The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Reduced hippocampal volume and verbal memory performance associated with interleukin-6 and tumor necrosis factor-alpha levels in chemotherapy-treated breast cancer survivors
Open accessAbstract
Many survivors of breast cancer show significant cognitive impairments, including memory deficits. Inflammation induced by chemotherapy may contribute to hippocampal changes that underlie these deficits. In this cross-sectional study, we measured bilateral hippocampal volumes from high-resolution magnetic resonance images in 42 chemotherapy-treated breast cancer survivors and 35 healthy female controls. Patients with breast cancer were, on average, 4.8 ± 3.4 years off-therapy. In a subset of these participants (20 breast cancer, 23 controls), we quantified serum cytokine levels. Left hippocampal volumes and memory performance were significantly reduced and interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNFα) concentrations were significantly elevated in the breast cancer group compared to controls. In the breast cancer group, lower left hippocampal volume was associated with higher levels of TNFα and lower levels of IL-6 with a significant interaction between these two cytokines suggesting a potential modulatory effect of IL-6 on TNFα. Verbal memory performance was associated with cytokine levels and left hippocampal volume in both groups. These findings provide evidence of altered hippocampal volume and verbal memory difficulties following breast cancer chemotherapy that may be mediated by TNFα and IL-6.
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Cytokines and their relationship to the symptoms and outcome of cancer
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Stress hormones and human memory function across the lifespan
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“Cortisol can also impair memory performance at low or high concentrations (Erickson et al., 2003; Lupien et al., 2005).”
Interleukin-6 Covaries Inversely with Hippocampal Grey Matter Volume in Middle-Aged Adults
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Inflammatory biomarkers and fatigue during radiation therapy for breast and prostate cancer
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Depression, cortisol, and suppressed cell-mediated immunity in metastatic breast cancer
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Cited by
Carreira, H., Williams, R., Müller, M., Harewood, R., Stanway, S., & Bhaskaran, K. (2018) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djy177 · Cited by 416
Cognitive Effects of Cancer and Cancer Treatments
Ahles, T. A., & Root, J. C. (2018) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050817-084903 · Cited by 367
Cognitive Training for Improving Executive Function in Chemotherapy-Treated Breast Cancer Survivors
Kesler, S., Hadi Hosseini, S. M., Heckler, C., Janelsins, M., Palesh, O., Mustian, K., & Morrow, G. (2013) · Clinical Breast Cancer · doi:10.1016/j.clbc.2013.02.004 · Cited by 300
“Most successful studies have involved training programs that ranged from 4 to 12 weeks or more, characterized by multiple hours (10-60) of distributed training.”
BackgroundSelf-citationClark, I. A., & Vissel, B. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0708-2 · Cited by 123
Ren, X., Keeney, J. T. R., Miriyala, S., Noel, T., Powell, D. K., Chaiswing, L., Bondada, S., St. Clair, D. K., & Butterfield, D. A. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.12.029 · Cited by 88
Metadata
- Authors
- Kesler, S., Janelsins, M., Koovakkattu, D., Palesh, O., Mustian, K., Morrow, G., & Dhabhar, F. S.
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 30
- Pages
- S109-S116
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W2137323524
- Cited by
- 312
- References
- 11
- FWCI
- 12.81
- Type
- journal article
- Language
- en
- Open access
- green
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- Kesler, S., Janelsins, M., Koovakkattu, D., Palesh, O., Mustian, K., Morrow, G., & Dhabhar, F. S. (2013). Reduced hippocampal volume and verbal memory performance associated with interleukin-6 and tumor necrosis factor-alpha levels in chemotherapy-treated breast cancer survivors. Brain, Behavior, and Immunity. https://doi.org/10.1016/j.bbi.2012.05.017
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