The DOI matches its Crossref record; 150 of the 150 references it cites were found in a registry or an index.
High-mobility group box 1 and cancer
Open accessAbstract
High-mobility group box 1 protein (HMGB1), a chromatin associated nuclear protein and extracellular damage associated molecular pattern molecule (DAMP), is an evolutionarily ancient and critical regulator of cell death and survival. Overexpression of HMGB1 is associated with each of the hallmarks of cancer including unlimited replicative potential, ability to develop blood vessels (angiogenesis), evasion of programmed cell death (apoptosis), self-sufficiency in growth signals, insensitivity to inhibitors of growth, inflammation, tissue invasion and metastasis. Our studies and those of our colleagues suggest that HMGB1 is central to cancer (abnormal wound healing) and many of the findings in normal wound healing as well. Here, we focus on the role of HMGB1 in cancer, the mechanisms by which it contributes to carcinogenesis, and therapeutic strategies based on targeting HMGB1.
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Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
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HMG-1 as a Late Mediator of Endotoxin Lethality in Mice
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High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal
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Cited by
The role of short chain fatty acids in health and disease
Tan, J., McKenzie, C., Potamitis, M., Thorburn, A. N., Mackay, C. R., & Macia, L. (2014) · Advances in immunology · doi:10.1016/b978-0-12-800100-4.00003-9 · Cited by 2,425
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Self-citationEndogenous HMGB1 regulates autophagy
Tang, D., Kang, R., Livesey, K. M., Cheh, C.-W., Farkas, A., Loughran, P., Hoppe, G., Bianchi, M. E., Tracey, K. J., Zeh, H. J., et al. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200911078 · Cited by 951
Self-citationHMGB1 release and redox regulates autophagy and apoptosis in cancer cells
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Self-citationp53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes
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Metadata
- Authors
- Tang, D., Kang, R., Zeh III, H. J., & Lotze, M. T.
- Venue
- Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 1799
- Issue
- 1-2
- Pages
- 131-140
- ISSN
- 1874-9399 (ISSN-L)
- OpenAlex
- W1969305254
- Cited by
- 512
- References
- 150
- FWCI
- 23.94
- Type
- journal article
- Language
- en
- Open access
- green
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- Tang, D., Kang, R., Zeh III, H. J., & Lotze, M. T. (2010). High-mobility group box 1 and cancer. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. https://doi.org/10.1016/j.bbagrm.2009.11.014
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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