired Mitochondrial Toxicity

Morén, C., Juárez‐Flores, D. L., Cardellach, F., & Garrabou, G. (2016) · Current Drug Metabolism · doi:10.2174/1389200217666160322143631 · Cited by 25

Functional/activity network (FAN) analysis of gene-phenotype connectivity liaised by grape polyphenol resveratrol

Hsieh, T., Wu, S.-T., Bennett, D. J., Doonan, B. B., Wu, E., & WU, J. M. (2016) · Oncotarget · doi:10.18632/oncotarget.9578 · Cited by 24

Autophagy as a Therapeutic Target of Natural Products Enhancing Embryo Implantation

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Resveratrol regulates neuronal glucose uptake and insulin sensitivity via P21-activated kinase 2 (PAK2)

Varshney, P., & Dey, C. S. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.02.070 · Cited by 24

Human skin gene expression: Natural (trans) resveratrol versus five resveratrol analogs for dermal applications

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Molecular mechanisms underlying cyclophosphamide-induced ovarian injury and protective strategies

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Wine and Olive Oil Phenolic Compounds Interaction in Humans

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Usefulness of resveratrol supplementation in decreasing cardiometabolic risk factors comparing subjects with metabolic syndrome and healthy subjects with or without obesity: meta-analysis using multinational, randomised, controlled trials

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Resveratrol potentiates the effect of dexamethasone in rat model of acute lung inflammation

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Targeting extracellular matrix remodeling in disease: Could resveratrol be a potential candidate?

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Resveratrol inhibits Erk1/2‐mediated adhesion of cancer cells via activating PP2A–PTEN signaling network

Chen, X., Hu, X., Li, Y., Zhu, C., Dong, X., Zhang, R., Ma, J., Huang, S., & Chen, L. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27100 · Cited by 22

Food phenolics stimulate adipocyte browning via regulating gut microecology

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The effect of trans-resveratrol on the physicochemical properties of lipid membranes with different cholesterol content

Płachta, Ł., Mach, M., Kowalska, M., & Wydro, P. (2023) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2023.184212 · Cited by 22

Insights into the Therapeutic and Pharmacological Properties of Resveratrol as a Nutraceutical Antioxidant Polyphenol in Health Promotion and Disease Prevention

Mohammadi, S., Moghadam, M. D., Nasiriasl, M., Akhzari, M., & Barazesh, M. (2024) · Current Clinical Pharmacology · doi:10.2174/0127724328268507231218051058 · Cited by 22

Selective separation and identification of metabolite groups of Polygonum cuspidatum extract in rat plasma using dispersion solid-phase extraction by magnetic molecularly imprinted polymers coupled with LC/Q-TOF-MS

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Dietary Approaches and Supplements in the Prevention of Cognitive Decline and Alzheimer';s Disease

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Exploring the potential of baicalin and resveratrol as PIM-1 kinase inhibitors: Therapeutic targeting of prostate and breast cancers

Rathi, A., Khan, A., Haider, S., Roy, S., Taiyab, A., Mahendru, S., Hussain, A., Chakrabarty, A., Islam, A., Hassan, M. I., et al. (2024) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2024.124026 · Cited by 21

Biorelevant physicochemical profiling of (E)- and (Z)-resveratrol determined from isomeric mixtures

Orgován, G., Gonda, I., & Noszál, B. (2016) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2016.09.019 · Cited by 20

Effects of oral administration of common antioxidant supplements on the energy metabolism of red blood cells. Attenuation of oxidative stress-induced changes in Rett syndrome erythrocytes by CoQ10

Pierro, D. D., Ciaccio, C., Sbardella, D., Tundo, G. R., Bernardini, R., Curatolo, P., Galasso, C., Pironi, V., Coletta, M., & Marini, S. (2019) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-019-03633-5 · Cited by 21

Resveratrol Inhibition of Renal Cancer Stem Cell Characteristics and Modulation of the Sonic Hedgehog Pathway

Sun, H., Zhang, T., Liu, R. R., Cao, W., Zhang, Z., Liu, Z., Qian, W., Wang, D., Yu, D., & Zhong, C. (2020) · Nutrition and Cancer · doi:10.1080/01635581.2020.1784966 · Cited by 21

Phytochemicals in cancer prevention and management

Thomas, R., Butler, E., Macchi, F., & Williams, M. (2015) · Cited by 20

Influence of the periprostatic adipose tissue in obesity-associated mouse urethral dysfunction and oxidative stress: Effect of resveratrol treatment

Alexandre, E. C., Calmasini, F. B., Sponton, A. C. D. S., de Oliveira, M. G., André, D. M., Silva, F. H., Delbin, M. A., Mónica, F. Z., & Antunes, E. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.08.010 · Cited by 20

Creating Space for Large Acceptors: Rational Biocatalyst Design for Resveratrol Glycosylation in an Aqueous System

Dirks‐Hofmeister, M. E., Verhaeghe, T., Winter, K. D., & Desmet, T. (2015) · Angewandte Chemie · doi:10.1002/ange.201503605 · Cited by 20

TRPA1 channels as targets for resveratrol and related stilbenoids

Nalli, M., Ortar, G., Moriello, A. S., Morera, E., Marzo, V. D., & PETROCELLIS, L. D. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.12.065 · Cited by 20

How Phytochemicals Prevent Chemical Carcinogens and/or Suppress Tumor Growth?

Bathaie, S. Z., Faridi, N., Nasimian, A., Heidarzadeh, H., & Tamanoi, F. (2015) · The Enzymes · doi:10.1016/bs.enz.2015.06.003 · Cited by 23

An evaluation of aversive memory and hippocampal oxidative status in streptozotocin-induced diabetic rats treated with resveratrol

Bagatini, P. B., Xavier, L. L., Bertoldi, K., Moysés, F. D. S., Lovatel, G. A., Neves, L. T., Barbosa, S., Saur, L., de Senna, P. N., Souto, A. A., et al. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.10.059 · Cited by 18

The role and current research status of resveratrol in the treatment of osteoarthritis and its mechanisms: a narrative review

Zou, X., Xu, H., & Qian, W. (2024) · Drug Metabolism Reviews · doi:10.1080/03602532.2024.2402751 · Cited by 18

Resveratrol and Female Fertility: A Systematic Review

Bertoldo, A., Pizzol, D., Yon, D. K., Callegari, M., Gobbo, V., Cuccurese, P., Butler, L. T., Caminada, S., Stebbing, J., Richardson, F., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312792 · Cited by 18

Resveratrol Protects against Restraint Stress Effects on Stomach and Spleen in Adult Male Mice

Ennab, W., Mustafa, S., Wei, Q., Lv, Z., Kavita, N. M. X., Ullah, S., & Shi, F. (2019) · Animals · doi:10.3390/ani9100736 · Cited by 18

A resveratrol analog termed 3,3′,4,4′,5,5′-hexahydroxy-trans-stilbene is a potent HIV-1 inhibitor

Han, Y.-S., Quashie, P. K., Mésplède, T., Xu, H., Quan, Y., Jaeger, W., Szekeres, T., & Wainberg, M. A. (2015) · Journal of Medical Virology · doi:10.1002/jmv.24271 · Cited by 18

Transcriptome Analysis Reveals the Genetic Basis of the Resveratrol Biosynthesis Pathway in an Endophytic Fungus (Alternaria sp. MG1) Isolated from Vitis vinifera

Che, J., Shi, J., Gao, Z., & Zhang, Y. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01257 · Cited by 18

Herbal antioxidants and renal ischemic-reperfusion injury; an updated review

Asgharpour, M., Tolouian, A. C., Bhaskar, L. V., Tolouian, R., & Massoudi, N. (2020) · Journal of Nephropharmacology · doi:10.34172/npj.2021.03 · Cited by 19

Incorporating natural anti-inflammatory compounds into yeast glucan particles increases their bioactivity in vitro

Šalamúnová, P., Cupalová, L., Majerská, M., Treml, J., Ruphuy, G., Šmejkal, K., Štĕpánek, F., Hanuš, J., & Hošek, J. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.12.107 · Cited by 18

Growth-Inhibiting Activity of Resveratrol Imine Analogs on Tumor Cells In Vitro

Wang, S., Willenberg, I., Krohn, M., Hecker, T., Meckelmann, S. W., Li, C., Pan, Y., Schebb, N. H., Steinberg, P., & Empl, M. T. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170502 · Cited by 18

Polyphenols in Obesity and Metabolic Syndrome

Pastor‐Villaescusa, B., Rodriguez, E. S., & Rangel-Huerta, Ó. D. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812504-5.00011-8 · Cited by 19

Distribution and metabolism of [14C]-resveratrol in human prostate tissue after oral administration of a “dietary-achievable” or “pharmacological” dose: what are the implications for anticancer activity?

Cai, H., Scott, E. N., Britton, R. G., Parrott, E. L., Ognibene, T. J., Malfatti, M. A., Khan, M. A., Steward, W. P., & Brown, K. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa414 · Cited by 17

Effects of Extracellular Osteoanabolic Agents on the Endogenous Response of Osteoblastic Cells

Alloisio, G., Ciaccio, C., Fasciglione, G. F., Tarantino, U., Marini, S., Coletta, M., & Gioia, M. (2021) · Cells · doi:10.3390/cells10092383 · Cited by 20

A short-term treatment with resveratrol improves the inflammatory conditions of Middle-aged mice skeletal muscles

Sirago, G., Toniolo, L., Crea, E., & Giacomello, E. (2022) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2022.2027889 · Cited by 17

Chinese Medicine as Supporting Therapy for Psoriasis: Past, Present, and Future

Yang, X., Cai, W.-L., Guo, C.-L., & Chen, Q.-H. (2022) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-022-3683-8 · Cited by 17

Between the Devil and the Deep Blue Sea—Resveratrol, Sulfotransferases and Sulfatases—A Long and Turbulent Journey from Intestinal Absorption to Target Cells

Szymkowiak, I., Kucińska, M., & Murias, M. (2023) · Molecules · doi:10.3390/molecules28083297 · Cited by 17

N-Monosubstituted Methoxy-oligo(ethylene glycol) Carbamate Ester Prodrugs of Resveratrol

Mattarei, A., Azzolini, M., Zoratti, M., Biasutto, L., & Paradisi, C. (2015) · Molecules · doi:10.3390/molecules200916085 · Cited by 17

Resveratrol-Mediated Expression of KLF15 in the Ischemic Myocardium is Associated with an Improved Cardiac Phenotype

Rogers, R. G., & Otis, J. S. (2017) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-016-6707-9 · Cited by 17

Advanced iron-overload cardiomyopathy in a genetic murine model is rescued by resveratrol therapy

Das, S. K., Zhabyeyev, P., Basu, R., Patel, V. B., Dyck, J. R. B., Kassiri, Z., & Oudit, G. Y. (2017) · Bioscience Reports · doi:10.1042/bsr20171302 · Cited by 18

Stilbenes from Vine Extracts: Therapeutic Potential and Mechanisms

Brás, L. A., Luís, Â., Châtel, G., Socorro, S., & Duarte, A. P. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178269 · Cited by 20

Natural Products as Cancer Chemo Preventive Agents: Where We Stand

Boretti, A. A. (2022) · Natural Product Communications · doi:10.1177/1934578x221144579 · Cited by 16

Polyphenols as Therapeutics in Respiratory Diseases: Moving from Preclinical Evidence to Potential Clinical Applications

Emran, T. B., Eva, T. A., Zehravi, M., Islam, F., Khan, J., Kareemulla, S., Arjun, U. V. N. V., Balakrishnan, A., Taru, P. P., Nainu, F., et al. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.93875 · Cited by 19

Natural Antioxidant Application on Fat Accumulation: Preclinical Evidence

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C-2 (E)-4-(Styryl)aniline substituted diphenylpyrimidine derivatives (Sty-DPPYs) as specific kinase inhibitors targeting clinical resistance related EGFRT790M mutant

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Resveratrol derivative excited postsynaptic potentiation specifically via PKCβ-NMDA receptor mediation

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Control of DNA structure and function by phytochemicals/DNA interaction: Resveratrol/piceatannol induces Cu2+-independent, cleavage of supercoiled plasmid DNA

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The Chemopreventive Effects of Polyphenols and Coffee, Based upon a DMBA Mouse Model with microRNA and mTOR Gene Expression Biomarkers

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Resveratrol inhibits steroidogenesis in human fetal adrenocortical cells at the end of first trimester

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Putative involvement of sirtuin modulators in LPS-induced sickness behaviour in mice

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Inhibition of Resveratrol Analogs on Human and Rat 3β-Hydroxysteroid Dehydrogenases: Structure–Activity Relationship and Docking Analysis

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Classical and atypical resistance of cancer cells as a target for resveratrol

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Resveratrol Normalizes Hyperammonemia Induced Pro-Inflammatory and Pro-Apoptotic Conditions in Rat Brain

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Development of Phospholipid Complex Loaded Self-Microemulsifying Drug Delivery System to Improve The Oral Bioavailability of Resveratrol

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Resveratrol in mammals: effects on aging biomarkers, age‐related diseases, and life span

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