Non-collagenous ECM proteins in blood vessel morphogenesis and cancer

Kostourou, Vassiliki; Papalazarou, Vassilis

doi:10.1016/j.bbagen.2014.02.018

Cited by 41Angiogenesis and VEGF in CancerCell Adhesion Molecules ResearchCellular Mechanics and Interactions

Non-collagenous ECM proteins in blood vessel morphogenesis and cancer

Kostourou, Vassiliki, Papalazarou, Vassilis·2014·Biochimica et Biophysica Acta (BBA) - General Subjects

DOI 10.1016/j.bbagen.2014.02.018

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Abstract

Background The extracellular matrix (ECM) is constituted by diverse composite structures, which determine the specific to each organ, histological architecture and provides cells with biological information, mechanical support and a scaffold for adhesion and migration. The pleiotropic effects of the ECM stem from the dynamic changes in its molecular composition and the ability to remodel in order to effectively regulate biological outcomes. Besides collagens, fibronectin and laminin are two major fiber-forming constituents of various ECM structures. Scope of review This review will focus on the properties and the biological functions of non-collagenous extracellular matrix especially on laminin and fibronectin that are currently emerging as important regulators of blood vessel formation and function in health and disease. Major conclusions The ECM is a fundamental component of the microenvironment of blood vessels, with activities extending beyond providing a vascular scaffold; extremely versatile it directly or indirectly modulates all essential cellular functions crucial for angiogenesis, including cell adhesion, migration, proliferation, differentiation and lumen formation. Specifically, fibronectin and laminins play decisive roles in blood vessel morphogenesis both during embryonic development and in pathological conditions, such as cancer. General significance Emerging evidence demonstrates the importance of ECM function during embryonic development, organ formation and tissue homeostasis. A wealth of data also illustrates the crucial role of the ECM in several human pathophysiological processes, including fibrosis, skeletal diseases, vascular pathologies and cancer. Notably, several ECM components have been identified as potential therapeutic targets for various diseases, including cancer. This article is part of a Special Issue entitled Matrix-mediated cell behaviour and properties.

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From Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine (2023) · cites this paper as [61]

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Human microvascular endothelial cells use beta 1 and beta 3 integrin receptor complexes to attach to laminin.
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Nuclear Transfer to Eggs and OocytesPreprint
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Dystroglycan in the Cerebellum is a Laminin α2‐chain Binding Protein at the Glial‐Vascular Interface and is Expressed in Purkinje cells
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Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin
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Fibronectin receptor functions in embryonic cells deficient in alpha 5 beta 1 integrin can be replaced by alpha V integrins.
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Laminin-Binding Integrins Induce Dll4 Expression and Notch Signaling in Endothelial Cells
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Mice lacking the EDB segment of fibronectin develop normally but exhibit reduced cell growth and fibronectin matrix assembly in vitro.
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VEGF is crucial for the hepatic vascular development required for lipoprotein uptake
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Identification of Endothelial Cell Binding Sites on the Laminin γ1 Chain
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Impeded Interaction between Schwann Cells and Axons in the Absence of Laminin α4
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Dynamics of Assembly and Reorganization of Extracellular Matrix Proteins
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Mutations in Lama1 Disrupt Retinal Vascular Development and Inner Limiting Membrane Formation
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Cardiomyopathy Associated with Microcirculation Dysfunction in Laminin α4 Chain-deficient Mice
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Cloning, expression analysis, and chromosomal localization of murine and human homologues of aXenopus Mix gene
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Laminin α2 is a component of brain capillary basement membrane: Reduced expression in dystrophic dy mice
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Comparative Analysis of the Distribution of Laminin Chains in the Basement Membranes in Some Malignant Epithelial Tumors: The α1 Chain of Laminin Shows a Selected Expression Pattern in Human Carcinomas
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Endothelial α3β1-Integrin Represses Pathological Angiogenesis and Sustains Endothelial-VEGF
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Laminin-1 Promotes Angiogenesis in Synergy with Fibroblast Growth Factor by Distinct Regulation of the Gene and Protein Expression Profile in Endothelial Cells
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Syndecan-4 modulates basic fibroblast growth factor 2 signaling in vivo
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Laminin deposition is dispensable for vasculogenesis but regulates blood vessel diameter independent of flow
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Vascular endothelial cells that express dystroglycan are involved in angiogenesis
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Syndecan-4 Deficiency Increases Susceptibility to κ-Carrageenan–Induced Renal Damage
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Overexpression of laminin ?1 chain in colonic cancer cells induces an increase in tumor growth
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Acute Depletion of Endothelial β3-Integrin Transiently Inhibits Tumor Growth and Angiogenesis in Mice
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Laminin deficits induce alterations in the development of dopaminergic neurons in the mouse retina
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Genetic ablation of the alpha 6‐integrin subunit in Tie1Cre mice enhances tumour angiogenesis
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Self-citation
Changes in extra cellular matrix remodelling and re-expression of fibronectin and tenascin-C splicing variants in human myocardial tissue of the right atrial auricle: implications for a targeted therapy of cardiovascular diseases using human SIP format antibodies
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Cilia – the masterplan
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Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine
Kasravi, M., Ahmadi, A., Babajani, A., Mazloomnejad, R., Hatamnejad, M. R., Shariatzadeh, S., Bahrami, S., & Niknejad, H. (2023) · Biomaterials Research · doi:10.1186/s40824-023-00348-z · Cited by 316 · see citing works
All Roads Lead to Directional Cell Migration
Shellard, A., & Mayor, R. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.08.002 · Cited by 172 · see citing works
Targeting Cancer Associated Fibroblasts in Liver Fibrosis and Liver Cancer Using Nanocarriers
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Thrombospondin-4 mediates TGF-β-induced angiogenesis
Muppala, S., Xiao, R., Krukovets, I., Verbovetskiy, D., Yendamuri, R. S., Habib, N. A., Raman, P., Plow, E. F., & Stenina‐Adognravi, O. (2017) · Oncogene · doi:10.1038/onc.2017.140 · Cited by 155 · see citing works
Function of cancer cell-derived extracellular matrix in tumor progression
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Common and specific effects of TIE2 mutations causing venous malformations
Nätynki, M., Kangas, J., Miinalainen, I., Sormunen, R. T., Pietilä, R. S., Soblet, J., Boon, L. M., Vikkula, M., Limaye, N., & Eklund, L. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv349 · Cited by 114 · see citing works
TIMP-1 activated carcinoma-associated fibroblasts inhibit tumor apoptosis by activating SDF1/CXCR4 signaling in hepatocellular carcinoma
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Laminins and cancer stem cells: Partners in crime?
Qin, Y., Rodin, S., Simonson, O. E., & Hollande, F. (2016) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2016.07.004 · Cited by 87 · see citing works
Lamellipodia are crucial for haptotactic sensing and response
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Skin vasculature and hair follicle cross-talking associated with stem cell activation and tissue homeostasis
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F-Actin–Anchored Focal Adhesions Distinguish Endothelial Phenotypes of Human Arteries and Veins
van Geemen, D., Smeets, M. W. J., van Stalborch, A.-M. D., Woerdeman, L. A. E., Daemen, M. J. A. P., Hordijk, P. L., & Huveneers, S. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.304180 · Cited by 73 · see citing works
Basic Components of Vascular Connective Tissue and Extracellular Matrix
Halper, J. T. (2017) · Advances in pharmacology · doi:10.1016/bs.apha.2017.08.012 · Cited by 60 · see citing works
Mindin regulates vascular smooth muscle cell phenotype and prevents neointima formation
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Radial Glia Cells Control Angiogenesis in the Developing Cerebral Cortex Through TGF-β1 Signaling
Siqueira, M., Francis, D., Gisbert, D., Gomes, F. C. A., & Stipursky, J. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0557-8 · Cited by 48 · see citing works
Muscle Tissue Damage Induced by the Venom of Bothrops asper: Identification of Early and Late Pathological Events through Proteomic Analysis
Herrera, C., Macêdo, J. K. A., Feoli, A., Escalante, T., Rucavado, A., Gutiérrez, J. M., & Fox, J. W. (2016) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0004599 · Cited by 47 · see citing works
Collagen fibers provide guidance cues for capillary regrowth during regenerative angiogenesis in zebrafish
Senk, A., & Djonov, V. (2021) · Scientific Reports · doi:10.1038/s41598-021-98852-6 · Cited by 45 · see citing works
SILAC–based quantitative MS approach for real-time recording protein-mediated cell-cell interactions
Wang, X., He, Y., Ye, Y., Zhao, X., Deng, S., He, G., Zhu, H., Xu, N., & Liang, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-26262-2 · Cited by 37 · see citing works
Identification of genes related to low‐grade glioma progression and prognosis based on integrated transcriptome analysis
Jiang, Y., He, J., Guo, Y., Tao, H., Pu, F., & Li, Y. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29577 · Cited by 34 · see citing works
Analysis of Soluble Molecular Fibronectin-Fibrin Complexes and EDA-Fibronectin Concentration in Plasma of Patients with Atherosclerosis
Lemańska-Perek, A., Krzyżanowska‐Gołąb, D., Pupek, M., Klimeczek, P., Witkiewicz, W., & Kątnik‐Prastowska, I. (2016) · Inflammation · doi:10.1007/s10753-016-0336-0 · Cited by 32 · see citing works
DNA hypermethylation of extracellular matrix‐related genes in human periodontal fibroblasts induced by stimulation for a prolonged period with lipopolysaccharide derived from Porphyromonas gingivalis
Takai, R., Uehara, O., Harada, F., Utsunomiya, M., Chujo, T., Yoshida, K., Sato, J., Nishimura, M., Chiba, I., & Abiko, Y. (2015) · Journal of Periodontal Research · doi:10.1111/jre.12330 · Cited by 23 · see citing works
Human kallikrein-related peptidase 12 stimulates endothelial cell migration by remodeling the fibronectin matrix
Kryza, T., Parent, C., Pardessus, J., Petit, A., Burlaud‐Gaillard, J., Reverdiau, P., Iochmann, S., Labas, V., Courty, Y., & Heuzé‐Vourc'h, N. (2018) · Scientific Reports · doi:10.1038/s41598-018-24576-9 · Cited by 21 · see citing works
A prospective cohort study of TIMP1 as prognostic biomarker in gastric and colon cancer
Macedo, F., Cunha, N., Pereira, T. C., Soares, R. F., Monteiro, A. R., Bonito, N., Valido, F., & Sousa, G. (2022) · Chinese Clinical Oncology · doi:10.21037/cco-22-69 · Cited by 18 · see citing works
Consequences of Extracellular Matrix Remodeling in Headway and Metastasis of Cancer along with Novel Immunotherapies: A Great Promise for Future Endeavor
Ray, S. K., & Mukherjee, S. (2021) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520621666210712090017 · Cited by 12 · see citing works
Molecular Pathways: Not a Simple Tube—The Many Functions of Blood Vessels
Orr, B. A., & Eberhart, C. G. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1641 · Cited by 11 · see citing works
Multi-Omics Analyses Revealed GOLT1B as a Potential Prognostic Gene in Breast Cancer Probably Regulating the Immune Microenvironment
Liu, J., Zhang, W., Cai, W., Chen, Y., Cai, X., Tang, D., Tang, M., & Dai, Y. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2021.805273 · Cited by 8 · see citing works
Biophysical Properties of the Extracellular Matrix in Cancer: Insights Into Immunotherapy
Zheng, X., Ke, F., Yao, M., Yang, H., Luo, Y., Liu, X., Chen, C., Zhang, J., Guo, X., Song, C., et al. (2025) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl44127 · Cited by 7 · see citing works
RNA-Seq Analysis of Equine Conceptus Transcripts during Embryo Fixation and Capsule Disappearance
Tachibana, Y., Sakurai, T., Bai, H., Shiota, K., NAMBO, Y., Nagaoka, K., & Imakawa, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114414 · Cited by 6 · see citing works
Vascular cell-matrix adhesion in development and cancer
Arapatzi, C., Rouni, G., & Kostourou, V. (2021) · The International Journal of Developmental Biology · doi:10.1387/ijdb.210204vk · Cited by 6 · see citing works
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Pathophysiological Mechanisms for Intracranial Aneurysms
Huang, Z., & Ling, C. (2025) · World Neurosurgery · doi:10.1016/j.wneu.2025.124273 · Cited by 4 · see citing works
Novel Radiopharmaceuticals for Therapy
Guidoccio, F., Mazzarri, S., Depalo, T., Orsini, F., Erba, P. A., & Mariani, G. (2022) · Springer eBooks · doi:10.1007/978-3-031-05494-5_36 · Cited by 3 · see citing works
Clinical biomarkers for cancer recognition and prevention: A novel approach with optical measurements
Latini, G., Felice, C. D., Barducci, A., Dipaola, L., Gentile, M., Andreassi, M. G., Correale, M., & Bianciardi, G. (2018) · Cancer Biomarkers · doi:10.3233/cbm-170050 · Cited by 3 · see citing works
Novel Radiopharmaceuticals for Therapy
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The role of m6A in vascular-related diseases: Regulatory mechanisms and therapeutic implications
Chen, C., Liu, W., Chen, X., & Ma, J. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.124081 · Cited by 1 · see citing works
More than a Scaffold: Extracellular Matrix in Vascular Signaling
Nikolić, I. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2907-8_7 · Cited by 1 · see citing works
Cell–Extracellular Matrix Adhesions in Vascular Endothelium
Valaris, S., & Kostourou, V. (2022) · Biology of extracellular matrix · doi:10.1007/978-3-031-19616-4_7 · Cited by 1 · see citing works
Self-citation
Endothelial cells control vascular growth via regulation of Notch signaling pathway in mesenchymal stromal cells
Beloglazova, I. B., Zubkova, E., Дергилев, К. В., Goltseva, Y., Kruchinin, S. N., & Parfyonova, Y. V. (2024) · Russian Cardiology Bulletin · doi:10.17116/cardiobulletin20241902132 · Cited by 1 · see citing works
Fibronectin Network Influences Endothelial Cell Migration During Vascular Morphogenesis in a Breast Cancer Model
Ellis, K. T. (2014)
Novel Radiopharmaceuticals for Therapy
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Control by CCM complex of the dialog between integrins and cadherins for the vascular stability
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Authors: Kostourou, V., & Papalazarou, V.
Affiliations: Alexander Fleming Biomedical Sciences Research Center (GR)
Corresponding author: Kostourou, Vassiliki
ORCID: Kostourou, Vassiliki
Papalazarou, Vassilis
Venue: Biochimica et Biophysica Acta (BBA) - General Subjects
Publisher: Elsevier BV
Published: 2014-08
Volume: 1840
Issue: 8
Pages: 2403-2413
ISSN: 0304-4165 (ISSN-L)
DOI: 10.1016/j.bbagen.2014.02.018
OpenAlex: W2049499388
Cited by: 41
References: 129
Citations by year: 2025: 3 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 5 · 2014: 5
FWCI: 0.60
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochimica et Biophysica Acta (BBA) - General Subjects (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Keywords: extracellular matrix, laminin, fibronectin, blood vessel morphogenesis, angiogenesis, cancer, vascular microenvironment, cell adhesion, cell migration, lumen formation, embryonic development, extracellular matrix remodeling, therapeutic target
MeSH terms: Animals, Blood Vessels, Collagen, Humans, Morphogenesis, Neoplasms, Extracellular Matrix Proteins, Neovascularization, Physiologic

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