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Crosstalk between apoptosis.; necrosis and autophagy
Open accessAbstract
Apoptosis and necrosis are the two major modes of cell death, the molecular mechanisms of which have been extensively studied. Although initially thought to constitute mutually exclusive cellular states, recent findings reveal cellular contexts that require a balanced interplay between these two modes of cellular demise. Several death initiator and effector molecules, signaling pathways and subcellular sites have been identified as key mediators in both processes, either by constituting common modules or alternatively by functioning as a switch allowing cells to decide which route to take, depending on the specific situation. Importantly, autophagy, which is a predominantly cytoprotective process, has been linked to both types of cell death, serving either a pro-survival or pro-death function. Here we review the recent literature that highlights the intricate interplay between apoptosis, necrosis and autophagy, focusing on the relevance and impact of this crosstalk in normal development and in pathology. This article is part of a Special Section entitled: Cell Death Pathways.
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“While autophagy is implicated in several paradigms of life extension and is generally considered an antiaging mechanism, autophagy is also a well-defined mechanism of cell death, autophagy-dependent cell death, ADCD [153,154,155].”
From The mitochondrial permeability transition: Nexus of aging, disease and longevity (2021) · cites this paper as [153]
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“signaling components of the two pathways (autophagy and apoptosis) have been reported and indicate a complex cross-talk [77].”
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“They also have a crosstalk mechanism to regulate each other [48-50].”
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Dual Role of Autophagy in Diseases of the Central Nervous System
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“…has previously been associated with a variety of diseases such as cancer (Gozuacik and Kimchi, 2004), muscular disorders (Danon’s disease) (Nishino et al., 2000), pathogen infections (Listeria monocytogenes) (Shintani and Klionsky, 2004), cerebral ischemia (Wei et al., 2012),…”
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“Despite equal cell death rates during mitosis, p53 loss increased cell viability in the subsequent interphase at 24 h after mitosis (Figure S2G), consistent with its known role in responding to DNA damage (Nikoletopoulou et al., 2013).”
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“mutual regulation between apoptosis and autophagy in the death signaling process mediated by mitochondria.(31,32) Thus,”
BackgroundAutophagy in Cancer Cell Death
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“PCD is an evolutionarily-conserved phenomenon and the most common and best-studied form of PCD is apoptosis (type I cell death) [1].”
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Luteolin, inflammation and cancer: Special emphasis on gut microbiota
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“Most of NF-kB activity influences the activation and functionality of T-lymphocytes and regulation of apoptosis, thus explaining its importance in tumorigenesis and other conditions.(27) in vitro studies have confirmed the capacity of luteolin to modulate NF-kB, in the upper-airways(28) (Figure 1).”
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“permeability and lysosome damage, eventually leading to cell death.(11,12) Previous studies have confirmed that microglia was”
ResultHakiminia, B., Alikiaii, B., Khorvash, F., & Mousavi, S. (2022) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12767 · Cited by 106
“The two formers are the most common types [92], and the latter may be run as a compensatory pathway to apoptosis [93].”
Background
Metadata
- Authors
- Nikoletopoulou, V., Markaki, M., Palikaras, K., & Tavernarakis, N.
- Affiliations
- Foundation for Research and Technology Hellas (GR)
- Corresponding author
- Tavernarakis, Nektarios
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 1833
- Issue
- 12
- Pages
- 3448-3459
- ISSN
- 0167-4889 (ISSN-L)
- OpenAlex
- W2059738518
- Cited by
- 1,366
- References
- 150
- Citations by year
- 2026: 43 · 2025: 58 · 2024: 80 · 2023: 91 · 2022: 113 · 2021: 147 · 2020: 133 · 2019: 146 · 2018: 136 · 2017: 141 · 2016: 122 · 2015: 107 · 2014: 43 · 2013: 5
- FWCI
- 8.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Funders
- European Research Council
- Ministry of National Education and Religious Affairs
- European Molecular Biology Organization
- Seventh Framework Programme
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Social Sciences › Anthropology › Death, Funerary Practices, and Mourning
- Keywords
- apoptosis, necrosis, autophagy, cell death crosstalk, cell death pathways, cell fate determination, development (biology), disease pathology
- MeSH terms
- Autophagy, Humans, Models, Biological, Necrosis, Signal Transduction, Apoptosis
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