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Cytokine levels in the blood may distinguish suicide attempters from depressed patients
Open accessAbstract
Elevated plasma cytokines is a common finding in Major Depressive Disorder (MDD), although not consistent. It is currently not known whether the inflammatory changes are confined to any specific subgroup of depressive patients. We here analyzed three inflammatory markers in suicidal and non-suicidal depressed patients, as well as healthy controls. Plasma interleukin (IL)-2, IL-6 and tumor necrosis factor (TNF)-α were measured in 47 suicide attempters, 17 non-suicidal depressed patients and 16 healthy controls. Study participants were evaluated using the Comprehensive Psychopathological Rating Scale (CPRS) with subscales for anxiety and degree of depression, as well as the Suicide Assessment Scale (SUAS). We found increased levels of IL-6 and TNF-α as well as decreased IL-2 concentrations in suicide attempters compared to non-suicidal depressed patients and healthy controls. The results were adjusted for potential confounders of cytokine expression, such as age, sex, body mass index (BMI), degree of depression, anxiety, personality disturbance, abuse and type of medication. These results demonstrate for the first time that suicidal patients display a distinct peripheral blood cytokine profile compared to non-suicidal depressed patients. Thus, our study provides further support for a role of inflammation in the pathophysiology of suicidality.
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“However, both increased [25][26][27] and decreased [28] levels of circulating peripheral inflammatory markers have been observed in suicide attempters compared with nonattempters.”
From SUICIDAL IDEATION IS ASSOCIATED WITH ELEVATED INFLAMMATION IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER: Research Article: Suicidal Ideation and Inflammation (2013) · cites this paper as [26]
In the citing paper
“Patients with major depressive disorder (MDD) who attempt or complete suicide have elevated inflammation compared to nonsuicidal patients with MDD.”
From SUICIDAL IDEATION IS ASSOCIATED WITH ELEVATED INFLAMMATION IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER: Research Article: Suicidal Ideation and Inflammation (2013) · cites this paper as [26]
In the citing paper
“previous research showing that suicide attempters have higher levels of inflammatory markers than comparison participants without a history of suicide attempts.[26,27]”
From SUICIDAL IDEATION IS ASSOCIATED WITH ELEVATED INFLAMMATION IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER: Research Article: Suicidal Ideation and Inflammation (2013) · cites this paper as [26]
Citations
Cites
Cytokines sing the blues: inflammation and the pathogenesis of depression
Raison, C. L., Capuron, L., & Miller, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.11.006 · Cited by 3,009
Cytokine-induced sickness behavior: where do we stand?
Dantzer, R. (2001) · Brain, Behavior, and Immunity · doi:10.1006/brbi.2000.0613 · Cited by 862
Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review
Potvin, S., Stip, E., Sepehry, A. A., Gendron, A., Bah, R., & Kouassi, E. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.09.024 · Cited by 858
Steiner, J., Bielau, H., Brisch, R., Danos, P., Ullrich, O., Mawrin, C., Bernstein, H.-G., & Bogerts, B. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.10.013 · Cited by 791
Cytokine Production and Treatment Response in Major Depressive Disorder
Lanquillon, S. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00134-7 · Cited by 735
Maes, M., Meltzer, H. Y., Bosmans, E., Bergmans, R., Vandoolaeghe, E., Ranjan, R., & Desnyder, R. (1995) · Journal of Affective Disorders · doi:10.1016/0165-0327(95)00028-l · Cited by 622
Lindqvist, D., Janelidze, S., Hagell, P., Erhardt, S., Samuelsson, M., Minthon, L., Hansson, O., Björkqvist, M., Träskman-Bendz, L., & Brundin, L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.01.030 · Cited by 524
Self-citationInflammation and the Phenomenology, Pathophysiology, Comorbidity, and Treatment of Bipolar Disorder
Goldstein, B. I., Kemp, D. E., Soczynska, J. K., & McIntyre, R. S. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08r04505 · Cited by 522
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Denicoff, K. D., RUBINOW, D. R., PAPA, M. Z., SIMPSON, C., SEIPP, C. A., LOTZE, M. T., Chang, A. E., ROSENSTEIN, D., & Rosenberg, S. A. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-107-2-293 · Cited by 456
Prerequisites for cytokine measurements in clinical trials with multiplex immunoassays
de Jager, W., Bourcier, K., Rijkers, G. T., Prakken, B. J., & Seyfert‐Margolis, V. (2009) · BMC Immunology · doi:10.1186/1471-2172-10-52 · Cited by 428
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Erhardt, S., Lim, C. K., Linderholm, K. R., Janelidze, S., Lindqvist, D., Samuelsson, M., Lundberg, K., Postolache, T. T., Träskman-Bendz, L., Guillemin, G. J., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.248 · Cited by 345
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Role of Inflammation in Suicide: From Mechanisms to Treatment
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“Evidence at this point is scarce, but indicates that the inflammatory changes and generation of kynurenine neurotoxic metabolites are, at least, more pronounced in suicidal individuals (Janelidze et al , 2011; O ’ Donovan et al , 2013; Sublette et al , 2011).”
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Gruol, D. L. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.10.023 · Cited by 254
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Sublette, M. E., Galfalvy, H. C., Fuchs, D., Lapidus, M., Grunebaum, M. F., Oquendo, M. A., John Mann, J., & Postolache, T. T. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.05.002 · Cited by 250
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O'Donovan, A., Rush, G., Hoatam, G., Hughes, B. M., McCrohan, A., Kelleher, C., O'Farrelly, C., & Malone, K. M. (2013) · Depression and Anxiety · doi:10.1002/da.22087 · Cited by 210
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Ma, K., Zhang, H., & Baloch, Z. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17050733 · Cited by 211
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Schnieder, T. P., Trencevska, I., Rosoklija, G., Stankov, A., Mann, J. J., Smiley, J., & Dwork, A. J. (2014) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000107 · Cited by 202
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Brundin, L., Sellgren, C. M., Lim, C. K., Grit, J., Pålsson, E., Landén, M., Samuelsson, M., Lundgren, K., Brundin, P., Fuchs, D., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.133 · Cited by 195
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Li, M., Zheng, H.-L., Luo, Y., He, J.-G., Wang, W., Han, J., Zhang, L., Wang, X., Ni, L., Zhou, H.-Y., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.76 · Cited by 163
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Maes, M., Anderson, G., Kubera, M., & Berk, M. (2014) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.888417 · Cited by 140
Lund-Sørensen, H., Benros, M. E., Madsen, T., Sørensen, H. J., Eaton, W. W., Postolache, T. T., Nordentoft, M., & Erlangsen, A. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.1594 · Cited by 131
Leonard, B. E. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.10.018 · Cited by 129
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Hacımusalar, Y., & Eşel, E. (2017) · Nöro Psikiyatri Arşivi · doi:10.5152/npa.2017.19482 · Cited by 123
Pandey, G. N., Rizavi, H. S., Zhang, H., Bhaumik, R., & Ren, X. (2018) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.170192 · Cited by 113
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Chopra, K., Kumar, B., & Kuhad, A. (2011) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2011.553603 · Cited by 76
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Chang, C.-C., Tzeng, N.-S., Kao, Y.-C., Yeh, C.-B., & Chang, H.-A. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.08.076 · Cited by 65
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Miná, V. A. L., Lacerda-Pinheiro, S. D. F., Maia, L. C., Pinheiro, R. F. F., Meireles, C. B., de Souza, S. I. R., Reis, A. O. A., Bianco, B. A. V., & Rolim, M. L. N. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.09.057 · Cited by 67
Li, Z., Qi, D., Chen, J., Zhang, C., Yi, Z., Yuan, C., Wang, Z., Hong, W., Yu, S., Cui, D., et al. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.05.005 · Cited by 63
Bao, H., Li, H., Jia, Y., Xiao, Y., Luo, S., Zhang, D., Han, L., Dai, L., Xiao, C., Feng, L., et al. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114561 · Cited by 63
Barzilay, R., Lobel, T. E., Krivoy, A., Shlosberg, D., Weizman, A., & Katz, N. (2015) · European Psychiatry · doi:10.1016/j.eurpsy.2015.09.461 · Cited by 61
Moretti, M., Budni, J., Freitas, A. E., Neis, V. B., Ribeiro, C. M., Balen, G. O., Rieger, D. K., Leal, R. B., & Rodrigues, A. L. S. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.03.006 · Cited by 58
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Weissmann, D., van der Laan, S., Underwood, M. D., Salvetat, N., Cavarec, L., Leviel, V., Molina, F., Mann, J. J., Arango, V., & Pujol, J. F. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.121 · Cited by 58
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Ogłodek, E. A., Szota, A. M., Just, M. J., Moś, D., & Araszkiewicz, A. S. (2014) · Pharmacological Reports · doi:10.1016/j.pharep.2014.06.001 · Cited by 54
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Wang, Q., Su, X., Jiang, X., Dong, X., Fan, Y., Zhang, J., Yu, C., Gao, W., Shi, S., Jiang, J., et al. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.055 · Cited by 49
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Auerbach, R. P., Pagliaccio, D., & Kirshenbaum, J. S. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_358 · Cited by 51
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Cubała, W. J., & Landowski, J. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.10.004 · Cited by 45
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Ventorp, F., Barzilay, R., Erhardt, S., Samuelsson, M., Träskman‐Bendz, L., Janelidze, S., Weizman, A., Offen, D., & Brundin, L. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.12.069 · Cited by 47
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Metadata
- Authors
- Janelidze, S., Mattei, D., Westrin, Å., Träskman-Bendz, L., & Brundin, L.
- Affiliations
- Lund University (SE)
- Corresponding author
- Brundin, Lena
- Venue
- Brain Behavior and Immunity
- Publisher
- Elsevier BV
- Published
- 2011-02
- Volume
- 25
- Issue
- 2
- Pages
- 335-339
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W2021691186
- Cited by
- 298
- References
- 23
- Citations by year
- 2026: 4 · 2025: 17 · 2024: 23 · 2023: 20 · 2022: 24 · 2021: 24 · 2020: 24 · 2019: 17 · 2018: 18 · 2017: 15 · 2016: 23 · 2015: 22 · 2014: 21 · 2013: 19 · 2012: 16
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- green
- lup.lub.lu.se
- Licence
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- suicide attempters, major depressive disorder, plasma cytokines, interleukin-6, interleukin-2, TNF-α, inflammation, inflammatory markers, suicidality, depression pathophysiology
- MeSH terms
- Adult, Antidepressive Agents, Major Depressive Disorder, Depressive Disorder, Female, Humans, Inflammation, Interleukin-2, Male, Psychiatric Status Rating Scales, Regression Analysis, Suicide, Attempted, Tumor Necrosis Factor-alpha, Interleukin-6, Cytokines, Diagnostic and Statistical Manual of Mental Disorders, Suicidal Ideation
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