RIP3 antagonizes a TSC2-mediated pro-survival pathway in glioblastoma cell death
Open accessAbstract
Glioblastomas are the deadliest type of brain cancer and are frequently associated with poor prognosis and a high degree of recurrence despite removal by surgical resection and treatment by chemo- and radio-therapy. Photodynamic therapy (PDT) is a treatment well known to induce mainly necrotic and apoptotic cell death in solid tumors. 5-Aminolevulinic acid (5-ALA)-based PDT was recently shown to sensitize human glioblastoma cells (LN-18) to a RIP3 (Receptor Interacting Protein 3)-dependent cell death which is counter-acted by activation of autophagy. These promising results led us to investigate the pathways involved in cell death and survival mechanisms occurring in glioblastoma following PDT. In the present study, we describe a new TSC2 (Tuberous Sclerosis 2)-dependent survival pathway implicating MK2 (MAPKAPK2) kinase and 14-3-3 proteins which conducts to the activation of a pro-survival autophagy. Moreover, we characterized a new RIP3/TSC2 complex where RIP3 is suggested to promote cell death by targeting TSC2-dependent survival pathway. These results highlight (i) a new role of TSC2 to protect glioblastoma against PDT-induced cell death and (ii) TSC2 and 14-3-3 as new RIP3 partners.
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Activation of tuberous sclerosis complex 2 protein is involved in induction of pro-survival autophagy, which can be inhibited by RIP3.
“There is evidence suggesting that activation of tuberous sclerosis complex 2 protein is involved in the induction of pro-survival autophagy, which can be inhibited by RIP3 [41].”
From 5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy (2023) · cites this paper as [41]
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- Authors
- Fettweis, G., Di Valentin, E., L'homme, L., Lassence, C., Dequiedt, F., Fillet, M., Coupienne, I., & Piette, J.
- Affiliations
- University of Liège (BE)
- Corresponding author
- Piette, Jacques
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 1864
- Issue
- 1
- Pages
- 113-124
- ISSN
- 0167-4889 (ISSN-L)
- OpenAlex
- W2545775933
- Cited by
- 26
- References
- 58
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 8 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 3
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
- PubMed (publishedVersion)
- Open Repository and Bibliography (University of Liège) (submittedVersion, other-oa)
- Funders
- F.R.S. - FNRS (92390, 3.4537.11)
- University of Liège (216589)
- Belgian Science Policy Office (P7/32)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- glioblastoma, RIPK3, TSC2, photodynamic therapy, 5-aminolevulinic acid, autophagy, 14-3-3 proteins, cell death, cell survival signaling, necroptosis, LN18 cells
- MeSH terms
- Autophagy-Related Protein 7, Tuberous Sclerosis Complex 2 Protein, MAP-Kinase-Activated Kinase 2, Aminolevulinic Acid, Animals, Autophagy, Cell Survival, Humans, Light, Neuroglia, Photochemotherapy, Protein Binding, Signal Transduction, Gene Expression Regulation, Neoplastic, Photosensitizing Agents, Protein Serine-Threonine Kinases, Gene Silencing, Tumor Suppressor Proteins, RNA, Small Interfering, Cell Line, Tumor, Intracellular Signaling Peptides and Proteins, 14-3-3 Proteins, Rats, Receptor-Interacting Protein Serine-Threonine Kinases, Clustered Regularly Interspaced Short Palindromic Repeats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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