Cited by 186Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsDementia and Cognitive Impairment Research

Lipids in Alzheimer’s disease: A century-old story

Foley, Paul·2010·Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Abstract

Three neuropathological features attracted the attention of Alzheimer in his examination of the brain of Auguste Deter: abnormal fibrillary structures, cortical depositions now termed "plaques," and glial proliferation, whereby he noted remarkable lipid granule accumulation in the glia. These features were also recorded by Perusini and Kraepelin, but by 1930 the lipoid deposits were no longer regarded by neuropathologists with great interest.

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Crossref · 10.1016/j.bbalip.2010.05.004

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12 of 12 references verified0 citation errors · 0 not checkable

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  • Lipid droplet accumulation is a component of Alzheimer's disease.

    “Since LD accumulation is a component of AD [67,68], and there are reduced levels of LPL in the dentate gyrus of patients with AD [27], it is plausible that reduced LPL in AD could contribute to LDAM physiology, increased CE load, microglial dysfunction, and disease progression.”

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Authors
Foley, P.
Affiliations
Neuroscience Research Australia (AU)
Corresponding author
Foley, Paul
Venue
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Publisher
Elsevier BV
Published
2010-08
Volume
1801
Issue
8
Pages
750-753
ISSN
1388-1981 (ISSN-L)
OpenAlex
W2040912634
Cited by
186
References
12
Citations by year
2026: 8 · 2025: 24 · 2024: 20 · 2023: 10 · 2022: 15 · 2021: 12 · 2020: 28 · 2019: 9 · 2018: 10 · 2017: 6 · 2016: 10 · 2015: 9 · 2014: 10 · 2013: 8 · 2012: 3
FWCI
3.25
Type
journal article
Language
en
Open access
closed
Locations
  • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Alzheimer's disease, lipids, lipid granules, glial cell proliferation, amyloid plaques, neurofibrillary tangles, history of Alzheimer's disease, neuropathology
MeSH terms
Alzheimer Disease, Brain, Humans, Lipids, History, 20th Century, History, 21st Century, Lipid Metabolism

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