Cited by 108Sleep and related disordersHealth disparities and outcomesObstructive Sleep Apnea Research

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Sleep disturbance and longitudinal risk of inflammation: Moderating influences of social integration and social isolation in the Coronary Artery Risk Development in Young Adults (CARDIA) study

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Cho, Hyong Jin, Seeman, Teresa E., Kiefe, Catarina I., Lauderdale, Diane S., Irwin, Michael R.·2015·Brain, Behavior, and Immunity

DOI 10.1016/j.bbi.2015.02.023PMC PMC4414819

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Abstract

Both sleep disturbance and social isolation increase the risk for morbidity and mortality. Systemic inflammation is suspected as a potential mechanism of these associations. However, the complex relationships between sleep disturbance, social isolation, and inflammation have not been examined in a population-based longitudinal study. This study examined the longitudinal association between sleep disturbance and systemic inflammation, and the moderating effects of social isolation on this association. The CARDIA study is a population-based longitudinal study conducted in four US cities. Sleep disturbance - i.e., insomnia complaints and short sleep duration - was assessed in 2962 African-American and White adults at baseline (2000-2001, ages 33-45years). Circulating C-reactive protein (CRP) was measured at baseline and follow-up (2005-2006). Interleukin-6 (IL-6) and subjective and objective social isolation (i.e., feelings of social isolation and social network size) were measured at follow-up. Sleep disturbance was a significant predictor of inflammation five years later after full adjustment for covariates (adjusted betas: 0.048, P=0.012 for CRP; 0.047, P=0.017 for IL-6). Further adjustment for baseline CRP revealed that sleep disturbance also impacted the longitudinal change in CRP levels over five years (adjusted beta: 0.044, P=0.013). Subjective social isolation was a significant moderator of this association between sleep disturbance and CRP (adjusted beta 0.131, P=0.002). Sleep disturbance was associated with heightened systemic inflammation in a general population over a five-year follow-up, and this association was significantly stronger in those who reported feelings of social isolation. Clinical interventions targeting sleep disturbances may be a potential avenue for reducing inflammation, particularly in individuals who feel socially isolated.

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Authors: Cho, H. J., Seeman, T. E., Kiefe, C. I., Lauderdale, D. S., & Irwin, M. R.
Affiliations: University of California, Los Angeles (US)
University of Massachusetts Chan Medical School (US)
University of Chicago (US)
Corresponding author: Cho, Hyong Jin
ORCID: Cho, Hyong Jin
Seeman, Teresa E.
Kiefe, Catarina I.
Irwin, Michael R.
Venue: Brain, Behavior, and Immunity
Publisher: Elsevier BV
Published: 2015-05
Volume: 46
Pages: 319-326
ISSN: 0889-1591 (ISSN-L)
DOI: 10.1016/j.bbi.2015.02.023
PMC: PMC4414819
OpenAlex: W2045027490
Cited by: 108
References: 51
Citations by year: 2026: 5 · 2025: 7 · 2024: 18 · 2023: 9 · 2022: 14 · 2021: 17 · 2020: 10 · 2019: 8 · 2018: 6 · 2017: 6 · 2016: 4 · 2015: 4
FWCI: 10.04
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain Behavior and Immunity (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: University of Alabama at Birmingham (N01-HC-95095, N01-HC-48047)
University of Minnesota (N01-HC-48048)
Northwestern University (N01-HC-48049)
Kaiser Foundation Research Institute (N01-HC-48050)
University of California (N01-HC-45134)
Harbor-University of California (N01-HC-05187)
Wake Forest University (N01-HC-45205)
New England Medical Center (N01-HC-45204)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Social Sciences › Health › Health disparities and outcomes
Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
Keywords: sleep disorders, insomnia, short sleep duration, systemic inflammation, C-reactive protein, interleukin-6, social isolation, social integration, social network size, moderating effect, young adults, CARDIA study
MeSH terms: Adult, C-Reactive Protein, Coronary Artery Disease, Female, Humans, Inflammation, Longitudinal Studies, Male, Middle Aged, Sleep, Sleep Wake Disorders, Social Behavior, Social Isolation, Interleukin-6

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Sleep disturbance and longitudinal risk of inflammation: Moderating influences of social integration and social isolation in the Coronary Artery Risk Development in Young Adults (CARDIA) study

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