The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.
Take five — Type VII secretion systems of Mycobacteria
Open accessAbstract
Mycobacteria use type VII secretion (T7S) systems to secrete proteins across their complex cell envelope. Pathogenic mycobacteria, such as the notorious pathogen Mycobacterium tuberculosis, have up to five of these secretion systems, named ESX-1 to ESX-5. At least three of these secretion systems are essential for mycobacterial virulence and/or viability. Elucidating T7S is therefore essential to understand the success of M. tuberculosis and other pathogenic mycobacteria as pathogens, and could be instrumental to identify novel targets for drug- and vaccine-development. Recently, significant progress has been achieved in the identification of T7S substrates and a general secretion motif. In addition, a start has been made with unraveling the mechanism of secretion and the structural analysis of the different subunits. This review summarizes these recent findings, which are incorporated in a working model of this complex machinery. This article is part of a Special Issue entitled: Protein trafficking and secretion in bacteria. Guest Editors: Anastassios Economou and Ross Dalbey.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“ESX-4 is one of the least well-characterized ESX systems, although it is considered the most ancestral esx locus in mycobacteria (21,82).”
From ESX/Type VII Secretion Systems—An Important Way Out for Mycobacterial Proteins (2019) · cites this paper as [82]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Bergey's Manual of Systematic Bacteriology
(1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-112-5-391_3 · Cited by 15,633
The Pfam Protein Families Database
Bateman, A. G. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.1.276 · Cited by 14,075
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E., et al. (1998) · Nature · doi:10.1038/31159 · Cited by 7,847
The Pfam protein families database
Punta, M., Coggill, P. C., Eberhardt, R. Y., Mistry, J., Tate, J., Boursnell, C., Pang, N., Forslund, K., Ceric, G., Clements, J., et al. (2012) · Nucleic Acids Research · doi:10.1093/nar/gkr1065 · Cited by 3,719
Genes required for mycobacterial growth defined by high density mutagenesis
Sassetti, C. M., Boyd, D. H., & Rubin, E. J. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03425.x · Cited by 2,544
Hsu, T., Hingley-Wilson, S. M., Chen, B., Chen, M., Dai, A. Z., Morin, P. M., Marks, C. B., Padiyar, J., Goulding, C., Gingery, M., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1635213100 · Cited by 731
Pym, A. S., Brodin, P., Brosch, R., Huerre, M., & Cole, S. T. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03237.x · Cited by 729
Strong, M., Sawaya, M. R., Wang, S., Phillips, M. L., Cascio, D., & Eisenberg, D. S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602606103 · Cited by 704
Type VI secretion requires a dynamic contractile phage tail-like structure
Basler, M., Pilhofer, M., Henderson, G. P., Jensen, G. J., & Mekalanos, J. J. (2012) · Nature · doi:10.1038/nature10846 · Cited by 676
Bergey’s Manual of Systematic Bacteriology
Wade, W. E., & Dewhirst, F. E. (2012) · Springer US · Cited by 649
Research works printed but not linked: 2
- Goodfellow, 2012, Order Corynebacteriales ord. nov., vol. 5, 235
- Burton, 2010, Membrane-associated DNA transport machines, Cold Spring Harb. Perspect. Biol., 2, a000406, 10.1101/cshperspect.a000406 · DOI
Cited by
Sorted by citations
Secretion systems in Gram-negative bacteria: Structural and mechanistic insights
Costa, T. R. D., Felisberto-Rodrigues, C., Meir, A., Prevost, M. S., Redzej, A., Trokter, M., & Waksman, G. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro3456 · Cited by 1,132
Bacterial Secretion Systems: An Overview
Green, E. R., & Mecsas, J. C. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.vmbf-0012-2015 · Cited by 1,090
ESX secretion systems: mycobacterial evolution to counter host immunity
Gröschel, M. I., Sayes, F., Simeone, R., Majlessi, L., & Brosch, R. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.131 · Cited by 382
Dallenga, T. K., Repnik, U., Corleis, B., Eich, J., Reimer, R., Griffiths, G. W., & Schaible, U. E. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.09.003 · Cited by 241
“The RD1 region encodes for certain virulence-associated gene products, including the ESAT-6/EsxA-CFP10 complex and its respective secretion apparatus components ESX1-5 (Houben et al., 2014; Parkash et al., 2009).”
Ohno, H. (2015) · The Journal of Biochemistry · doi:10.1093/jb/mvv121 · Cited by 224
Metadata
- Authors
- Houben, E. N. G., Korotkov, K. V., & Bitter, W.
- Affiliations
- Vrije Universiteit Amsterdam (NL)
- University of Kentucky (US)
- Corresponding author
- Houben, Edith N.G.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 1843
- Issue
- 8
- Pages
- 1707-1716
- ISSN
- 0167-4889 (ISSN-L)
- OpenAlex
- W2107983230
- Cited by
- 223
- References
- 93
- Citations by year
- 2026: 6 · 2025: 15 · 2024: 8 · 2023: 5 · 2022: 9 · 2021: 37 · 2020: 19 · 2019: 21 · 2018: 20 · 2017: 22 · 2016: 30 · 2015: 24 · 2014: 7
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- VU Research Portal (publishedVersion, other-oa)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- National Institute of General Medical Sciences (P20GM103486)
- Netherlands Organization for Scientific Research (NWO)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
- Keywords
- type VII secretion system, ESX secretion system, Mycobacterium tuberculosis, mycobacterial virulence, bacterial protein secretion, secretion mechanism, ESX-1, therapeutic target, vaccine targets
- MeSH terms
- Bacterial Proteins, Cell Wall, Humans, Mycobacterium tuberculosis, Tuberculosis, Protein Structure, Tertiary, Molecular Chaperones, Protein Transport, Bacterial Secretion Systems
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
