APP Function and Lipids: A Bidirectional Link

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429 · see citing works

Alzheimer's disease: the amyloid cascade hypothesis

Hardy, J. A., & Higgins, G. A. (1992) · Science · doi:10.1126/science.1566067 · Cited by 7,484 · see citing works

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404 · see citing works

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., & Müller-Hill, B. (1987) · Nature · doi:10.1038/325733a0 · Cited by 4,619 · see citing works

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431 · see citing works

Lipid rafts as a membrane-organizing principle

Lingwood, D., & Simons, K. (2010) · Science · doi:10.1126/science.1174621 · Cited by 4,417 · see citing works

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268 · see citing works

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., et al. (1995) · Nature · doi:10.1038/375754a0 · Cited by 4,051 · see citing works

Evidence for the Formation of Symmetric and Asymmetric DLPC-DAPC Lipid Bilayer Domains

Ritter, M., Schmidt, S., Jakab, M., Paulmichl, M., & Henderson, R. M. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350122 · Cited by 3,923 · see citing works

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., et al. (1999) · Science · doi:10.1126/science.286.5440.735 · Cited by 3,876 · see citing works

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Shankar, G. M., Li, S., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., et al. (2008) · Nature Medicine · doi:10.1038/nm1782 · Cited by 3,685 · see citing works

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

Grundke-Iqbal, I., Iqbal, K., Tung, Y. C., Quinlan, M., Wisniewski, H. M., & Binder, L. I. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.13.4913 · Cited by 3,676 · see citing works

Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

Lambert, M. P., Barlow, A. K., Chromy, B. A., Edwards, C., Freed, R., Liosatos, M., Morgan, T. E., Rozovsky, I., Trommer, B., Viola, K. L., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6448 · Cited by 3,506 · see citing works

Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface

Brown, D. A., & Rose, J. K. (1992) · Cell · doi:10.1016/0092-8674(92)90189-j · Cited by 2,921 · see citing works

The projected effect of risk factor reduction on Alzheimer's disease prevalence

Barnes, D. E., & Yaffe, K. S. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70072-2 · Cited by 2,668 · see citing works

The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease

Jarrett, J. T., Berger, E. P., & Lansbury, P. T. (1993) · Biochemistry · doi:10.1021/bi00069a001 · Cited by 2,022 · see citing works

Prevalence of Dementia in the United States: The Aging, Demographics, and Memory Study

Plassman, B. L., Langa, K. M., Fisher, G. G., Heeringa, S. G., Weir, D. R., Ofstedal, M. B., Burke, J. R., Hurd, M. D., Potter, G. G., Rodgers, W. L., et al. (2007) · Neuroepidemiology · doi:10.1159/000109998 · Cited by 1,932 · see citing works

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

Corder, E. H., Saunders, A. M., Risch, N. J., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Rimmler, J. B., Locke, P. A., Conneally, P. M., Schmader, K. E., et al. (1994) · Nature Genetics · doi:10.1038/ng0694-180 · Cited by 1,920 · see citing works

The chemistry and antioxidant properties of tocopherols and tocotrienols

Kamal‐Eldin, A., & Appelqvist, L. (1996) · Lipids · doi:10.1007/bf02522884 · Cited by 1,836 · see citing works

Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease

Gómez-Isla, T., Price, J. L., McKeel Jr., D. W., Morris, J. C., Growdon, J. H., & Hyman, B. T. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-14-04491.1996 · Cited by 1,796 · cited 1× · see citing works

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

Grundke, I., Iqbal, K., Quinlan, M., Tung, Y. C., Zaidi, M. S., & Wisniewski, H. M. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38495-8 · Cited by 1,780 · see citing works

Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)

Iwatsubo, T., Odaka, A., Suzuki, N., Mizusawa, H., Nukina, N., & Ihara, Y. (1994) · Neuron · doi:10.1016/0896-6273(94)90458-8 · Cited by 1,774 · see citing works

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

Cuvillier, O., Pirianov, G., Kleuser, B., Vanek, P. G., Coso, O. A., Gutkind, J. S., & Spiegel, S. (1996) · Nature · doi:10.1038/381800a0 · Cited by 1,532 · see citing works

Effect of Dietary trans Fatty Acids on High-Density and Low-Density Lipoprotein Cholesterol Levels in Healthy Subjects

Mensink, R. P., & Katan, M. (1990) · New England Journal of Medicine · doi:10.1056/nejm199008163230703 · Cited by 1,425 · see citing works

Decreased Prevalence of Alzheimer Disease Associated With 3-Hydroxy-3-Methyglutaryl Coenzyme A Reductase Inhibitors

Wolozin, B. L. (2000) · Archives of Neurology · doi:10.1001/archneur.57.10.1439 · Cited by 1,401 · see citing works

Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type

Levy, E., Carman, M. D., Fernandez-Madrid, I. J., Power, M. D., Lieberburg, I. M., van Duinen, S. G., Bots, G. T. A. M., Luyendijk, W., & Frangione, B. (1990) · Science · doi:10.1126/science.2111584 · Cited by 1,380 · see citing works

Regulated Intramembrane Proteolysis

Brown, M. S., Ye, J., Rawson, R. B., & Goldstein, J. L. (2000) · Cell · doi:10.1016/s0092-8674(00)80675-3 · Cited by 1,329 · see citing works

Human ApoE isoforms differentially regulate brain amyloid-β peptide clearance

Castellano, J. M., Kim, J., Stewart, F. R., Jiang, H., DeMattos, R. B., Patterson, B. W., Fagan, A. M., Morris, J. C., Mawuenyega, K. G., Cruchaga, C., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002156 · Cited by 1,227 · cited 1× · see citing works

A Transcriptively Active Complex of APP with Fe65 and Histone Acetyltransferase Tip60

Cao, X., & Südhof, T. C. (2001) · Science · doi:10.1126/science.1058783 · Cited by 1,202 · see citing works

Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons

Simons, M., Keller, P., Strooper, B. D., Beyreuther, K. T., Dotti, C. G., & Simons, K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6460 · Cited by 1,167 · see citing works

Amyloid Precursor Protein Trafficking, Processing, and Function

Thinakaran, G., & Koo, E. H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r800019200 · Cited by 1,141 · see citing works

Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

Cutler, R. G., Kelly, J., Storie, K., Pedersen, W. A., Tammara, A., Hatanpaa, K. J., Troncoso, J. C., & Mattson, M. P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305799101 · Cited by 1,135 · see citing works

Consumption of Fish and n-3 Fatty Acids and Risk of Incident Alzheimer Disease

Morris, M. C., Evans, D. A., Bienias, J. L., Tangney, C. C., Bennett, D. A., Wilson, R. S., Aggarwal, N., & Schneider, J. (2003) · Archives of Neurology · doi:10.1001/archneur.60.7.940 · Cited by 1,135 · see citing works

Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease

Lammich, S., Kojro, E., Postina, R., Gilbert, S., Pfeiffer, R., Jasionowski, M., Haass, C., & Fahrenholz, F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3922 · Cited by 1,132 · see citing works

Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts

Ehehalt, R., Keller, P., Haass, C., Thiele, C., & Simons, K. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200207113 · Cited by 1,107 · see citing works

Thematic review series: brain lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal

Dietschy, J. M., & Turley, S. D. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r400004-jlr200 · Cited by 1,095 · see citing works

Functions of plasmalogen lipids in health and disease

Braverman, N. E., & Moser, A. B. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.05.008 · Cited by 1,082 · see citing works

Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo

Fassbender, K. C., Simons, M., Bergmann, C., Stroick, M., Lütjohann, D., Keller, P., Runz, H., Kühl, S., Bertsch, T., von Bergmann, K., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081620098 · Cited by 1,078 · see citing works

The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina

Lauritzen, L. (2001) · Progress in Lipid Research · doi:10.1016/s0163-7827(00)00017-5 · Cited by 1,066 · see citing works

Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

Nguyen, L. N., Ma, D., Shui, G., Wong, P., Cazenave-Gassiot, A., Zhang, X., Wenk, M. R., Goh, E. L. K., & Silver, D. L. (2014) · Nature · doi:10.1038/nature13241 · Cited by 1,048 · see citing works

4‐Hydroxynonenal‐Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease

Sayre, L., Zelasko, D. A., Harris, P. L. R., Perry, G., Salomon, R. G., & Smith, M. A. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68052092.x · Cited by 1,032 · see citing works

Plasma phospholipids identify antecedent memory impairment in older adults

Mapstone, M. E., Cheema, A. K., Fiandaca, M. S., Zhong, X., Mhyre, T. R., MacArthur, L. H., Hall, W. J., Fisher, S. G., Peterson, D. R., Haley, J. M., et al. (2014) · Nature Medicine · doi:10.1038/nm.3466 · Cited by 1,031 · see citing works

Hypercholesterolemia Accelerates the Alzheimer's Amyloid Pathology in a Transgenic Mouse Model

Refolo, L. M., Pappolla, M. A., Malester, B., LaFrancois, J. J., Bryant‐Thomas, T., Wang, R., Tint, G. S., Sambamurti, K., & Duff, K. (2000) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0304 · Cited by 1,003 · see citing works

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

Koo, E. H., & Squazzo, S. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32449-3 · Cited by 989 · see citing works

Linking lipids to Alzheimer's disease: cholesterol and beyond

Di Paolo, G., & Kim, T.-W. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3012 · Cited by 972 · see citing works

Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments

Haass, C., Koo, E. H., Mellon, A., Hung, A. Y., & Selkoe, D. J. (1992) · Nature · doi:10.1038/357500a0 · Cited by 899 · see citing works

Dietary fat intake and the risk of incident dementia in the Rotterdam study

Kalmijn, S., Launer, L. J., Ott, A., Witteman, J. C. M., Hofman, A., & Breteler, M. M. B. (1997) · Annals of Neurology · doi:10.1002/ana.410420514 · Cited by 895 · cited 1× · see citing works

Reconstitution of γ-secretase activity

Edbauer, D., Winkler, E., Regula, J. T., Pesold, B., Steiner, H., & Haass, C. (2003) · Nature Cell Biology · doi:10.1038/ncb960 · Cited by 882 · see citing works

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

Ma, J., Yee, A., Brewer, H. B., Das, S., & Potter, H. (1994) · Nature · doi:10.1038/372092a0 · Cited by 871 · see citing works

ALZHEIMER'S DISEASE INTERNATIONAL

Graham, N., & Brodaty, H. (1997) · International Journal of Geriatric Psychiatry · doi:10.1002/(sici)1099-1166(199707)12:7 · Cited by 852 · see citing works

A Familial Alzheimer's Disease Locus on Chromosome 1

Levy‐Lahad, E., Wijsman, E. M., Nemens, E. J., Anderson, L., Goddard, K. A. B., Weber, J. L., Bird, T. D., & Schellenberg, G. D. (1995) · Science · doi:10.1126/science.7638621 · Cited by 812 · see citing works

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10

Kojro, E., Gimpl, G., Lammich, S., März, W., & Fahrenholz, F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081612998 · Cited by 804 · see citing works

The Genetics of Alzheimer's Disease

Bertram, L., & Tanzi, R. E. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-385883-2.00008-4 · Cited by 784 · see citing works

Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease

Holtzman, D. M., Herz, J., & Bu, G. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006312 · Cited by 782 · see citing works

Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms.

Weisgraber, K. H., Rall, S. C., & Mahley, R. W. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52510-8 · Cited by 777 · see citing works

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

Deane, R., Sagare, A., Hamm, K., Parisi, M., Lane, S., Finn, M. B., Holtzman, D. M., & Zlokovic, B. V. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36663 · Cited by 771 · see citing works

Docosahexaenoic Acid Supplementation and Cognitive Decline in Alzheimer Disease: A Randomized Trial

Quinn, J. F., Raman, R., Thomas, R. G., Yurko-Mauro, K., Nelson, E. B., Van Dyck, C., Galvin, J. E., Emond, J., Jack, C. R., Weiner, M., et al. (2010) · JAMA · doi:10.1001/jama.2010.1510 · Cited by 764 · see citing works

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

Kimberly, W. T., LaVoie, M. J., Ostaszewski, B. L., Ye, W., Wolfe, M. S., & Selkoe, D. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1037392100 · Cited by 763 · see citing works

ω-3 Fatty Acid Treatment in 174 Patients With Mild to Moderate Alzheimer Disease: OmegAD Study: A Randomized Double-blind Trial

Freund-Levi, Y., Eriksdotter-Jönhagen, M., Cederholm, T., Basun, H., Faxén-Irving, G., Garlind, A., Vedin, I., Vessby, B., Wahlund, L.-O., & Palmblad, J. (2006) · Archives of Neurology · doi:10.1001/archneur.63.10.1402 · Cited by 751 · see citing works

The genetics of Alzheimer disease

Tanzi, R. E. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006296 · Cited by 727 · see citing works

Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model

Calon, F., Lim, G. P., Yang, F., Morihara, T., Teter, B., Ubeda, O., Rostaing, P., Triller, A., Salem, N., Ashe, K. H., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.013 · Cited by 707 · see citing works

A Diet Enriched with the Omega-3 Fatty Acid Docosahexaenoic Acid Reduces Amyloid Burden in an Aged Alzheimer Mouse Model

Lim, G. P., Calon, F., Morihara, T., Yang, F., Teter, B., Ubeda, O. J., Salem, N., Frautschy, S. A., & Cole, G. M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4225-04.2005 · Cited by 687 · see citing works

Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease

Markesbery, W. R., & Lovell, M. A. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00009-8 · Cited by 680 · see citing works

Fatty acid composition of brain phospholipids in aging and in Alzheimer’s disease

Söderberg, M., Edlund, C., Kristensson, K., & Dallner, G. (1991) · Lipids · doi:10.1007/bf02536067 · Cited by 667 · see citing works

Apolipoprotein E ε4 Allele, Elevated Midlife Total Cholesterol Level, and High Midlife Systolic Blood Pressure Are Independent Risk Factors for Late-Life Alzheimer Disease

Kivipelto, M., Helkala, E., Laakso, M. P., Hänninen, T., Hallikainen, M., Alhainen, K., Iivonen, S., Mannermaa, A., Tuomilehto, J., Nissinen, A. M., et al. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-137-3-200208060-00006 · Cited by 645 · see citing works

Comparative Lipidomic Analysis of Mouse and Human Brain with Alzheimer Disease

Chan, R. B., Oliveira, T. G., Cortes, E. P., Honig, L. S., Duff, K. E., Small, S. A., Wenk, M. R., Shui, G., & Di Paolo, G. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.274142 · Cited by 630 · see citing works

Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis

Han, X., M. Holtzman, D., W. McKeel, D., Kelley, J., & Morris, J. C. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00997.x · Cited by 626 · see citing works

ADAM10 is the physiologically relevant, constitutive α‐secretase of the amyloid precursor protein in primary neurons

Kuhn, P., Wang, H., Dislich, B., Colombo, A., Zeitschel, U., Ellwart, J. W., Kremmer, E., Roßner, S., & Lichtenthaler, S. F. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.167 · Cited by 621 · cited 1× · see citing works

Physiological compartmental analysis of α-linolenic acid metabolism in adult humans

Pawlosky, R. J., Hibbeln, J. R., Novotny, J. A., & Salem, N. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31576-5 · Cited by 593 · see citing works

Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometry

Han, X., Holtzman, D. M., & McKeel, D. W. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00332.x · Cited by 573 · see citing works

Induction of Alzheimer-like β-Amyloid Immunoreactivity in the Brains of Rabbits with Dietary Cholesterol

Sparks, D. L., Scheff, S. W., Hunsaker, J. C., Liu, H., Landers, T. M., & Gross, D. R. (1994) · Experimental Neurology · doi:10.1006/exnr.1994.1044 · Cited by 559 · see citing works

Midlife Serum Cholesterol and Increased Risk of Alzheimer’s and Vascular Dementia Three Decades Later

Solomon, A., Kivipelto, M., Wolozin, B., Zhou, J., & Whitmer, R. A. (2009) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000231980 · Cited by 557 · see citing works

GM1 ganglioside–bound amyloid β–protein (Aβ): A possible form of preamyloid in Alzheimer's disease

Yanagisawa, K., Odaka, A., Suzuki, N., & Ihara, Y. (1995) · Nature Medicine · doi:10.1038/nm1095-1062 · Cited by 544 · see citing works

Dietary Fats and the Risk of Incident Alzheimer Disease

Morris, M. C., Evans, D. A., Bienias, J. L., Tangney, C., Bennett, D. A., Aggarwal, N. T., Schneider, J. S., & Wilson, R. S. (2003) · Archives of Neurology · doi:10.1001/archneur.60.2.194 · Cited by 530 · see citing works

Fatty acid analysis of blood plasma of patients with alzheimer's disease, other types of dementia, and cognitive impairment

Conquer, J. A., Tierney, M. C., Zecevic, J., Bettger, W. J., & Fisher, R. H. (2000) · Lipids · doi:10.1007/s11745-000-0646-3 · Cited by 523 · see citing works

A Cholesterol-Lowering Drug Reduces β-Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease

Refolo, L. M., Pappolla, M. A., LaFrancois, J. J., Malester, B., Schmidt, S. D., Thomas-Bryant, T., Tint, G. S., Wang, R., Mercken, M. H., Petanceska, S. S., et al. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0422 · Cited by 521 · see citing works

Deregulation of sphingolipid metabolism in Alzheimer’s disease

He, X., Huang, Y., Li, B., Gong, C.-X., & Schuchman, E. H. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.05.010 · Cited by 516 · see citing works

Fish, meat, and risk of dementia: cohort study

Barberger‐Gateau, P. (2002) · BMJ · doi:10.1136/bmj.325.7370.932 · Cited by 486 · see citing works

MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer’s disease ☆ ☆This research was supported by grants P01 AG09466 and P30 AG10161 from the National Institute on Aging, National Institutes of Health.

Dickerson, B. C., Goncharova, I. I., Sullivan, M., Forchetti, C., Wilson, R. S., Bennett, D. A., Beckett, L. A., & deToledo‐Morrell, L. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00271-8 · Cited by 481 · see citing works

Dietarytrans fatty acids: effects on plasma lipids and lipoproteins of healthy men and women

Judd, J., Clevidence, B., Muesing, R. A., Wittes, J. T., Sunkin, M. E., & Podczasy, J. J. (1994) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/59.4.861 · Cited by 457 · see citing works

Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process

De Strooper, B. (2010) · Physiological Reviews · doi:10.1152/physrev.00023.2009 · Cited by 455 · see citing works

Regulation of cholesterol and sphingomyelin metabolism by amyloid-β and presenilin

Grimm, M. O. W., Grimm, H. S., Pätzold, A. J., Zinser, E. G., Halonen, R., Duering, M., Tschäpe, J., Strooper, B. D., Müller, U., Shen, J., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1313 · Cited by 446 · see citing works

Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe

Feldman, H. H., Doody, R. S., Kivipelto, M., Sparks, D. L., Waters, D. D., Jones, R. W., Schwam, E., Schindler, R., Hey-Hadavi, J., DeMicco, D. A., et al. (2010) · Neurology · doi:10.1212/wnl.0b013e3181d6476a · Cited by 438 · see citing works

Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease.

Smith, M. A., Kutty, R. K., Richey, P. L., Yan, S. D., Stern, D., Chader, G. J., Wiggert, B. O., Petersen, R. B., & Perry, G. L. (1994) · PubMed Central · Cited by 425 · see citing works

Association of γ-Secretase with Lipid Rafts in Post-Golgi and Endosome Membranes

Vetrivel, K. S., Cheng, H., Lin, W., Sakurai, T., Li, T., Nukina, N., Wong, P. C., Xu, H., & Thinakaran, G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407986200 · Cited by 413 · see citing works

Structures, Biosynthesis, and Functions of Gangliosides-an Overview

Yu, R. K., Tsai, Y., Ariga, T., & Yanagisawa, M. (2011) · Journal of Oleo Science · doi:10.5650/jos.60.537 · Cited by 413 · see citing works

The effects of omega-3 fatty acids monotherapy in Alzheimer's disease and mild cognitive impairment: A preliminary randomized double-blind placebo-controlled study

Chiu, C.-C., Su, K., Cheng, T., Liu, H., Chang, C.-J., Dewey, M. E., Stewart, R. J., & Huang, S. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.05.015 · Cited by 406 · see citing works

<i>APOE</i> -ε4 count predicts age when prevalence of AD increases, then declines: The Cache County Study

Breitner, J. C. S., Wyse, B. W., Anthony, J. C., Welsh-Bohmer, K. A., Steffens, D. C., Norton, M. C., Tschanz, J. T., Plassman, B. L., Meyer, M. R., Skoog, I., et al. (1999) · Neurology · doi:10.1212/wnl.53.2.321 · Cited by 397 · see citing works

A detergent-insoluble membrance compartment contains Aβ in vivo

Lee, S., Liyanage, U. K., Bickel, P. E., Xia, W., Lansbury, P. T., & Kosik, K. S. (1998) · Nature Medicine · doi:10.1038/nm0698-730 · Cited by 395 · see citing works

Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study

Haag, M. D. M., Hofman, A., Koudstaal, P. J., Stricker, B. H. C., & Breteler, M. M. B. (2009) · Journal of Neurology, Neurosurgery &amp; Psychiatry · doi:10.1136/jnnp.2008.150433 · Cited by 393 · see citing works

Longer Forms of Amyloid β Protein: Implications for the Mechanism of Intramembrane Cleavage by γ-Secretase

Qi-Takahara, Y., Morishima-Kawashima, M., Tanimura, Y., Dolios, G., Hirotani, N., Horikoshi, Y., Kametani, F., Maeda, M., Saido, T. C., Wang, R., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1575-04.2005 · Cited by 391 · see citing works

Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease

Wolozin, B. L., Wang, S. W., Li, N.-C., Lee, A. F., Lee, T. A., & Kazis, L. E. (2007) · BMC Medicine · doi:10.1186/1741-7015-5-20 · Cited by 385 · see citing works

Amyloid-β forms fibrils by nucleated conformational conversion of oligomers

Lee, J., Culyba, E. K., Powers, E. T., & Kelly, J. W. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.624 · Cited by 383 · see citing works

Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease

Sanchez-Mejia, R. O., Newman, J. W. I., Toh, S., Yu, G.-Q., Zhou, Y., Halabisky, B., Cissé, M., Scearce-Levie, K. A., Cheng, I. H.-J., Gan, L., et al. (2008) · Nature Neuroscience · doi:10.1038/nn.2213 · Cited by 369 · see citing works

Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer's disease model rats

Hashimoto, M., Hossain, S., Shimada, T., Sugioka, K., Yamasaki, H., Fujii, Y., Ishibashi, Y., Oka, J., & Shido, O. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00905.x · Cited by 364 · see citing works

Docosahexaenoic acid in the diet: its importance in maintenance and restoration of neural membrane function

Horrocks, L. A., & Farooqui, A. A. (2004) · Prostaglandins, Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2003.12.011 · Cited by 356 · see citing works

The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor

von Rotz, R. C., Kohli, B. M., Bosset, J., Meier, M. G., Suzuki, T., Nitsch, R. M., & Konietzko, U. (2004) · Journal of Cell Science · doi:10.1242/jcs.01323 · Cited by 348 · see citing works

A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease

Sano, M., Bell, K. L., Galasko, D., Galvin, J. E., Thomas, R. G., van Dyck, C. H., & Aisen, P. S. S. (2011) · Neurology · doi:10.1212/wnl.0b013e318228bf11 · Cited by 336 · see citing works

The metabolism and function of sphingolipids and glycosphingolipids

Lahiri, S., & Futerman, A. H. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7076-0 · Cited by 334 · see citing works

Membrane Lipids, Selectively Diminished in Alzheimer Brains, Suggest Synapse Loss as a Primary Event in Early‐Onset Form (Type I) and Demyelination in Late‐Onset Form (Type II)

Svennerholm, L. T., & Gottfries, C. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.62031039.x · Cited by 327 · see citing works

Dietary Docosahexaenoic Acid and Docosapentaenoic Acid Ameliorate Amyloid-β and Tau Pathology via a Mechanism Involving Presenilin 1 Levels

Green, K. N., Martínez‐Coria, H., Khashwji, H., Hall, E. B., Yurko‐Mauro, K., Ellis, L., & LaFerla, F. M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0055-07.2007 · Cited by 326 · see citing works

Novel Therapeutic Approach for the Treatment of Alzheimer's Disease by Peripheral Administration of Agents with an Affinity to β-Amyloid

Matsuoka, Y., Saito, M., LaFrancois, J. J., Saito, M., Gaynor, K., Olm, V., Wang, L., Casey, E., Lu, Y., Shiratori, C., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00029.2003 · Cited by 324 · see citing works

Diet and risk of dementia: Does fat matter?: The Rotterdam Study

Engelhart, M. J., Geerlings, M. I., Ruitenberg, A., van Swieten, J. C., Hofman, A., Witteman, J. C. M., & Breteler, M. M. B. (2002) · Neurology · doi:10.1212/01.wnl.0000038345.77753.46 · Cited by 324 · see citing works

Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction

Kotani, S., Sakaguchi, E., Warashina, S., Matsukawa, N., Ishikura, Y., Kiso, Y., Sakakibara, M., Yoshimoto, T., Guo, J., & Yamashima, T. (2006) · Neuroscience Research · doi:10.1016/j.neures.2006.06.010 · Cited by 320 · see citing works

Acceleration of Amyloid Fibril Formation by Specific Binding of Aβ-(1–40) Peptide to Ganglioside-containing Membrane Vesicles

Choo, L.-P., Garzon-Rodriguez, W., Glabe, C. G., & Surewicz, W. K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.37.22987 · Cited by 312 · see citing works

Dietary fat intake and 6-year cognitive change in an older biracial community population

Morris, M. C., Evans, D. A., Bienias, J. L., Tangney, C., & Wilson, R. S. (2004) · Neurology · doi:10.1212/01.wnl.0000123250.82849.b6 · Cited by 311 · see citing works

Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case–control study

Tully, A.-M., Roche, H. M., Doyle, R., Fallon, C., Bruce, I., LAWLOR, B. A., Coakley, D., & Gibney, M. J. (2003) · British Journal Of Nutrition · doi:10.1079/bjn2002804 · Cited by 309 · see citing works

Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology

Pappolla, M. A., Bryant‐Thomas, T., Herbert, D., Pacheco, J., Garcia, M. F., Manjón, M., Gironès, X., Henry, T. L., Matsubara, E., Zambón, D., et al. (2003) · Neurology · doi:10.1212/01.wnl.0000070182.02537.84 · Cited by 308 · see citing works

Compartmentalization of β-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

Riddell, D. R., Christie, G., Hussain, I., & Dingwall, C. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00394-3 · Cited by 303 · see citing works

Brain Membrane Phospholipid Alterations in Alzheimer's Disease

Pettegrew, J. W., Panchalingam, K., Hamilton, R. L., & McClure, R. J. (2001) · Neurochemical Research · doi:10.1023/a:1011603916962 · Cited by 292 · see citing works

Lipids as Modulators of Proteolytic Activity of BACE

Kalvodova, L., Kahya, N., Schwille, P., Ehehalt, R., Verkade, P., Drechsel, D. N., & Simons, K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504484200 · Cited by 289 · see citing works

Cholesterol depletion induces large scale domain segregation in living cell membranes

Hao, M., Mukherjee, S., & Maxfield, F. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231377398 · Cited by 289 · see citing works

Chronic Administration of Docosahexaenoic Acid Ameliorates the Impairment of Spatial Cognition Learning Ability in Amyloid β–Infused Rats

Hashimoto, M., Tanabe, Y., Fujii, Y., Kikuta, T., Shibata, H., & Shido, O. (2005) · The Journal of Nutrition · doi:10.1093/jn/135.3.549 · Cited by 288 · see citing works

Cholesterol retention in Alzheimer's brain is responsible for high β- and γ-secretase activities and Aβ production

Xiong, H., Callaghan, D., Jones, A., Walker, D. G., Lue, L., Beach, T. G., Sue, L. I., Woulfe, J., Xu, H., Stanimirovic, D. B., et al. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.10.005 · Cited by 283 · see citing works

Amyloid-β peptide induces oligodendrocyte death by activating the neutral sphingomyelinase–ceramide pathway

Lee, J.-T., Xu, J., Lee, J.-M., Ku, G., Han, X., Yang, D.-I., Chen, S., & Hsu, C. Y. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200307017 · Cited by 280 · see citing works

Oxidative stress and β-amyloid protein in Alzheimer’s disease

Cai, Z., Zhao, B., & Ratka, A. (2011) · NeuroMolecular Medicine · doi:10.1007/s12017-011-8155-9 · Cited by 279 · see citing works

Statin Use and the Risk of Incident Dementia

Rea, T. D., Breitner, J. C. S., Psaty, B. M., Fitzpatrick, A. L., López, O. L., Newman, A. B., Hazzard, W. R., Zandi, P. P., Burke, G. L., Lyketsos, C. G., et al. (2005) · Archives of Neurology · doi:10.1001/archneur.62.7.1047 · Cited by 277 · see citing works

Sphingolipids and gangliosides of the nervous system in membrane function and dysfunction

Chaves, E., & Sipione, S. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.12.010 · Cited by 273 · see citing works

Direct and Potent Regulation of γ-Secretase by Its Lipid Microenvironment

Osenkowski, P., Ye, W., Wang, R., Wolfe, M. S., & Selkoe, D. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801925200 · Cited by 269 · see citing works

Dietary Copper and High Saturated and trans Fat Intakes Associated With Cognitive Decline

Morris, M. C., Evans, D. A., Tangney, C., Bienias, J. L., Schneider, J. A., Wilson, R. S., & Scherr, P. A. (2006) · Archives of Neurology · doi:10.1001/archneur.63.8.1085 · Cited by 268 · see citing works

Associations Between Serum Cholesterol Levels and Cerebral Amyloidosis

Reed, B., Villeneuve, S., Mack, W., DeCarli, C., Chui, H. C., & Jagust, W. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2013.5390 · Cited by 267 · see citing works

Docosahexaenoic acid affects cell signaling by altering lipid rafts

Stillwell, W. H., Shaikh, S. R., Zerouga, M., Siddiqui, R. A., & Wassall, S. R. (2005) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:2005046 · Cited by 266 · see citing works

Increased ceramide in brains with Alzheimer's and other neurodegenerative diseases

Filippov, V., Song, M. A., Zhang, K., Vinters, H. V., Tung, S., Kirsch, W. M., Yang, J., & Duerksen-Hughes, P. J. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-111202 · Cited by 264 · see citing works

Synapse loss in the temporal lobe in Alzheimer's disease

Scheff, S. W., & PRICE, D. A. (1993) · Annals of Neurology · doi:10.1002/ana.410330209 · Cited by 263 · see citing works

Peripheral ethanolamine plasmalogen deficiency: a logical causative factor in Alzheimer's disease and dementia

Goodenowe, D. B., Cook, L. L., Liu, J., Lu, Y., Jayasinghe, D., Ahiahonu, P. W. K., Heath, D., Yamazaki, Y., Flax, J., Krenitsky, K. F., et al. (2007) · Journal of Lipid Research · doi:10.1194/jlr.p700023-jlr200 · Cited by 253 · see citing works

Disease and anatomic specificity of ethanolamine plasmalogen deficiency in Alzheimer's disease brain

Ginsberg, L., Rafique, S., Xuereb, J. H., Rapoport, S. I., & Gershfeld, N. L. (1995) · Brain Research · doi:10.1016/0006-8993(95)00931-f · Cited by 248 · see citing works

Gene Expression Alterations in the Sphingolipid Metabolism Pathways during Progression of Dementia and Alzheimer’s Disease: A Shift Toward Ceramide Accumulation at the Earliest Recognizable Stages of Alzheimer’s Disease?

Katsel, P., Li, C., & Haroutunian, V. H. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9297-x · Cited by 240 · see citing works

A Seed for Alzheimer Amyloid in the Brain

Hayashi, H., Kimura, N., Yamaguchi, H., Hasegawa, K., Yokoseki, T., Shibata, M. S., Yamamoto, N., Michikawa, M., Yoshikawa, Y., Terao, K., et al. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0861-04.2004 · Cited by 239 · see citing works

Rab5-stimulated Up-regulation of the Endocytic Pathway Increases Intracellular β-Cleaved Amyloid Precursor Protein Carboxyl-terminal Fragment Levels and Aβ Production

Grbovic, O. M., Mathews, P. M., Jiang, Y., Schmidt, S. D., Dinakar, R., Terio, N. B., Ceresa, B. P., Nixon, R. A., & Cataldo, A. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304122200 · Cited by 236 · see citing works

Statins for the treatment of dementia

McGuinness, B., Craig, D., Bullock, R. A., Malouf, R. S., & Passmore, P. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007514.pub3 · Cited by 233 · see citing works

Cholesterol metabolism and transport in the pathogenesis of Alzheimer’s disease

Martins, I. J., Berger, T. R., Sharman, M. J., Verdile, G., Fuller, S. J., & Martins, R. N. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06408.x · Cited by 233 · see citing works

Regulated intramembrane proteolysis - lessons from amyloid precursor protein processing

Lichtenthaler, S. F., Haass, C., & Steiner, H. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07248.x · Cited by 230 · see citing works

Omega-3 Fatty Acids Enhance Phagocytosis of Alzheimer's Disease-Related Amyloid-β 42 by Human Microglia and Decrease Inflammatory Markers

Hjorth, E., Zhu, M., Toro, V. C., Vedin, I., Palmblad, J. E. W., Cederholm, T., Freund‐Levi, Y., Irving, G. F., Wahlund, L., Basun, H., et al. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130131 · Cited by 229 · see citing works

Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood–brain barrier: An in situ cerebral perfusion study

Ouellet, M., Émond, V., Chen, C. T., Julien, C., Bourasset, F., Oddo, S., LaFerla, F. M., Bazinet, R. P., & Calon, F. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.04.018 · Cited by 227 · see citing works

Impact of <i>APOE</i> genotype on neuropathologic and neurochemical markers of Alzheimer disease

Tiraboschi, P., Hansen, L. A., Masliah, E., Alford, M., Thal, L. J., & Corey-Bloom, J. (2004) · Neurology · doi:10.1212/01.wnl.0000128091.92139.0f · Cited by 226 · see citing works

Identification of New Functional Inhibitors of Acid Sphingomyelinase Using a Structure−Property−Activity Relation Model

Kornhuber, J., Tripal, P., Reichel, M., Terfloth, L., Bleich, S., Wiltfang, J., & Gulbins, E. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm070524a · Cited by 225 · see citing works

Structural membrane alterations in Alzheimer brains found to be associated with regional disease development; increased density of gangliosides GM1 and GM2 and loss of cholesterol in detergent‐resistant membrane domains

Molander‐Melin, M., Blennow, K., Bogdanović, N., Dellheden, B., Månsson, J., & Fredman, P. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02849.x · Cited by 224 · see citing works

Serum ceramides increase the risk of Alzheimer disease

Mielke, M. M., Bandaru, V. V. R., Haughey, N. J., Xia, J., Fried, L. P., Yaşar, S., Albert, M., Varma, V. R., Harris, G., Schneider, E. B., et al. (2012) · Neurology · doi:10.1212/wnl.0b013e318264e380 · Cited by 223 · see citing works

Docosahexaenoic Acid Reduces Amyloid β Production via Multiple Pleiotropic Mechanisms

Grimm, M. O. W., Kuchenbecker, J., Grösgen, S., Burg, V. K., Hundsdörfer, B., Rothhaar, T. L., Frieß, P., de Wilde, M. C., Broersen, L. M., Penke, B., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.182329 · Cited by 221 · see citing works

Soluble oligomers of amyloid-β peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway

Malaplate, C., Florent‐Béchard, S., Youssef, I., Koziel, V., Sponne, I., Kriem, B., Leininger‐Muller, B., Olivier, J. L., Oster, T., & Pillot, T. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.02.010 · Cited by 213 · see citing works

Generation of an Apoptotic Intracellular Peptide by γ-Secretase Cleavage of Alzheimer's Amyloid ß Protein Precursor

Passer, B. J., Pellegrini, L., Russo, C., Siegel, R. M., Lenardo, M. J., Schettini, G., Bachmann, M. F., Tabaton, M., & D'adamio, L. (2000) · Journal of Alzheimer s Disease · doi:10.3233/jad-2000-23-408 · Cited by 207 · see citing works

Association of apolipoprotein E phenotypes with late onset Alzheimer's disease: population based study

Kuusisto, J., Koivisto, K. J., Kervinen, K., Mykkänen, L. M., Helkala, E.-L., Vanhanen, M., Hänninen, T., Pyörälä, K., Kesäniemi, Y. A., Riekkinen, P. J., et al. (1994) · BMJ · doi:10.1136/bmj.309.6955.636 · Cited by 207 · see citing works

Lipid Rafts and Alzheimer’s Disease: Protein-Lipid Interactions and Perturbation of Signaling

Hicks, D. A., Nalivaeva, N. N., & Turner, A. J. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00189 · Cited by 205 · see citing works

Effects of fatty acid unsaturation numbers on membrane fluidity and α-secretase-dependent amyloid precursor protein processing

Yang, X., Sheng, W., Sun, G. Y., & Lee, J. C. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.12.004 · Cited by 202 · see citing works

Disturbed Choline Plasmalogen and Phospholipid Fatty Acid Concentrations in Alzheimer's Disease Prefrontal Cortex

Igarashi, M., Ma, K., Gao, F., Kim, H., Rapoport, S. I., & Rao, J. S. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101608 · Cited by 200 · see citing works

Cleavage of Alzheimer's Amyloid Precursor Protein by α-Secretase Occurs at the Surface of Neuronal Cells

Parvathy, S., Hussain, I., Karran, E. H., Turner, A. J., & Hooper, N. M. (1999) · Biochemistry · doi:10.1021/bi9906827 · Cited by 200 · see citing works

Interactions of acid sphingomyelinase and lipid bilayers in the presence of the tricyclic antidepressant desipramine

Kölzer, M., Werth, N., & Sandhoff, K. (2004) · FEBS Letters · doi:10.1016/s0014-5793(04)00033-x · Cited by 200 · see citing works

Statins, incident Alzheimer disease, change in cognitive function, and neuropathology

Arvanitakis, Z., Schneider, J. A., Wilson, R. S., Bienias, J. L., Kelly, J. F., Evans, D. A., & Bennett, D. A. (2008) · Neurology · doi:10.1212/01.wnl.0000288181.00826.63 · Cited by 199 · see citing works

Astroglial expression of ceramide in Alzheimer's disease brains: A role during neuronal apoptosis

Satoi, H., Tomimoto, H., Ohtani, R., Kitano, T., Kondo, T., Watanabe, M., Oka, N., Akiguchi, I., Furuya, S., Hirabayashi, Y., et al. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.08.056 · Cited by 195 · see citing works

Lipids in Alzheimer’s disease: A century-old story

Foley, P. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.05.004 · Cited by 186 · see citing works

Fibrillar Amyloid-β Peptides Kill Human Primary Neurons via NADPH Oxidase-mediated Activation of Neutral Sphingomyelinase

Jana, A., & Pahan, K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404635200 · Cited by 185 · see citing works

BACE1 activity is modulated by cell-associated sphingosine-1-phosphate

Takasugi, N., Sasaki, T., Suzuki, K., Osawa, S., Isshiki, H., Hori, Y., Shimada, N., Higo, T., Yokoshima, S., Fukuyama, T., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6467-10.2011 · Cited by 181 · see citing works

LIFE EXPECTANCY IN ALZHEIMER'S DISEASE (AD)

Zanetti, O. O., Solerte, S. B., & Cantoni, F. (2009) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2009.09.035 · Cited by 159 · see citing works

Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer’s Disease

Grimm, M. O. W., Mett, J., Stahlmann, C. P., Haupenthal, V. J., Zimmer, V. C., & Hartmann, T. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00098 · Cited by 159 · see citing works

Interactions of plasmalogens and their diacyl analogs with singlet oxygen in selected model systems

Broniec, A., Klosinski, R., Pawlak, A. M., Wrona, M., Thompson, D. H., & Sarna, T. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.01.002 · Cited by 159 · see citing works

Plasma Sphingomyelins are Associated with Cognitive Progression in Alzheimer's Disease

Mielke, M. M., Haughey, N. J., Bandaru, V. V. R., Weinberg, D. D., Darby, E. J., Zaidi, N., Pavlik, V., Doody, R. S., & Lyketsos, C. G. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110405 · Cited by 158 · see citing works

Dietary fat types and 4‐year cognitive change in community‐dwelling older women

Okereke, O. I., ROSNER, B. A., Kim, D. H., Kang, J. H., Cook, N. R., Manson, J. E., Buring, J. E., Willett, W. C., & Grodstein, F. (2012) · Annals of Neurology · doi:10.1002/ana.23593 · Cited by 157 · see citing works

Comparison of Cis and Trans Fatty Acid Containing Phosphatidylcholines on Membrane Properties

Roach, C. A., Feller, S. E., Ward, J. A., Shaikh, S. R., Zérouga, M., & Stillwell, W. H. (2004) · Biochemistry · doi:10.1021/bi049917r · Cited by 157 · see citing works

Omega-3 fatty acids: potential role in the management of early Alzheimer’s disease

Jicha, G. A. (2010) · Clinical Interventions in Aging · doi:10.2147/cia.s5231 · Cited by 153 · see citing works

Equimolar Production of Amyloid β-Protein and Amyloid Precursor Protein Intracellular Domain from β-Carboxyl-terminal Fragment by γ-Secretase

Kakuda, N., Funamoto, S., Yagishita, S., Takami, M., Osawa, S., Dohmae, N., & Ihara, Y. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513453200 · Cited by 150 · see citing works

Midlife vascular risk factors and the risk of Alzheimer’s disease: A systematic review and meta-analysis

Meng, X.-F., Yu, J.-T., Wang, H.-F., Tan, M.-S., Wang, C., Tan, C.-C., & Tan, L. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140954 · Cited by 150 · see citing works

Omega-3 fatty acids and risk of dementia: the Canadian Study of Health and Aging

Kröger, E., Verreault, R., Carmichael, P.-H., Lindsay, J., Julien, P., Dewailly, É., Ayotte, P., & Laurin, D. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26987 · Cited by 149 · see citing works

ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain

Bandaru, V. V. R., Troncoso, J. C., Wheeler, D., Pletniková, O., Wang, J., Conant, K., & Haughey, N. J. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.07.024 · Cited by 147 · see citing works

Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid β protein

Carey, R. M., Balcz, B. A., G.‐Coviella, I. L., & Slack, B. E. (2005) · BMC Cell Biology · doi:10.1186/1471-2121-6-30 · Cited by 135 · see citing works

Truncated Carboxyl-Terminal Fragments of β-Amyloid Precursor Protein Are Processed to Amyloid β-Proteins 40 and 42

Funamoto, S., Morishima‐Kawashima, M., Tanimura, Y., Hirotani, N., Saido, T. C., & Ihara, Y. (2004) · Biochemistry · doi:10.1021/bi049399k · Cited by 131 · see citing works

The critical need for defining preclinical biomarkers in Alzheimer's disease

Fiandaca, M. S., Mapstone, M. E., Cheema, A. K., & Federoff, H. J. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.04.015 · Cited by 129 · see citing works

Independent Inhibition of Alzheimer Disease β- and γ-Secretase Cleavage by Lowered Cholesterol Levels

Grimm, M. O. W., Grimm, H. S., Tomic, I., Beyreuther, K. T., Hartmann, T., & Bergmann, C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801520200 · Cited by 128 · see citing works

Cognitive decline strongly correlates with cortical atrophy in Alzheimer’s dementia

Mouton, P. R., Martin, L. J., Calhoun, M. E., Forno, G. D., & Price, D. L. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00080-3 · Cited by 128 · see citing works

Elimination of GD3 synthase improves memory and reduces amyloid-β plaque load in transgenic mice

Bernardo, A., Harrison, F. E., McCord, M., Zhao, J., Bruchey, A., Davies, S. S., Jackson Roberts, L., Mathews, P. M., Matsuoka, Y., Ariga, T., et al. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.12.022 · Cited by 127 · see citing works

Novel Role for Apolipoprotein E in the Central Nervous System

Han, X., Cheng, H., Fryer, J. D., Fagan, A. M., & Holtzman, D. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212340200 · Cited by 126 · see citing works

GM1 ganglioside-mediated accumulation of amyloid β-protein on cell membranes

Wakabayashi, M., Okada, T., Kozutsumi, Y., & Matsuzaki, K. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.01.060 · Cited by 125 · see citing works

Lovastatin enhances Aβ production and senile plaque deposition in female Tg2576 mice

Park, I.-H., Hwang, E. M., Hong, H., Boo, J. H., Oh, S. S., Lee, J., Jung, M. W., Bang, O. Y., Kim, S. U., & Mook‐Jung, I. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00155-0 · Cited by 124 · see citing works

Docosahexaenoic acid-induced amelioration on impairment of memory learning in amyloid β-infused rats relates to the decreases of amyloid β and cholesterol levels in detergent-insoluble membrane fractions

Hashimoto, M., Hossain, S., AGDUL, H., & Shido, O. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.11.011 · Cited by 123 · see citing works

Inhibition of Glycosphingolipid Biosynthesis Reduces Secretion of the β-Amyloid Precursor Protein and Amyloid β-Peptide*[boxs]

Tamboli, I. Y., Prager, K., Barth, E., Heneka, M. T., Sandhoff, K., & Walter, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414525200 · Cited by 122 · see citing works

Role of Cholesterol in APP Metabolism and Its Significance in Alzheimer’s Disease Pathogenesis

Maulik, M., Westaway, D. A., Jhamandas, J. H., & Kar, S. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8337-y · Cited by 117 · see citing works

From brain to food: Analysis of phosphatidylcholins, lyso-phosphatidylcholins and phosphatidylcholin–plasmalogens derivates in Alzheimer's disease human post mortem brains and mice model via mass spectrometry

Grimm, M. O. W., Grösgen, S., Riemenschneider, M. J., Tanila, H., Grimm, H. S., & Hartmann, T. (2011) · Journal of Chromatography A · doi:10.1016/j.chroma.2011.07.073 · Cited by 117 · see citing works

Effects of Membrane Lipids on the Activity and Processivity of Purified γ-Secretase

Holmes, O. W., Paturi, S., Ye, W., Wolfe, M. S., & Selkoe, D. J. (2012) · Biochemistry · doi:10.1021/bi300303g · Cited by 117 · see citing works

Plasmalogen synthesis is regulated via alkyl‐dihydroxyacetonephosphate‐synthase by amyloid precursor protein processing and is affected in Alzheimer’s disease

Grimm, M. O. W., Kuchenbecker, J., Rothhaar, T. L., Grösgen, S., Hundsdörfer, B., Burg, V. K., Frieß, P., Müller, U., Grimm, H. S., Riemenschneider, M. J., et al. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07070.x · Cited by 115 · see citing works

Formation of Toxic Fibrils of Alzheimer’s Amyloid β-Protein-(1–40) by Monosialoganglioside GM1, a Neuronal Membrane Component

Okada, T., Wakabayashi, M., Ikeda, K., & Matsuzaki, K. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.05.069 · Cited by 115 · see citing works

Enrichment of cholesterol in microdissected Alzheimer’s disease senile plaques as assessed by mass spectrometry

Panchal, M., Loeper, J., Cossec, J., Perruchini, C., Lazar, A. N., Pompon, D., & Duyckaerts, C. J. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m001859 · Cited by 115 · see citing works

Dietary trans–fatty acids alter adipocyte plasma membrane fatty acid composition and insulin sensitivity in rats

Ibrahim, A., Natarajan, S., & Ghafoorunissa (2005) · Metabolism · doi:10.1016/j.metabol.2004.08.019 · Cited by 113 · see citing works

Long-chain polyunsaturated fatty acids in maternal and infant nutrition

Muskiet, F. A. J., van Goor, S. A., Kuipers, R. S., Velzing‐Aarts, F. V., Smit, E. N., Bouwstra, H., Dijck-Brouwer, J., Boersma, E. R., & Hadders‐Algra, M. (2006) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2006.05.010 · Cited by 113 · see citing works

Fatty Acid Oxidation in the Pathogenesis of Alzheimer's Disease

Montine, T. J., & Morrow, J. D. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62347-4 · Cited by 112 · see citing works

Overview of trans fatty acids: Biochemistry and health effects

Bhardwaj, S., Passi, S. J., & Misra, A. (2011) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2012.03.002 · Cited by 112 · see citing works

Human brain gangliosides in development, aging and disease

Kraĉun, I., Rösner, H., Drnovsek, V., Heffer, M., Cosovi?, C., & Lauc, G. (1991) · The International Journal of Developmental Biology · doi:10.1387/ijdb.1814411 · Cited by 112 · see citing works

Cerebrospinal fluid sulfatide is decreased in subjects with incipient dementia

Han, X., Fagan, A. M., Cheng, H., Morris, J. C., Xiong, C., & Holtzman, D. M. (2003) · Annals of Neurology · doi:10.1002/ana.10618 · Cited by 111 · see citing works

Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels

Ko, M. H., & Puglielli, L. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m804901200 · Cited by 111 · see citing works

Functional γ-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and γ-secretase substrates

Baulac, S., LaVoie, M. J., Kimberly, W. T., Strahle, J. M., Wolfe, M. S., Selkoe, D. J., & Xia, W. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(03)00123-2 · Cited by 109 · see citing works

Association of Alzheimer disease pathology with abnormal lipid metabolism

Matsuzaki, T., Sasaki, K., Hata, J., Hirakawa, Y., Fujimi, K., Ninomiya, T., Suzuki, S. O., Kanba, S., Kiyohara, Y., & Iwaki, T. (2011) · Neurology · doi:10.1212/wnl.0b013e31822e145d · Cited by 108 · see citing works

Monounsaturated, Trans, and Saturated Fatty Acids and Cognitive Decline in Women

Naqvi, A. Z., Harty, B. J., Mukamal, K. J., Stoddard, A. M., Vitolins, M. Z., & Dunn, J. E. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03402.x · Cited by 104 · see citing works

A diet high in omega-3 fatty acids does not improve or protect cognitive performance in Alzheimer’s transgenic mice

Arendash, G. W., Jensen, M. T., Salem, N., Hussein, N., Cracchiolo, J. R., Dickson, A., Leighty, R. E., & Potter, H. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.08.018 · Cited by 103 · see citing works

Specific changes of sulfatide levels in individuals with pre‐clinical Alzheimer's disease: an early event in disease pathogenesis

Cheng, H., Wang, M., Li, J., Cairns, N. J., & Han, X. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12368 · Cited by 103 · see citing works

Elevated cerebrospinal fluid sphingomyelin levels in prodromal Alzheimer's disease

Košiček, M., Zetterberg, H., Andreasen, N., Peter‐Katalinić, J., & Hecimovic, S. K. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.04.019 · Cited by 102 · see citing works

Generation of Alzheimer Disease-associated Amyloid β42/43 Peptide by γ-Secretase Can Be Inhibited Directly by Modulation of Membrane Thickness

Winkler, E., Kamp, F., Scheuring, J., Ebke, A., Fukumori, A., & Steiner, H. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.356659 · Cited by 101 · see citing works

GM1 ganglioside regulates the proteolysis of amyloid precursor protein

Zha, Q., Ruan, Y., Hartmann, T., Beyreuther, K. T., & Zhang, D. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001509 · Cited by 100 · see citing works

Effects of Omega-3 Fatty Acids on Inflammatory Markers in Cerebrospinal Fluid and Plasma in Alzheimer’s Disease: The OmegAD Study

Freund‐Levi, Y., Hjorth, E., Lindberg, C., Cederholm, T., Irving, G. F., Vedin, I., Palmblad, J. E. W., Wahlund, L., Schultzberg, M., Basun, H., et al. (2009) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000218081 · Cited by 100 · see citing works

Surgery, neuroinflammation and cognitive impairment

Alam, A., Hana, Z., Jin, Z., Suen, K. C., & Ma, D. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.10.021 · Cited by 483 · see citing works

Application of Metabolomics in Alzheimer’s Disease

Wilkins, J. M., & Trushina, E. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2017.00719 · Cited by 268 · see citing works

Sex Differences in Neuropathology and Cognitive Behavior in APP/PS1/tau Triple-Transgenic Mouse Model of Alzheimer’s Disease

Yang, J., Wang, Z., Cai, H.-Y., Li, Y., Hu, M.-M., Wu, M., & Qi, J. (2018) · Neuroscience Bulletin · doi:10.1007/s12264-018-0268-9 · Cited by 161 · see citing works

Sphingolipids as prognostic biomarkers of neurodegeneration, neuroinflammation, and psychiatric diseases and their emerging role in lipidomic investigation methods

van Kruining, D., Luo, Q., van Echten‐Deckert, G., Mielke, M. M., Bowman, A. P., Ellis, S. R., Oliveira, T. G., & Martínez‐Martínez, P. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.04.009 · Cited by 135 · see citing works

Lipid Profiling of Alzheimer’s Disease Brain Highlights Enrichment in Glycerol(phospho)lipid, and Sphingolipid Metabolism

Akyol, S., Ugur, Z., Yılmaz, A., Ustun, I., Gorti, S. K. K., Oh, K., McGuinness, B., Passmore, P., Kehoe, P. G., Maddens, M. E., et al. (2021) · Cells · doi:10.3390/cells10102591 · Cited by 134 · see citing works

β-Amyloid and the Pathomechanisms of Alzheimer’s Disease: A Comprehensive View

Penke, B., Bogár, F., & Fülöp, L. (2017) · Molecules · doi:10.3390/molecules22101692 · Cited by 135 · see citing works

Genetic architecture of Alzheimer's disease

Neuner, S. M., TCW, J., & Goate, A. M. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104976 · Cited by 126 · see citing works

Omega-3 fatty acids, lipids, and apoE lipidation in Alzheimer's disease: a rationale for multi-nutrient dementia prevention

Grimm, M. O. W., Michaelson, D. M., & Hartmann, T. (2017) · Journal of Lipid Research · doi:10.1194/jlr.r076331 · Cited by 110 · see citing works

ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer’s disease models

Zhao, Y., Hu, D., Wang, R., Sun, X., Ropelewski, P., Hubler, Z. M. L., Lundberg, K. C., Wang, Q., Adams, D., Xu, R., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28769-9 · Cited by 97 · see citing works

Shedding Light on the Molecular Pathology of Amyloid Plaques in Transgenic Alzheimer’s Disease Mice Using Multimodal MALDI Imaging Mass Spectrometry

Kaya, I., Zetterberg, H., Blennow, K., & Hanrieder, J. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00121 · Cited by 87 · see citing works

Sphingolipids in Alzheimer's disease, how can we target them?

Crivelli, S. M., Giovagnoni, C., Visseren, L., Scheithauer, A.-L., de Wit, N. M., den Hoedt, S., Losen, M. H., Mulder, M. T., Walter, J., de Vries, H. E., et al. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.12.003 · Cited by 87 · see citing works

Cholesterol Metabolism in Aging and Age-Related Disorders

Saher, G. (2023) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-091922-034237 · Cited by 81 · see citing works

Integrative metabolomics science in Alzheimer’s disease: Relevance and future perspectives

Lista, S., González‐Domínguez, R., López‐Ortiz, S., González‐Domínguez, Á., Menéndez, H., Martín-Hernández, J., Lucía, A., Emanuele, E., Centonze, D., Imbimbo, B. P., et al. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101987 · Cited by 75 · see citing works

APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brain

Lefterov, I., Wolfe, C. M., Fitz, N. F., Nam, K. N., Letronne, F., Biedrzycki, R. J., Kofler, J., Han, X., Wang, J., Schug, J., et al. (2019) · Alzheimer's Research &amp; Therapy · doi:10.1186/s13195-019-0558-0 · Cited by 74 · see citing works

Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism

Acker, Z. P. V., Perdok, A., Hellemans, R., North, K., Vorsters, I., Cappel, C. C., Dehairs, J., Swinnen, J. V., Sannerud, R., Bretou, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38501-w · Cited by 69 · see citing works

Lipidome disruption in Alzheimer’s disease brain: detection, pathological mechanisms, and therapeutic implications

He, S., Xu, Z., & Han, X. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00803-6 · Cited by 62 · see citing works

Shared Causal Paths underlying Alzheimer’s dementia and Type 2 Diabetes

Hu, Z., Jiao, R., Wang, P., Zhu, Y., Zhao, J., Jager, P. L. D., Bennett, D. A., Li, J., & Xiong, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-60682-3 · Cited by 63 · see citing works

Presenilins and γ-Secretase in Membrane Proteostasis

Oikawa, N., & Walter, J. (2019) · Cells · doi:10.3390/cells8030209 · Cited by 62 · see citing works

PPARβ/δ‐agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1ΔE9 astrocytes

Konttinen, H., Gureviciene, I., Oksanen, M., Grubman, A., Loppi, S. H., Huuskonen, M. T., Korhonen, P., Lampinen, R., Keuters, M. H., Belaya, I., et al. (2018) · Glia · doi:10.1002/glia.23534 · Cited by 52 · see citing works

Astaxanthin exerts protective effects similar to bexarotene in Alzheimer's disease by modulating amyloid-beta and cholesterol homeostasis in blood-brain barrier endothelial cells

Fanaee‐Danesh, E., Gali, C. C., Tadić, J., Zandl‐Lang, M., Kober, A. C., Agujetas, V. R., de Dios, C., Tam‐Amersdorfer, C., Stracke, A., Albrecher, N. M., et al. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.04.019 · Cited by 52 · see citing works

Preferred Endocytosis of Amyloid Precursor Protein from Cholesterol-Enriched Lipid Raft Microdomains

Cho, Y. Y., Kwon, O.-H., & Chung, S. (2020) · Molecules · doi:10.3390/molecules25235490 · Cited by 49 · see citing works

Key Peptides and Proteins in Alzheimer’s Disease

Penke, B., Bogár, F., Paragi, G., Gera, J., & Fülöp, L. (2019) · Current Protein and Peptide Science · doi:10.2174/1389203720666190103123434 · Cited by 50 · see citing works

Paraoxonase Role in Human Neurodegenerative Diseases

Reichert, C. O., Levy, D., & Bydlowski, S. P. (2020) · Antioxidants · doi:10.3390/antiox10010011 · Cited by 49 · see citing works

Lipidomic alterations in lipoproteins of patients with mild cognitive impairment and Alzheimer’s disease by asymmetrical flow field-flow fractionation and nanoflow ultrahigh performance liquid chromatography-tandem mass spectrometry

Kim, S. H., Yang, J. S., Lee, J. C., Lee, J.-Y., Lee, J., Kim, E., & Moon, M. H. (2018) · Journal of Chromatography A · doi:10.1016/j.chroma.2018.07.018 · Cited by 47 · see citing works

Amyloid-Mediated Mechanisms of Membrane Disruption

Sciacca, M. F. M., Rosa, C. L., & Milardi, D. (2021) · Biophysica · doi:10.3390/biophysica1020011 · Cited by 45 · see citing works

Alzheimer’s Disease, a Lipid Story: Involvement of Peroxisome Proliferator-Activated Receptor α

Sáez-Orellana, F., Octave, J., & Pierrot, N. (2020) · Cells · doi:10.3390/cells9051215 · Cited by 45 · see citing works

Lipid-Binding Proteins in Brain Health and Disease

Corraliza-Gómez, M., Sánchez, D., & Ganfornina, M. D. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01152 · Cited by 42 · see citing works

The Impact of Medium Chain and Polyunsaturated ω-3-Fatty Acids on Amyloid-β Deposition, Oxidative Stress and Metabolic Dysfunction Associated with Alzheimer’s Disease

Mett, J. (2021) · Antioxidants · doi:10.3390/antiox10121991 · Cited by 40 · see citing works

Early signature in the blood lipidome associated with subsequent cognitive decline in the elderly: A case-control analysis nested within the Three-City cohort study

Lefèvre‐Arbogast, S., Hejblum, B. P., Helmer, C., Klose, C. D., Manach, C., Low, D. Y., Urpí-Sardà, M., Andrés‐Lacueva, C., González‐Domínguez, R., Aigner, L., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103216 · Cited by 37 · see citing works

Alzheimer's disease mechanisms in peripheral cells: Promises and challenges

Trushina, E. V. (2019) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2019.06.008 · Cited by 35 · see citing works

DHCR24 reverses Alzheimer’s disease-related pathology and cognitive impairment via increasing hippocampal cholesterol levels in 5xFAD mice

Zhang, W.-B., Huang, Y. M., Guo, X., Zhang, M.-Q., Yuan, X.-S., & Zu, H. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01593-y · Cited by 34 · see citing works

Real-time nanoscale organization of amyloid precursor protein

Kedia, S., Ramakrishna, P., Netrakanti, P. R., Jose, M., Sibarita, J., Nadkarni, S., & Nair, D. K. (2020) · Nanoscale · doi:10.1039/d0nr00052c · Cited by 33 · see citing works

The interplay between lipid and Aβ amyloid homeostasis in Alzheimer’s Disease: risk factors and therapeutic opportunities

García‐Viñuales, S., Sciacca, M. F. M., Lanza, V., Santoro, A. M., Grasso, G., Tundo, G. R., Sbardella, D., Coletta, M., Grasso, G., Rosa, C. L., et al. (2021) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2021.105072 · Cited by 33 · see citing works

Peripheral Mitochondrial Dysfunction: A Potential Contributor to the Development of Metabolic Disorders and Alzheimer’s Disease

Sultana, M. A., Hia, R. A., Akinsiku, O., & Hegde, V. K. (2023) · Biology · doi:10.3390/biology12071019 · Cited by 31 · see citing works

The role of UNC5C in Alzheimer’s disease

Li, Q., Wang, B.-L., Sun, F.-R., Li, J., Cao, X., & Tan, L. (2018) · Annals of Translational Medicine · doi:10.21037/atm.2018.04.43 · Cited by 29 · see citing works

Structural Studies Providing Insights into Production and Conformational Behavior of Amyloid-β Peptide Associated with Alzheimer’s Disease Development

Urban, A. S., Pavlov, K. V., Kamynina, A. V., Okhrimenko, I. S., Arseniev, A. S., & Bocharov, E. V. (2021) · Molecules · doi:10.3390/molecules26102897 · Cited by 29 · see citing works

ApoE isoforms and carboxyl-terminal-truncated apoE4 forms affect neuronal BACE1 levels and Aβ production independently of their cholesterol efflux capacity

Dafnis, I., Raftopoulou, C., Mountaki, C., Megalou, E. V., Zannis, V. I., & Chroni, A. (2018) · Biochemical Journal · doi:10.1042/bcj20180068 · Cited by 29 · see citing works

Novel Insight in Idiopathic Normal Pressure Hydrocephalus (iNPH) Biomarker Discovery in CSF

Torretta, E., Arosio, B., Barbacini, P., Capitanio, D., Rossi, P. D., Moriggi, M., Clerici, M., Mari, D., Cesari, M., & Gelfi, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158034 · Cited by 28 · see citing works

Membrane lipid remodeling modulates γ-secretase processivity

Dawkins, E., Derks, R. J. E., Schifferer, M., Trambauer, J., Winkler, E., Simons, M., Paquet, D., Giera, M. A., Kamp, F., & Steiner, H. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.103027 · Cited by 27 · see citing works

The C99 domain of the amyloid precursor protein resides in the disordered membrane phase

Capone, R. F., Tiwari, A., Hadziselimovic, A., Peskova, Y. B., Hutchison, J. M., Sanders, C. R., & Kenworthy, A. K. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100652 · Cited by 27 · see citing works

Vitamin B12 Attenuates Changes in Phospholipid Levels Related to Oxidative Stress in SH-SY5Y Cells

Theiss, E. L., Griebsch, L. V., Lauer, A. A., Janitschke, D., Erhardt, V. K. J., Haas, E. C., Kuppler, K. N., Radermacher, J., Walzer, O., Portius, D., et al. (2022) · Cells · doi:10.3390/cells11162574 · Cited by 24 · see citing works

Spatially resolved mass spectrometry analysis of amyloid plaque‐associated lipids

Blank, M., & Hopf, C. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15216 · Cited by 24 · see citing works

Medium-Chain Length Fatty Acids Enhance Aβ Degradation by Affecting Insulin-Degrading Enzyme

Mett, J., Lauer, A. A., Janitschke, D., Griebsch, L. V., Theiss, E. L., Grimm, H. S., Koivisto, H., Tanila, H., Hartmann, T., & Grimm, M. O. W. (2021) · Cells · doi:10.3390/cells10112941 · Cited by 24 · see citing works

Lipids and lipoproteins may play a role in the neuropathology of Alzheimer’s disease

Akyol, Ö., Akyol, S., Chou, M., Chen, S., Liu, C., Selek, S., Soares, J. C., & Chen, C. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1275932 · Cited by 24 · see citing works

Cellular hormetic response to 27-hydroxycholesterol promotes neuroprotection through AICD induction of MAST4 abundance and kinase activity

Gongol, B., Marin, T., Jeppson, J. D., Mayagoitia, K., Shin, S. D., Sanchez, N., Kirsch, W. M., Vinters, H. V., Wilson, C. G., Ghribi, O., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-13933-9 · Cited by 23 · see citing works

Short-Term Fish Oil Treatment Changes the Composition of Phospholipids While Not Affecting the Expression of Mfsd2a Omega-3 Transporter in the Brain and Liver of the 5xFAD Mouse Model of Alzheimer’s Disease

Milanović, D., Petrović, S., Brkić, M., Avramović, V., Perović, M., Ivković, S., Glibetić, M., & Kanazir, S. (2018) · Nutrients · doi:10.3390/nu10091250 · Cited by 23 · see citing works

FTY720 decreases ceramides levels in the brain and prevents memory impairments in a mouse model of familial Alzheimer’s disease expressing APOE4

Crivelli, S. M., Luo, Q., van Kruining, D., Giovagnoni, C., Mané-Damas, M., den Hoedt, S., Berkeš, D., de Vries, H. E., Mulder, M. T., Walter, J., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113240 · Cited by 22 · see citing works

Alteration in synaptic nanoscale organization dictates amyloidogenic processing in Alzheimer's disease

Kedia, S., Ramakrishna, P., Netrakanti, P. R., Singh, N., Sisodia, S. S., Jose, M., Kumar, S., Mahadevan, A., Ramanan, N., Nadkarni, S., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101924 · Cited by 21 · see citing works

The mechanism of bile acid metabolism regulating lipid metabolism and inflammatory response in T2DM through the gut-liver axis

Wang, Y., Lv, B., Liu, N., Tao, S., Dou, J., Li, J., Deng, R., Yang, X., & Jiang, G. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e35421 · Cited by 21 · see citing works

Glycosylation status of nicastrin influences catalytic activity and substrate preference of γ-secretase

Moniruzzaman, M., Ishihara, S., Nobuhara, M., Higashide, H., & Funamoto, S. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.05.126 · Cited by 21 · see citing works

Acral melanoma in skin of color: current insights and future directions: a narrative review

Nadelmann, E., Singh, A., Abbruzzese, M., Adeuyan, O., Kenchappa, D., Kovrizhkin, K., Lightman, M., Samouha, A., Tao, K., Yun, J., et al. (2025) · Cancers · doi:10.3390/cancers17030468 · Cited by 20 · see citing works

Structural Determinant of β-Amyloid Formation: From Transmembrane Protein Dimerization to β-Amyloid Aggregates

Papadopoulos, N., Suelves, N., Perrin, F., Vadukul, D. M., Vrancx, C., Constantinescu, S. N., & Kienlen-Campard, P. (2022) · Biomedicines · doi:10.3390/biomedicines10112753 · Cited by 20 · see citing works

When lipid homeostasis runs havoc: Lipotoxicity links lysosomal dysfunction to autophagy

Tegeder, I., & Kögel, D. (2020) · Matrix Biology · doi:10.1016/j.matbio.2020.11.005 · Cited by 19 · see citing works

Shotgun lipidomics of liver and brain tissue of Alzheimer’s disease model mice treated with acitretin

Lauer, A. A., Janitschke, D., Guilherme, M. D. S., Nguyen, V. T. T., Bachmann, C. M., Qiao, S., Schrul, B., Boehm, U., Grimm, H. S., Hartmann, T., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-94706-3 · Cited by 18 · see citing works

A Targeted Mass Spectrometry Approach to Identify Peripheral Changes in Metabolic Pathways of Patients with Alzheimer’s Disease

Reveglia, P., Paolillo, C., Angiolillo, A., Ferretti, G., Angelico, R., Sirabella, R., Corso, G., Matrone, C., & Costanzo, A. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119736 · Cited by 17 · see citing works

Modulation of Mitochondrial Function as a Therapeutic Strategy for Neurodegenerative Diseases

Trushina, E. V., Nguyen, T. K. O., & Trushin, S. (2023) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2023.108 · Cited by 17 · see citing works

In vitro Neuroprotective Potential and Lipidomics Study of Olive Leaves Extracts Enriched in Triterpenoids

Gallego, R., Suárez-Montenegro, Z. J., Ibáñez, E., Herrero, M., Valdés, A., & Cifuentes, A. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.769218 · Cited by 17 · see citing works

A bidirectional link between sulfatide and Alzheimer’s disease

Zimmer, V. C., Lauer, A. A., Haupenthal, V. J., Stahlmann, C. P., Mett, J., Grösgen, S., Hundsdörfer, B., Rothhaar, T. L., Endres, K., Eckhardt, M., et al. (2023) · Cell chemical biology · doi:10.1016/j.chembiol.2023.10.021 · Cited by 16 · see citing works

Neuroprotective Effects of Resveratrol by Modifying Cholesterol Metabolism and Aβ Processing in SAMP8 Mice

Sánchez-Melgar, A., Izquierdo-Ramírez, P. J., Griñán‐Ferré, C., Pallàs, M., Martı́n, M., & Albasanz, J. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147580 · Cited by 16 · see citing works

All- d -Enantiomeric Peptide D3 Designed for Alzheimer’s Disease Treatment Dynamically Interacts with Membrane-Bound Amyloid-β Precursors

Bocharov, E. V., Gremer, L., Urban, A. S., Okhrimenko, I. S., Volynsky, P. E., Nadezhdin, K. D., Bocharova, O. V., Kornilov, D. A., Zagryadskaya, Y. A., Kamynina, A. V., et al. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00632 · Cited by 14 · see citing works

Familial L723P Mutation Can Shift the Distribution between the Alternative APP Transmembrane Domain Cleavage Cascades by Local Unfolding of the Ε-Cleavage Site Suggesting a Straightforward Mechanism of Alzheimer’s Disease Pathogenesis

Bocharov, E. V., Nadezhdin, K. D., Urban, A. S., Volynsky, P. E., Pavlov, K. V., Efremov, R. G., Arseniev, A. S., & Bocharova, O. V. (2019) · ACS Chemical Biology · doi:10.1021/acschembio.9b00309 · Cited by 15 · see citing works

The impact of capsaicinoids on APP processing in Alzheimer’s disease in SH-SY5Y cells

Grimm, M. O. W., Blümel, T., Lauer, A. A., Janitschke, D., Stahlmann, C. P., Mett, J., Haupenthal, V. J., Miederer, A.-M., Niemeyer, B. A., Grimm, H. S., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-66009-6 · Cited by 15 · see citing works

Micro-Raman spectroscopy of lipid halo and dense-core amyloid plaques: aging process characterization in the Alzheimer's disease APPswePS1ΔE9 mouse model

Fonseca, E. A., Lafetá, L., Campos, J. L. E., Cunha, R. S., Barbosa, A. S., Romano‐Silva, M. A., Vieira, R. P., Malard, L. M., & Jório, A. (2021) · The Analyst · doi:10.1039/d1an01078f · Cited by 15 · see citing works

Who's in, who's out? Re‐evaluation of lipid raft residents

Mlinac, K., Ilić, K., Zjalić, M., Mandić, D., Debeljak, Ž., Balog, M., Damjanović, V., Hrvat, N. M., Habek, N., Bognar, S. K., et al. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15446 · Cited by 14 · see citing works

A Lipid-Raft Theory of Alzheimer's Disease

Rappoport, A. (2024) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-052024-115455 · Cited by 14 · see citing works

Membrane Cholesterol Is a Critical Determinant for Hippocampal Neuronal Polarity

Jose, M., Sivanand, A., & Channakeshava, C. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.746211 · Cited by 13 · see citing works

In vivo evidence of cortical amyloid deposition in the adult form of Niemann Pick type C

Esposito, M., Dubbioso, R., Tozza, S., Iodice, R., Aiello, M., Nicolai, E., Cavaliere, C., Salvatore, M., Santoro, L., & Manganelli, F. (2019) · Heliyon · doi:10.1016/j.heliyon.2019.e02776 · Cited by 13 · see citing works

New insight into the role of altered brain cholesterol metabolism in the pathogenesis of AD: A unifying cholesterol hypothesis and new therapeutic approach for AD

Yang, X., Yao, K., Zhang, M., Zhang, W., & Zu, H. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111321 · Cited by 12 · see citing works

Platelet APP Processing: Is It a Tool to Explore the Pathophysiology of Alzheimer’s Disease? A Systematic Review

Carbone, M. G., Pagni, G., Tagliarini, C., Marazziti, D., & Pomara, N. (2021) · Life · doi:10.3390/life11080750 · Cited by 11 · see citing works

Effects of chain length of saturated fatty acids on Aβ generation in SH-SY5Y cells

Liu, J.-J., Zhang, W., Wang, S., Jia, Z., Shi, Y., Yang, L., & Shi, R. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.01.024 · Cited by 10 · see citing works

Disturbances in PP2A methylation and one-carbon metabolism compromise Fyn distribution, neuritogenesis, and APP regulation

Taleski, G., Schuhmacher, D., Su, H. K., Sontag, J., & Sontag, E. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.016069 · Cited by 10 · see citing works

Tau/Aβ chimera peptides: A Thioflavin-T and MALDI-TOF study of Aβ amyloidosis in the presence of Cu(II) or Zn(II) ions and total lipid brain extract (TLBE) vesicles

Sciacca, M. F. M., Natale, G. D., Milardi, D., & Pappalardo, G. (2021) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2021.105085 · Cited by 10 · see citing works

The oxidative aging model integrated various risk factors in type 2 diabetes mellitus at system level

Chen, Y., Yao, L., Zhao, S., Xu, M., Ren, S., Xie, L., Liu, L., & Wang, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1196293 · Cited by 9 · see citing works

Origins of nervous tissue susceptibility to ferroptosis

Snyder, J., & Wu, Z. (2023) · Cell Insight · doi:10.1016/j.cellin.2023.100091 · Cited by 9 · see citing works

Cellular cholesterol loss by DHCR24 knockdown leads to Aβ production by changing APP intracellular localization

Huang, Y. M., Zhang, W., Guo, X., Zhang, Y., Wu, J., & Zu, H. (2023) · Journal of Lipid Research · doi:10.1016/j.jlr.2023.100367 · Cited by 8 · see citing works

Methylxanthines Induce a Change in the AD/Neurodegeneration-Linked Lipid Profile in Neuroblastoma Cells

Janitschke, D., Lauer, A. A., Bachmann, C. M., Winkler, J., Griebsch, L. V., Pilz, S. M., Theiss, E. L., Grimm, H. S., Hartmann, T., & Grimm, M. O. W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042295 · Cited by 8 · see citing works

Covalent modifications of the amyloid beta peptide by hydroxynonenal: Effects on metal ion binding by monomers and insights into the fibril topology

Grasso, G., Komatsu, H., & Axelsen, P. H. (2017) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2017.06.007 · Cited by 7 · see citing works

Cellular Cholesterol Loss Impairs Synaptic Vesicle Mobility via the CAMK2/Synapsin-1 Signaling Pathway

Qurban, A., Zhang, M., Zu, H., & Yao, K. (2025) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl27111 · Cited by 6 · see citing works

Diverse Interactions of Sterols with Amyloid Precursor Protein Transmembrane Domain Can Shift Distribution Between Alternative Amyloid-β Production Cascades in Manner Dependent on Local Lipid Environment

Volynsky, P. E., Urban, A. S., Pavlov, K. V., Bershatsky, Y. V., Bocharova, O. V., Kryuchkova, A. K., Zlobina, V. V., Gavrilenkova, A. A., Dolotova, S. M., Kamynina, A. V., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020553 · Cited by 5 · see citing works

Gemfibrozil-Induced Intracellular Triglyceride Increase in SH-SY5Y, HEK and Calu-3 Cells

Bachmann, C. M., Janitschke, D., Lauer, A. A., Erhardt, T., Hartmann, T., Grimm, M. O. W., & Grimm, H. S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032972 · Cited by 5 · see citing works

Astaxanthin alleviates ganglioside metabolism disorder in the cortex of Alzheimer's disease mice

Wang, Z., Wang, X., Ma, Y., Cong, P., Wang, X., Song, Y., Xu, J., & Xue, C. (2023) · Food & Function · doi:10.1039/d3fo03223j · Cited by 5 · see citing works

Lipidomics

Benedusi, V. (2018) · Materials and Methods · doi:10.13070/mm.en.8.2665 · Cited by 4 · see citing works

Neuronal endolysosomal alterations induced by Apolipoprotein E4 emerge over time in primary neurons

Nyberg, E., Konings, S. C., Lindblom, N., Israelsson, B., Klementieva, O. L., Martinsson, I., & Gouras, G. K. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110479 · Cited by 3 · see citing works

Exploring the connection between dementia and cardiovascular risk with a focus on ADAM10

Targas, A. B. A., Victoriano, P. H. M., Garcia, M. B. B., Alexandre-Silva, V., & Cominetti, M. R. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167825 · Cited by 3 · see citing works

A VEGF Fragment Encompassing Residues 10–30 Inhibits Aβ1–42 Amyloid Aggregation and Exhibits Neuroprotective Properties Matching the Full-Length Protein

Zimbone, S., Giuffrida, M. L., Sciacca, M. F. M., Carrotta, R., Librizzi, F., Milardi, D., & Grasso, G. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00669 · Cited by 3 · see citing works

Interacting Models of Amyloid-β and Tau Proteins: An Approach to Identify Drug Targets in Alzheimer’s Disease

Khadgawat, P., Siddesha, J. M., Shashank, D., & Shashanka, K. P. (2021) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-210018 · Cited by 3 · see citing works

Transient cholesterol interactions with the amyloid precursor protein involved in Alzheimer’s disease pathogenesis

Zlobina, V. V., Mitkevich, V. A., Bershatsky, Y. V., Volynsky, P. E., Pavlov, K. V., Karbyshev, M. S., Okhrimenko, I. S., Kozin, S. A., Efremov, R. G., Makarov, A. А., et al. (2025) · Biophysical Reviews · doi:10.1007/s12551-025-01358-y · Cited by 2 · see citing works

Cetoleic acid and other long-chain unsaturated fatty acids as neuroprotective nutraceuticals

Tang, P., Ruiz-Pastor, M. J., Lewis, A. E., Fladmark, K. E., Kobro-Flatmoen, A., Halskau, Ø., & Lal, P. (2026) · Lipids in Health and Disease · doi:10.1186/s12944-026-02876-8 · Cited by 2 · see citing works

A lipid-raft theory of Alzheimer's disease

Rappoport, A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-44-345008-2.00017-5 · Cited by 2 · see citing works

Unveiling ribosomal dysfunction and impaired signaling pathways in the cortical region of 5xFAD mice

Agrawal, K., Egbejiogu, B. C., Adeyelu, T. T., Burk, D., Murray, K. K., Walls, A. W., Jones, K. A., Campagna, S. R., Francis, J., Ghosh, S., et al. (2026) · Acta Neuropathologica Communications · doi:10.1186/s40478-026-02254-6 · Cited by 1 · see citing works

Effect of hypercholestermic diet on the amyloid precursor protein (APP) deposition with some behavior alterations in male rats

Raheem, H. A., Albazi, W. J., Altaee, R., & Jhoni, G. H. (2023) · Journal of Kerbala for Agricultural Sciences · doi:10.59658/jkas.v10i2.1188 · Cited by 1 · see citing works

Potential Candidate Genes and Pathways Affecting the Metabolism of Jaw Fats in Risso’s Dolphin: Based on TranscriptomicsPreprint

Senevirathna, J. D. M., Yonezawa, R., Igarashi, Y., Saka, T., Yoshitake, K., Kinoshita, S., Funasaka, N., & Asakawa, S. (2021) · Research Square · doi:10.21203/rs.3.rs-144280/v1 · Cited by 1 · see citing works

Exploring sphingolipid function in the pathogenesis of Alzheimer’s disease

Luo, Q. (2022) · doi:10.26481/dis.20220215ql

Rodent models of Alzheimer’s disease

Kasza, Á. (2018) · doi:10.14232/phd.9743

The effect of PC20:0 and di-C7-PC amphiphilic surfactants on the aggregation of Aβ1–40 and Aβ1–42 using molecular dynamics simulation

Abdulkareem, S. M., Housaindokht, M. R., & Bozorgmehr, M. R. (2023) · Journal of the Iranian Chemical Society · doi:10.1007/s13738-023-02761-6

Taliglucerase Alfa Modulates Aβ Load and Autophagy-Related Pathways in Mouse Hippocampal Neurons Exposed to oAβ1-42Preprint

Özkurt, Ç., Köse, S., Karasu, Ç., Kortholt, A., & Kelicen‐Uğur, P. (2025) · Research Square · doi:10.21203/rs.3.rs-7094261/v1

Additional file 2 of DHCR24 reverses Alzheimer’s disease-related pathology and cognitive impairment via increasing hippocampal cholesterol levels in 5xFAD mice

Zhang, W.-B., Huang, Y., Guo, X.-R., Zhang, M.-Q., 袁向山, & Zu, H.-B. (2024) · Figshare · doi:10.6084/m9.figshare.26598869

Additional file 1 of DHCR24 reverses Alzheimer’s disease-related pathology and cognitive impairment via increasing hippocampal cholesterol levels in 5xFAD mice

Zhang, W.-B., Huang, Y., Guo, X.-R., Zhang, M.-Q., 袁向山, & Zu, H.-B. (2024) · Figshare · doi:10.6084/m9.figshare.26598866

Étude épidémiologique de la relation entre exposome alimentaire et vieillissement cérébral : du nutriment candidat à une approche systémique

Lefèvre‐Arbogast, S. (2019) · doi:10.70675/6915e632z663fz4caaz9c7az455ad25755da

Les APP-CTFs au cœur du processus pathologique de la maladie d’Alzheimer : contribution du système lysosomal-autophagique et de la sécrétion exosomale

Bécot, A. (2019) · doi:10.70675/21765754zb9e7z40f9zb951z367e5fa4bcac

The role of APP proteolytic processing in lipid metabolism

Grimm, M. O. W., Rothhaar, T. L., & Hartmann, T. (2011) · Experimental Brain Research · doi:10.1007/s00221-011-2975-6 · Cited by 68 · see citing works

Role of amyloid beta in lipid homeostasis

Grösgen, S., Grimm, M. O. W., Frieß, P., & Hartmann, T. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.05.002 · Cited by 90 · see citing works

Cross-talk of membrane lipids and Alzheimer-related proteins

Walter, J., & van Echten‐Deckert, G. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-34 · Cited by 77 · see citing works

Amyloid beta-protein and lipid metabolism

Zinser, E. G., Hartmann, T., & Grimm, M. O. W. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.02.014 · Cited by 55 · see citing works

www.elsevier.com/locate/bbamem Review Amyloid beta-protein and lipid metabolism

Zinser, E. G., Hartmann, T., & Grimm, M. O. W. (2007)