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Omega-3 supplementation lowers inflammation and anxiety in medical students: A randomized controlled trial
Open accessAbstract
Observational studies have linked lower omega-3 (n-3) polyunsaturated fatty acids (PUFAs) and higher omega-6 (n-6) PUFAs with inflammation and depression, but randomized controlled trial (RCT) data have been mixed. To determine whether n-3 decreases proinflammatory cytokine production and depressive and anxiety symptoms in healthy young adults, this parallel group, placebo-controlled, double-blind 12-week RCT compared n-3 supplementation with placebo. The participants, 68 medical students, provided serial blood samples during lower-stress periods as well as on days before an exam. The students received either n-3 (2.5 g/d, 2085 mg eicosapentaenoic acid and 348 mg docosahexanoic acid) or placebo capsules that mirrored the proportions of fatty acids in the typical American diet. Compared to controls, those students who received n-3 showed a 14% decrease in lipopolysaccharide (LPS) stimulated interleukin 6 (IL-6) production and a 20% reduction in anxiety symptoms, without significant change in depressive symptoms. Individuals differ in absorption and metabolism of n-3 PUFA supplements, as well as in adherence; accordingly, planned secondary analyses that used the plasma n-6:n-3 ratio in place of treatment group showed that decreasing n-6:n-3 ratios led to lower anxiety and reductions in stimulated IL-6 and tumor necrosis factor alpha (TNF-α) production, as well as marginal differences in serum TNF-α. These data suggest that n-3 supplementation can reduce inflammation and anxiety even among healthy young adults. The reduction in anxiety symptoms associated with n-3 supplementation provides the first evidence that n-3 may have potential anxiolytic benefits for individuals without an anxiety disorder diagnosis. ClinicalTrials.gov identifier: NCT00519779.
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“Although omega-3 supplementation was unrelated to changes in depression in this study”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Kiecolt-Glaser, Belury, Andridge, Malarkey, & Glaser, 2011
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“medical students who received omega-3 supplementation exhibited a 14% reduction in LPS-stimulated IL-6 production and a 20% reduction in anxiety symptoms compared to those in the control group”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Kiecolt-Glaser, Belury, Andridge, Malarkey, & Glaser, 2011
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“various RCTs have shown that omega-3 fatty acid supplementation reduces inflammation142–144 and may thus have health-promoting effects141–144”
From Chronic inflammation in the etiology of disease across the life span (2019) · cites this paper as [142]
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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION
Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267
The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research
Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989) · Psychiatry Research · doi:10.1016/0165-1781(89)90047-4 · Cited by 35,234
An inventory for measuring clinical anxiety: Psychometric properties.
Beck, A. T., Epstein, N., Brown, G., & Steer, R. A. (1988) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.56.6.893 · Cited by 14,407
Everitt, B. S. (2001) · Psychology Press eBooks · doi:10.4324/9781410605542-11 · Cited by 6,877
Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease
Kris-Etherton, P. M., Harris, W. S., & Appel, L. J. (2002) · Circulation · doi:10.1161/01.cir.0000038493.65177.94 · Cited by 3,707
Cytokines sing the blues: inflammation and the pathogenesis of depression
Raison, C. L., Capuron, L., & Miller, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.11.006 · Cited by 3,009
Origins and evolution of the Western diet: health implications for the 21st century1,2
Cordain, L., Eaton, S. B., Sebastian, A., Mann, N., Lindeberg, S., Watkins, B. A., O’Keefe, J. H., & Brand-Miller, J. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn.81.2.341 · Cited by 2,397
Stress-induced immune dysfunction: implications for health
Glaser, R., & Kiecolt-Glaser, J. K. (2005) · Nature Reviews Immunology · doi:10.1038/nri1571 · Cited by 2,190
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- Maes, 1998, Fatty acids, cytokines, and major depression, Biol. Psychiatry, 43, 313
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Yarbrough, K. B., & Simpson, E. L. (2019) · Harper's Textbook of Pediatric Dermatology · doi:10.1002/9781119142812.ch18
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Duttaroy, A. K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822405-2.00020-7
Sanches, L. N. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.5.2020.tde-19082021-104636
Meyer, B. J. (2018) · MDPI eBooks · doi:10.3390/books978-3-03842-972-2
El Baz, A. H., Zaki, M. A., Wakeel, E., & M, E.-S. T. (2018) · The Egyptian Journal of Hospital Medicine · doi:10.21608/ejhm.2018.9798
Nieman, D. C. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737032981.793575943
Protective effect of nutrition and supplements on COVID-19 management
Khan, S. A., & Mehrotra, N. (2022) · Annals of Phytomedicine An International Journal · doi:10.54085/ap.covid19.2022.11.3.4
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Mantzorou, M., Serdari, A., Kostopoulos, M., & Giaginis, C. (2021) · Austin Journal of Nutrition and Food sciences · doi:10.26420/austinjnutrifoodsci.2021.1158
Fawzia, N., Lestari, W., Nurwidya, F., Agustin, H., & Hasyim, A. A. (2023) · Jurnal Respirasi · doi:10.20473/jr.v9-i.3.2023.194-199
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Joshi, T., Nandave, M., & Sah, A. N. (2023) · Springer eBooks · doi:10.1007/978-981-99-7652-2_25
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Lembke, P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-29114-2.00018-0
Bioprospecting Nutraceuticals for Human Welfare
Hegde, M., Mishra, A., Kunnumakkara, A. B., & Aggarwal, B. B. (2024) · Springer eBooks · doi:10.1007/978-3-031-71674-4_16
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Littrell, J. L. (2024) · Integrated science · doi:10.1007/978-3-031-72079-6_2
McRoberts, A. J., & Martin, B. R. (2025) · Journal of Chiropractic Medicine · doi:10.1016/j.jcm.2025.09.018
Ren, X.-L., Chen, W., Ya, C., Gao, G., Jin, J.-G., Lou, E.-Y., Huang, C., Zhang, H., Lan, H., Jiang, Q.-X., et al. (2025) · Nutrition Journal · doi:10.1186/s12937-025-01265-8
Bafkar, N., Zeraattalab-Motlagh, S., Jayedi, A., & Shab-Bidar, S. (2024) · Figshare · doi:10.6084/m9.figshare.26736075
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Yang, J. M., Yuan, N., Guo, T. Y., Feng, Y., Guo, S., Zhou, D., Lin, P., Wang, A. G., & Jin, Y. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1725031
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Feitosa, N. D. A., Sousa, A. J. O., de Araújo, M. C. F., Lima, J. F., do Nascimento, J. E. T., Sobreira, F. R. S., Assis, C. E. B. S. D., Silva, H. A. M. D., Lima, G. F., & de Araújo, J. I. F. (2026) · Disciplinarum Scientia | Naturais e Tecnológicas · doi:10.37779/nt.v27i1.5714
Chataigner, M. (2021) · theses.fr (ABES) · doi:10.70675/a4317690zc4c8z4ba6za738zd457c6bb9b74
Scollon, C. N. (2026) · Routledge eBooks · doi:10.4324/9781003023272
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Cabrera, V., Marcotti, A., Macchione, A. F., Abate, P., Fernanda, P. M., & Balaszczuk, V. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111758
Annissa, Kurniati, H., Utami, S., Febriani, L., & Polwandari, F. (2026) · Jurnal Pengabdian Masyarakat dan Riset Pendidikan · doi:10.31004/jerkin.v4i4.5863
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Belury, M. A., Cole, R. M., Ni, A., Kolipaka, A., Nanjappa, M., Thompson, K., Kalhori, A., Zarich, S., Choriego, R. E., Jiménez-Flores, R., et al. (2026) · Diabetes Obesity and Metabolism · doi:10.1111/dom.71237
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Metadata
- Authors
- Kiecolt-Glaser, J. K., Belury, M. A., Andridge, R., Malarkey, W. B., & Glaser, R.
- Affiliations
- The Ohio State University (US)
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 25
- Issue
- 8
- Pages
- 1725-1734
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC3191260
- OpenAlex
- W2140758044
- Cited by
- 340
- References
- 70
- Citations by year
- 2026: 19 · 2025: 18 · 2024: 30 · 2023: 24 · 2022: 31 · 2021: 32 · 2020: 24 · 2019: 28 · 2018: 18 · 2017: 21 · 2016: 13 · 2015: 24 · 2014: 26 · 2013: 15 · 2012: 17
- FWCI
- 17.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Ohio State University
- National Institutes of Health (UL1TR000090)
- National Cancer Institute (CA16058, P30CA016058)
- National Center for Complementary and Alternative Medicine
- National Center for Research Resources (UL1RR025755)
- NIH Clinical Center
- National Center for Advancing Translational Sciences
- National Center for Complementary and Integrative Health (R21AT003912, AT003912)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- omega-3 fatty acids, n-6/n-3 ratio, inflammation, anxiety, depression, medical students, eicosapentaenoic acid, docosahexaenoic acid, interleukin-6, TNF-α, lipopolysaccharide stimulation, exam stress, young adults
- MeSH terms
- Adult, Affect, Anxiety, Depression, Diet, Double-Blind Method, Fatty Acids, Female, Humans, Inflammation, Male, Neutrophils, Patient Compliance, Stress, Psychological, Health Behavior, Exercise, Fatty Acids, Omega-3, Cytokines, Sample Size, Dietary Supplements, Young Adult
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