Cited by 196Advanced Drug Delivery SystemsHydrogels: synthesis, properties, applicationsOcular Surface and Contact Lens

Hyaluronic acid in ocular drug delivery

Zhang, Xiaodan, Wei, Danyi, Xu, Yang, Zhu, Qiang·2021·Carbohydrate Polymers

Abstract

As a naturally-occurring polysaccharide which could be found in various ophthalmic tissues, hyaluronic acid (HA) has a wide range of applications in the eye, including treatment of dry eye, vitreous substitutes and ophthalmic viscosurgical devices. Besides that, HA can be used as an effective drug carrier for ocular disease treatment due to its excellent biocompatibility, biodegradability, bioadhesion properties, viscoelasticity and receptor interaction characteristic. This review summarizes recent advances in HA-based drug delivery systems for ocular disease treatment in which it could be used as drug-polymer conjugate, drug carrier substrates, and surface modifications of the carrier. To achieve the optimum drug delivery efficacy under varied ophthalmic diseases, the molecular weight (MW) and amount of HA should be selected rationally and applied to design diverse delivery systems.

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Crossref · 10.1016/j.carbpol.2021.118006

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Authors
Zhang, X., Wei, D., Xu, Y., & Zhu, Q.
Affiliations
Nantong University (CN)
Corresponding author
Zhu, Qiang
Venue
Carbohydrate Polymers
Publisher
Elsevier BV
Published
2021-07
Volume
264
Pages
118006
ISSN
0144-8617 (ISSN-L)
OpenAlex
W3151813161
Cited by
196
References
256
Citations by year
2026: 26 · 2025: 41 · 2024: 50 · 2023: 49 · 2022: 22 · 2021: 8
FWCI
2.88
Type
journal article
Language
en
Open access
closed
Locations
  • Carbohydrate Polymers (publishedVersion)
  • PubMed (publishedVersion)
Funders
Natural Science Foundation of Jiangsu Province (BK20190922)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ocular Surface and Contact Lens
Keywords
hyaluronic acid, ocular drug delivery, drug carriers, polymer-drug conjugates, ophthalmic viscosurgical devices, vitreous substitutes, dry eye, bioadhesion, molecular weight, surface modification, biodegradable polymers, receptor targeting
MeSH terms
Animals, Drug Carriers, Eye Diseases, Humans, Hyaluronic Acid, Micelles, Polymers, Dry Eye Syndromes, Drug Delivery Systems, Immunoconjugates, Hydrogels, Nanoparticles, Administration, Ophthalmic

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