Social support, social integration, and inflammatory cytokines: a meta-analysis

Uchino, Bert N.; Trettevik, Ryan; Kent de Grey, Robert G.; Cronan, Sierra; Hogan, Jasara; Baucom, Brian R. W.

doi:10.1037/hea0000594

Cited by 320Health disparities and outcomesTryptophan and brain disordersStress Responses and Cortisol

Social support, social integration, and inflammatory cytokines: a meta-analysis

Uchino, Bert N., Trettevik, Ryan, Kent de Grey, Robert G., Cronan, Sierra, Hogan, Jasara, Baucom, Brian R. W.·2018·Health Psychology

DOI 10.1037/hea0000594

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Abstract

OBJECTIVE: Social support and social integration have been linked to lower rates of morbidity and mortality. However, the biological mechanisms responsible for such links need greater attention to advance theory and unique intervention opportunities. The main aim of this article was to conduct a meta-analytic review of the association between social support-social integration and inflammatory cytokines (e.g., interleukin-6, C-reactive protein) and test several proposed moderators from prior qualitative reviews. METHOD: . The review identified 41 studies with a total of 73,037 participants. RESULTS: The omnibus meta-analysis showed that social support-social integration were significantly related to lower levels of inflammation (Zr = -.073). These results were not moderated by the operationalization of social relationships or the type of population, cytokine, and design. CONCLUSIONS: These data suggest that inflammation is at least one important biological mechanism linking social support and social integration to the development and course of disease. Future work should continue to build on this review and address next-generation questions regarding antecedent processes, mechanisms, and other potential moderators. (PsycINFO Database Record

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Such inflammation is a potent driver of diseases such as cardiovascular disease, cancers, and diabetes.
“Such inflammation is a potent driver of diseases such as cardiovascular disease, cancers, and diabetes (Emerging Risk Factors Collaboration, 2010; Kiecolt-Glaser et al., 2010; Uchino et al., 2018; Zhou et al., 2012).”
From Social media use and systemic inflammation: The moderating role of self-esteem (2021) · cites this paper as Uchino et al., 2018
Social integration and related social processes are reliably associated with lower levels of IL-6 and CRP.
“Emerging research indicates that social integration and related social processes (e.g., social support, quality of social interactions) are reliably associated with lower levels of IL-6 and CRP (see Uchino et al., 2018 for a meta-analysis).”
From Social media use and systemic inflammation: The moderating role of self-esteem (2021) · cites this paper as Uchino et al., 2018

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Psychosocial Vulnerabilities to Upper Respiratory Infectious Illness: Implications for Susceptibility to Coronavirus Disease 2019 (COVID-19)
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Social support and treatment adherence in patients with end‐stage renal disease: A systematic review
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Social Engagement and Amyloid-β-Related Cognitive Decline in Cognitively Normal Older Adults
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Social Safety Theory: Understanding social stress, disease risk, resilience, and behavior during the COVID-19 pandemic and beyond
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Glucocorticoid resistance and β2-adrenergic receptor signaling pathways promote peripheral pro-inflammatory conditions associated with chronic psychological stress: A systematic review across species
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Effects of psychosocial support interventions on survival in inpatient and outpatient healthcare settings: A meta-analysis of 106 randomized controlled trials
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Gender differences in social networks and physical and mental health: are social relationships more health protective in women than in men?
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The immediate effect of discrimination on mental health: A meta-analytic review of the causal evidence.
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Resilience: Safety in the Aftermath of Traumatic Stressor Experiences
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Lower Social Support is Associated with Accelerated Epigenetic Aging: Results from the Health and Retirement Study
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Core social network size is associated with physical activity participation for fitness app users: The role of social comparison and social support
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Social frailty and the incidence of motoric cognitive risk syndrome in older adults
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Perceived social support and chronic inflammation: The moderating role of self-esteem.
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A Biopsychosocial Approach to Grief, Depression, and the Role of Emotional Regulation
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Social Integration, Social Support, and All-Cause, Cardiovascular Disease and Cause-Specific Mortality: A Prospective Cohort Study
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Association of intergenerational relationship and supports with cognitive performance in older adults: A systematic review
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Youth Adversities Amplify the Association between Adult Stressors and Chronic Inflammation in a Domain Specific Manner: Nuancing the Early Life Sensitivity Model
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Why inflammation and the activities of the immune system matter for social and personality psychology (and not only for those who study health)
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A proinflammatory diet is associated with inflammatory gene expression among healthy, non-obese adults: Can social ties protect against the risks?
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Psychoneuroimmunology in the time of COVID-19: Why neuro-immune interactions matter for mental and physical health
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Automatic mapping of multiplexed social receptive fields by deep learning and GPU-accelerated 3D videography
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The biology of aging in a social world: Insights from free-ranging rhesus macaques
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Improving well-being via adaptive reuse: transformative repurposed service organizations
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Social connectedness, functional capacity, and longevity: A focus on positive relations with others
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An Extension to the stress-buffering model: Timing of support across the lifecourse
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Social Integration and Quality of Social Relationships as Protective Factors for Inflammation in a Nationally Representative Sample of Black Women
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Positive and Negative Affect and Salivary Markers of Inflammation Among Young Adults
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Autonomic nervous system activity predicts increasing serum cytokines in children
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Social support and stress, depression, and cardiovascular disease
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Standardization and adaptability for dissemination of telephone peer support for high-risk groups: general evaluation and lessons learned
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Networks, cultures, and institutions: Toward a social immunology
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Exploring the relationship between resilience and internet addiction in Chinese college students: The mediating roles of life satisfaction and loneliness.
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Social media use and systemic inflammation: The moderating role of self-esteem
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Perceived role overload and physical symptom experience among caregivers of older adults: The moderating effect of social support
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Association between Family Support, Stress, and Sleep Quality among College Students during the COVID-19 Online Learning Period
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Sociality predicts individual variation in the immunity of free-ranging rhesus macaques
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Social support and frailty progression in community-dwelling older adults
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Does inflammation provide a link between psychosocial work characteristics and diabetes? Analysis of the role of interleukin-6 and C-reactive protein in the Whitehall II cohort study
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Attachment style and changes in systemic inflammation following migration to a new country among international students
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The reciprocal associations between social deficits, social engagement, and inflammation: Longitudinal evidence comparing venous blood samples and dried blood spots and mapping the modifying role of phenotypic and genotypic depression
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Social frailty and its association with cognitive trajectories in older adults: a prospective cohort study
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Are Social Relationships an Underestimated Resource for Mental Health in Persons Experiencing Physical Disability? Observational Evidence From 22 Countries
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Does psychological treatment of major depression reduce cardiac risk biomarkers? An exploratory randomized controlled trial
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When skinfolk are kinfolk: Higher perceived support and acceptance characterize close same‐race (vs. interracial) relationships for people of color
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Effects of Multi-Component Exercise on Sleep Quality in Middle-Aged Adults
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Testing Life Course Models Whereby Juvenile and Adult Adversity Combine to Influence Speed of Biological Aging
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Stress-buffering effect of social support on immunity and infectious risk during chemotherapy for breast cancer
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Perceived social support-giving moderates the association between social relationships and interleukin-6 levels in blood
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Perceived relationship support moderates the association of contextual stress with inflammation among African Americans.
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Review of the Association Between Number of Social Roles and Cardiovascular Disease: Graded or Threshold Effect?
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Perceived Loneliness and Severe Sleep Disorders in Adult Women during the Covid-19 Quarantine: A Cross-Sectional Study in Colombia
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Frailty and the risk of infection-related hospitalizations in older age: Differences by sex
Trevisan, C., Noale, M., Amidei, C. B., Ferroni, E., Basso, C., Fedeli, U., Baggio, G., Maggi, S., & Sergi, G. (2022) · Maturitas · doi:10.1016/j.maturitas.2022.10.009 · Cited by 18 · see citing works
Liposaccharide-induced sustained mild inflammation fragments social behavior and alters basolateral amygdala activity
Loh, M. K., Stickling, C. P., Schrank, S., Hanshaw, M., Ritger, A. C., Dilosa, N., Finlay, J., Ferrara, N. C., & Rosenkranz, J. A. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06308-8 · Cited by 17 · see citing works
Cultivating a healthy neuro‐immune network: A health psychology approach
Bower, J. E., Kuhlman, K. R., Haydon, M. D., Boyle, C. C., & Radin, A. S. (2019) · Social and Personality Psychology Compass · doi:10.1111/spc3.12498 · Cited by 20 · see citing works
Social Support and Antibody Responses to Vaccination: A Meta-Analysis
Uchino, B. N., Landvatter, J., Zee, K. S., & Bolger, N. P. (2020) · Annals of Behavioral Medicine · doi:10.1093/abm/kaaa029 · Cited by 18 · see citing works
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Social Integration
Holt‐Lunstad, J., & Lefler, M. (2019) · Springer eBooks · doi:10.1007/978-3-319-69892-2_646-2 · Cited by 26 · see citing works
The potential role of network-oriented interventions for survivors of sexual and gender-based violence among asylum seekers in Belgium
Ogbe, E., Jbour, A., Rahbari, L., Unnithan, M., & Degomme, O. (2021) · BMC Public Health · doi:10.1186/s12889-020-10049-0 · Cited by 17 · see citing works
HIV-related stress predicts depression over five years among people living with HIV
Liu, Z., Chen, X., Li, J., Xie, Z., Huang, Y., & Luo, D. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1163604 · Cited by 18 · see citing works
A preliminary investigation of attachment style and inflammation in African-American young adults
Ehrlich, K. B., Stern, J. A., Eccles, J. S., Dinh, J., Hopper, E. A., Kemeny, M. E., Adam, E. K., & Cassidy, J. A. (2018) · Attachment & Human Development · doi:10.1080/14616734.2018.1541516 · Cited by 16 · see citing works
Inhibition of pro-inflammatory cytokines by selected southern African medicinal plants in LPS-stimulated RAW 264.7 macrophages
Khumalo, G. P., Nguyen, T., Wyk, B.-E. V., Feng, Y., & Cock, I. E. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117268 · Cited by 16 · see citing works
The psychosocial anti-inflammatories: Sense of control, purpose in life, and social support in relation to inflammation, functional health and chronic conditions in adulthood
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Social support, social participation, and cardiovascular reactivity to stress in the Midlife in the United States (MIDUS) study
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Stress Management and Resilience Building
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Perceived social support and ambulatory blood pressure during daily life: a meta-analysis
Uchino, B. N., Baucom, B., Landvatter, J., de Grey, R. G. K., Tacana, T., Flores, M., & Ruiz, J. M. (2022) · Journal of Behavioral Medicine · doi:10.1007/s10865-021-00273-3 · Cited by 17 · see citing works
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Social support and telomere length: a meta-analysis
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Does psychological treatment of major depression reduce cardiac risk biomarkers? An exploratory randomized controlled trial
Euteneuer, F., Neuert, M., Salzmann, S., Fischer, S., Ehlert, U., & Rief, W. (2022) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-218437 · Cited by 15 · see citing works
Associations of perceived stress, depressive symptoms, and caregiving with inflammation: a longitudinal study
Elayoubi, J., Haley, W. E., Roth, D. L., Cushman, M., Sheehan, O. C., Howard, V. J., Hladek, M. D., & Hülür, G. (2022) · International Psychogeriatrics · doi:10.1017/s1041610222000370 · Cited by 16 · see citing works
Patterns of adolescent perceived social support and inflammation in adulthood within major racial groups: Findings from a longitudinal, nationally representative sample
Millwood, S. N., & Manczak, E. M. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.02.017 · Cited by 15 · see citing works
Positive and negative aspects of social relations and low-grade inflammation in Copenhagen Aging and Midlife Biobank
Nilsson, C. J., Nørgaard, S., Foverskov, E., Brüünsgaard, H., Andersen, P. K., & Lund, R. (2020) · European Journal of Ageing · doi:10.1007/s10433-020-00561-y · Cited by 14 · see citing works
Does social isolation affect physical and mental health? A test of the social causation hypothesis using dynamic panel models with fixed effects
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Social capital: an independent dimension of healthy ageing
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Cannabidiol prevents cognitive and social deficits in a male rat model of Alzheimer’s disease through CB1 activation and inflammation modulation
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Multiple group membership, social network size, allostatic load and well-being: A mediation analysis
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Self-citation

Authors: Uchino, B. N., Trettevik, R., Kent de Grey, R. G., Cronan, S., Hogan, J., & Baucom, B. R. W.
ORCID: Uchino, Bert N.
Hogan, Jasara
Baucom, Brian R. W.
Venue: Health Psychology
Publisher: American Psychological Association (APA)
Published: 2018-05
Volume: 37
Issue: 5
Pages: 462-471
ISSN: 0278-6133 (ISSN-L)
1930-7810
DOI: 10.1037/hea0000594
OpenAlex: W2792810717
Semantic Scholar: 7d168fbdd00e3ec2efcb8e68133c1428db3bbd0f
Cited by: 320
References: 81
Citations by year: 2026: 37 · 2025: 45 · 2024: 48 · 2023: 46 · 2022: 43 · 2021: 47 · 2020: 24 · 2019: 26 · 2018: 3
FWCI: 26.66
Type: journal article
Language: en
Open access: closed
Locations: Health Psychology (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Health › Health disparities and outcomes
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: social support, social integration, inflammatory cytokines, inflammation, interleukin-6, C-reactive protein, biological mechanisms, interpersonal relationships, health outcomes
MeSH terms: Humans, Inflammation, Social Support, Cytokines

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Social support, social integration, and inflammatory cytokines: a meta-analysis

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