Nuclear-encoded mitochondrial proteins and their role in cardioprotection
Open accessAbstract
During myocardial ischemia/reperfusion, mitochondria are both a source and a target of injury. In cardioprotective maneuvers such as ischemic and pharmacological pre- and postconditioning mitochondria have a decisive role. Since about 99% of the mitochondrial proteins are encoded in the nucleus, deleterious and protective mitochondrial effects most likely comprise the import of cytosolic proteins. The present review therefore discusses the role of mitochondria in myocardial ischemia/reperfusion injury and protection from it, focusing on some cytosolic proteins, which are translocated into mitochondria before, during, or following ischemia/reperfusion. Both morphological and functional alterations are discussed at the level of the heart, the cardiomyocyte and/or the mitochondrion itself. This article is part of a Special Issue entitled: Mitochondria and Cardioprotection.
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The 80S ribosome contains 79 proteins and four rRNAs, and there are approximately 1,500 mitochondrial proteins.
“The 80S ribosome contains 79 proteins and four rRNAs, and there are ~1,500 mitochondrial proteins (Boengler et al., 2011).”
From Skeletal Muscle Ribosome and Mitochondrial Biogenesis in Response to Different Exercise Training Modalities (2021) · cites this paper as Boengler et al., 2011
Section 1, “The mitochondrial proteome” (page unavailable), reports about 650 proteins allocated to the mitochondrial matrix and 850 to mitochondrial membranes in an analysis of the murine cardiac proteome. That supports roughly 1,500 in that specific setting, but the copy does not state that mitochondrial proteins number approximately 1,500 generally. It does not address the claimed composition of the 80S ribosome (searched: 80S ribosome, 79 proteins, four rRNAs). (LLM, conf=0.85)
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- Authors
- Boengler, K., Heusch, G., & Schulz, R.
- Affiliations
- Essen University Hospital (DE)
- Justus-Liebig-Universität Gießen (DE)
- Corresponding author
- Boengler, Kerstin
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 1813
- Issue
- 7
- Pages
- 1286-1294
- ISSN
- 0167-4889 (ISSN-L)
- OpenAlex
- W2118927393
- Cited by
- 68
- References
- 145
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 12 · 2018: 4 · 2017: 7 · 2016: 4 · 2015: 1 · 2014: 4 · 2013: 4 · 2012: 3
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- nuclear-encoded mitochondrial proteins, mitochondrial protein import, cardioprotection, myocardial ischemia-reperfusion injury, mitochondrial dysfunction, ischemic preconditioning, postconditioning, cardiomyocytes, mitochondrial morphology
- MeSH terms
- Animals, Cardiotonic Agents, Humans, Mitochondria, Heart, Myocardium, Myocardial Reperfusion Injury, Ischemic Preconditioning, Myocardial, Mitochondrial Proteins, Myocytes, Cardiac, Mice
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