Depression, traumatic stress and interleukin-6
Abstract
Background Recent evidence indicates that various types of interactions between nervous and immune system are important in pathogenesis of depression. These findings show that a significant role in developing depression play pro-inflammatory cytokines that may mediate its psychological, and neurobiological manifestations. Great importance among these cytokine molecules plays interleukin-6 (IL-6). There is growing evidence that this inflammatory process related to depression may be influenced by psychological stress as well as organic inflammatory conditions. These findings suggest that specific influences related to traumatic stress and dissociation could be found in close relationship to increased level of cytokine IL-6. Methods In the present study we have performed psychometric measurement of depression (BDI-II), traumatic stress symptoms (TSC-40) and dissociation (DES, SDQ-20), and immunochemical measure of serum IL-6 in 40 inpatients with unipolar depression (mean age 42.3+/-6.8). Results The results show that IL-6 is significantly correlated to BDI-II (Spearman R=0.47, p<0.01), TSC-40 (Spearman R=0.32, p<0.05), SDQ-20 (Spearman R=0.34, p<0.05) but not to DES (Spearman R=0.25, p=0.11). Conclusion The findings of the present study indicate that increased level of IL-6 in depression could be directly related to symptoms of traumatic stress and somatoform dissociation.
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Among individuals with depression, higher levels of traumatic stress-related symptoms and somatoform dissociation have been related to higher levels of interleukin-6.
“Interestingly, among individuals with depression, higher levels of traumatic stress-related symptoms and somatoform dissociation have been related to higher levels of interleukin-6 (Bob et al., 2010).”
From A review of the relation between dissociation, memory, executive functioning and social cognition in military members and civilians with neuropsychiatric conditions (2016) · cites this paper as Bob et al., 2010
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- Authors
- Bob, P., Raboch, J., Maes, M., Susta, M., Pavlat, J., Jasova, D., Vevera, J., Uhrova, J., Benakova, H., & Zima, T.
- Affiliations
- Charles University (CZ)
- Corresponding author
- Bob, Petr
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 120
- Issue
- 1-3
- Pages
- 231-234
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2063105933
- Cited by
- 97
- References
- 44
- Citations by year
- 2026: 2 · 2025: 2 · 2023: 1 · 2022: 5 · 2021: 7 · 2020: 7 · 2019: 6 · 2018: 14 · 2017: 3 · 2016: 10 · 2015: 6 · 2014: 6 · 2013: 9 · 2012: 6
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- depression, interleukin-6, traumatic stress, dissociation, somatoform dissociation, inflammatory cytokines, neuroimmune interactions, major depressive disorder, serum cytokine levels, psychological stress
- MeSH terms
- Adult, Depressive Disorder, Dissociative Disorders, Female, Humans, Male, Psychometrics, Severity of Illness Index, Somatoform Disorders, Stress Disorders, Post-Traumatic, Interleukin-6
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