Adipose Inflammation in Obesity: Relationship With Circulating Levels of Inflammatory Markers and Association With Surgery-Induced Weight Loss
Abstract
Context: The inflammatory state of the adipose tissue is believed to contribute to systemic low-grade inflammation in obesity. Objective: This study assessed the relationship between adipose and circulating inflammatory markers as well as the influence of adipose inflammation on bariatric surgery-induced weight reduction. Design: This was a cross-sectional and longitudinal study (up to 14 mo). Setting: The study was conducted in the digestive/bariatric surgery department of the Tivoli and Jean Villar clinics, Bordeaux, France. Patients: Thirty-seven obese patients [body mass index (BMI) > 35–40 kg/m2)] seeking bariatric surgery were included. Twenty-eight of them were successively followed up at 1–3 months after surgery and 25 between 6 and 14 months after surgery. Main Outcome Measures: Fasting serum samples were collected before surgery to assess concentrations of inflammatory markers. Samples of visceral adipose tissue were extracted during surgery and gene expression of cytokines and immune cell markers were evaluated using quantitative RT-PCR. Pre- and postsurgery weight and BMI were collected. Results: Gene expression of several cytokines were strongly intercorrelated in the visceral adipose tissue. Adipose expression of macrophage and T cell markers were related to adipose expression of TNF-α and IL-1 receptor antagonist (P < .01) and to systemic levels of TNF-α (P < .01) and IL-6 (P < .05). A higher inflammatory state of the adipose tissue predicted a lower BMI reduction after surgery (P < .05), notably at early stages after surgery. Conclusions: These findings support the involvement of macrophages and T cells in adipose inflammation and provide new information regarding the role of the visceral adipose tissue in the inflammatory state of obesity and its impact on obesity treatment outcomes, such as surgery-induced weight loss.
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Inflammatory status is probably best defined by a combination of several cytokine concentrations rather than one cytokine only.
“Given that the inflammatory status is probably best defined by a combination of several cytokine concentrations rather than one cytokine only, composite scores of inflammation were calculated using a standard method for identifying latent factors, i.e. Principal Component Analysis, which has been used in several previous studies (Hsu et al. 2009; Lasselin et al. 2012; Lasselin et al. 2014).”
From Low-grade inflammation may moderate the effect of behavioral treatment for chronic pain in adults (2016) · cites this paper as Lasselin et al. 2014
Cites
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664 · see citing works
Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543 · see citing works
Adipocytokines: mediators linking adipose tissue, inflammation and immunity
Tilg, H., & Moschen, A. R. (2006) · Nature reviews. Immunology · doi:10.1038/nri1937 · Cited by 3,195 · see citing works
Kanda, H. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26498 · Cited by 2,682 · see citing works
Elevated C-reactive protein levels in overweight and obese adults
Visser, M. (1999) · JAMA · doi:10.1001/jama.282.22.2131 · Cited by 2,494 · see citing works
Nishimura, S., Manabe, I., Nagasaki, M., Eto, K., Yamashita, H., Ohsugi, M., Otsu, M., Hara, K., Ueki, K., Sugiura, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.1964 · Cited by 2,230 · see citing works
Adipokines: inflammation and the pleiotropic role of white adipose tissue
Trayhurn, P., & Wood, I. S. (2004) · British Journal of Nutrition · doi:10.1079/bjn20041213 · Cited by 2,210 · see citing works
Obesity-induced inflammatory changes in adipose tissue
Wellen, K. E., & Hotamisligil, G. S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200320514 · Cited by 1,823 · see citing works
Fain, J. N., Madan, A. K., Hiler, M. L., Cheema, P. S., & Bahouth, S. W. (2004) · Endocrinology · doi:10.1210/en.2003-1336 · Cited by 1,571 · see citing works
Visceral fat adipokine secretion is associated with systemic inflammation in obese humans
Fontana, L., Eagon, J. C., Trujillo, M. E., Scherer, P. E., & Klein, S. (2007) · Diabetes · doi:10.2337/db06-1656 · Cited by 1,417 · see citing works
Cancello, R., Henegar, C., Viguerie, N., Taleb, S., Poitou, C., Rouault, C., Coupaye, M., Pelloux, V., Hugol, D., Bouillot, J.-L., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.8.2277 · Cited by 1,164 · see citing works
Bastard, J., Jardel, C., Bruckert, É., Blondy, P., Capeau, J., Laville, M., Vidal, H., & Hainque, B. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6839 · Cited by 1,102 · see citing works
Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-α and IL-6
Park, H. S., Park, J. Y., & Yu, R. (2005) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2004.11.007 · Cited by 964 · see citing works
Neopterin as a Marker for Immune System Activation
Murr, C., Widner, B., Wirleitner, B., & Fuchs, D. (2002) · Current Drug Metabolism · doi:10.2174/1389200024605082 · Cited by 737 · see citing works
Regulatory Mechanisms for Adipose Tissue M1 and M2 Macrophages in Diet-Induced Obese Mice
Fujisaka, S., Usui, I., Bukhari, A., Ikutani, M., Oya, T., Kanatani, Y., Tsuneyama, K., Nagai, Y., Takatsu, K., Urakaze, M., et al. (2009) · Diabetes · doi:10.2337/db08-1475 · Cited by 715 · see citing works
Kintscher, U., Hartge, M., Hess, K., Foryst-Ludwig, A., Clemenz, M., Wabitsch, M., Fischer-Posovszky, P., Barth, T. F. E., Dragun, D., Skurk, T., et al. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.165100 · Cited by 692 · see citing works
Wu, H., Ghosh, S., Perrard, X. D., Feng, L., García, G., Perrard, J. L., Sweeney, J. F., Peterson, L. E., Chan, L., Smith, C. W., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.638379 · Cited by 682 · see citing works
Weight loss regulates inflammation‐related genes in white adipose tissue of obese subjects
ClÉment, K., Viguerie, N., Poitou, C., Carette, C., Pelloux, V., Curat, C. A., Sicard, A., Rome, S., Benis, A., Zucker, J., et al. (2004) · The FASEB Journal · doi:10.1096/fj.04-2204com · Cited by 640 · see citing works
Leptin secretion from subcutaneous and visceral adipose tissue in women.
van Harmelen, V., Reynisdottir, S., Eriksson, P. O., Thörne, A., Hoffstedt, J., Lönnqvist, F., & Arner, P. (1998) · Diabetes · doi:10.2337/diabetes.47.6.913 · Cited by 611 · see citing works
From Blood Monocytes to Adipose Tissue-Resident Macrophages
Curat, C. A., Miranville, A., Sengenès, C., Diehl, M., Tonus, C., Busse, R., & Bouloumié, A. (2004) · Diabetes · doi:10.2337/diabetes.53.5.1285 · Cited by 600 · see citing works
Rausch, M. E., Weisberg, S., Vardhana, P., & Tortoriello, D. V. (2008) · International Journal of Obesity · doi:10.1038/sj.ijo.0803744 · Cited by 585 · see citing works
Zeyda, M., Farmer, D., Todoric, J., Aszmann, O. C., Speiser, M., Györi, G., Zlabinger, G. J., & Stulnig, T. M. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803632 · Cited by 553 · see citing works
Romagnani, S. (1999) · Inflammatory Bowel Diseases · doi:10.1097/00054725-199911000-00009 · Cited by 534 · see citing works
Christiansen, T., Richelsen, B., & Bruun, J. M. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802839 · Cited by 411 · see citing works
Obesity and inflammation: the effects of weight loss
Forsythe, L. K., Wallace, J. M. W., & Livingstone, M. B. E. (2008) · Nutrition Research Reviews · doi:10.1017/s0954422408138732 · Cited by 381 · see citing works
Aron‐Wisnewsky, J., Tordjman, J., Poitou, C., Darakhshan, F., Hugol, D., Basdevant, A., Aissat, A., Guerre-Millo, M., & Clément, K. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0925 · Cited by 379 · see citing works
Maachi, M., Piéroni, L., Bruckert, É., Jardel, C., Fellahi, S., Hainque, B., Capeau, J., & Jp, B. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802718 · Cited by 379 · see citing works
Deiuliis, J. A., Shah, Z., Shah, N., NEEDLEMAN, B. J., Mikami, D. J., Narula, V. K., Perry, K. A., Hazey, J. W., Kampfrath, T., Kollengode, M. S., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016376 · Cited by 314 · see citing works
Hepatic steatosis, low-grade chronic inflammation and hormone/growth factor/adipokine imbalance
Tarantino, G. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i38.4773 · Cited by 225 · see citing works
Gruen, M. L., Hao, M., Piston, D. W., & Hasty, A. H. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00062.2007 · Cited by 171 · see citing works
What about non-alcoholic fatty liver disease as a new criterion to define metabolic syndrome?
Tarantino, G. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i22.3375 · Cited by 167 · see citing works
Zeyda, M., Huber, J., Prager, G., & Stulnig, T. M. (2010) · Obesity · doi:10.1038/oby.2010.123 · Cited by 143 · see citing works
Capuron, L., Poitou, C., Machaux-Tholliez, D., Frochot, V., Bouillot, J., Basdevant, A., Layé, S., & Clément, K. (2010) · Psychological Medicine · doi:10.1017/s0033291710001984 · Cited by 115 · see citing works
Self-citationFatigue symptoms relate to systemic inflammation in patients with type 2 diabetes
Lasselin, J., Layé, S., Dexpert, S., Aubert, A., Gonzalez, C., Gin, H., & Capuron, L. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.03.003 · Cited by 77 · see citing works
Self-citationAssociation between insulin resistance, body mass and neopterin concentrations
Ledochowski, M., Murr, C., Widner, B., & Fuchs, D. (1999) · Clinica Chimica Acta · doi:10.1016/s0009-8981(99)00019-4 · Cited by 74 · see citing works
Tarantino, G., Lobello, R., Scopacasa, F., Contaldo, F., Pasanisi, F., Cirillo, M., Caterina, M. D., Conca, P., Terracciano, D., Gennarelli, N., et al. (2007) · Clinical and investigative medicine · doi:10.25011/cim.v30i5.2895 · Cited by 26 · see citing works
Hepatic steatosis in overweight/obese females: Newscreening method for those at risk
Tarantino, G., Pizza, G., Colao, A., Pasanisi, F., Conca, P., Colicchio, P., Finelli, C., Contaldo, F., Somma, C. D., & Savastano, S. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.5693 · Cited by 18 · see citing works
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Metabolic Messengers: tumour necrosis factor
Sethi, J. K., & Hotamışlıgil, G. S. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00470-z · Cited by 426 · see citing works
Favennec, M., Hennart, B., Caiazzo, R., Leloire, A., Yengo, L., Verbanck, M., Arredouani, A., Marre, M., Pigeyre, M., Bessède, A., et al. (2015) · Obesity · doi:10.1002/oby.21199 · Cited by 261 · see citing works
Solmi, M., Veronese, N., Favaro, A., Santonastaso, P., Manzato, E., Sergi, G., & Correll, C. U. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.09.031 · Cited by 222 · see citing works
‘Adipaging’: ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue
Pérez, L. M., Pareja‐Galeano, H., Sanchis‐Gomar, F., Emanuele, E., Lucia, A., & Gálvez, B. G. (2016) · The Journal of Physiology · doi:10.1113/jp271691 · Cited by 215 · see citing works
Tryptophan Metabolic Pathways Are Altered in Obesity and Are Associated With Systemic Inflammation
Cussotto, S., Delgado, I., Anesi, A., Dexpert, S., Aubert, A., Beau, C., Forestier, D., Ledaguenel, P., Magne, E., Mattivi, F., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00557 · Cited by 189 · see citing works
Self-citationRole of Adiposity-Driven Inflammation in Depressive Morbidity
Capuron, L., Lasselin, J., & Castanon, N. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.123 · Cited by 182 · see citing works
Self-citationCastanon, N., Luheshi, G. N., & Layé, S. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00229 · Cited by 179 · see citing works
Self-citationNeuropsychiatric Comorbidity in Obesity: Role of Inflammatory Processes
Castanon, N., Lasselin, J., & Capuron, L. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00074 · Cited by 160 · see citing works
Self-citationRole of T Cells in Malnutrition and Obesity
Gerriets, V. A., & MacIver, N. J. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00379 · Cited by 148 · see citing works
Western Diet: Implications for Brain Function and Behavior
López-Taboada, I., González‐Pardo, H., & Conejo, N. M. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.564413 · Cited by 141 · see citing works
Adipose tissue macrophages: Unique polarization and bioenergetics in obesity
Caslin, H. L., Bhanot, M., Bolus, W. R., & Hasty, A. H. (2020) · Immunological Reviews · doi:10.1111/imr.12853 · Cited by 121 · see citing works
The Interplay between Obesity and Inflammation
Săvulescu-Fiedler, I., Mihalcea, R., Dragosloveanu, Ş., Scheau, C., Baz, R. O., Căruntu, A., Scheau, A.-E., Căruntu, C., & Benea, S. N. (2024) · Life · doi:10.3390/life14070856 · Cited by 134 · see citing works
Energy balance and gastrointestinal cancer: risk, interventions, outcomes and mechanisms
Ulrich, C. M., Himbert, C., Holowatyj, A. N., & Hursting, S. D. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0053-2 · Cited by 109 · see citing works
Vancassel, S., Capuron, L., & Castanon, N. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00499 · Cited by 95 · see citing works
Self-citationMeasures of adiposity predict interleukin-6 responses to repeated psychosocial stress
McInnis, C. M., Thoma, M. V., Gianferante, D., Hanlin, L. C., Chen, X., Breines, J. G., Hong, S., & Rohleder, N. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.07.018 · Cited by 87 · see citing works
Chitinase 3 Like-1: An Emerging Molecule Involved in Diabetes and Diabetic Complications
Rosa, M. D., & Malaguarnera, L. (2016) · Pathobiology · doi:10.1159/000444855 · Cited by 75 · see citing works
Bariatric surgery: remission of inflammation, cardiometabolic benefits, and common adverse effects
Biobaku, F., Ghanim, H., Monte, S. V., Caruana, J. A., & Dandona, P. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaa049 · Cited by 68 · see citing works
The role of adipose tissue in fatty liver diseases
Parker, R. (2018) · Liver Research · doi:10.1016/j.livres.2018.02.002 · Cited by 70 · see citing works
Low-grade inflammation may moderate the effect of behavioral treatment for chronic pain in adults
Lasselin, J., Kemani, M. K., Kanstrup, M., Olsson, G. L., Axelsson, J., Andreasson, A., Lekander, M., & Wicksell, R. K. (2016) · Journal of Behavioral Medicine · doi:10.1007/s10865-016-9769-z · Cited by 66 · see citing works
Self-citationEpigenome-wide profiling of DNA methylation in paired samples of adipose tissue and blood
Huang, Y., Chu, S. H., Loucks, E. B., Lin, C., Eaton, C. B., Buka, S. L., & Kelsey, K. T. (2016) · Epigenetics · doi:10.1080/15592294.2016.1146853 · Cited by 64 · see citing works
Connaughton, R. M., McMorrow, A. M., McGillicuddy, F. C., Lithander, F. E., & Roche, H. M. (2016) · Proceedings of The Nutrition Society · doi:10.1017/s0029665116000070 · Cited by 63 · see citing works
Omega-3 polyunsaturated fatty acid levels and dysregulations in biological stress systems
Thesing, C. S., Bot, M., Milaneschi, Y., Giltay, E. J., & Penninx, B. W. J. H. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.07.002 · Cited by 64 · see citing works
GLP-1: A Mediator of the Beneficial Metabolic Effects of Bariatric Surgery?
Manning, S., Pucci, A. B. F., & Batterham, R. L. (2015) · Physiology · doi:10.1152/physiol.00027.2014 · Cited by 63 · see citing works
Demidowich, A. P., Davis, A. I., Dedhia, N., & Yanovski, J. A. (2016) · Medical Hypotheses · doi:10.1016/j.mehy.2016.04.039 · Cited by 60 · see citing works
Molecular Mechanisms Linking Omega-3 Fatty Acids and the Gut–Brain Axis
Zinkow, A., Grodzicki, W., Czerwińska, M., & Dziendzikowska, K. (2024) · Molecules · doi:10.3390/molecules30010071 · Cited by 62 · see citing works
Brain tumor necrosis factor-α mediates anxiety-like behavior in a mouse model of severe obesity
Fourrier, C., Bosch‐Bouju, C., Boursereau, R., Sauvant, J., Aubert, A., Capuron, L., Ferreira, G., Layé, S., & Castanon, N. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.11.316 · Cited by 55 · see citing works
Self-citationObesity and weight loss could alter the properties of adipose stem cells?
Baptista, L. S. (2015) · World Journal of Stem Cells · doi:10.4252/wjsc.v7.i1.165 · Cited by 55 · see citing works
Catalán, V., Gómez‐Ambrosi, J., Rodrı́guez, A., Ramírez, B., Valentí, V., Moncada, R., Silva, C., Salvador, J., & Frühbeck, G. (2015) · Genes & Nutrition · doi:10.1007/s12263-015-0460-8 · Cited by 52 · see citing works
Adipose Tissue 12/15 Lipoxygenase Pathway in Human Obesity and Diabetes
Lieb, D. C., Brotman, J. J., Hatcher, M. A., Aye, M.-S., Cole, B. K., Haynes, B. A., Wohlgemuth, S. D., Fontana, M. A., Beydoun, H. A., Nadler, J. L., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4461 · Cited by 49 · see citing works
Mentoor, I., Engelbrecht, A., van Jaarsveld, P. J., & Nell, T. A. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00758 · Cited by 51 · see citing works
de Freitas, W. R., de Oliveira, L. V. F., Perez, E. A., Ilias, E. J., Lottenberg, C. P., Silva, A. S., Urbano, J. J., Oliveira‐Junior, M. C., Vieira, R. P., Alves, M. R., et al. (2018) · Obesity Surgery · doi:10.1007/s11695-017-3104-9 · Cited by 46 · see citing works
Chu, K., Cadar, D., Iob, E., & Frank, P. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.11.016 · Cited by 45 · see citing works
Childhood maltreatment increases the risk for visceral obesity
Li, L., Chassan, R. A., Bruer, E. H., Gower, B. A., & Shelton, R. C. (2015) · Obesity · doi:10.1002/oby.21143 · Cited by 41 · see citing works
MASH as an emerging cause of hepatocellular carcinoma: current knowledge and future perspectives
Karin, M., & Kim, J. Y. (2024) · Molecular Oncology · doi:10.1002/1878-0261.13685 · Cited by 43 · see citing works
Maternal obesity and immune dysregulation in mother and infant: A review of the evidence
Rizzo, G. S., & Sen, S. (2014) · Paediatric Respiratory Reviews · doi:10.1016/j.prrv.2014.10.005 · Cited by 35 · see citing works
Quercioli, A., Burger, F., Thomas, A., Lauer, E., da Silva, A. R., Mach, F., Vuilleumier, N., Bobbioni-Harsch, E., Golay, A., Montecucco, F., et al. (2014) · Thrombosis and Haemostasis · doi:10.1160/th14-06-0506 · Cited by 35 · see citing works
Strączkowski, M., Nikołajuk, A., Majewski, R., Filarski, R., Stefanowicz, M., Matulewicz, N., & Karczewska‐Kupczewska, M. (2018) · Endocrine · doi:10.1007/s12020-018-1619-z · Cited by 31 · see citing works
Fatty acids: Adiposity and breast cancer chemotherapy, a bad synergy?
Mentoor, I., Engelbrecht, A., & Nell, T. A. (2018) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2018.11.009 · Cited by 30 · see citing works
Huet, L., Delgado, I., Dexpert, S., Sauvant, J., Aouizerate, B., Beau, C., Forestier, D., Ledaguenel, P., Magne, E., & Capuron, L. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.02.031 · Cited by 30 · see citing works
Self-citationDeora, N., & Venkatraman, K. (2022) · Journal of Ayurveda and Integrative Medicine · doi:10.1016/j.jaim.2022.100675 · Cited by 30 · see citing works
Cardinal, P., de Oliveira, C. M., Sauvant, J., Foury, A., Darnaudéry, M., Vancassel, S., Castanon, N., & Capuron, L. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02330-9 · Cited by 29 · see citing works
Self-citationPinter, A., Schwarz, P. E. H., Gerdes, S., Simon, J. C., Saalbach, A., Rush, J. S., Melzer, N., Kramps, T., Häberle, B. M., & Reinhardt, M. (2021) · Nutrients · doi:10.3390/nu13093015 · Cited by 28 · see citing works
Favennec, M., Hennart, B., Verbanck, M., Pigeyre, M., Caiazzo, R. J., Raverdy, V., Verkindt, H., Leloire, A., Guillemin, G. J., Yengo, L., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158051 · Cited by 27 · see citing works
Lasselin, J., Benson, S., Hebebrand, J., Boy, K., Weskamp, V., Handke, A. E., Hasenberg, T., Remy, M., Föcker, M., Unteroberdörster, M., et al. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.05.071 · Cited by 26 · see citing works
Self-citationInvolvement of inflammatory cytokines in obesity and its complications
Tilinca, M. C., Barabás‐Hajdu, E., Ferencz, G. T., & Nemes-Nagy, E. (2018) · Revista română de medicină de laborator · doi:10.2478/rrlm-2018-0019 · Cited by 24 · see citing works
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Bajaj, J. S., & Nagy, L. E. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.05.031 · Cited by 21 · see citing works
Rosenblatt, A., Faintuch, J., & Cecconello, I. (2015) · Obesity Surgery · doi:10.1007/s11695-015-1663-1 · Cited by 21 · see citing works
Koehler, K. B., de Moraes, R. A. G., Rodrigues, J. B., Portela, B. S. M., Miguel, G. P. S., Pedrosa, R. G., & Haraguchi, F. K. (2019) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2019.05.018 · Cited by 20 · see citing works
Liu, H., Dong, H., Zhou, Y., Jin, M., Hao, H., Yuan, Y., & Jia, H. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1482003 · Cited by 18 · see citing works
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Pathogenesis of obesity-associated cardiovascular diseases: Key role of biomolecules
Sood, S., Mittal, N., Singh, T. G., & Devi, S. (2023) · Health Sciences Review · doi:10.1016/j.hsr.2023.100098 · Cited by 16 · see citing works
Factors Affecting Metabolic Outcomes Post Bariatric Surgery: Role of Adipose Tissue
Keshavjee, S., Schwenger, K. J. P., Yadav, J., Jackson, T. D., Okrainec, A., & Allard, J. P. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10040714 · Cited by 15 · see citing works
A longitudinal, randomized and controlled study of app-delivered mindfulness in the workplace
Emory University, & Mascaro, J. (2020) · Journal of Wellness · doi:10.18297/jwellness/vol2/iss1/4 · Cited by 12 · see citing works
“For example, one study found that patients with high levels of inflammation prior to bariatric surgery had less weight loss after the surgical intervention [61].”
ResultWang, R., Ganbold, M., Ferdousi, F., Tominaga, K., & Isoda, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310419 · Cited by 13 · see citing works
Esquivel-Campos, A. L., Pérez‐Ramos, J., Cisneros, J., Herrera, I., Rivera-Rosales, R. M., Montaño, M., & Ramos, C. (2014) · Toxicology Mechanisms and Methods · doi:10.3109/15376516.2014.956911 · Cited by 13 · see citing works
Ganbold, M., Ferdousi, F., Arimura, T., Tominaga, K., & Isoda, H. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.577259 · Cited by 13 · see citing works
The Phantom Satiation Hypothesis of Bariatric Surgery
Gautron, L. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.626085 · Cited by 14 · see citing works
Schachtner, T., Stein, M., & Reinke, P. (2016) · Transplant Immunology · doi:10.1016/j.trim.2016.11.005 · Cited by 11 · see citing works
Trouwborst, I., Wouters, K., Jocken, J. W. E., Jardon, K. M. C., Gijbels, A., Dagnelie, P. C., van Greevenbroek, M. M. J., Kallen, C., Stehouwer, C. D. A., Schalkwijk, C. G., et al. (2023) · Obesity · doi:10.1002/oby.23714 · Cited by 11 · see citing works
Fatriani, R., Pratiwi, F. A. K., Annisa, A., Septaningsih, D. A., Aziz, S. A., Miladiyah, I., Kusumastuti, S. A., Nasution, M. A. F., Ramadhan, D., & Kusuma, W. A. (2024) · PLoS ONE · doi:10.1371/journal.pone.0305544 · Cited by 8 · see citing works
The Evaluation of Serum Endocan, Interleukin-6, and CRP Levels Following Sleeve Gastrectomy
Sarıyıldız, G. T., Demir, C., Demir, M. E., Arslan, A., Banlı, O., & Dursun, A. D. (2023) · International Journal of General Medicine · doi:10.2147/ijgm.s436213 · Cited by 8 · see citing works
Relationship Between Markers of Chronic Inflammation and Copper Nutritional Status in Obese Women
Sousa, M. D. P., Fontenelle, L. C., de Sousa, T. G. V., dos Santos, L. R., Cruz, K. J. C., Soares, T. D. C., Bráz, D. C., Sousa, J. M. D. C. E., Henriques, G. S., Silva, V. C., et al. (2022) · Biological Trace Element Research · doi:10.1007/s12011-022-03407-z · Cited by 8 · see citing works
Obesity and type 2 diabetes as chronic inflammation: how does the cytokine evidence align?
Bhatia, K., Gupta, V. K., & Upadhyay, S. K. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1721206 · Cited by 13 · see citing works
Osorio-Conles, Ó., Olbeyra, R. P., Vidal, J., Ibarzábal, A., Balibrea, J. M., & de Hollanda, A. (2023) · Cells · doi:10.3390/cells12091262 · Cited by 7 · see citing works
Abnormal Vessel Architecture Persists in the Microvasculature of the Massive Weight Loss Patient
Katzel, E. B., Shakir, S., Kostereva, N., Lannau, B., Gimbel, M. L., Nguyen, V. T., Cruz, C. D. L., Marra, K. G., & Gusenoff, J. A. (2015) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000001905 · Cited by 7 · see citing works
Obesity and Depression: Shared Pathophysiology and Translational Implications
Huet, L., Delgado, I., Aouizerate, B., Castanon, N., & Capuron, L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813333-0.00016-0 · Cited by 7 · see citing works
Self-citationChat, I. K.-Y., Hansson, L. S., Lekander, M., Jacobsen, C. S., Benson, S., Hebebrand, J., Bender, V., Handke, A. E., Hasenberg, T., Treadway, M. T., et al. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.106548 · Cited by 4 · see citing works
Self-citationRadkhah, H., Alirezaei, A., Parhizkar, P., Khalooeifard, R., Khoundabi, B., Najjari, K., Talebpour, M., & Hajebi, R. (2024) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000002257 · Cited by 4 · see citing works
Ribeiro, D. A., da Silva, G. N., Malacarne, I. T., Pisani, L. P., & Salvadori, D. M. F. (2024) · Pathophysiology · doi:10.3390/pathophysiology31030026 · Cited by 4 · see citing works
Hajri, T., Ewing, D. R., Talishinskiy, T., Amianda, E. A., Eid, S. R., & Schmidt, H. J. (2021) · Journal of Nutrition · doi:10.1093/jn/nxab167 · Cited by 4 · see citing works
Role of Inflammation in Neuropsychiatric Comorbidity of Obesity: Experimental and Clinical Evidence
Fourrier, C., Capuron, L., & Castanon, N. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811073-7.00020-9 · Cited by 4 · see citing works
Self-citationMendes, T. B., Generoso, G., Fabiano, R. C., Halpern, B., Janovsky, C. C. P. S., Romero, C. M., Santos, R. D., Benseñor, I. M., Lotufo, P. A., & Bittencourt, M. S. (2025) · The Lancet Regional Health - Americas · doi:10.1016/j.lana.2025.101281 · Cited by 3 · see citing works
Mazidi, M., Gao, H.-K., Li, L., & Ferns, G. A. (2017) · Bariatric Surgical Practice and Patient Care · doi:10.1089/bari.2017.0002 · Cited by 3 · see citing works
Rizzo, L. F. L., Mana, D. L., & Bruno, O. D. (2014) · PubMed · Cited by 3 · see citing works
Fernandes, B. L., Cozer, A. W. D., Souza, F. C. V., Santiago, L. D., Lima, M. R., Leite, P. M., Silveira, A. M. S., Enes, B. N., Ottoni, M. H. F., Gama, R. S., et al. (2024) · Obesities · doi:10.3390/obesities4040041 · Cited by 2 · see citing works
Montet, J., Montalban, E., Dexpert, S., Magne, E., Beau, C., Forestier, D., Ledaguenel, P., Gostner, J. M., Fuchs, D., Aouizerate, B., et al. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.106547 · Cited by 2 · see citing works
Self-citationGiuliani, N. D. R., Modolin, M., Cintra, W., Rocha, R. I., & Gemperli, R. (2021) · Revista Brasileira de Cirurgia Plástica · doi:10.5935/2177-1235.2021rbcp0058 · Cited by 2 · see citing works
Radziavicius, C. C., Radziavicius, F. R. C., Pereira, E. C., Azzalis, L. A., Castelo, P. M., Junqueira, V. B. C., de Souza, F. I. S., Sarni, R. O. S., Rocha, K. C., Oliveira, R. B., et al. (2015) · International Archives of Medicine · doi:10.3823/1667 · Cited by 2 · see citing works
Martínez, D. M., Castro, A. C. N., & Pustovrh, M. C. (2020) · Salud Uninorte · doi:10.14482/sun.35.2.618 · Cited by 2 · see citing works
Chen, X. P., Wang, Y., Wu, J., He, Y., Chen, H., Ye, H., & Liu, J. (2026) · Journal of Diabetes Research · doi:10.1155/jdr/6450867 · Cited by 1 · see citing works
Giant Mice Reveal New Roles for GH in Regulating the Adipose Immune Microenvironment
Odle, A. K., Drew, P. D., & Childs, G. V. (2015) · Endocrinology · doi:10.1210/en.2015-1205 · Cited by 1 · see citing works
The Ultrasonography Image of Abdominal Fat
ALD, R. L. D. (2015) · Emergency Medicine Open Access · doi:10.4172/2165-7548.1000246 · Cited by 1 · see citing works
Obesity, Stress, Inflammation, and Psychoneuroimmunology
Yan, Q. (2016) · Springer eBooks · doi:10.1007/978-3-319-45111-4_8 · Cited by 1 · see citing works
Saputro, A., Prasetyo, S. A., Sobirin, M. A., Mughni, A., & Prajoko, Y. W. (2023) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v15i4.2240 · Cited by 1 · see citing works
Obesity‐ and Neuroinflammation‐Associated Mood and Cognitive Disorders
Castanon, N., Luheshi, G. N., & Layé, S. (2015) · Wiley eBooks · doi:10.1002/9781118732748.ch9
Self-citationDeath by Sugar: The Impact of Sugar on Acutely Ill Patients
Schultze, B., & Ridner, S. H. (2015) · The Journal for Nurse Practitioners · doi:10.1016/j.nurpra.2015.01.025
The Role of Fat Grafting and Adipose-Derived Stem Cells in Breast Reconstruction
Vyas, K. S. (2016) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2016.350
Insulin sensitivity is mediated by glucose in the hepatoportal region in the rat
Johnson, H. M. (2017) · The Sydney eScholarship Repository (The University of Sydney)
Lytvyak, E., Zarrinpar, A., Ore, C. L. D., Lee, E., Yazdani-Boset, K., Horgan, S., & Grunvald, E. L. (2024) · Obesity Pillars · doi:10.1016/j.obpill.2024.100111
Etude de la voie de la kynurénine dans la symptomatologie du sujet obèse
Huet, L. (2019) · theses.fr (ABES) · doi:10.70675/ff26d7c8z4c5fz4c86z9e6ezd8d843268447
Immune-metabolic landscape and sleeve gastrectomy outcomes
Choi, J., Yu, Y., Kim, E. R., Park, S., Yoon, S., Park, J., Lee, H.-S., Kwon, J., Yun, J. H., Kim, Y. H., et al. (2026) · International Journal of Surgery · doi:10.1097/js9.0000000000005429
Dåstøl, V. Ø., Caspersen, I. H., Haftorn, K. L., Hestetun, S. V., Bastakoti, S., Andreassen, O. A., Brantsæter, A. L., Håberg, S. E., Costenbader, K. H., Størdal, K., et al. (2026) · RMD Open · doi:10.1136/rmdopen-2026-006940
Yang, Y., Mo, Z., Wu, Z., Guan, B., Cheng, L., Wu, L., Ding, W., Wei, R., Luo, X., Li, Y., et al. (2026) · Obesity Surgery · doi:10.1007/s11695-026-08952-3
- Authors
- Lasselin, J., Magne, E., Beau, C., Ledaguenel, P., Dexpert, S., Aubert, A., Layé, S., & Capuron, L.
- Affiliations
- Université de Bordeaux (FR)
- Service de Chirurgie Digestive et Pariétale, Clinique Tivoli (E.M., C.B., P.L.), F-33000 Bordeaux, France
- Corresponding author
- Capuron, Lucile
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2014-01-01
- Volume
- 99
- Issue
- 1
- Pages
- E53-E61
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2097737322
- Cited by
- 96
- References
- 39
- Citations by year
- 2026: 7 · 2025: 1 · 2024: 10 · 2023: 6 · 2022: 4 · 2021: 8 · 2020: 8 · 2019: 4 · 2018: 11 · 2017: 3 · 2016: 11 · 2015: 14 · 2014: 9
- FWCI
- 8.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Oskar-Bordeaux (Universite de Bordeaux) (submittedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-11-JSV1-0006)
- Institut National de la Recherche Agronomique
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- adipose tissue inflammation, obesity, bariatric surgery, weight loss, visceral adipose tissue, cytokine gene expression, TNF-α, interleukin-1 receptor antagonist, interleukin-6, macrophages, T cells, low-grade inflammation, inflammatory markers
- MeSH terms
- Adipose Tissue, Adult, Cross-Sectional Studies, Female, Humans, Longitudinal Studies, Male, Middle Aged, Obesity, Biomarkers, Weight Loss, Panniculitis, Inflammation Mediators, Bariatric Surgery
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