Cited by 104Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsDown syndrome and intellectual disability research

Neuroinflammation in the Aging Down Syndrome Brain; Lessons from Alzheimer's Disease

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Wilcock, Donna M.·2012·Current Gerontology and Geriatrics Research

Abstract

Down syndrome (DS) is the most genetic cause of mental retardation and is caused by the triplication of chromosome 21. In addition to the disabilities caused early in life, DS is also noted as causing Alzheimer's-disease-like pathological changes in the brain, leading to 50–70% of DS patients showing dementia by 60–70 years of age. Inflammation is a complex process that has a key role to play in the pathogenesis of Alzheimer's disease. There is relatively little understood about inflammation in the DS brain and how the genetics of DS may alter this inflammatory response and change the course of disease in the DS brain. The goal of this review is to highlight our current understanding of inflammation in Alzheimer's disease and predict how inflammation may affect the pathology of the DS brain based on this information and the known genetic changes that occur due to triplication of chromosome 21.

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Authors
Wilcock, D. M.
Affiliations
University of Kentucky (US)
Corresponding author
Wilcock, Donna M.
Venue
Current Gerontology and Geriatrics Research
Published
2012
Volume
2012
Pages
1-10
ISSN
  • 1687-7063 (ISSN-L)
  • 1687-7071
OpenAlex
W1972160270
Cited by
104
References
115
Citations by year
2026: 4 · 2025: 9 · 2024: 9 · 2023: 5 · 2022: 6 · 2021: 11 · 2020: 12 · 2019: 11 · 2018: 4 · 2017: 4 · 2016: 6 · 2015: 11 · 2014: 8 · 2013: 1 · 2012: 3
FWCI
4.93
Type
journal article
Language
en
Open access
Locations
  • Current Gerontology and Geriatrics Research (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • UKnowledge (University of Kentucky) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
Keywords
Down syndrome, neuroinflammation, Alzheimer's disease, dementia, brain aging, Alzheimer's disease pathogenesis

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