Tubercle bacilli rely on a type VII army for pathogenicity

Stoop, Esther J.M.; Bitter, Wilbert; van der Sar, Astrid M.

doi:10.1016/j.tim.2012.07.001

Cited by 90Tuberculosis Research and EpidemiologyBacterial Genetics and BiotechnologyMycobacterium research and diagnosis

Tubercle bacilli rely on a type VII army for pathogenicity

Stoop, Esther J.M., Bitter, Wilbert, van der Sar, Astrid M.·2012·Trends in Microbiology

DOI 10.1016/j.tim.2012.07.001

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Abstract

Mycobacteria, such as the major human pathogen Mycobacterium tuberculosis, have a highly unusual and characteristic diderm cell envelope that protects them against harmful conditions. Protein secretion across this hydrophobic barrier requires specialized secretion systems. Recently, a type VII secretion (T7S) pathway has been identified that fulfills this function. Pathogenic mycobacteria have up to five different T7S systems, some of which play a crucial role in virulence. The interactions between secreted substrates and host molecules are only starting to become clear and will help in furthering our understanding of the persistence of these enigmatic pathogens. In this review, we discuss current knowledge on the role of T7S systems in mycobacterial virulence.

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A number of secreted effectors, including EsxA (ESAT-6), EsxB (CFP-10), EspA, EspC, and PE/PPE proteins, have been suggested to intervene in host cellular and immune signaling pathways.
“Indeed, a number of secreted effectors, including EsxA (ESAT-6), EsxB (CFP-10), and ESX-1 secretion-associated proteins (Esp), such as EspA or EspC, as well as proteins that carry the characteristic N-terminal motifs Pro-Glu (PE) and Pro-Pro-Glu (PPE), have been suggested to intervene in host cellular and immune signaling pathways (11,24,25).”
From ESX/Type VII Secretion Systems—An Important Way Out for Mycobacterial Proteins (2019) · cites this paper as [24]

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Authors: Stoop, E. J. M., Bitter, W., & van der Sar, A. M.
Affiliations: Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
ORCID: Stoop, Esther J.M.
Bitter, Wilbert
Venue: Trends in Microbiology
Publisher: Elsevier BV
Published: 2012-10
Volume: 20
Issue: 10
Pages: 477-484
ISSN: 0966-842X (ISSN-L)
DOI: 10.1016/j.tim.2012.07.001
OpenAlex: W2012732153
Cited by: 90
References: 82
Citations by year: 2026: 3 · 2025: 5 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 6 · 2018: 5 · 2017: 2 · 2016: 15 · 2015: 10 · 2014: 13 · 2013: 12 · 2012: 1
FWCI: 1.43
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Trends in Microbiology (publishedVersion)
PubMed (publishedVersion)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
VU Research Portal (publishedVersion)
Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
Pure Amsterdam UMC (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: Ministerie van Economische Zaken
Ministerie van Onderwijs, Cultuur en Wetenschap
Topics: Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
Keywords: type VII secretion system, Mycobacterium tuberculosis, mycobacteria, virulence factors, protein secretion, host-pathogen interaction, bacterial pathogenicity
MeSH terms: Bacterial Proteins, Humans, Models, Biological, Mycobacterium tuberculosis, Protein Transport, Virulence Factors, Bacterial Secretion Systems

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Tubercle bacilli rely on a type VII army for pathogenicity

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