Neuroendocrine influences on cancer progression
Open accessAbstract
During the past decade, new studies have continued to shed light on the role of neuroendocrine regulation of downstream physiological and biological pathways relevant to cancer growth and progression. More specifically, our knowledge of the effects of the sympathetic nervous system (SNS) on cancer biology has been greatly expanded by new data demonstrating how the cellular immune response, inflammatory processes, tumor-associated angiogenesis, and tumor cell invasion and survival converge to promote tumor growth. This review will summarize these studies, while synthesizing clinical, cellular and molecular research that has continued to unearth the biological events mediating the interplay between SNS-related processes and cancer progression.
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Elevated anxiety or depression in adults with metastatic cancer can be associated with earlier cancer-related mortality.
“and earlier cancer-related mortality [20–22]”
From A randomized controlled trial of a multi-modal palliative care intervention to promote advance care planning and psychological well-being among adults with advanced cancer: study protocol. (2022) · cites this paper as [21]
The Tumor Cell Survival and Anoikis section (page unavailable) reports that depression in ovarian cancer patients was associated with increased FAK activation, which was in turn associated with decreased survival. The Angiogenesis section also links distress in ovarian cancer patients to elevated IL-6, a marker associated with shorter survival. Neither passage establishes that anxiety or depression in adults with metastatic cancer is directly associated with earlier cancer-related mortality. (LLM, conf=0.82)
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- Authors
- Armaiz-Pena, G. N., Cole, S. W., Lutgendorf, S. K., & Sood, A. K.
- Affiliations
- University of California, Los Angeles (US)
- University of Iowa (US)
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Sood, Anil K.
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 30
- Pages
- S19-S25
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC3467346
- OpenAlex
- W2113048638
- Cited by
- 145
- References
- 72
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 6 · 2023: 11 · 2022: 10 · 2021: 10 · 2020: 9 · 2019: 18 · 2018: 10 · 2017: 10 · 2016: 10 · 2015: 19 · 2014: 6 · 2013: 7 · 2012: 2
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (CA 109298, R01CA110793, U54CA151668, CA 110793, CA-104825, R01CA109298, CA140933, R01CA104825, R01CA140933, P50CA083639, P30CA016672)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- neuroendocrine regulation, tumor progression, sympathetic nervous system, tumor growth, cell-mediated immunity, inflammation, tumor angiogenesis, tumor invasion, tumor cell survival
- MeSH terms
- Animals, Humans, Neoplasms, Neovascularization, Pathologic, Neurosecretory Systems, Disease Progression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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