Cited by 130Animal Nutrition and PhysiologyRuminant Nutrition and Digestive PhysiologyVeterinary medicine and infectious diseases

Modulation of gastrointestinal barrier and nutrient transport function in farm animals by natural plant bioactive compounds–a comprehensive review

Patra, Amlan Kumar, Amasheh, Salah, Aschenbach, Jörg Rudolf·2019·Critical Reviews in Food Science and Nutrition

Abstract

The use of antibiotics in diets has been restricted in several countries as a precautionary measure to avoid development of antibiotic resistance among pathogenic microorganisms. This regulation promoted the exploration of natural plant bioactive compounds (PBCs) as feed additives to improve productivity, welfare and health of livestock and poultry. Along with several beneficial attributes of PBCs, including antimicrobial, antioxidant and various pharmacological effects, they also improve barrier function and nutrient transport in the gastrointestinal (GI) tract. This comprehensive review discusses the effects of different PBCs on the integrity, nutrient transport and permeability of GI epithelia and their mechanism of actions. Dietary PBCs influence the maintenance and enhancement of GI integrity via a number of mechanisms including altered signaling pathways and expression of several tight junction proteins (claudins, occludin, and zonula occludens proteins), altered expression of various cytokines, chemokines, complement components and their transcription factors, goblet cell abundance and mucin gene expression, and the modulation of the cellular immune system. They also affect nutrient transporter gene expression and active absorption of nutrients, minerals and ammonia. One intriguing perspective is to select an effective dose at which a specific PBC could improve GI barrier function and nutrient absorption. The effective doses and clear-cut molecular mechanisms for PBCs are yet to be elucidated to understand discrepant observations among different studies and to improve the targeted biotechnological and pharmaceutical uses of PBCs in farm animals. The latter will also enable a more successful use of such PBCs in humans.

Integrity signals

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Crossref · 10.1080/10408398.2018.1486284

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Authors
Patra, A. K., Amasheh, S., & Aschenbach, J. R.
Affiliations
  • West Bengal University of Animal and Fishery Sciences (IN)
  • Freie Universität Berlin (DE)
Corresponding author
Patra, Amlan Kumar
Venue
Critical Reviews in Food Science and Nutrition
Published
2018-07-12
Volume
59
Issue
20
Pages
3237-3266
ISSN
  • 1040-8398 (ISSN-L)
  • 1549-7852
OpenAlex
W2808156997
Cited by
130
References
262
Citations by year
2026: 18 · 2025: 19 · 2024: 16 · 2023: 16 · 2022: 14 · 2021: 17 · 2020: 16 · 2019: 9 · 2018: 5
FWCI
1.40
Type
journal article
Language
en
Open access
closed
Locations
  • Critical Reviews in Food Science and Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
  • Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Ruminant Nutrition and Digestive Physiology
  • Health Sciences › Veterinary › Small Animals › Veterinary medicine and infectious diseases
Keywords
phytochemicals, gastrointestinal barrier function, nutrient transport, tight junction proteins, claudins, occludin, intestinal permeability, goblet cells, mucin gene expression, feed additives, livestock, poultry, antibiotic alternatives, antioxidant activity, antimicrobial activity, cytokines, effective dose
MeSH terms
Nutrients, Animals, Immunity, Cellular, Intestinal Mucosa, Signal Transduction, Gastrointestinal Tract, Livestock, Tight Junction Proteins, Phytochemicals

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