Cited by 116Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsDementia and Cognitive Impairment Research

Interleukin-18 produced by peripheral blood cells is increased in Alzheimer’s disease and correlates with cognitive impairment

Bossù, Paola, Ciaramella, Antonio, Salani, Francesca, Bizzoni, Federica, Varsi, Erika, Di Iulio, Fulvia, Giubilei, Franco, Gianni, Walter +5 more·2008·Brain Behavior and Immunity

Abstract

A body of evidence indicates that inflammation plays a pivotal role in AD pathogenesis. IL-18 is a pro-inflammatory cytokine produced in the brain, emerging to be implicated in AD. Although no differences in circulating IL-18 levels were measured between AD patients and controls, a significant increased production of IL-18 was obtained from stimulated blood mononuclear cells of AD patients. This was true particularly in AD subjects carrying the C/C genotype at the -607 position of IL-18 gene promoter. Furthermore, a significant correlation between IL-18 production and cognitive decline was observed in AD patients. Overall, these data indicate that IL-18-related inflammatory pathways, probably also in virtue of polymorphic IL-18 gene influence, are exacerbated in AD patients, and that this cytokine may indeed participate in pathogenic processes leading to dementia.

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Crossref · 10.1016/j.bbi.2007.10.001

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Authors
Bossù, P., Ciaramella, A., Salani, F., Bizzoni, F., Varsi, E., Di Iulio, F., Giubilei, F., Gianni, W., Trequattrini, A., Moro, M. L., Bernardini, S., Caltagirone, C., & Spalletta, G.
Affiliations
  • Fondazione Santa Lucia (IT)
  • Sapienza University of Rome (IT)
  • Istituto Nazionale di Riposo e Cura per Anziani (IT)
  • Città di Castello Hospital (IT)
  • University of Rome Tor Vergata (IT)
Venue
Brain Behavior and Immunity
Publisher
Elsevier BV
Published
2008-05
Volume
22
Issue
4
Pages
487-492
ISSN
0889-1591 (ISSN-L)
OpenAlex
W2048253779
Cited by
116
References
22
Citations by year
2026: 8 · 2025: 8 · 2024: 5 · 2023: 8 · 2022: 6 · 2021: 3 · 2020: 6 · 2019: 3 · 2018: 9 · 2017: 5 · 2016: 8 · 2015: 4 · 2014: 8 · 2013: 6 · 2012: 10
FWCI
3.33
Type
journal article
Language
en
Open access
closed
Locations
  • Brain Behavior and Immunity (publishedVersion)
  • PubMed (publishedVersion)
  • Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
IL-18, Alzheimer's disease, peripheral blood mononuclear cells, inflammation, cognitive impairment, dementia, inflammatory cytokines
MeSH terms
Aged, Alzheimer Disease, Cognition Disorders, Female, Humans, Leukocytes, Mononuclear, Lipopolysaccharides, Male, Polymorphism, Genetic, Promoter Regions, Genetic, Severity of Illness Index, Interleukin-18, Intercellular Signaling Peptides and Proteins

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