Cited by 145Cancer, Stress, Anesthesia, and Immune ResponseImmune cells in cancerVagus Nerve Stimulation Research

Neuroendocrine influences on cancer progression

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Armaiz-Pena, Guillermo N., Cole, Steve W., Lutgendorf, Susan K., Sood, Anil K.·2013·Brain, Behavior, and Immunity

Abstract

During the past decade, new studies have continued to shed light on the role of neuroendocrine regulation of downstream physiological and biological pathways relevant to cancer growth and progression. More specifically, our knowledge of the effects of the sympathetic nervous system (SNS) on cancer biology has been greatly expanded by new data demonstrating how the cellular immune response, inflammatory processes, tumor-associated angiogenesis, and tumor cell invasion and survival converge to promote tumor growth. This review will summarize these studies, while synthesizing clinical, cellular and molecular research that has continued to unearth the biological events mediating the interplay between SNS-related processes and cancer progression.

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Crossref · 10.1016/j.bbi.2012.06.005

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  • Elevated anxiety or depression in adults with metastatic cancer can be associated with earlier cancer-related mortality.

    “and earlier cancer-related mortality [20–22]”

    From A randomized controlled trial of a multi-modal palliative care intervention to promote advance care planning and psychological well-being among adults with advanced cancer: study protocol. (2022) · cites this paper as [21]

    The Tumor Cell Survival and Anoikis section (page unavailable) reports that depression in ovarian cancer patients was associated with increased FAK activation, which was in turn associated with decreased survival. The Angiogenesis section also links distress in ovarian cancer patients to elevated IL-6, a marker associated with shorter survival. Neither passage establishes that anxiety or depression in adults with metastatic cancer is directly associated with earlier cancer-related mortality. (LLM, conf=0.82)

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Authors
Armaiz-Pena, G. N., Cole, S. W., Lutgendorf, S. K., & Sood, A. K.
Affiliations
  • University of California, Los Angeles (US)
  • University of Iowa (US)
  • The University of Texas MD Anderson Cancer Center (US)
Corresponding author
Sood, Anil K.
Venue
Brain, Behavior, and Immunity
Publisher
Elsevier BV
Published
2013-03
Volume
30
Pages
S19-S25
ISSN
0889-1591 (ISSN-L)
OpenAlex
W2113048638
Cited by
145
References
72
Citations by year
2026: 5 · 2025: 11 · 2024: 6 · 2023: 11 · 2022: 10 · 2021: 10 · 2020: 9 · 2019: 18 · 2018: 10 · 2017: 10 · 2016: 10 · 2015: 19 · 2014: 6 · 2013: 7 · 2012: 2
FWCI
1.46
Type
journal article
Language
en
Open access
Locations
  • Brain Behavior and Immunity (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute (CA 109298, R01CA110793, U54CA151668, CA 110793, CA-104825, R01CA109298, CA140933, R01CA104825, R01CA140933, P50CA083639, P30CA016672)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Keywords
neuroendocrine regulation, tumor progression, sympathetic nervous system, tumor growth, cell-mediated immunity, inflammation, tumor angiogenesis, tumor invasion, tumor cell survival
MeSH terms
Animals, Humans, Neoplasms, Neovascularization, Pathologic, Neurosecretory Systems, Disease Progression

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