Lipids in Alzheimer’s disease: A century-old story
Abstract
Three neuropathological features attracted the attention of Alzheimer in his examination of the brain of Auguste Deter: abnormal fibrillary structures, cortical depositions now termed "plaques," and glial proliferation, whereby he noted remarkable lipid granule accumulation in the glia. These features were also recorded by Perusini and Kraepelin, but by 1930 the lipoid deposits were no longer regarded by neuropathologists with great interest.
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Lipid droplet accumulation is a component of Alzheimer's disease.
“Since LD accumulation is a component of AD [67,68], and there are reduced levels of LPL in the dentate gyrus of patients with AD [27], it is plausible that reduced LPL in AD could contribute to LDAM physiology, increased CE load, microglial dysfunction, and disease progression.”
From Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation (2021) · cites this paper as [68]
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- Authors
- Foley, P.
- Affiliations
- Neuroscience Research Australia (AU)
- Corresponding author
- Foley, Paul
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 1801
- Issue
- 8
- Pages
- 750-753
- ISSN
- 1388-1981 (ISSN-L)
- OpenAlex
- W2040912634
- Cited by
- 186
- References
- 12
- Citations by year
- 2026: 8 · 2025: 24 · 2024: 20 · 2023: 10 · 2022: 15 · 2021: 12 · 2020: 28 · 2019: 9 · 2018: 10 · 2017: 6 · 2016: 10 · 2015: 9 · 2014: 10 · 2013: 8 · 2012: 3
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, lipids, lipid granules, glial cell proliferation, amyloid plaques, neurofibrillary tangles, history of Alzheimer's disease, neuropathology
- MeSH terms
- Alzheimer Disease, Brain, Humans, Lipids, History, 20th Century, History, 21st Century, Lipid Metabolism
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