Stress-induced remodeling of lymphoid innervation
Open accessAbstract
Lymphoid organs have long been known to harbor neural fibers from the sympathetic division of the autonomic nervous system, but recent studies suggest a surprising degree of plasticity in the density of innervation. This review summarizes data showing that behavioral stress can increase the density of catecholaminergic neural fibers within lymphoid organs of adult primates. Stress-induced neural densification is associated with increased expression of neurotrophic factors, and functional consequences include alterations in lymph node cytokine expression and increased replication of a lymphotropic virus. The finding that behavioral stress can tonically alter lymph node neural structure suggests that behavioral factors could exert long-term regulatory influences on the initiation, maintenance, and resolution of immune responses.
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Experimental animal models show that CTRA gene expression profiles can be induced in leukocytes by repeated social threat, unstable social hierarchies, and low social status.
“Subsequent studies using experimental animal models has shown that CTRA gene expression profiles can be induced in leukocytes by repeated social threat [9], unstable social hierarchies [8], [29], and low social status [7].”
From Human Social Genomics (2014) · cites this paper as [29]
The resulting increase in neurotransmitter delivery to the lymph node increases throughput from the brain to the immune system and induces a persistent shift in the gene regulatory program of tissue-resident cells, including down-regulating Type I interferon transcription and host resistance to viral infection.
“The resulting increase in neurotransmitter delivery to the lymph node increases throughput from the brain to the immune system and thereby induces a persistent shift in the gene regulatory program of the tissue-resident pool of cells (e.g., down-regulating Type I interferon transcription and host resistance to viral infection [29]).”
From Human Social Genomics (2014) · cites this paper as [29]
A third pathway by which adverse social conditions can induce persistent transcriptional alterations in immune cells involves up-regulation of the NGF gene that supports growth and differentiation of SNS nerve fibers innervating lymph nodes.
“A third pathway by which adverse social conditions can induce persistent transcriptional alterations in immune cells involves up-regulation of the NGF gene that supports the growth and differentiation of the SNS nerve fibers innervating lymph nodes [29].”
From Human Social Genomics (2014) · cites this paper as [29]
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- Authors
- Sloan, E. K., Capitanio, J. P., & Cole, S. W.
- Affiliations
- University of California, Los Angeles (US)
- University of California, Davis (US)
- Corresponding author
- Cole, Steve W.
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 22
- Issue
- 1
- Pages
- 15-21
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC2754291
- OpenAlex
- W2023957242
- Cited by
- 62
- References
- 46
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 7 · 2015: 3 · 2014: 5 · 2013: 2 · 2012: 7
- FWCI
- 0.28
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (MH049033, R01MH049033)
- National Institute of Allergy and Infectious Diseases (R01AI052737, AI052737)
- National Center for Research Resources (P51RR000169, RR 000169)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Keywords
- behavioral stress, sympathetic innervation, neuroplasticity, neurotrophic factors, neuroimmune interactions, immune regulation, primates
- MeSH terms
- Adrenergic beta-Antagonists, Animals, Humans, Immune System, Kinetics, Lymphoid Tissue, Nerve Growth Factors, Nervous System, Stress, Physiological
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