Cited by 1,366Cell death mechanisms and regulationAutophagy in Disease and TherapyDeath, Funerary Practices, and Mourning

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Crosstalk between apoptosis.; necrosis and autophagy

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Nikoletopoulou, Vassiliki, Markaki, Maria, Palikaras, Konstantinos, Tavernarakis, Nektarios·2013·Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

DOI 10.1016/j.bbamcr.2013.06.001

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Abstract

Apoptosis and necrosis are the two major modes of cell death, the molecular mechanisms of which have been extensively studied. Although initially thought to constitute mutually exclusive cellular states, recent findings reveal cellular contexts that require a balanced interplay between these two modes of cellular demise. Several death initiator and effector molecules, signaling pathways and subcellular sites have been identified as key mediators in both processes, either by constituting common modules or alternatively by functioning as a switch allowing cells to decide which route to take, depending on the specific situation. Importantly, autophagy, which is a predominantly cytoprotective process, has been linked to both types of cell death, serving either a pro-survival or pro-death function. Here we review the recent literature that highlights the intricate interplay between apoptosis, necrosis and autophagy, focusing on the relevance and impact of this crosstalk in normal development and in pathology. This article is part of a Special Section entitled: Cell Death Pathways.

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1 retracted

The NAD-dependent deacetylase SIRT2 is required for programmed necrosis
Narayan, N., Lee, I. H., Borenstein, R., Sun, J., Wong, R. P., Tong, G., Fergusson, M. M., Liu, J., Rovira, I. I., Cheng, H.-L., et al. (2012) · Nature · doi:10.1038/nature11700 · Cited by 136 · cited 2×
“Recent ﬁ ndings indicate that SIRT2 is also involved in the regulation of necroptosis [130].”
Background
Retracted
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,673
p53, the cellular gatekeeper for growth and division
Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227 · cited 1×
“3; [135,136]), or through activation of theULK1complex[137,138].”
Cell Death: The Significance of Apoptosis
Wyllie, A. H., Kerr, J. F. R., & Currie, A. R. (1980) · International review of cytology · doi:10.1016/s0074-7696(08)62312-8 · Cited by 7,151 · cited 1×
“Mechanistically, necrosis is typically not associated with activation of caspases, and it is thought that it mediates cell demise in response to damage, or in pathology [10,11], but not during normal development.”
Background
Autophagy in the Pathogenesis of Disease
Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069 · cited 1×
“Completion of the autophagosome is followed by fusion with a lysosome to form an autolysosome, where the captured material is degraded by specific acidic hydrolases [12].”
Background
Autophagy fights disease through cellular self-digestion
Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452 · cited 1×
“Although it is primarily considered to have a cytoprotective function, autophagy can also promote cell death during normal development (reviewed in [13]), as well as, in disease (reviewed in [14]).”
Background
TOR signaling in growth and metabolism
Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787 · cited 1×
“Low insulin – IGF1 signaling, nutrient or energy limitation and stress converge to downregulate the activity of TOR [83].”
Background
Cellular survival: a play in three Akts
Datta, S. R., Brunet, A., & Greenberg, M. E. (1999) · Genes & Development · doi:10.1101/gad.13.22.2905 · Cited by 4,216 · cited 1×
“AKT ability to prevent apoptosis in some cells is established through phosphorylation and inhibition of pro-apoptotic mediators such as Bad and caspase-9 [44].”
Background
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914 · cited 1×
“3; [135,136]), or through activation of theULK1complex[137,138].”

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“7A and B), which has been reported to play a causal role in apoptosis [43], as well as the apoptotic protein PARP-1 [44] (Fig.”
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BackgroundInfluential
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Wang, P., Chen, X., Wang, Y., Jia, C., Liu, X., Wang, Y., Wu, H., Cai, H., Shen, H., & Le, W. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03412-5 · Cited by 31
Combined effects of hyperthermia and chemotherapy on the regulate autophagy of oral squamous cell carcinoma cells under a hypoxic microenvironment
Shi, F., Luo, D., Zhou, X., Sun, Q., Shen, P., & Wang, S. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00538-5 · Cited by 32
“The previous study shows that both apoptosis and autophagy are activated in response to metabolic stress [59], and accumulating evidence reveals that autophagy and apoptosis can cooperate, antagonize or assist each other, thus influencing the differential fate of the cell [60].”
Background
Temperature-dependent and time-dependent effects of hyperthermia mediated by dextran-coated La0.7Sr0.3MnO3: in vitro studies
Paknikar, K. M., Haghniaz, R., & Umrani, R. D. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s78167 · Cited by 32
ω-3 Fatty acids reverse lipotoxity through induction of autophagy in nonalcoholic fatty liver disease
Chen, Y., Xu, C., Yan, T., Yu, C., & Li, Y. (2015) · Nutrition · doi:10.1016/j.nut.2015.05.022 · Cited by 32
Pan-Bcl-2 inhibitor Obatoclax is a potent late stage autophagy inhibitor in colorectal cancer cells independent of canonical autophagy signaling
Koehler, B. C., Jassowicz, A., Scherr, A., Lorenz, S., Radhakrishnan, P., Kautz, N., Elßner, C., Weiß, J., Jaeger, D., Schneider, M., et al. (2015) · BMC Cancer · doi:10.1186/s12885-015-1929-y · Cited by 32
“Within the autophagy signaling network, crosstalks with classical apoptosis pathways have been identified [37, 38].”
Background
The Protective Effects of Levo-Tetrahydropalmatine on ConA-Induced Liver Injury Are via TRAF6/JNK Signaling
Yu, Q., Liu, T., Li, S., Feng, J., Wu, L., Wang, W., Chen, K., Xia, Y., Niu, P., Xu, L., et al. (2018) · Mediators of Inflammation · doi:10.1155/2018/4032484 · Cited by 32
Plasma Membrane Channel TRPM4 Mediates Immunogenic Therapy–Induced Necrosis
Ghosh, S., Yang, R., Duraki, D., Zhu, J., Kim, J. E., Jabeen, M., Mao, C., Dai, X., Livezey, M. R., Boudreau, M. W., et al. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-0157 · Cited by 31
Mitochondrial Fission Increases Apoptosis and Decreases Autophagy in Renal Proximal Tubular Epithelial Cells Treated with High Glucose
Lee, W., Chiu, C.-H., Chen, J., Chen, C.-H., & Chang, H. (2016) · DNA and Cell Biology · doi:10.1089/dna.2016.3261 · Cited by 32
“This interaction of autophagy and apoptosis may determine the outcome of cellular stress (Maiuri et al. , 2007; Nikoletopoulou et al. , 2013; Marino et al. , 2014).”
Sodium fluoride induces apoptosis and autophagy via the endoplasmic reticulum stress pathway in MC3T3-E1 osteoblastic cells
Li, X., Li, M., Wang, F., Hu, X., & Yu, Y. (2018) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-018-3454-1 · Cited by 31
Protective role of the deSUMOylating enzyme SENP3 in myocardial ischemia-reperfusion injury
Rawlings, N., Lee, L. J., Nakamura, Y., Wilkinson, K. A., & Henley, J. M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0213331 · Cited by 31
HMGB1-mediated apoptosis and autophagy in ischemic heart diseases
Foglio, E., Pellegrini, L., Germani, A., Russo, M. A., & Limana, F. (2019) · Vascular Biology · doi:10.1530/vb-19-0013 · Cited by 31
Free Radical Medicine and Biology
Das, K. K., Das, S. N., Biradar, M. S., Bobbarala, V., & Tata, S. S. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.77829 · Cited by 32
Angiotensin-(1-7) Prevents Lipopolysaccharide-Induced Autophagy via the Mas Receptor in Skeletal Muscle
Rivera, J. C. A., Ábrigo, J., Tacchi, F., Simón, F., Brandan, E., Santos, R. A. S., Bäder, M., Chiong, M., & Cabello‐Verrugio, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249344 · Cited by 32
“These facts are consistent with the possibility of the two pools of BCL-2, as previously suggested [41,42].”
Result
Platelet-rich plasma protects rat chondrocytes from interleukin-1β-induced apoptosis
Yang, J., Lu, Y. C., & Guo, A. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5767 · Cited by 31
“Previous studies have reported that IL-1 β may stimulate apoptosis of chondrocytes and tendon cells (22,23) by upregulating the expression of Bax and caspase-3 (24), and suppressing the expression of Bcl-2 and PARP (25).”
8‐Hydroxyquinoline, Derivatives and Metal‐Complexes: A Review of Antileukemia Activities
Gasparin, C. B., & Pilger, D. A. (2023) · ChemistrySelect · doi:10.1002/slct.202204219 · Cited by 31
Raddeanin a Suppresses Glioblastoma Growth by Inducing ROS Generation and Subsequent JNK Activation to Promote Cell Apoptosis
Peng, F., Wang, X., Shu, M., Yang, M., Wang, L., Ouyang, Z., Shen, C., Hou, X., Zhao, B., Wang, X., et al. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000490187 · Cited by 30
Antiproliferative Effect of Trifolium Pratens L. Extract in Human Breast Cancer Cells
Khazaei, M., & Pazhouhi, M. (2018) · Nutrition and Cancer · doi:10.1080/01635581.2018.1521443 · Cited by 31
“P53 induces autophagy through target of rapamycin inhibition and also through transcriptional activation of damage-regulated autophagy modulator (17).”
Background
Marine Invertebrate Extracts Induce Colon Cancer Cell Death via ROS-Mediated DNA Oxidative Damage and Mitochondrial Impairment
Ruiz-Torres, V., Rodríguez‐Pérez, C., Herranz‐López, M., Martín-García, B., Gómez‐Caravaca, A. M., Arraéz-Román, D., Segura‐Carretero, A., Barrajón‐Catalán, E., & Micol, V. (2019) · Biomolecules · doi:10.3390/biom9120771 · Cited by 29
Veratramine suppresses human HepG2 liver cancer cell growth in vitro and in vivo by inducing autophagic cell death
Yin, L., Xia, Y., Xu, P., Zheng, W., Gao, Y., Xie, F., & Zhao-ning, J. (2020) · Oncology Reports · doi:10.3892/or.2020.7622 · Cited by 30
“Studies have revealed that there are four relationships between autophagy and apoptosis (19,20): i) Autophagy precedes apoptosis and maintains cell homeostasis; ii) apoptosis inhibits autophagic cell death and inhibition of apoptosis stimulates autophagic cell death; iii) autophagy degrades damaged organelles and prot…”
Background
Energy disorders caused by mitochondrial dysfunction contribute to α-amatoxin-induced liver function damage and liver failure
Chen, X., Shao, B., Yu, C., Yao, Q., Peibin, M., Li, W., Li, B., & Sun, C. (2020) · Toxicology Letters · doi:10.1016/j.toxlet.2020.10.003 · Cited by 30
Calcitriol alleviates ethanol-induced hepatotoxicity via AMPK/mTOR-mediated autophagy
Fang, Y., Xu, Y., You, K., Zhang, J., Yang, F., & Li, Y.-X. (2020) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2020.108694 · Cited by 30
Gramicidin A-based unimolecular channel: cancer cell-targeting behavior and ion transport-induced apoptosis
Haoyang, W., Xiao, Q., Ye, Z., Fu, Y., Zhang, D., Li, J., Xiao, L., Li, Z., & Hou, J. (2021) · Chemical Communications · doi:10.1039/d0cc08073j · Cited by 30
Genetic mutations and molecular mechanisms of Fuchs endothelial corneal dystrophy
Liu, X., Zheng, T., Zhao, C., Zhang, Y., Liu, H., Wang, L., & Liu, P. (2021) · Eye and Vision · doi:10.1186/s40662-021-00246-2 · Cited by 30
Oligomycin A Induces Apoptosis‐to‐Pyroptosis Switch against Melanoma with Sensitized Immunotherapy
Wang, L., Lü, D., Huo, M., & Xu, H. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202106332 · Cited by 31
Anticancer activity of ruthenium(II) plumbagin complexes with polypyridyl as ancillary ligands via inhibiting energy metabolism and GADD45A-mediated cell cycle arrest
Li, Y., Zhu, X., Chen, N.-F., Chen, S., Yang, Y., Liang, H., & Chen, Z. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114312 · Cited by 29
Extracellular HMGB1 interacts with RAGE and promotes chemoresistance in acute leukemia cells
Lai, W., Li, X., Kong, Q., Chen, H., Li, Y., Xu, L., & Fang, J. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02387-9 · Cited by 30
SIRPα maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis
Wang, D., Lin, Y., Xu, F., Zhang, H., Zhu, X., Liu, Z., Hu, Y., Dong, G., Sun, B., Yu, Y., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104278 · Cited by 32
Stromal cell‐derived small extracellular vesicles enhance radioresistance of prostate cancer cells via interleukin‐8‐induced autophagy
Wang, X., Xu, F., Kou, H., Zheng, Y., Yang, J., Xu, Z., Yao, F., Sun, W., Zhu, S., Jiang, Q. L., et al. (2023) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12342 · Cited by 32
“However, numerous studies have demonstrated that metabolic stress-mediated autophagic cell death is provoked by the crosstalk between autophagy and apoptosis, ferroptosis, or necrosis (Dai et al., 2020; Kessel & Reiners, 2020; Nikoletopoulou et al., 2013).”
Saligenin cyclic-o-tolyl phosphate (SCOTP) induces autophagy of rat spermatogonial stem cells
Xu, L., Liu, M.-L., Wang, J., Yu, M. Y., & Chen, J. (2016) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.01.004 · Cited by 30
Mono(2-ethylhexyl) phthalate induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis in human endothelial cells
Wu, X., Jiang, L., Sun, X., Yao, X., Bai, Y., Liu, X., Liu, N., Zhai, X., Wang, S., & Yang, G. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.05.069 · Cited by 31
Involvement of autophagy and apoptosis and lipid accumulation in sclerotial morphogenesis of Morchella importuna
He, P., Wang, K., Cai, Y., Hu, X., Zheng, Y., Zhang, J., & Liu, W. (2018) · Micron · doi:10.1016/j.micron.2018.03.005 · Cited by 30
E-prostanoid 3 receptor deficiency on myeloid cells protects against ischemic acute kidney injury via breaking the auto-amplification loop of necroinflammation
Leng, J., Zhao, W., Guo, J., Yu, G., Zhu, G., Ge, J., He, D., Xu, Y., Chen, X., Zhou, Y., et al. (2022) · Kidney International · doi:10.1016/j.kint.2022.08.019 · Cited by 30
Mitochondrial dysfunction and NLRP3 inflammasome: key players in kidney stone formation
Su, B., Ren, Y., Yao, W., Su, Y., & He, Q. (2024) · British Journal of Urology · doi:10.1111/bju.16454 · Cited by 32
“Autophagy levels have been found to be elevated in patients with CaOx kidney stones, and the main cause of increased autophagy levels is the accumulation of ROS and cellular damage caused by the in ﬂ ammatory response [77,78].”
Lup-20(29)-en-3β,28-di-yl-nitrooxy acetate affects MCF-7 proliferation through the crosstalk between apoptosis and autophagy in mitochondria
Yan, X., Yang, L., Feng, G., Yu, Z., Xiao, M., Cai, W., Xing, Y., Bai, S., Guo, J., Wang, Z., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0255-5 · Cited by 30
Impact of vitamin D and vitamin D receptor on the trophoblast survival capacity in preeclampsia
Hutabarat, M., Wibowo, N., Obermayer-Pietsch, B. M., & Huppertz, B. (2018) · PLoS ONE · doi:10.1371/journal.pone.0206725 · Cited by 29
Ginsenoside Rg1 Alleviates Podocyte Injury Induced by Hyperlipidemia via Targeting the mTOR/NF‐κB/NLRP3 Axis
Wang, T., Gao, Y., Yue, R., Wang, X., Shi, Y., Xu, J., Wu, B., & Li, Y. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/2735714 · Cited by 31
Organelle-specific mechanisms of drug-induced autophagy-dependent cell death
Zein, L., Fulda, S., Kögel, D., & van Wijk, S. J. L. (2020) · Matrix Biology · doi:10.1016/j.matbio.2020.12.003 · Cited by 29
Overexpression of TNFα induces senescence, autophagy and mitochondrial dysfunctions in melanoma cells
Tyčiaková, S., Valova, V., Svitkova, B., & Matúšková, M. (2021) · BMC Cancer · doi:10.1186/s12885-021-08237-1 · Cited by 33
“Weinelt N, Karathanasis C, Smith S, Medler J, Malkusch S, Fulda S, et al. Quantitative single-molecule imaging of TNFR1 reveals zafirlukast as antagonist of TNFR1 clustering and TNFα-induced NF-ĸB signaling.”
BackgroundInfluential
Mitochondrial stress adaptation promotes resistance to aromatase inhibitor in human breast cancer cells via ROS/calcium up-regulated amphiregulin–estrogen receptor loop signaling
Wang, S., Chang, Y.-L., Tzeng, Y. T., Wu, C.-L., Wang, Y.-Z., Tseng, L., Chen, S., & Lee, H. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.09.043 · Cited by 28
Morphofunctional and signaling molecules overlap of the pineal gland and thymus: role and significance in aging
Paltsev, M. A., Polyakova, V. O., Kvetnoy, I. M., Anderson, G., Kvetnaia, T. V., Linkova, N. S., Paltseva, E. M., Rubino, R., Cosmo, S. D., Cata, A. D., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7863 · Cited by 29
“The key proteins in these two overlapping apoptotic pathways are: p53 in caspase-dependent apoptosis; and mitochondrial AIF [21].”
Background
Synthesis of new sarsasapogenin derivatives with cytotoxicity and apoptosis-inducing activities in human breast cancer MCF-7 cells
Wang, W., Wang, D., Wang, Z., Yao, G., Li, X., Gao, P., Li, L., Zhang, Y., Wang, S., & Song, S. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.12.011 · Cited by 29
Manipulating the mitochondria activity in human hepatic cell line Huh7 by low-power laser irradiation
Lynnyk, A., Lunová, M., Jirsa, M., Egorova, D., Kulikov, A., Kubinová, Š., Lunov, O., & Dejneka, A. (2018) · Biomedical Optics Express · doi:10.1364/boe.9.001283 · Cited by 28
Drug-induced thrombocytopenia: Focus on platelet apoptosis
Silva, E. D., & Kim, H. (2018) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.01.015 · Cited by 29
GAS5/miR-21 Axis as a Potential Target to Rescue ZCL-082-Induced Autophagy of Female Germline Stem Cells In Vitro
Li, B., Hu, X., Yang, Y., Zhu, M., Zhang, J., Wang, Y., Pei, X., Zhou, H., & Wu, J. (2019) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2019.06.012 · Cited by 28
Targeting Programmed Cell Death to Improve Stem Cell Therapy: Implications for Treating Diabetes and Diabetes-Related Diseases
Zhāng, Q., Wan, X.-X., Hu, X., Zhao, W., Ban, X.-X., Huang, Y., Yan, W., & Xiong, K. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.809656 · Cited by 28
“Distinct Forms of PCD IN SC for Transplantation Apoptosis Apoptosis is characterized by the breaking up of cell in apoptotic bodies (Nikoletopoulou et al., 2013).”
Background

Authors: Nikoletopoulou, V., Markaki, M., Palikaras, K., & Tavernarakis, N.
Affiliations: Foundation for Research and Technology Hellas (GR)
Corresponding author: Tavernarakis, Nektarios
ORCID: Nikoletopoulou, Vassiliki
Markaki, Maria
Palikaras, Konstantinos
Tavernarakis, Nektarios
Venue: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Publisher: Elsevier BV
Published: 2013-12
Volume: 1833
Issue: 12
Pages: 3448-3459
ISSN: 0167-4889 (ISSN-L)
DOI: 10.1016/j.bbamcr.2013.06.001
OpenAlex: W2059738518
Cited by: 1,366
References: 150
Citations by year: 2026: 43 · 2025: 58 · 2024: 80 · 2023: 91 · 2022: 113 · 2021: 147 · 2020: 133 · 2019: 146 · 2018: 136 · 2017: 141 · 2016: 122 · 2015: 107 · 2014: 43 · 2013: 5
FWCI: 8.50
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 365 d)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
PubMed (publishedVersion)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Funders: European Research Council
Ministry of National Education and Religious Affairs
European Molecular Biology Organization
Seventh Framework Programme
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Social Sciences › Anthropology › Death, Funerary Practices, and Mourning
Keywords: apoptosis, necrosis, autophagy, cell death crosstalk, cell death pathways, cell fate determination, development (biology), disease pathology
MeSH terms: Autophagy, Humans, Models, Biological, Necrosis, Signal Transduction, Apoptosis

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Crosstalk between apoptosis.; necrosis and autophagy

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