Nervous system regulation of the cancer genome
Open accessAbstract
Genomics-based analyses have provided deep insight into the basic biology of cancer and are now clarifying the molecular pathways by which psychological and social factors can regulate tumor cell gene expression and genome evolution. This review summarizes basic and clinical research on neural and endocrine regulation of the cancer genome and its interactions with the surrounding tumor microenvironment, including the specific types of genes subject to neural and endocrine regulation, the signal transduction pathways that mediate such effects, and therapeutic approaches that might be deployed to mitigate their impact. Beta-adrenergic signaling from the sympathetic nervous system has been found to up-regulated a diverse array of genes that contribute to tumor progression and metastasis, whereas glucocorticoid-regulated genes can inhibit DNA repair and promote cancer cell survival and resistance to chemotherapy. Relationships between socio-environmental risk factors, neural and endocrine signaling to the tumor microenvironment, and transcriptional responses by cancer cells and surrounding stromal cells are providing new mechanistic insights into the social epidemiology of cancer, new therapeutic approaches for protecting the health of cancer patients, and new molecular biomarkers for assessing the impact of behavioral and pharmacologic interventions.
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In solid epithelial tumors such as breast, ovarian, and prostate cancers, low social support is associated with increased expression of many gene modules that promote cancer progression and metastasis, including inflammation, wound repair, angiogenesis, and resistance to programmed cell death.
“In these solid epithelial tumors, low social support is associated with increased expression of many gene modules that promote cancer progression and metastasis, including transcripts involved in inflammation, wound repair (epithelial-mesenchymal transition), blood vessel growth (angiogenesis), and resistance to programmed cell death (anoikis and chemotherapy resistance) [42].”
From Human Social Genomics (2014) · cites this paper as [42]
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Transcriptional Modulation of the Developing Immune System by Early Life Social AdversityPreprint
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Sympathetic nervous system regulation of the tumour microenvironment
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Self-citationThe Emerging Field of Human Social Genomics
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Self-citationThe circadian clock in cancer development and therapy
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Stress and coping in women with breast cancer:unravelling the mechanisms to improve resilience
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- Authors
- Cole, S. W.
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 30
- Pages
- S10-S18
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC3600385
- OpenAlex
- W1996048876
- Cited by
- 41
- References
- 129
- Citations by year
- 2026: 3 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 6 · 2014: 3 · 2013: 4
- FWCI
- 0.57
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (NCI R01-CA116778)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- cancer genome, neural regulation, hormonal regulation, tumor microenvironment, beta-adrenergic signaling, sympathetic nervous system, glucocorticoids, DNA repair, chemoresistance, tumor progression, metastasis, socio-environmental risk factors, signaling pathways, stromal cells, biomarkers, behavioral interventions, pharmacological interventions
- MeSH terms
- Animals, Humans, Neoplasms, Nervous System, Signal Transduction, Gene Expression Regulation, Neoplastic, Tumor Microenvironment, Transcriptome
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