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Genes and miRNA expression signatures in peripheral blood mononuclear cells in healthy subjects and patients with metabolic syndrome after acute intake of extra virgin olive oil

D'Amore, Simona, Vacca, Michele, Cariello, Marica, Graziano, Giusi, D'Orazio, Andria, Salvia, Roberto, Sasso, Rosa Cinzia, Sabbà, Carlo, Palasciano, Giuseppe, Moschetta, Antonio·2016·Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

DOI 10.1016/j.bbalip.2016.07.003

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Abstract

Extra virgin olive oil (EVOO) consumption has been associated with reduced cardiovascular risk but molecular mechanisms underlying its beneficial effects are not fully understood. Here we aimed to identify genes and miRNAs expression changes mediated by acute high- and low-polyphenols EVOO intake. Pre- and post-challenge gene and miRNAs expression analysis was performed on the peripheral blood mononuclear cells (PBMCs) of 12 healthy subjects and 12 patients with metabolic syndrome (MS) by using microarray and RT-qPCR. In healthy subjects, acute intake of EVOO rich in polyphenols was able to ameliorate glycaemia and insulin sensitivity, and to modulate the transcription of genes and miRNAs involved in metabolism, inflammation and cancer, switching PBMCs to a less deleterious inflammatory phenotype; weaker effects were observed in patients with MS as well as in healthy subjects following low-polyphenol EVOO challenge. Concluding, our study shows that acute high-polyphenols EVOO intake is able to modify the transcriptome of PBMCs through the modulation of different pathways associated with the pathophysiology of cardio-metabolic disease and cancer. These beneficial effects are maximized in healthy subjects, and by the use of EVOO cultivars rich in polyphenols. Nutrigenomic changes induced by EVOO thus legitimate the well-known beneficial effects of EVOO in promoting human health and, potentially, preventing the onset of cardiovascular disease and cancer.

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Authors: D'Amore, S., Vacca, M., Cariello, M., Graziano, G., D'Orazio, A., Salvia, R., Sasso, R. C., Sabbà, C., Palasciano, G., & Moschetta, A.
Affiliations: University of Bari Aldo Moro (IT)
Istituto Tumori Bari (IT)
Corresponding author: Moschetta, Antonio
ORCID: Cariello, Marica
Graziano, Giusi
Salvia, Roberto
Sabbà, Carlo
Palasciano, Giuseppe
Moschetta, Antonio
Venue: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Publisher: Elsevier BV
Published: 2016-11
Volume: 1861
Issue: 11
Pages: 1671-1680
ISSN: 1388-1981 (ISSN-L)
DOI: 10.1016/j.bbalip.2016.07.003
OpenAlex: W2464528610
Cited by: 107
References: 54
Citations by year: 2026: 2 · 2025: 4 · 2024: 12 · 2023: 14 · 2022: 8 · 2021: 15 · 2020: 20 · 2019: 12 · 2018: 12 · 2017: 6 · 2016: 2
FWCI: 4.89
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
PubMed (publishedVersion)
CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
Funders: Apulian Region - Italy (CIP PS_101)
Programma Operativo Nazionale (PON01_01958 PIVOLIO)
Italian Association for Cancer Research (IG 10410)
Fondazione Umberto Veronesi (fellowship)
Medical Research Council (MC_PC_13030)
Topics: Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
Keywords: extra virgin olive oil, metabolic syndrome, polyphenols, peripheral blood mononuclear cells, microRNA expression, gene expression, nutrigenomics, insulin sensitivity, glycemia, inflammation, cardiovascular disease prevention, cancer prevention
MeSH terms: Olive Oil, Adult, Feeding Behavior, Female, Gene Expression Regulation, Humans, Leukocytes, Mononuclear, Male, Reproducibility of Results, Gene Expression Profiling, Metabolic Syndrome, MicroRNAs, Polyphenols, Real-Time Polymerase Chain Reaction, Healthy Volunteers

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Genes and miRNA expression signatures in peripheral blood mononuclear cells in healthy subjects and patients with metabolic syndrome after acute intake of extra virgin olive oil

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