Cited by 68Cardiac Ischemia and ReperfusionMitochondrial Function and PathologyCell death mechanisms and regulation

Nuclear-encoded mitochondrial proteins and their role in cardioprotection

Open access
Boengler, Kerstin, Heusch, Gerd, Schulz, Rainer·2011·Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Abstract

During myocardial ischemia/reperfusion, mitochondria are both a source and a target of injury. In cardioprotective maneuvers such as ischemic and pharmacological pre- and postconditioning mitochondria have a decisive role. Since about 99% of the mitochondrial proteins are encoded in the nucleus, deleterious and protective mitochondrial effects most likely comprise the import of cytosolic proteins. The present review therefore discusses the role of mitochondria in myocardial ischemia/reperfusion injury and protection from it, focusing on some cytosolic proteins, which are translocated into mitochondria before, during, or following ischemia/reperfusion. Both morphological and functional alterations are discussed at the level of the heart, the cardiomyocyte and/or the mitochondrion itself. This article is part of a Special Issue entitled: Mitochondria and Cardioprotection.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.bbamcr.2011.01.009

Cites

143 of 143 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The 80S ribosome contains 79 proteins and four rRNAs, and there are approximately 1,500 mitochondrial proteins.

    “The 80S ribosome contains 79 proteins and four rRNAs, and there are ~1,500 mitochondrial proteins (Boengler et al., 2011).”

    From Skeletal Muscle Ribosome and Mitochondrial Biogenesis in Response to Different Exercise Training Modalities (2021) · cites this paper as Boengler et al., 2011

    Section 1, “The mitochondrial proteome” (page unavailable), reports about 650 proteins allocated to the mitochondrial matrix and 850 to mitochondrial membranes in an analysis of the murine cardiac proteome. That supports roughly 1,500 in that specific setting, but the copy does not state that mitochondrial proteins number approximately 1,500 generally. It does not address the claimed composition of the 80S ribosome (searched: 80S ribosome, 79 proteins, four rRNAs). (LLM, conf=0.85)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

2 retracted

Flagged first, then by citations

2 of the 145 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Boengler, K., Heusch, G., & Schulz, R.
Affiliations
  • Essen University Hospital (DE)
  • Justus-Liebig-Universität Gießen (DE)
Corresponding author
Boengler, Kerstin
Venue
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Publisher
Elsevier BV
Published
2011-07
Volume
1813
Issue
7
Pages
1286-1294
ISSN
0167-4889 (ISSN-L)
OpenAlex
W2118927393
Cited by
68
References
145
Citations by year
2026: 1 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 12 · 2018: 4 · 2017: 7 · 2016: 4 · 2015: 1 · 2014: 4 · 2013: 4 · 2012: 3
FWCI
0.53
Type
journal article
Language
en
Open access
Locations
  • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords
nuclear-encoded mitochondrial proteins, mitochondrial protein import, cardioprotection, myocardial ischemia-reperfusion injury, mitochondrial dysfunction, ischemic preconditioning, postconditioning, cardiomyocytes, mitochondrial morphology
MeSH terms
Animals, Cardiotonic Agents, Humans, Mitochondria, Heart, Myocardium, Myocardial Reperfusion Injury, Ischemic Preconditioning, Myocardial, Mitochondrial Proteins, Myocytes, Cardiac, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review