Cited by 298Tryptophan and brain disordersSuicide and Self-Harm StudiesTreatment of Major Depression

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Cytokine levels in the blood may distinguish suicide attempters from depressed patients

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Janelidze, Shorena, Mattei, Daniele, Westrin, Åsa, Träskman-Bendz, Lil, Brundin, Lena·2011·Brain Behavior and Immunity

DOI 10.1016/j.bbi.2010.10.010

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Abstract

Elevated plasma cytokines is a common finding in Major Depressive Disorder (MDD), although not consistent. It is currently not known whether the inflammatory changes are confined to any specific subgroup of depressive patients. We here analyzed three inflammatory markers in suicidal and non-suicidal depressed patients, as well as healthy controls. Plasma interleukin (IL)-2, IL-6 and tumor necrosis factor (TNF)-α were measured in 47 suicide attempters, 17 non-suicidal depressed patients and 16 healthy controls. Study participants were evaluated using the Comprehensive Psychopathological Rating Scale (CPRS) with subscales for anxiety and degree of depression, as well as the Suicide Assessment Scale (SUAS). We found increased levels of IL-6 and TNF-α as well as decreased IL-2 concentrations in suicide attempters compared to non-suicidal depressed patients and healthy controls. The results were adjusted for potential confounders of cytokine expression, such as age, sex, body mass index (BMI), degree of depression, anxiety, personality disturbance, abuse and type of medication. These results demonstrate for the first time that suicidal patients display a distinct peripheral blood cytokine profile compared to non-suicidal depressed patients. Thus, our study provides further support for a role of inflammation in the pathophysiology of suicidality.

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Authors: Janelidze, S., Mattei, D., Westrin, Å., Träskman-Bendz, L., & Brundin, L.
Affiliations: Lund University (SE)
Corresponding author: Brundin, Lena
ORCID: Janelidze, Shorena
Mattei, Daniele
Westrin, Åsa
Brundin, Lena
Venue: Brain Behavior and Immunity
Publisher: Elsevier BV
Published: 2011-02
Volume: 25
Issue: 2
Pages: 335-339
ISSN: 0889-1591 (ISSN-L)
DOI: 10.1016/j.bbi.2010.10.010
OpenAlex: W2021691186
Cited by: 298
References: 23
Citations by year: 2026: 4 · 2025: 17 · 2024: 23 · 2023: 20 · 2022: 24 · 2021: 24 · 2020: 24 · 2019: 17 · 2018: 18 · 2017: 15 · 2016: 23 · 2015: 22 · 2014: 21 · 2013: 19 · 2012: 16
FWCI: 5.10
Type: journal article
Language: en
Open access: green
lup.lub.lu.se
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain Behavior and Immunity (publishedVersion)
PubMed (publishedVersion)
Lund University Publications (Lund University) (submittedVersion, other-oa)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: suicide attempters, major depressive disorder, plasma cytokines, interleukin-6, interleukin-2, TNF-α, inflammation, inflammatory markers, suicidality, depression pathophysiology
MeSH terms: Adult, Antidepressive Agents, Major Depressive Disorder, Depressive Disorder, Female, Humans, Inflammation, Interleukin-2, Male, Psychiatric Status Rating Scales, Regression Analysis, Suicide, Attempted, Tumor Necrosis Factor-alpha, Interleukin-6, Cytokines, Diagnostic and Statistical Manual of Mental Disorders, Suicidal Ideation

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Cytokine levels in the blood may distinguish suicide attempters from depressed patients

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