Cited by 1,366Cell death mechanisms and regulationAutophagy in Disease and TherapyDeath, Funerary Practices, and Mourning

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Crosstalk between apoptosis.; necrosis and autophagy

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Nikoletopoulou, Vassiliki, Markaki, Maria, Palikaras, Konstantinos, Tavernarakis, Nektarios·2013·Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

DOI 10.1016/j.bbamcr.2013.06.001

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Abstract

Apoptosis and necrosis are the two major modes of cell death, the molecular mechanisms of which have been extensively studied. Although initially thought to constitute mutually exclusive cellular states, recent findings reveal cellular contexts that require a balanced interplay between these two modes of cellular demise. Several death initiator and effector molecules, signaling pathways and subcellular sites have been identified as key mediators in both processes, either by constituting common modules or alternatively by functioning as a switch allowing cells to decide which route to take, depending on the specific situation. Importantly, autophagy, which is a predominantly cytoprotective process, has been linked to both types of cell death, serving either a pro-survival or pro-death function. Here we review the recent literature that highlights the intricate interplay between apoptosis, necrosis and autophagy, focusing on the relevance and impact of this crosstalk in normal development and in pathology. This article is part of a Special Section entitled: Cell Death Pathways.

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1 retracted

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Background
Retracted
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Background
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“It has been established that mitochondria are central initiators of the apoptotic intrinsic pathways, but they may also participate in other forms of RCD such as necroptosis, and ferroptosis (Nikoletopoulou et al., 2013).”
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“Upon stimulation by TNF-α , both apoptosis and necroptosis may be activated simultaneously (Nikoletopoulou et al., 2013), influenced by cell type and environmental factors.”
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Fabrizi, C., Pompili, E., Somma, F., Vito, S. D., Ciraci, V., Artico, M., Lenzi, P., Fornai, F., & Fumagalli, L. (2016) · Journal of Applied Toxicology · doi:10.1002/jat.3344 · Cited by 19
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Background
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Background
In vitro cytotoxicity of chemical preservatives on human fibroblast cells
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“Finally, the investigated preservatives did not induce a significant increase in the Annexin V−/PI+ population, which is a fraction of cells with permeabilized membranes, suggesting the induction of necrotic cell death (Nikoletopoulou et al., 2013).”
Background
Excessive apoptosis and disordered autophagy flux contribute to the neurotoxicity induced by high iodine in Sprague-Dawley rat
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“Studies have demonstrated that oxidative stress can cause inflamma‐ tion, but no inflammation occurs during cell apoptosis (41,42).”
Background
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Luzio, A., Parra, S., da Costa, B. K., Santos, D., Álvaro, A. R., & Monteiro, S. M. (2021) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2021.103674 · Cited by 19
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“This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).”
BackgroundInfluential
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“There are several lines of evidence in the literature that ATP is involved in the regulation of inflammasome activation and programmed cell death in particular [26,27].”
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Background
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“Although autophagy is primarily considered to have a cytoprotective function, it can also promote cell death through a sort of self-cannibalism (Nikoletopoulou et al., 2013).”
Background
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Background
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“Interactions among components of the two pathways suggest that they have a complex cross-talk, which is often caused by similar stimuli (Nikoletopoulou et al. 2013).”
Background
Protective Effects of Ursolic Acid Against Cytotoxicity Induced by Corticosterone: Role of Protein Kinases
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“org 9 (Nikoletopoulou et al., 2013; Yoshida, 2017; Chen et al., 2019), our experimental results demonstrated that the addition of either 3-MA or wortmannin, two autophagy inhibitors, successfully corrected the combined regimen-triggered S-phase arrest, however, had little effect on the apoptosis/necrosis induction (Fi…”
Result
Molecular probes for selective detection of cysteine cathepsins
Schleyer, K. A., & Cui, L. (2021) · Organic & Biomolecular Chemistry · doi:10.1039/d1ob00225b · Cited by 18
Fluvastatin attenuated ischemia/reperfusion-induced autophagy and apoptosis in cardiomyocytes through down-regulation HMGB1/TLR4 signaling pathway
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Icariin activates autophagy to trigger TGFβ1 upregulation and promote angiogenesis in EA.hy926 human vascular endothelial cells
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“A lack of autophagy may lead to adverse cellular outcomes, such as apoptosis [5].”
Background
Retracted

Authors: Nikoletopoulou, V., Markaki, M., Palikaras, K., & Tavernarakis, N.
Affiliations: Foundation for Research and Technology Hellas (GR)
Corresponding author: Tavernarakis, Nektarios
ORCID: Nikoletopoulou, Vassiliki
Markaki, Maria
Palikaras, Konstantinos
Tavernarakis, Nektarios
Venue: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Publisher: Elsevier BV
Published: 2013-12
Volume: 1833
Issue: 12
Pages: 3448-3459
ISSN: 0167-4889 (ISSN-L)
DOI: 10.1016/j.bbamcr.2013.06.001
OpenAlex: W2059738518
Cited by: 1,366
References: 150
Citations by year: 2026: 43 · 2025: 58 · 2024: 80 · 2023: 91 · 2022: 113 · 2021: 147 · 2020: 133 · 2019: 146 · 2018: 136 · 2017: 141 · 2016: 122 · 2015: 107 · 2014: 43 · 2013: 5
FWCI: 8.50
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 365 d)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
PubMed (publishedVersion)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Funders: European Research Council
Ministry of National Education and Religious Affairs
European Molecular Biology Organization
Seventh Framework Programme
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Social Sciences › Anthropology › Death, Funerary Practices, and Mourning
Keywords: apoptosis, necrosis, autophagy, cell death crosstalk, cell death pathways, cell fate determination, development (biology), disease pathology
MeSH terms: Autophagy, Humans, Models, Biological, Necrosis, Signal Transduction, Apoptosis

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Crosstalk between apoptosis.; necrosis and autophagy

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