SIRT1 attenuates neuroinflammation by deacetylating HSPA4 in a mouse model of Parkinson's disease

Yang, Yinuo; Zhang, Shouping; Guan, Jindong; Jiang, Yuhui; Zhang, Jing; Luo, Lan; Sun, Cheng

doi:10.1016/j.bbadis.2022.166365

Cited by 41Parkinson's Disease Mechanisms and TreatmentsSirtuins and Resveratrol in MedicineNeuroinflammation and Neurodegeneration Mechanisms

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SIRT1 attenuates neuroinflammation by deacetylating HSPA4 in a mouse model of Parkinson's disease

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Yang, Yinuo, Zhang, Shouping, Guan, Jindong, Jiang, Yuhui, Zhang, Jing, Luo, Lan, Sun, Cheng·2022·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI 10.1016/j.bbadis.2022.166365

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Abstract

As a deacetylase, SIRT1 plays essential roles in various physiological events, from development to lifespan regulation. SIRT1 has been shown neuroprotective effects in neurodegeneration disorders such as Parkinson's disease (PD). However, the underlying molecular mechanisms are still not well understood. Here, we generated transgenic mice with increased expression of Sirt1 in the brain and examined the potential roles of SIRT1 in PD. Our data showed that SIRT1 repressed proinflammatory cytokine expression both in microglia and astrocytes. In MPTP induced PD model mice, lower levels of microglia and astrocyte activation were observed in SIRT1 transgenic mice. Moreover, the tyrosine hydroxylase (TH) loss in the substantia nigra pars compacta (SNpc) and striatum induced by MPTP was also attenuated by SIRT1. As a consequence, the behavioral defects induced by MPTP were largely prevented in SIRT1 transgenic mice. Mechanistically, SIRT1 interacts with heat shock 70 kDa protein 4 (HSPA4) and deacetylates it at 305, 351 and 605 lysine residues. This deacetylation modification induces the nuclear translocation of HSPA4 and thus to repress proinflammatory cytokine expression. On the contrary, mutated HSPA4, in which 305/351/605 lysine residues were replaced with arginine, was mainly localized in the cytoplasm and losses its repression on proinflammatory cytokine expression. Taken together, our data indicate that SIRT1 plays beneficial roles in PD model mice, which is likely due to, at least in part, its anti-inflammation activity in glial cells by deacetylating HSPA4. Furthermore, HSPA4 might be a druggable target for developing novel agents for treating neuroinflammation associated disorders such as PD.

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Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degenerationPreprint
Rademacher, K., Doric, Z., Haddad, D., Mamaligas, A. A., Liao, S.-C., Creed, R. B., Kano, K., Chatterton, Z., Fu, Y., Garcia, J. H., et al. (2025) · eLife · doi:10.7554/elife.98775.2 · Cited by 1
Reviewer #3 (Public Review): Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration
Rademacher, K., Doric, Z., Haddad, D., et al. (2024) · eLife · doi:10.7554/elife.98775.1.sa1
Reviewer #1 (Public Review): Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration
Rademacher, K., Doric, Z., Haddad, D., et al. (2024) · eLife · doi:10.7554/elife.98775.1.sa3
Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degenerationPreprint
Rademacher, K., Doric, Z., Haddad, D., Mamaligas, A. A., Liao, S.-C., Creed, R. B., Kano, K., Chatterton, Z., Fu, Y., Garcia, J. H., et al. (2024) · eLife · doi:10.7554/elife.98775.1
Author response: Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration
Rademacher, K., Doric, Z., Haddad, D., Mamaligas, A. A., Liao, S.-C., Creed, R. B., Kano, K., Chatterton, Z., Fu, Y., Garcia, J. H., et al. (2024) · eLife · doi:10.7554/elife.98775.1.sa0
Reviewer #2 (Public Review):: Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration
Rademacher, K., Doric, Z., Haddad, D., et al. (2024) · eLife · doi:10.7554/elife.98775.1.sa2
eLife Assessment: Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration
Ding, J. (2024) · eLife · doi:10.7554/elife.98775.1.sa4
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Vastrad, B. M., & Vastrad, C. M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.13.638207
Reviewer #2 (Public review): Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration
(2025) · eLife · doi:10.7554/elife.98775.3.sa2
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Self-citation
Proteomic profiling reveals the potential mechanisms and regulatory targets of sirtuin 4 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson’s mouse model
Weng, H., Song, W., Fu, K., Guan, Y., Cai, G., Huang, E., Chen, X., Zou, H., & Ye, Q. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1035444 · Cited by 13

Authors: Yang, Y., Zhang, S., Guan, J., Jiang, Y., Zhang, J., Luo, L., & Sun, C.
Affiliations: Nantong University (CN)
Affiliated Hospital of Nantong University (CN)
Corresponding author: Luo, Lan
Sun, Cheng
ORCID: Jiang, Yuhui
Zhang, Jing
Luo, Lan
Sun, Cheng
Venue: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Publisher: Elsevier BV
Published: 2022-05
Volume: 1868
Issue: 5
Pages: 166365
ISSN: 0925-4439 (ISSN-L)
DOI: 10.1016/j.bbadis.2022.166365
OpenAlex: W4211191470
Cited by: 41
References: 57
Citations by year: 2026: 5 · 2025: 11 · 2024: 16 · 2023: 4 · 2022: 5
FWCI: 4.99
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 365 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: SIRT1, HSPA4, Parkinson's disease, neuroinflammation, histone deacetylation, microglial activation, astrocyte activation, inflammatory cytokines, MPTP-induced neurotoxicity, substantia nigra pars compacta, striatum, nuclear translocation, druggable targets
MeSH terms: Neuroinflammatory Diseases, Acetylation, Animals, Disease Models, Animal, Lysine, Mice, Inbred C57BL, Parkinson Disease, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Cytokines, HSP110 Heat-Shock Proteins, Mice, Sirtuin 1

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SIRT1 attenuates neuroinflammation by deacetylating HSPA4 in a mouse model of Parkinson's disease

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