Forced swimming sabotages the morphological and synaptic maturation of newborn granule neurons and triggers a unique pro-inflammatory milieu in the hippocampus

From inflammation to sickness and depression: when the immune system subjugates the brain

Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works

Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants

Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321 · see citing works

Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus

Malberg, J. E., Eisch, A. J., Nestler, E. J., & Duman, R. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09104.2000 · Cited by 3,111 · see citing works

Resting-State Functional Connectivity in Major Depression: Abnormally Increased Contributions from Subgenual Cingulate Cortex and Thalamus

Greicius, M. D., Flores, B. H., Menon, V., Glover, G. H., Solvason, H. B., Kenna, H., Reiss, A. L., & Schatzberg, A. F. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.020 · Cited by 2,214 · see citing works

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., et al. (2011) · Nature · doi:10.1038/nature10357 · Cited by 1,763 · see citing works

Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis

Sierra, A., Encinas, J. M., Deudero, J. J. P., Chancey, J. H., Enikolopov, G., Overstreet-Wadiche, L. S., Tsirka, S. E., & Maletic-Savatic, M. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.08.014 · Cited by 1,622 · see citing works

Resting Microglia Directly Monitor the Functional State of Synapses <i>In Vivo</i> and Determine the Fate of Ischemic Terminals

Wake, H., Moorhouse, A. J., Jinno, S., Kohsaka, S., & Nabekura, J. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4363-08.2009 · Cited by 1,619 · see citing works

Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants

Detke, M. J., Rickels, M. R., & Lucki, I. (1995) · Psychopharmacology · doi:10.1007/bf02245592 · Cited by 1,438 · see citing works

Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus

Zhao, C., Teng, E. M., Summers, R. G., Ming, G.-L., & Gage, F. H. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3648-05.2006 · Cited by 1,257 · see citing works

Cytokines and major depression

Schiepers, O. J. G., Wichers, M. C., & Maes, M. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.11.003 · Cited by 1,235 · see citing works

Microglia: new roles for the synaptic stripper

Kettenmann, H., Kirchhoff, F., & Verkhratsky, A. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.023 · Cited by 1,173 · see citing works

Exposure to excess glucocorticoids alters dendritic morphology of adult hippocampal pyramidal neurons

Woolley, C. S., Gould, E., & McEwen, B. S. (1990) · Brain Research · doi:10.1016/0006-8993(90)90778-a · Cited by 1,020 · see citing works

Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus

Cameron, H. A., & Gould, E. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90224-0 · Cited by 999 · see citing works

Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis

Kreisel, T., Frank, M. G., Licht, T., Reshef, R., Ben-Menachem-Zidon, O., Baratta, M. V., Maier, S. F., & Yirmiya, R. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.155 · Cited by 663 · see citing works

Adrenal hormones suppress cell division in the adult rat dentate gyrus

Gould, E., Cameron, H. A., Daniels, D., Woolley, C. S., & McEwen, B. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-09-03642.1992 · Cited by 652 · see citing works

Neurotransmitter receptors on microglia

Pocock, J. M., & Kettenmann, H. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.07.007 · Cited by 650 · see citing works

Adult-Generated Hippocampal Neurons Allow the Flexible Use of Spatially Precise Learning Strategies

Garthe, A., Behr, J., & Kempermann, G. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005464 · Cited by 597 · see citing works

Pathogenesis of depression: Insights from human and rodent studies

Ménard, C., Hodes, G. E., & Russo, S. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.053 · Cited by 593 · see citing works

Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses

Frank, M. G., Baratta, M. V., Sprunger, D. B., Watkins, L. R., & Maier, S. F. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.03.005 · Cited by 578 · see citing works

Chronic stress alters the density and morphology of microglia in a subset of stress-responsive brain regions

Tynan, R. J., Naicker, S., Hinwood, M., Nalivaiko, E., Buller, K. M., Pow, D. V., Day, T. A., & Walker, F. R. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.02.001 · Cited by 531 · see citing works

Exposure to Acute Stress Induces Brain Interleukin-1β Protein in the Rat

Nguyen, K. T., Deak, T., Owens, S. M., Kohno, T., Fleshner, M., Watkins, L. R., & Maier, S. F. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-06-02239.1998 · Cited by 460 · see citing works

Cytokines as mediators of depression: what can we learn from animal studies?

Dunn, A. J., Swiergiel, A. H., & Beaurepaire, R. D. (2005) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.023 · Cited by 459 · see citing works

Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment

Meshi, D., Drew, M. R., Saxe, M., Ansorge, M. S., David, D. J. P., Santarelli, L., Malapani, C., Moore, H. M., & Hen, R. (2006) · Nature Neuroscience · doi:10.1038/nn1696 · Cited by 458 · see citing works

VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants

Warner-Schmidt, J. L., & Duman, R. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610282104 · Cited by 438 · see citing works

Dysregulation of the fibroblast growth factor system in major depression

Evans, S. J., Choudary, P. V., Neal, C. R., Li, J. Z., Vawter, M. P., Tomita, H., Lopez, J. F., Thompson, R. C., Meng, F., Stead, J. D., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406788101 · Cited by 424 · see citing works

Stress-induced elevation of glucocorticoids increases microglia proliferation through NMDA receptor activation

Nair, A., & Bonneau, R. H. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.09.012 · Cited by 392 · see citing works

The role of inflammatory mediators in the biology of major depression: Central nervous system cytokines modulate the biological substrate of depressive symptoms, regulate stress-responsive systems, and contribute to neurotoxicity and neuroprotection

Licinio, J., & Wong, M.-L. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000586 · Cited by 380 · see citing works

Glucocortcoids mediate the stress-induced extracellular accumulation of glutamate

Moghaddam, B., Bolinao, M. L., Stein-Behrens, B., & Sapolsky, R. (1994) · Brain Research · doi:10.1016/0006-8993(94)91622-5 · Cited by 378 · see citing works

Plasma Protein Biomarkers for Depression and Schizophrenia by Multi Analyte Profiling of Case-Control Collections

Domenici, E., Willé, D. R., Tozzi, F., Prokopenko, I., Miller, S. L., McKeown, A., Brittain, C. F., Rujescu, D., Giegling, I., Turck, C. W., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009166 · Cited by 347 · see citing works

Short-term glucocorticoid manipulations affect neuronal morphology and survival in the adult dentate gyrus

Gould, E. A., Woolley, C. S., & McEwen, B. S. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90407-u · Cited by 334 · see citing works

Chronic Stress Induced Remodeling of the Prefrontal Cortex: Structural Re-Organization of Microglia and the Inhibitory Effect of Minocycline

Hinwood, M., Tynan, R. J., Charnley, J. L., Beynon, S. B., Day, T. A., & Walker, F. R. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs151 · Cited by 325 · see citing works

Acute and Chronic Stress-Induced Disturbances of Microglial Plasticity, Phenotype and Function

Walker, F. R., Nilsson, M., & Jones, K. (2013) · Current Drug Targets · doi:10.2174/13894501113149990208 · Cited by 324 · see citing works

Evidence for synaptic stripping by cortical microglia

Trapp, B. D., Wujek, J. R., Criste, G. A., Jalabi, W., Yin, X., Kidd, G. J., Stohlman, S. A., & Ransohoff, R. M. (2006) · Glia · doi:10.1002/glia.20462 · Cited by 318 · see citing works

Fractalkine regulation of microglial physiology and consequences on the brain and behavior

Paolicelli, R. C., Bisht, K., & Tremblay, M. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00129 · Cited by 314 · see citing works

Polymorphisms in Inflammation-Related Genes Are Associated with Susceptibility to Major Depression and Antidepressant Response

Wong, M.-L., Dong, C., Maestre-Mesa, J., & Licinio, J. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.59 · Cited by 295 · see citing works

Clinical and Biochemical Manifestations of Depression: Relation to the Neurobiology of Stress

Gold, P. W., Machado-Vieira, R., & Pavlatou, M. G. (2015) · Neural Plasticity · doi:10.1155/2015/581976 · Cited by 259 · cited 7× · see citing works

Altered microglia morphology and higher resilience to stress-induced depression-like behavior in CX3CR1-deficient mice

Hellwig, S., Brioschi, S., Dieni, S., Frings, L., Masuch, A., Blank, T., & Biber, K. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.11.008 · Cited by 252 · see citing works

Fractalkine receptor deficiency impairs microglial and neuronal responsiveness to chronic stress

Milior, G., Lecours, C., Samson, L., Bisht, K., Poggini, S., Pagani, F., Deflorio, C., Lauro, C., Alboni, S., Limatola, C., et al. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.07.024 · Cited by 247 · see citing works

Stress induced morphological microglial activation in the rodent brain: Involvement of interleukin-18

Sugama, S., Fujita, M., Hashimoto, M., & Conti, B. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.02.043 · Cited by 216 · see citing works

Identifying blood biomarkers for mood disorders using convergent functional genomics

Le-Niculescu, H., Kurian, S. M., Yehyawi, N., Dike, C., Patel, S. D., Edenberg, H. J., Tsuang, M. T., Salomon, D. R., Nürnberger, J. I., & Niculescu, A. B. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.11 · Cited by 211 · see citing works

Age‐dependent expression of glucocorticoid‐ and mineralocorticoid receptors on neural precursor cell populations in the adult murine hippocampus

Garcia, A. D. R., Steiner, B., Kronenberg, G., Bick‐Sander, A., & Kempermann, G. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00130.x · Cited by 209 · see citing works

Heat stress-induced memory impairment is associated with neuroinflammation in mice

Lee, W., Moon, M., Kim, H. G., Lee, T. H., & Oh, M. S. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0324-6 · Cited by 188 · see citing works

The role of mTOR in depression and antidepressant responses

Abelaira, H. M., Réus, G. Z., Neotti, M. V., & Quevedo, J. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.02.014 · Cited by 186 · see citing works

Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus

Frank, M. G., Hershman, S. A., Weber, M. D., Watkins, L. R., & Maier, S. F. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.11.006 · Cited by 183 · see citing works

A role for microglia in synaptic plasticity?

Tremblay, M.-È., & Majewska, A. K. (2011) · Communicative &amp; Integrative Biology · doi:10.4161/cib.4.2.14506 · Cited by 176 · see citing works

Chemokines Promote Quiescence and Survival of Human Neural Progenitor Cells

Krathwohl, M. D., & Kaiser, J. L. (2004) · Stem Cells · doi:10.1634/stemcells.22-1-109 · Cited by 168 · see citing works

Central administration of insulin-like growth factor-I decreases depressive-like behavior and brain cytokine expression in mice

Park, S.-E., Dantzer, R., Kelley, K. W., & McCusker, R. H. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-12 · Cited by 157 · see citing works

Induction of cyclooxygenase-2 accounts for restraint stress-induced oxidative status in rat brain

Madrigal, J. L. M., Moro, M. A., Lizasoain, I., Lorenzo, P., Fernández, A. P., Rodrigo, J., Boscá, L., & Leza, J. C. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300187 · Cited by 155 · see citing works

Knockdown of the glucocorticoid receptor alters functional integration of newborn neurons in the adult hippocampus and impairs fear-motivated behavior

Fitzsimons, C. P., van Hooijdonk, L. W. A., Schouten, M., Zalachoras, I., Brinks, V., Zheng, T., Schouten, T. G., Saaltink, D., Dijkmans, T. F., Steindler, D. A., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.123 · Cited by 147 · see citing works

Sequential development of synapses in dendritic domains during adult neurogenesis

Kelsch, W., Lin, C.-W., & Lois, C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807970105 · Cited by 145 · see citing works

Prenatal stress is a vulnerability factor for altered morphology and biological activity of microglia cells

Ślusarczyk, J., Trojan, E., Głombik, K., Budziszewska, B., Kubera, M., Lasoń, W., Popiołek-Barczyk, K., Mika, J., Wędzony, K., & Basta‐Kaim, A. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00082 · Cited by 135 · see citing works

GSK-3β overexpression causes reversible alterations on postsynaptic densities and dendritic morphology of hippocampal granule neurons in vivo

Llorens-Martı́n, M., Fuster-Matanzo, A., Teixeira, C. M., Jurado‐Arjona, J., Ulloa, F., DeFelipe, J., Rábano, A., Hernández, F., Soriano, E., & Ávila, J. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.4 · Cited by 133 · see citing works

Insights from interferon-α-related depression for the pathogenesis of depression associated with inflammation

Hoyo-Becerra, C., Schlaak, J., & Hermann, D. M. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.06.200 · Cited by 117 · see citing works

Stress-induced cytokine changes in rats

Himmerich, H., Fischer, J., Bauer, K., Kirkby, K. C., Sack, U., & Krügel, U. (2013) · European Cytokine Network · doi:10.1684/ecn.2013.0338 · Cited by 107 · see citing works

Long-term deficiency of circulating and hippocampal insulin-like growth factor I induces depressive behavior in adult mice: a potential model of geriatric depression

Mitschelen, M., Yan, H., Farley, J. A., Warrington, J. P., Han, S., Hereñú, C. B., Csiszar, A., Ungvari, Z., Bailey-Downs, L. C., Bass, C. E., et al. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.04.032 · Cited by 103 · see citing works

Glucocorticoids facilitate the retention of acquired immobility during forced swimming

Veldhuis, H. D., Korte, C. C. M. M. D., & de Kloet, E. R. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90693-4 · Cited by 103 · see citing works

Increasing the Levels of Insulin-Like Growth Factor-I by an IGF Binding Protein Inhibitor Produces Anxiolytic and Antidepressant-Like Effects

Malberg, J. E., Platt, B., Rizzo, S. J. S., Ring, R. H., Lucki, I., Schechter, L. E., & Rosenzweig-Lipson, S. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301358 · Cited by 101 · see citing works

Depression, traumatic stress and interleukin-6

Bob, P., Raboch, J., Maes, M., Susta, M., Pavlat, J., Jasova, D., Vevera, J., Uhrova, J., Benakova, H., & Zima, T. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.03.017 · Cited by 97 · see citing works

Inflammation and increased IDO in hippocampus contribute to depression-like behavior induced by estrogen deficiency

Xu, Y., Sheng, H., Tang, Z., Lu, J., & Ni, X. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.04.017 · Cited by 94 · see citing works

Effect of acute heat stress on adrenocorticotropic hormone, cortisol, interleukin-2, interleukin-12 and apoptosis gene expression in rats

WANG, L., Liu, F., Luo, Y., Zhu, L., & Li, G. (2015) · Biomedical Reports · doi:10.3892/br.2015.445 · Cited by 91 · see citing works

Peripheral Chemokine Levels in Women with Recurrent Major Depression with Suicidal Ideation

Grassi-Oliveira, R., Brieztke, E., Teixeira, A., Pezzi, J. C., Zanini, M., Lopes, R. P., & Bauer, M. E. (2012) · Revista Brasileira de Psiquiatria · doi:10.1590/s1516-44462012000100013 · Cited by 91 · cited 1× · see citing works

Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behaviour responses to systemic poly I:C

Murray, C., Griffin, É. W., O'Loughlin, E. K., Lyons, A., Sherwin, E., Ahmed, S., Stevenson, N. J., Harkin, A., & Cunningham, C. M. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.04.009 · Cited by 87 · see citing works

Novel connection between newborn granule neurons and the hippocampal CA2 field

Llorens-Martín, M., Jurado-Arjona, J., Avila, J., & Hernández, F. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2014.10.021 · Cited by 83 · see citing works

Antidepressant Compounds Can Be Both Pro- and Anti-Inflammatory in Human Hippocampal Cells

Horowitz, M. A., Wertz, J., Zhu, D., Cattaneo, A., Musaelyan, K., Nikkheslat, N., Thuret, S., Pariante, C. M., & Zunszain, P. A. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu076 · Cited by 78 · see citing works

Insulin-like growth factor 2 mitigates depressive behavior in a rat model of chronic stress

Luo, Y., Xu, Y., Cao, W.-Y., Zhong, X., Duan, J., Wang, X., Hu, Z., Li, F., Zhang, J.-Y., Zhou, M., et al. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.10.011 · Cited by 76 · see citing works

Increased prevalence of mood disorders and suicidal ideation in type 2 diabetic patients

Ceretta, L. B., Réus, G. Z., Abelaira, H. M., Jornada, L. K., Schwalm, M. T., Hoepers, N., Tomazi, C., Gulbis, K. C., Ceretta, R. A., & Quevedo, J. (2012) · Acta Diabetologica · doi:10.1007/s00592-012-0435-9 · Cited by 73 · see citing works

A pre-conditioning stress accelerates increases in mouse plasma inflammatory cytokines induced by stress

Cheng, Y., Jope, R. S., & Beurel, E. (2015) · BMC Neuroscience · doi:10.1186/s12868-015-0169-z · Cited by 70 · see citing works

Both increases in immature dentate neuron number and decreases of immobility time in the forced swim test occurred in parallel after environmental enrichment of mice

Llorens-Martı́n, M., Rueda, N., Martínez‐Cué, C., Torres‐Alemán, I., Flórez, J., & Trejo, J. L. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.04.054 · Cited by 69 · see citing works

Advances in Biomarkers of Major Depressive Disorder

Huang, T., & Lin, C.-C. (2015) · Advances in clinical chemistry · doi:10.1016/bs.acc.2014.11.003 · Cited by 67 · see citing works

Peripherally triggered and GSK-3β-driven brain inflammation differentially skew adult hippocampal neurogenesis, behavioral pattern separation and microglial activation in response to ibuprofen

Llorens-Martı́n, M., Jurado‐Arjona, J., Fuster-Matanzo, A., Hernández, F., Rábano, A., & Ávila, J. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.92 · Cited by 67 · see citing works

The effects of depression and use of antidepressive medicines during pregnancy on the methylation status of the IGF2 imprinted control regions in the offspring

Soubry, A., Murphy, S. K., Huang, Z., Murtha, A. P., Schildkraut, J. M., Jirtle, R. L., Wang, F., Kurtzberg, J., Demark‐Wahnefried, W., Forman, M., et al. (2011) · Clinical Epigenetics · doi:10.1186/1868-7083-3-2 · Cited by 67 · see citing works

Depolarization induces downregulation of DNMT1 and DNMT3 in primary cortical cultures

Sharma, R. P., Tun, N., & Grayson, D. R. (2008) · Epigenetics · doi:10.4161/epi.3.2.6103 · Cited by 63 · see citing works

Autoantibodies and depression

Iseme, R. A., McEvoy, M., Kelly, B. J., Agnew, L. L., Attia, J., & Walker, F. R. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.01.008 · Cited by 51 · see citing works

Toward Omics-Based, Systems Biomedicine, and Path and Drug Discovery Methodologies for Depression-Inflammation Research

Maes, M. H. J., Nowak, G., Caso, J. R., Leza, J. C., Song, C., Kubera, M., Klein, H. C., Gałecki, P., Noto, C. D. S., Glaab, E., et al. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9183-5 · Cited by 49 · see citing works

Involvement of fractalkine and macrophage inflammatory protein‐1 alpha in moderate‐severe depression

Merendino, R. A., Di Pasquale, G., De Luca, F., Di Pasquale, L., Ferlazzo, E., Martino, G., Palumbo, M. C., Morabito, F., & Gangemi, S. (2004) · Mediators of Inflammation · doi:10.1080/09511920410001713484 · Cited by 47 · see citing works

Hippocampal gene expression in a rat model of depression after electroacupuncture at the Baihui and Yintang acupoints

Duan, D., Yang, X., Tu, Y., & Chen, L. (2014) · Neural Regeneration Research · doi:10.4103/1673-5374.125333 · Cited by 39 · see citing works

Mifepristone Prevents Stress-Induced Apoptosis in Newborn Neurons and Increases AMPA Receptor Expression in the Dentate Gyrus of C57/BL6 Mice

Llorens-Martı́n, M., & Trejo, J. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028376 · Cited by 36 · see citing works

Serum IL-7 and G-CSF in major depressive disorder

Lehto, S. M., Huotari, A., NISKANEN, L. K., Herzig, K., Tolmunen, T., Viinamäki, H. T., Koivumaa-Honkanen, H. T., Honkalampi, K. M., Sinikallio, S., Ruotsalainen, H. J., et al. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.03.033 · Cited by 34 · see citing works

Peripheral Eotaxin-1 (CCL11) Levels and Mood Disorder Diagnosis in a Population-Based Sample of Young Adults

Magalhaes, P. V. S., Jansen, K., Stertz, L., Ferrari, P., Pinheiro, R. T., da Silva, R. A., & Kapczinski, F. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.10.007 · Cited by 33 · see citing works

Stress susceptibility-specific phenotype associated with different hippocampal transcriptomic responses to chronic tricyclic antidepressant treatment in mice

Lisowski, P., Juszczak, G. R., Gościk, J., Stankiewicz, A. M., Wieczorek, M., Zwierzchowski, L., & Swiergiel, A. H. (2013) · BMC Neuroscience · doi:10.1186/1471-2202-14-144 · Cited by 30 · see citing works

Serotonin gene polymorphisms and lifetime mood disorders in predicting interferon-induced depression in chronic hepatitis C

Cozzolongo, R., Porcelli, P., Cariola, F., Giannuzzi, V., Lanzilotta, E., Gentile, M., Sonnante, G., & Leandro, G. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.04.056 · Cited by 18 · see citing works

Behavioral analysis during the forced swimming test using a joystick device

Gersner, R., Dar, D. E., Shabat-Simon, M., & Zangen, A. (2004) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.09.017 · Cited by 17 · see citing works

Association between Interlukin-6 (IL-6), Interlukin-10 (IL-10) and depression in patients undergoing Hematopoietic stem cell transplantation.

Ardakani, M. T., Mehrpooya, M., Mehdizadeh, M., Hajifathali, A., & Abdolahi, A. (2015) · PubMed Central · Cited by 17 · see citing works

Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression

Wang, H., He, Y., Sun, Z., Ren, S., Liu, M., Wang, G., & Yang, J. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02492-0 · Cited by 591 · see citing works

Adult neurogenesis, glia, and the extracellular matrix

Cope, E. C., & Gould, E. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.03.023 · Cited by 236 · see citing works

Absence of CX3CR1 impairs the internalization of Tau by microglia

Bolós, M., Llorens-Martín, M., Perea, J. R., Jurado-Arjona, J., Rábano, A., Hernández, F., & Avila, J. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0200-1 · Cited by 231 · see citing works

Alzheimer’s disease as an inflammatory disease

Bolós, M., Perea, J. R., & Avila, J. (2017) · BioMolecular Concepts · doi:10.1515/bmc-2016-0029 · Cited by 216 · see citing works

Adult neurogenesis in the mammalian dentate gyrus

Abbott, L. C., & Nigussie, F. (2019) · Anatomia Histologia Embryologia · doi:10.1111/ahe.12496 · Cited by 171 · see citing works

Absence of microglial CX3CR1 impairs the synaptic integration of adult-born hippocampal granule neurons

Bolós, M., Perea, J. R., Terreros‐Roncal, J., Pallas‐Bazarra, N., Jurado‐Arjona, J., Ávila, J., & Llorens-Martı́n, M. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.10.002 · Cited by 109 · see citing works

Neurobehavioral comorbidities of epilepsy: Role of inflammation

Mazarati, A. M., Lewis, M. L., & Pittman, Q. J. (2017) · Epilepsia · doi:10.1111/epi.13786 · Cited by 96 · see citing works

The emerging tale of microglia in psychiatric disorders

Rahimian, R., Wakid, M., O’Leary, L. A., & Mechawar, N. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.023 · Cited by 91 · see citing works

The protective effects of resveratrol on social stress-induced cytokine release and depressive-like behavior

Finnell, J. E., Lombard, C. M., Melson, M. N., Singh, N. P., Nagarkatti, M., Nagarkatti, P. S., Fadel, J. R., Wood, C. S., & Wood, S. K. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.08.019 · Cited by 86 · see citing works

Adult-Born Hippocampal Neurons Undergo Extended Development and Are Morphologically Distinct from Neonatally-Born Neurons

Cole, J. D., Espinueva, D. F., Seib, D. R., Ash, A. M., Cooke, M. B., Cahill, S. P., O’Leary, T. P., Kwan, S. S., & Snyder, J. S. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1665-19.2020 · Cited by 83 · see citing works

Neuroinflammatory alterations in trait anxiety: modulatory effects of minocycline

Rooney, S., Sah, A., Unger, M. S., Kharitonova, M. V., Sartori, S. B., Schwarzer, C., Aigner, L., Kettenmann, H., Wolf, S. A., & Singewald, N. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00942-y · Cited by 65 · see citing works

Epilepsy Associated Depression: An Update on Current Scenario, Suggested Mechanisms, and Opportunities

Singh, T., & Goel, R. K. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03274-5 · Cited by 51 · see citing works

The Social Component of Environmental Enrichment Is a Pro-neurogenic Stimulus in Adult c57BL6 Female Mice

Moreno‐Jiménez, E. P., Jurado‐Arjona, J., Ávila, J., & Llorens-Martı́n, M. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00062 · Cited by 42 · see citing works

Melatonin Reverses the Depression-associated Behaviour and Regulates Microglia, Fractalkine Expression and Neurogenesis in Adult Mice Exposed to Chronic Mild Stress

Vega‐Rivera, N. M., Ortíz‐López, L., Granados-Juárez, A., Estrada-Camarena, E. M., & Ramírez-Rodríguez, G. B. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.05.014 · Cited by 39 · see citing works

Establishing an osteoimmunomodulatory coating loaded with aspirin on the surface of titanium primed with phase-transited lysozyme

Zhang, W., Lu, X., Yuan, Z., Shen, M., Song, Y., Liu, H., Deng, J., Zhong, X., & Zhang, X. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s190766 · Cited by 32 · see citing works

The GSK‐3‐inhibitor VP2.51 produces antidepressant effects associated with adult hippocampal neurogenesis

Pérez-Domper, P., Palomo, V., Gradari, S., Gil, C., de Ceballos, M. D., Martínez, A., & Trejo, J. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.12.019 · Cited by 29 · see citing works

Do changes in microglial status underlie neurogenesis impairments and depressive-like behaviours induced by psychological stress? A systematic review in animal models

Nieto-Quero, A., Chaves-Peña, P., Santín, L. J., Pérez‐Martín, M., & Pedraza, C. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100356 · Cited by 31 · see citing works

MicroRNA-22 Controls Aberrant Neurogenesis and Changes in Neuronal Morphology After Status Epilepticus

Beamer, E. H., Jurado‐Arjona, J., Jimenez-Mateos, E. M., Morgan, J., Reschke, C. R., Kenny, A., de Leo, G., Olivos-Oré, L. A., Arribas-Blázquez, M., Madden, S. F., et al. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00442 · Cited by 27 · see citing works

The triangular relationship of physical activity, depression, and inflammatory markers: A large cross-sectional analysis with NHANES data

Guo, X., & Le, Y. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.09.008 · Cited by 25 · see citing works

Exercising New Neurons to Vanquish Alzheimer Disease

Llorens-Martı́n, M. (2018) · Brain Plasticity · doi:10.3233/bpl-180065 · Cited by 24 · see citing works

Schisantherin B Improves the Pathological Manifestations of Mice Caused by Behavior Desperation in Different Ages-Depression with Cognitive Impairment

Xu, M., Xiao, F., Wang, M., Yan, T., Yang, H., Wu, B., Bi, K., & Jia, Y. (2018) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2018.074 · Cited by 24 · see citing works

Decreased plasma glial cell line-derived neurotrophic factor level in major depressive disorder is associated with age and clinical severity

Sun, J., Kong, L., Wu, F., Wei, Y., Zhu, Y., Yin, Z., Deng, X., Jiang, X., Tang, Y., & Wang, F. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.11.068 · Cited by 22 · see citing works

Untold New Beginnings: Adult Hippocampal Neurogenesis and Alzheimer’s Disease

Teixeira, C. M., Pallas‐Bazarra, N., Bolós, M., Terreros‐Roncal, J., Ávila, J., & Llorens-Martı́n, M. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-179918 · Cited by 20 · see citing works

Stress, hippocampal neurogenesis and cognition: functional correlations

Lucassen, P. J., & Oomen, C. A. (2016) · Frontiers in Biology · doi:10.1007/s11515-016-1412-4 · Cited by 20 · see citing works

Combined use of dasatinib and quercetin alleviates overtraining-induced deficits in learning and memory through eliminating senescent cells and reducing apoptotic cells in rat hippocampus

Wang, C., Kang, Y., Liu, P., Liu, W., Chen, W., Hayashi, T., Mizuno, K., Hattori, S., Fujisaki, H., & Ikejima, T. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114260 · Cited by 18 · see citing works

Azithromycin preserves adult hippocampal neurogenesis and behavior in a mouse model of sepsis

Rodríguez-Moreno, C. B., Cañeque‐Rufo, H., Flor‐García, M., Terreros‐Roncal, J., Moreno‐Jiménez, E. P., Pallas‐Bazarra, N., Bressa, C., Larrosa, M., Cafini, F., & Llorens-Martı́n, M. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.01.005 · Cited by 15 · see citing works

Enriched Environment Attenuates Enhanced Trait Anxiety in Association with Normalization of Aberrant Neuro-Inflammatory Events

Sah, A., Rooney, S., Kharitonova, M. V., Sartori, S. B., Wolf, S. A., & Singewald, N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113052 · Cited by 17 · see citing works

Maturation dynamics of the axon initial segment (AIS) of newborn dentate granule cells in young adult C57BL/6J mice

Bolós, M., Terreros-Roncal, J., Perea, Jr., Pallas-Bazarra, N., Ávila, J., & Llorens-Martín, M. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.2253-18.2019 · Cited by 14 · see citing works

Early Life Stress- and Sex-Dependent Effects on Hippocampal Neurogenesis

Lucassen, P. J., Kőrösi, A., Krugers, H. J., & Oomen, C. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802175-0.00013-9 · Cited by 10 · see citing works

New insights into hypothalamic neurogenesis disruption after acute and intense stress: implications for microglia and inflammation

Infantes-López, M. I., Nieto-Quero, A., Chaves-Peña, P., Zambrana-Infantes, E. N., Cifuentes, M., Márquez, J., Pedraza, C., & Pérez‐Martín, M. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1190418 · Cited by 9 · see citing works

Maturation of newborn neurons predicts social memory persistence in mice

Jaimes, L. F., Mansk, L. M. Z., Almeida‐Santos, A. F., & Pereira, G. S. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108102 · Cited by 7 · see citing works

How Swimming Modulates Inflammatory Pathways in Pain, Neurodegenerative, and Metabolic Disorders

Kooshki, M., Rezeai-Farimani, R., Moradpour, A., Rahimi, V. B., & Askari, V. R. (2025) · Brain Sciences · doi:10.3390/brainsci15101121 · Cited by 3 · see citing works

Immunomodulatory T cell death associated gene-8 (TDAG8) receptor in depression-associated behaviors

McMurray, K. M. J., Vollmer, L. L., Ahlbrand, R. A., Thomas, J. D., Winter, A. S., Lewkowich, I. P., & Sah, R. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.112598 · Cited by 3 · see citing works

The effects of agomelatine on cognitive functions and neurogenesis in male and female rats subjected to acute stress

Bakkaloğlu, U., Tan, B., Yazgan, K., Yalçın, B., Yay, A. H., Babür, E., & Gölgeli, A. (2025) · Neurophysiology · doi:10.1007/s11062-026-10006-4 · Cited by 1 · see citing works

Depression in Epilepsy

Kwon, O. (2024) · Springer eBooks · doi:10.1007/978-981-97-1821-4_12 · Cited by 1 · see citing works

Pubertal maternal presence reduces anxiety and increases adult neurogenesis in Kunming mice offspring

Yu, P., Cheng, M., Wang, N., Wu, C., & qiang, K. (2024) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2024.173839 · Cited by 1 · see citing works

Generation of Neurons and Their Integration in Pre-Existing Circuits in the Postnatal Brain: Signalling in Physiological and Regenerative Contexts

Mira, H., Díez del Corral, R., & Morales, A. V. (2020) · Frontiers research topics · doi:10.3389/978-2-88963-988-5

Faculty Opinions recommendation of Neuroinflammatory alterations in trait anxiety: modulatory effects of minocycline.

Hollander, E., & Uzunova, G. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.738414892.793578080

What do we know about adult mammalian hippocampal neurogenesis so far?

Jeremić, R., Brkić, P., & Đačić, S. (2024) · Medicinski podmladak · doi:10.5937/mp75-42260

Reversal of Maternal Heat Stress-Induced Social Behavioral Deficits in Offspring: The Role of Beta-Hydroxybutyrate in Regulating Neurogenesis and NeuroinflammationPreprint

Zhu, X., Zhang, Z., Gong, X., Zhao, T., Li, Y., Lv, H., Wu, Y., Huang, J., Zhao, S., & Qing, S. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5173199

Additional file 1 of Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression

Wang, H., He, Y., Sun, Z., Ren, S., Liu, M., Wang, G., & Yang, J. (2022) · Figshare · doi:10.6084/m9.figshare.20012331

Redefining post-stress depression as a spatiotemporal five-disease multimorbidity trajectory: ghrelin-driven anchoring by Shugan absorbed compounds

Huang, X., Zhou, R., Xu, C., Qian, H., Huang, Y., Gao, Z., 赵秋龙, Xu, M., Shi, S., 于爱玲, et al. (2026) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2026.1004159

Neuronal Overexpression of Glycogen Synthase Kinase‐3β Accelerates Age‐Related Glial, Vascular, and Inflammatory Remodeling of the Murine Dentate Gyrus

Prádanos-Senén, A. V., Rodríguez-Moreno, C. B., & Llorens-Martı́n, M. (2026) · Glia · doi:10.1002/glia.70248

Repeated forced swimming impairs prepulse inhibition and alters brain-derived neurotrophic factor and astroglial parameters in rats

Borsoï, M., Antonio, C. B., Müller, L. G., Viana, A. F., Hertzfeldt, V., Lunardi, P. S., Zanotto, C., Nardin, P., Ravazzolo, A. P., Rates, S. M. K., et al. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.11.012 · Cited by 27 · see citing works

Neonatal Proinflammatory Stress Modifies Maturation of Parvalbumin—Perineuronal Net Markers and Elicits Sex-Dependent Microglial Changes in Hippocampus of Juvenile Rats

Манолова, А. О., Kvichansky, A. A., Odrinskaya, М. S., Лазарева, Н. А., Stepanichev, M. Y., & Gulyaeva, N. V. (2026) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093026600326

Swimming exercise reverses chronic unpredictable mild stress–induced depression-like behaviors and alleviates neuroinflammation and collapsing response mediator protein-2–mediated neuroplasticity injury in adult male mice

Xie, Y., Wu, Z., Sun, L., Zhou, L., Xiao, L., Wang, H., & Wang, G. (2022) · Neuroreport · doi:10.1097/wnr.0000000000001779 · Cited by 14 · see citing works

Effects of Forced Swimming Stress on ERK and Histone H3 Phosphorylation in Limbic Areas of Roman High- and Low-Avoidance Rats

Morello, N., Plicato, O., Piludu, M. A., Poddighe, L., Serra, M. P., Quartu, M., Corda, M. G., Giorgi, O., & Giustetto, M. (2017) · PLOS ONE · doi:10.1371/journal.pone.0170093 · Cited by 19 · see citing works

Eur. J. Neurosci.

Bilang‐Bleuel, A., Ulbricht, S., Chandramohan, Y., Carli, S., Droste, S., & Reul, J. (2005) · MPG.PuRe (Max Planck Society)