The DOI matches its Crossref record; 51 of the 54 references it cites were found in a registry or an index.
Genes and miRNA expression signatures in peripheral blood mononuclear cells in healthy subjects and patients with metabolic syndrome after acute intake of extra virgin olive oil
Abstract
Extra virgin olive oil (EVOO) consumption has been associated with reduced cardiovascular risk but molecular mechanisms underlying its beneficial effects are not fully understood. Here we aimed to identify genes and miRNAs expression changes mediated by acute high- and low-polyphenols EVOO intake. Pre- and post-challenge gene and miRNAs expression analysis was performed on the peripheral blood mononuclear cells (PBMCs) of 12 healthy subjects and 12 patients with metabolic syndrome (MS) by using microarray and RT-qPCR. In healthy subjects, acute intake of EVOO rich in polyphenols was able to ameliorate glycaemia and insulin sensitivity, and to modulate the transcription of genes and miRNAs involved in metabolism, inflammation and cancer, switching PBMCs to a less deleterious inflammatory phenotype; weaker effects were observed in patients with MS as well as in healthy subjects following low-polyphenol EVOO challenge. Concluding, our study shows that acute high-polyphenols EVOO intake is able to modify the transcriptome of PBMCs through the modulation of different pathways associated with the pathophysiology of cardio-metabolic disease and cancer. These beneficial effects are maximized in healthy subjects, and by the use of EVOO cultivars rich in polyphenols. Nutrigenomic changes induced by EVOO thus legitimate the well-known beneficial effects of EVOO in promoting human health and, potentially, preventing the onset of cardiovascular disease and cancer.
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“As concerns possible mechanisms for a chemopreventive role of the MedDiet, several in vitro [174] and in vivo [175,176] studies have described dramatic changes in the transcription of genes and micro-RNAs involved in the pathophysiology of cardiometabolic diseases and cancer, following EVOO interventions.”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [175]
In the citing paper
“Interestingly, the cAMP response element binding protein (CREB) binding protein gene (CREBBP) was downregulated following acute EVOO intervention, in both normal weight and obese individuals [175].”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [175]
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Potential Health Benefits of Olive Oil and Plant Polyphenols
Gorzynik-Debicka, M., Przychodzeń, P., Cappello, F., Kuban‐Jankowska, A., Marino, A., Knap, N., Woźniak, M., & Górska‐Ponikowska, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030686 · Cited by 656
Healthy Effects of Plant Polyphenols: Molecular Mechanisms
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Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases
Mirabelli, M., Chiefari, E., Arcidiacono, B., Corigliano, D. M., Brunetti, F. S., Maggisano, V., Russo, D., Foti, D. P., & Brunetti, A. (2020) · Nutrients · doi:10.3390/nu12041066 · Cited by 272
“Interestingly, the cAMP response element binding protein (CREB) binding protein gene (CREBBP) was downregulated following acute EVOO intervention, in both normal weight and obese individuals [175].”
BackgroundInfluentialEffects of Polyphenol Intake on Metabolic Syndrome: Current Evidences from Human Trials
Chiva‐Blanch, G., & Badimón, L. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/5812401 · Cited by 211
Metadata
- Authors
- D'Amore, S., Vacca, M., Cariello, M., Graziano, G., D'Orazio, A., Salvia, R., Sasso, R. C., Sabbà, C., Palasciano, G., & Moschetta, A.
- Affiliations
- University of Bari Aldo Moro (IT)
- Istituto Tumori Bari (IT)
- Corresponding author
- Moschetta, Antonio
- ORCID
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 1861
- Issue
- 11
- Pages
- 1671-1680
- ISSN
- 1388-1981 (ISSN-L)
- OpenAlex
- W2464528610
- Cited by
- 107
- References
- 54
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 12 · 2023: 14 · 2022: 8 · 2021: 15 · 2020: 20 · 2019: 12 · 2018: 12 · 2017: 6 · 2016: 2
- FWCI
- 4.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
- Funders
- Apulian Region - Italy (CIP PS_101)
- Programma Operativo Nazionale (PON01_01958 PIVOLIO)
- Italian Association for Cancer Research (IG 10410)
- Fondazione Umberto Veronesi (fellowship)
- Medical Research Council (MC_PC_13030)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Keywords
- extra virgin olive oil, metabolic syndrome, polyphenols, peripheral blood mononuclear cells, microRNA expression, gene expression, nutrigenomics, insulin sensitivity, glycemia, inflammation, cardiovascular disease prevention, cancer prevention
- MeSH terms
- Olive Oil, Adult, Feeding Behavior, Female, Gene Expression Regulation, Humans, Leukocytes, Mononuclear, Male, Reproducibility of Results, Gene Expression Profiling, Metabolic Syndrome, MicroRNAs, Polyphenols, Real-Time Polymerase Chain Reaction, Healthy Volunteers
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