The DOI matches its Crossref record; 232 of the 232 references it cites were found in a registry or an index.
Interpreting the language of histone and DNA modifications
Open accessAbstract
A major mechanism regulating the accessibility and function of eukaryotic genomes are the covalent modifications to DNA and histone proteins that dependably package our genetic information inside the nucleus of every cell. Formally postulated over a decade ago, it is becoming increasingly clear that post-translational modifications (PTMs) on histones act singly and in combination to form a language or ‘code’ that is read by specialized proteins to facilitate downstream functions in chromatin. Underappreciated at the time was the level of complexity harbored both within histone PTMs and their combinations, as well as within the proteins that read and interpret the language. In addition to histone PTMs, newly-identified DNA modifications that can recruit specific effector proteins has raised further awareness that histone PTMs operate within a broader language of epigenetic modifications to orchestrate the dynamic functions associated with chromatin. Here, we highlight key recent advances in our understanding of the epigenetic language encompassing histone and DNA modifications and foreshadow challenges that lie ahead as we continue our quest to decipher the fundamental mechanisms of chromatin regulation.
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1 retracted
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Cited by
Zitnik, M., Nguyen, F., Wang, B., Leskovec, J., Goldenberg, A., & Hoffman, M. M. (2019) · Information Fusion · doi:10.1016/j.inffus.2018.09.012 · Cited by 675
The impact of cellular metabolism on chromatin dynamics and epigenetics
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Absence of a simple code: how transcription factors read the genome
Slattery, M., Zhou, T., Yang, L., Dantas Machado, A. C., Gordân, R., & Rohs, R. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.07.002 · Cited by 537
Post-Translational Modifications of Histones That Influence Nucleosome Dynamics
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Epigenetic inheritance and the missing heritability
Trerotola, M., Relli, V., Simeone, P., & Alberti, S. (2015) · Human Genomics · doi:10.1186/s40246-015-0041-3 · Cited by 318
“the bromodomain motif that docks onto acetylated lysines [92]), which drive chromatin packaging around nucleosomes [88, 91] (Fig.”
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Metadata
- Authors
- Rothbart, S. B., & Strahl, B. D.
- Venue
- Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 1839
- Issue
- 8
- Pages
- 627-643
- ISSN
- 1874-9399 (ISSN-L)
- OpenAlex
- W2063271327
- Cited by
- 720
- References
- 232
- FWCI
- 29.45
- Type
- journal article
- Language
- en
- Open access
- green
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