Interleukin-18 produced by peripheral blood cells is increased in Alzheimer’s disease and correlates with cognitive impairment
Abstract
A body of evidence indicates that inflammation plays a pivotal role in AD pathogenesis. IL-18 is a pro-inflammatory cytokine produced in the brain, emerging to be implicated in AD. Although no differences in circulating IL-18 levels were measured between AD patients and controls, a significant increased production of IL-18 was obtained from stimulated blood mononuclear cells of AD patients. This was true particularly in AD subjects carrying the C/C genotype at the -607 position of IL-18 gene promoter. Furthermore, a significant correlation between IL-18 production and cognitive decline was observed in AD patients. Overall, these data indicate that IL-18-related inflammatory pathways, probably also in virtue of polymorphic IL-18 gene influence, are exacerbated in AD patients, and that this cytokine may indeed participate in pathogenic processes leading to dementia.
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Higher expression of NLRP3, ASC, caspase-1, caspase-5, IL-1β, and IL-18 was found in PBMCs of AD patients.
“The higher expression of NLRP3, ASC, caspase-1, caspase-5, IL-1β, and IL-18 was additionally found in the PBMCs of AD patients (224, 226, 227).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [227]
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- Authors
- Bossù, P., Ciaramella, A., Salani, F., Bizzoni, F., Varsi, E., Di Iulio, F., Giubilei, F., Gianni, W., Trequattrini, A., Moro, M. L., Bernardini, S., Caltagirone, C., & Spalletta, G.
- Affiliations
- Fondazione Santa Lucia (IT)
- Sapienza University of Rome (IT)
- Istituto Nazionale di Riposo e Cura per Anziani (IT)
- Città di Castello Hospital (IT)
- University of Rome Tor Vergata (IT)
- ORCID
- Venue
- Brain Behavior and Immunity
- Publisher
- Elsevier BV
- Published
- 2008-05
- Volume
- 22
- Issue
- 4
- Pages
- 487-492
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W2048253779
- Cited by
- 116
- References
- 22
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 5 · 2023: 8 · 2022: 6 · 2021: 3 · 2020: 6 · 2019: 3 · 2018: 9 · 2017: 5 · 2016: 8 · 2015: 4 · 2014: 8 · 2013: 6 · 2012: 10
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- IL-18, Alzheimer's disease, peripheral blood mononuclear cells, inflammation, cognitive impairment, dementia, inflammatory cytokines
- MeSH terms
- Aged, Alzheimer Disease, Cognition Disorders, Female, Humans, Leukocytes, Mononuclear, Lipopolysaccharides, Male, Polymorphism, Genetic, Promoter Regions, Genetic, Severity of Illness Index, Interleukin-18, Intercellular Signaling Peptides and Proteins
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