The DOI matches its Crossref record; 120 of the 120 references it cites were found in a registry or an index.
Hyaluronan: Biosynthesis and signaling
Open accessAbstract
BACKGROUND Hyaluronan is a critical component of extracellular matrix with several different roles. Besides the contribution to the tissue hydration, mechanical properties and correct architecture, hyaluronan plays important biological functions interacting with different molecules and receptors. SCOPE OF REVIEW The review addresses the control of hyaluronan synthesis highlighting the critical role of hyaluronan synthase 2 in this context as well as discussing the recent findings related to covalent modifications which influence the enzyme activity. Moreover, the interactions with specific receptors and hyaluronan are described focusing on the importance of polymer size in the modulation of hyaluronan signaling. MAJOR CONCLUSIONS Due to its biological effects on cells recently described, it is evident how hyaluronan is to be considered not only a passive component of extracellular matrix but also an actor involved in several scenarios of cell behavior. GENERAL SIGNIFICANCE The effects of metabolism on the control of hyaluronan synthesis both in healthy and pathologic conditions are critical and still not completely understood. The hyaluronan capacity to bind several receptors triggering specific pathways may represent a valid target for new approach in several therapeutic strategies. This article is part of a Special Issue entitled Matrix-mediated cell behaviour and properties.
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Cites
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CD44 is the principal cell surface receptor for hyaluronate
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LYVE-1, a New Homologue of the CD44 Glycoprotein, Is a Lymph-specific Receptor for Hyaluronan
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Abatangelo, G., Vindigni, V., Avruscio, G., Pandis, L., & Brun, P. (2020) · Cells · doi:10.3390/cells9071743 · Cited by 533
Hyaluronan: molecular size‐dependent signaling and biological functions in inflammation and cancer
Tavianatou, A. G., Caon, I., Franchi, M., Piperigkou, Z., Galesso, D., & Karamanos, N. K. (2019) · The FEBS Journal · doi:10.1111/febs.14777 · Cited by 462
Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics
Karamanos, N. K., Piperigkou, Z., Theocharis, A. D., Watanabe, H., Franchi, M., Baud, S., Brézillon, S., Götte, M., Passi, A., Vigetti, D., et al. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00354 · Cited by 367
Self-citationKnopf‐Marques, H., Pravda, M., Wolfova, L., Velebny, V., Schaaf, P., Vrana, N. E., & Lavalle, P. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201600316 · Cited by 257
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Metadata
- Authors
- Vigetti, D., Karousou, E., Viola, M., Deleonibus, S., De Luca, G., & Passi, A.
- Venue
- Biochimica et Biophysica Acta (BBA) - General Subjects
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 1840
- Issue
- 8
- Pages
- 2452-2459
- ISSN
- 0304-4165 (ISSN-L)
- OpenAlex
- W1976237200
- Cited by
- 318
- References
- 120
- FWCI
- 11.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Vigetti, D., Karousou, E., Viola, M., Deleonibus, S., De Luca, G., & Passi, A. (2014). Hyaluronan: Biosynthesis and signaling. Biochimica et Biophysica Acta (BBA) - General Subjects. https://doi.org/10.1016/j.bbagen.2014.02.001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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