Cited by 1,366Cell death mechanisms and regulationAutophagy in Disease and TherapyDeath, Funerary Practices, and Mourning

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Crosstalk between apoptosis.; necrosis and autophagy

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Nikoletopoulou, Vassiliki, Markaki, Maria, Palikaras, Konstantinos, Tavernarakis, Nektarios·2013·Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

DOI 10.1016/j.bbamcr.2013.06.001

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Abstract

Apoptosis and necrosis are the two major modes of cell death, the molecular mechanisms of which have been extensively studied. Although initially thought to constitute mutually exclusive cellular states, recent findings reveal cellular contexts that require a balanced interplay between these two modes of cellular demise. Several death initiator and effector molecules, signaling pathways and subcellular sites have been identified as key mediators in both processes, either by constituting common modules or alternatively by functioning as a switch allowing cells to decide which route to take, depending on the specific situation. Importantly, autophagy, which is a predominantly cytoprotective process, has been linked to both types of cell death, serving either a pro-survival or pro-death function. Here we review the recent literature that highlights the intricate interplay between apoptosis, necrosis and autophagy, focusing on the relevance and impact of this crosstalk in normal development and in pathology. This article is part of a Special Section entitled: Cell Death Pathways.

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Background
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Background
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Background
Arsenic trioxide-induced autophagy affected the antioxidant capacity and apoptosis rate of chicken hepatocytes
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Fluorescence microscopic approach for detection of two different modes of breast cancer cell death induced by nanosecond pulsed electric field
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Macrophage autophagy contributes to immune liver injury in trichloroethylene sensitized mice: Critical role of TNF‐α mediating mTOR pathway
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“TNF ‐ α triggers both autophagy and prosurvival NF ‐ κ B signaling via receptor TNFR1 (Nikoletopoulou et al., 2013).”
Background
Determination of Inhibitory Effect of PKM2 Enzyme and Antitumoral Activity of Novel Coumarin-naphthoquinone Hybrids
Borges, A. D. A., Ouverney, G., Arruda, A. T. S., Ribeiro, A. V., Ribeiro, R. C. B., de Souza, A. S., da Fonseca, A. C. C., de Queiroz, L. N., de Almeida, E. C. P., Pontes, B., et al. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673298471240605072658 · Cited by 12
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“…in mutants lacking certain PCD pathway regulatory genes Stress mediated PCD occurs by activating specific pathways that have been classified into three major processes including apoptosis, autophagy and necroptosis (Carmona-Gutierrez et al. 2010; Portt et al. 2011; Nikoletopoulou et al. 2013).”
Background
JNK1 and JNK3 play a significant role in both neuronal apoptosis and necrosis. Evaluation based on in vitro approach using tert-butylhydroperoxide induced oxidative stress in neuro-2A cells and perturbation through 3-aminobenzamide
Muthaiah, V. P. K., Michael, F. M., Palaniappan, T., Rajan, S. S., Chandrasekaran, K., & Venkatachalam, S. (2017) · Toxicology in Vitro · doi:10.1016/j.tiv.2017.02.015 · Cited by 11
Receptor interacting protein kinase 3 promotes cisplatin-induced necroptosis in apoptosis-resistant HepG2/DDP cells
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Parameters for Optoperforation-Induced Killing of Cancer Cells Using Gold Nanoparticles Functionalized With the C-terminal Fragment of Clostridium Perfringens Enterotoxin
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Sulforaphane and Albumin Attenuate Experimental Intestinal Ischemia-Reperfusion Injury
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“Two principal apoptotic pathways include the mitochondrial or intrinsic pathway and the death receptor or extrinsic pathway (Nikoletopoulou et al. 2013; Shirvani et al. 2021).”
Background
Marek’s disease virus prolongs survival of primary chicken B-cells by inducing a senescence-like phenotype
Trapp-Fragnet, L., Schermuly, J., Kohn, M., Bertzbach, L. D., Pfaff, F., Denesvre, C., Kaufer, B. B., & Härtle, S. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1010006 · Cited by 11
“In addition, the autophagy and apoptosis pathways have been shown to be tightly interconnected, and under many physiological conditions, autophagy antagonizes apoptosis [34,35].”
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Synthesis of 8-Fluoroneocryptolepine and Evaluation for Cytotoxic Activity against AGS Cancer Cells
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Metal-free salan-type compound induces apoptosis and overcomes multidrug resistance in leukemic and lymphoma cells in vitro
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“The most thoroughly investigated mechanism of controlled cell demise is apoptosis, in which a cell undergoes an active process in response to certain death triggers, leading to loss of organelles and ultimately fragmentation into apoptotic bodies (Nikoletopoulou et al. 2013).”
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Albendazole-induced autophagy blockade contributes to elevated apoptosis in cholangiocarcinoma cells through AMPK/mTOR activation
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BGP-15 Protects against Doxorubicin-Induced Cell Toxicity via Enhanced Mitochondrial Function
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A Novel Drosophila Model of Alzheimer’s Disease to Study Aβ Proteotoxicity in the Digestive Tract
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Upregulation of necroptosis markers RIPK3/MLKL and their crosstalk with autophagy-related protein Beclin-1 in primary immune thrombocytopenia
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“Necroptosis is morphologically like necrosis but distinctive from apoptosis however both necroptosis and apoptosis shared the same range of triggering factors [3, 11].”
Background
Melatonin Supplement Plus Exercise Effectively Counteracts the Challenges of Isoproterenol-Induced Cardiac Injury in Rats
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Autophagy in an extruded disc compared to the remaining disc after lumbar disc herniation in the same patient
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“Interactions among components of the two different forms of cell death indicate a complex crosstalk, which is often induced by similar stimuli [28, 29].”
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“Although both processes are different, they could be related, as necroptosis is defined as a programmed form of necrotic death and can be ignited by the same death signals that induce apoptosis but also by pathogen recognition receptors, including Toll-like receptors and NOD-like receptors (64, 65).”
Background
Design of new Mcl-1 inhibitors for cancer using fragments hybridization, molecular docking, and molecular dynamics studies
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“It is widely recognized in cancer biology that apoptosis evasion is a key feature of cancer, as it helps cancer cells evade the body’s natural mechanisms for eliminating abnormal or damaged cells (Croce, 2008; Muller, 2017; Nikoletopoulou et al., 2013; Petsri et al., 2020; Pistritto et al., 2016).”
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Glaucocalyxin A suppresses multiple myeloma progression in vitro and in vivo through inhibiting the activation of STAT3 signaling pathway
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“Morphologically, the necrotic cells are characterized by the swelling of organelles, rupture of the plasma membrane (cell lysis), the nucleus becomes distended (nucleus intact) and usually followed by inflammatory reactions (Nikoletopoulou et al., 2013).”
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Interplay between Caspase 9 and X-linked Inhibitor of Apoptosis Protein (XIAP) in the oocyte elimination during fetal mouse development
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From street to lab: in vitro hepatotoxicity of buphedrone, butylone and 3,4-DMMC
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Authors: Nikoletopoulou, V., Markaki, M., Palikaras, K., & Tavernarakis, N.
Affiliations: Foundation for Research and Technology Hellas (GR)
Corresponding author: Tavernarakis, Nektarios
ORCID: Nikoletopoulou, Vassiliki
Markaki, Maria
Palikaras, Konstantinos
Tavernarakis, Nektarios
Venue: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Publisher: Elsevier BV
Published: 2013-12
Volume: 1833
Issue: 12
Pages: 3448-3459
ISSN: 0167-4889 (ISSN-L)
DOI: 10.1016/j.bbamcr.2013.06.001
OpenAlex: W2059738518
Cited by: 1,366
References: 150
Citations by year: 2026: 43 · 2025: 58 · 2024: 80 · 2023: 91 · 2022: 113 · 2021: 147 · 2020: 133 · 2019: 146 · 2018: 136 · 2017: 141 · 2016: 122 · 2015: 107 · 2014: 43 · 2013: 5
FWCI: 8.50
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 365 d)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
PubMed (publishedVersion)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Funders: European Research Council
Ministry of National Education and Religious Affairs
European Molecular Biology Organization
Seventh Framework Programme
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Social Sciences › Anthropology › Death, Funerary Practices, and Mourning
Keywords: apoptosis, necrosis, autophagy, cell death crosstalk, cell death pathways, cell fate determination, development (biology), disease pathology
MeSH terms: Autophagy, Humans, Models, Biological, Necrosis, Signal Transduction, Apoptosis

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