Cited by 218Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsNeurological Disease Mechanisms and Treatments

Alzheimer’s disease as an inflammatory disease

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Bolós, Marta, Perea, Juan Ramón, Avila, Jesús·2017·BioMolecular Concepts

Abstract

Alzheimer's disease (AD) is a neurodegenerative condition characterized by the formation of amyloid-β plaques, aggregated and hyperphosphorylated tau protein, activated microglia and neuronal cell death, ultimately leading to progressive dementia. In this short review, we focus on neuroinflammation in AD. Specifically, we describe the participation of microglia, as well as other factors that may contribute to inflammation, in neurodegeneration.

Integrity signals

Registry

Crossref · 10.1515/bmc-2016-0029

Cites

89 of 89 references verified0 citation errors · 0 not checkable

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  • Persistent activation of microglia and astrocytes elevates inflammatory mediators like chemokines and cytokines, and ROS and RNS release, with neurotoxic effects and responsible for chronic neurological/neurodegenerative disorders.

    “Persistent activation of microglia and astrocytes elevates inflammatory mediators like chemokines and cytokines [79], the ROS and RNS release, with neurotoxic effects and responsible for chronic neurological/neurodegenerative disorders [80,81,82].”

    From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [79]

  • In Alzheimer's disease, the increase in soluble Aβ oligomeric species, aggregated Aβ plaques and neurofibrillary tangles of hyperphosphorylated Tau proteins leads to activation of microglia and thus to neuroinflammation.

    “In AD, the increase in soluble Aβ oligomeric species, aggregated Aβ plaques and neurofibrillary tangles of hyperphosphorylated Tau proteins leads to activation of microglia and thus to neuroinflammation [79,139,140].”

    From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [79]

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Authors
Bolós, M., Perea, J. R., & Avila, J.
Affiliations
  • Consejo Superior de Investigaciones Científicas (ES)
  • Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED) , Valderrebollo 5 , - Madrid , Spain
Venue
BioMolecular Concepts
Published
2017-02-23
Volume
8
Issue
1
Pages
37-43
ISSN
  • 1868-5021 (ISSN-L)
  • 1868-503X
OpenAlex
W2589440020
Cited by
216
References
90
Citations by year
2026: 7 · 2025: 17 · 2024: 11 · 2023: 18 · 2022: 20 · 2021: 44 · 2020: 23 · 2019: 27 · 2018: 34 · 2017: 15
FWCI
2.60
Type
journal article
Language
en
Open access
Locations
  • BioMolecular Concepts (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords
Alzheimer's disease, neuroinflammation, microglia, amyloid plaques, tau hyperphosphorylation, neurodegeneration, dementia, neuronal cell death
MeSH terms
Alzheimer Disease, Animals, Humans, Inflammation, tau Proteins, Microglia, Neurodegenerative Diseases

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