The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock
Open accessAbstract
Sirtuins (SIRT1-7) are NAD(+)-dependent histone deacetylases (HDACs) that play an important role in the control of metabolism and proliferation and the development of age-associated diseases like oncologic, cardiovascular and neurodegenerative diseases. Cambinol was originally described as a compound inhibiting the activity of SIRT1 and SIRT2, with efficient anti-tumor activity in vivo. Here, we studied the effects of cambinol on microbial sensing by mouse and human immune cells and on host innate immune responses in vivo. Cambinol inhibited the expression of cytokines (TNF, IL-1β, IL-6, IL-12p40, and IFN-γ), NO and CD40 by macrophages, dendritic cells, splenocytes and whole blood stimulated with a broad range of microbial and inflammasome stimuli. Sirtinol, an inhibitor of SIRT1 and SIRT2 structurally related to cambinol, also decreased macrophage response to TLR stimulation. On the contrary, selective inhibitors of SIRT1 (EX-527 and CHIC-35) and SIRT2 (AGK2 and AK-7) used alone or in combination had no inhibitory effect, suggesting that cambinol and sirtinol act by targeting more than just SIRT1 and SIRT2. Cambinol and sirtinol at anti-inflammatory concentrations also did not inhibit SIRT6 activity in in vitro assay. At the molecular level, cambinol impaired stimulus-induced phosphorylation of MAPKs and upstream MEKs. Going well along with its powerful anti-inflammatory activity, cambinol reduced TNF blood levels and bacteremia and improved survival in preclinical models of endotoxic shock and septic shock. Altogether, our data suggest that pharmacological inhibitors of sirtuins structurally related to cambinol may be of clinical interest to treat inflammatory diseases.
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Cambinol inhibits NAD-dependent deacetylases implicated in the regulation of many biological processes including metabolic control.
“Cambinol inhibits NAD-dependent deacetylases implicated in the regulation of many biological processes including metabolic control (Lugrin et al. 2013).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Lugrin et al. 2013
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- Authors
- Lugrin, J., Ciarlo, E., Santos, A., Grandmaison, G., Dos Santos, I., Le Roy, D., & Roger, T.
- Affiliations
- Centre Hospitalier Universitaire Vaudois (CH)
- Corresponding author
- Roger, Thierry
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 1833
- Issue
- 6
- Pages
- 1498-1510
- ISSN
- 0167-4889 (ISSN-L)
- OpenAlex
- W1981486972
- Cited by
- 67
- References
- 82
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 3 · 2019: 10 · 2018: 9 · 2017: 6 · 2016: 8 · 2015: 6 · 2014: 1 · 2013: 1
- FWCI
- 2.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Funders
- Swiss National Science Foundation (310000_114073, 310030_132744)
- Swiss Society for Infectious Diseases
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- sirtuin inhibitors, SIRT1, SIRT2, SIRT6, MAPK signaling, MEK phosphorylation, innate immunity, inflammation, septic shock, endotoxic shock, sirtinol, macrophages, dendritic cells, TLR stimulation, inflammasome, cytokines, TNF-α, bacteremia, anti-inflammatory agents
- MeSH terms
- Animals, Benzamides, Cells, Cultured, Flow Cytometry, Humans, Immunity, Innate, Inflammation, Klebsiella Infections, Klebsiella pneumoniae, Macrophages, Mice, Inbred BALB C, Naphthalenes, Naphthols, Pyrimidinones, RNA, Messenger, Shock, Septic, Blotting, Western, Cytokines, Apoptosis, Reverse Transcriptase Polymerase Chain Reaction, Mitogen-Activated Protein Kinases, Sirtuins, Cell Proliferation, Mice, Real-Time Polymerase Chain Reaction
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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