Stress hormone-mediated invasion of ovarian cancer cells
Open accessAbstract
Purpose: There is growing evidence that stress and other behavioral factors may affect cancer progression and patient survival. The underlying mechanisms for this association are poorly understood. The purpose of this study is to determine the effects of stress-associated hormones norepinephrine, epinephrine, and cortisol on the invasive potential of ovarian cancer cells. Experimental Design: The ovarian cancer cells EG, SKOV3, and 222 were exposed to increasing levels of either norepinephrine, epinephrine, or cortisol, and the in vitro invasive potential was determined using the membrane invasion culture system. Additionally, the effects of these stress hormones on matrix metalloproteinase-2 (MMP-2) and MMP-9 were determined by ELISA. The effects of the β-adrenergic agonist isoproterenol on in vivo tumor growth were determined using nude mice. Results: Stress levels of norepinephrine increased the in vitro invasiveness of ovarian cancer cells by 89% to 198%. Epinephrine also induced significant increases in invasion in all three cell lines ranging from 64% to 76%. Cortisol did not significantly affect invasiveness of the EG and 222 cell lines but increased invasion in the SKOV3 cell line (P = 0.01). We have previously shown that ovarian cancer cells express β-adrenergic receptors. The β-adrenergic antagonist propanolol (1 μmol/L) completely blocked the norepinephrine-induced increase in invasiveness. Norepinephrine also increased tumor cell expression of MMP-2 (P = 0.02 for both SKOV3 and EG cells) and MMP-9 (P = 0.01 and 0.04, respectively), and pharmacologic blockade of MMPs abrogated the effects of norepinephrine on tumor cell invasive potential. Isoproterenol treatment resulted in a significant increase in tumor volume and infiltration in the SKOV3ip1 in vivo model, which was blocked by propranolol. Conclusions: These findings provide direct experimental evidence that stress hormones can enhance the invasive potential of ovarian cancer cells. These effects are most likely mediated by stimulation of MMPs.
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Findings from animal and in vitro studies back up the human data on psychosocial factors and tumor progression.
“Parallel findings in animal and in vitro models support these data [11, 16–22].”
From Living Well: Protocol for a web-based program to improve quality of life in rural and urban ovarian cancer survivors (2024) · cites this paper as [17]
MMP upregulation and invasiveness of tumor cells were reversed by propranolol treatment.
“Furthermore, MMP upregulation and invasiveness of the tumor cells were reversed by propranolol treatment, highlighting the link between stress hormones and MMPs (Sood et al, 2006).”
From Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal (2017) · cites this paper as Sood et al, 2006
Stress levels of NE increase MMP-9 and MMP-2 that increase invasive potential of tumor cells.
“It is known within the cancer literature that stress levels of NE increase MMP-9 and MMP-2 that increase invasive potential of the tumor cells (Sood et al, 2006;Yang et al, 2006).”
From Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal (2017) · cites this paper as Sood et al, 2006
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The Influence of Psychological Stress on the Initiation and Progression of Diabetes and Cancer
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Nervous system regulation of the cancer genome
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Self-citation
- Authors
- Sood, A. K., Bhatty, R., Kamat, A. A., Landen, C. N., Han, L., Thaker, P. H., Li, Y., Gershenson, D. M., Lutgendorf, S., & Cole, S. W.
- Affiliations
- Gynecologic Oncology Group (US)
- 3College of Medicine;
- University of Iowa (US)
- 5Division of Hematology-Oncology, Department of Medicine, University of California, Los Angeles, Los Angeles, California
- Venue
- Clinical Cancer Research
- Published
- 2006-01-15
- Volume
- 12
- Issue
- 2
- Pages
- 369-375
- ISSN
- 1078-0432 (ISSN-L)
- 1557-3265
- PMC
- PMC3141061
- OpenAlex
- W2034249705
- Cited by
- 491
- References
- 71
- Citations by year
- 2026: 12 · 2025: 11 · 2024: 25 · 2023: 21 · 2022: 29 · 2021: 23 · 2020: 27 · 2019: 28 · 2018: 19 · 2017: 22 · 2016: 33 · 2015: 29 · 2014: 23 · 2013: 37 · 2012: 34
- FWCI
- 12.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UH3TR000943)
- National Cancer Institute (R01CA110793, CA10929801, R01CA109298, CA 11079301)
- National Institute of Allergy and Infectious Diseases (AI 52737, R01AI052737)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Keywords
- ovarian cancer, tumor invasion, stress hormones, norepinephrine, epinephrine, cortisol, MMP-2, MMP-9, beta-adrenergic receptors, propranolol, isoproterenol, tumor growth
- MeSH terms
- Animals, Enzyme-Linked Immunosorbent Assay, Epinephrine, Female, Humans, Hydrocortisone, Isoproterenol, Mice, Nude, Neoplasm Invasiveness, Norepinephrine, Ovarian Neoplasms, Tumor Cells, Cultured, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Mice
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