Axonal Transport Enables Neuron-to-Neuron Propagation of Human Coronavirus OC43
Open accessAbstract
Coronaviruses may invade the CNS, disseminate, and participate in the induction of neurological diseases. Their neuropathogenicity is being increasingly recognized in humans, and the presence and persistence of human coronaviruses (HCoV) in human brains have been proposed to cause long-term sequelae. Using our mouse model relying on natural susceptibility to HCoV OC43 and neuronal cell cultures, we have defined the most relevant path taken by HCoV OC43 to access and spread to and within the CNS toward the brain stem and spinal cord and studied in cell culture the underlying modes of intercellular propagation to better understand its neuropathogenesis. Our data suggest that axonal transport governs HCoV OC43 egress in the CNS, leading to the exacerbation of neuropathogenesis. Exploiting knowledge on neuroinvasion and dissemination will enhance our ability to control viral infection within the CNS, as it will shed light on underlying mechanisms of neuropathogenesis and uncover potential druggable molecular virus-host interfaces.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Several RNA viruses can undergo axonal transport to different brain structures causing acute encephalitis.
“Several RNA viruses can undergo axonal transport to different brain structures causing acute encephalitis [164–166].”
From Cognitive decline following acute viral infections: literature review and projections for post-COVID-19 (2022) · cites this paper as [166]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Zaki, A. M., van Boheemen, S., Bestebroer, T. M., Osterhaus, A. D. M. E., & Fouchier, R. A. M. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1211721 · Cited by 5,677 · see citing works
Identification of a novel coronavirus in patients with severe acute respiratory syndrome
Drosten, C., Günther, S., Preiser, W., van der Werf, S., Brodt, H.-R., Becker, S., Rabenau, H., Panning, M., Kolesnikova, L., Fouchier, R. A. M., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030747 · Cited by 4,574 · see citing works
Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome
Rota, P. A., Oberste, M. S., Monroe, S. S., Nix, W. A., Campagnoli, R. P., Icenogle, J. P., Peñaranda, S., Bankamp, B., Maher, K., Chen, M., et al. (2003) · Science · doi:10.1126/science.1085952 · Cited by 2,477 · see citing works
Multiple organ infection and the pathogenesis of SARS
Gu, J., Gong, E., Zhang, B., Zheng, J., Gao, Z., Zhong, Y., Zou, W., Zhan, J., Wang, S., Xie, Z., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050828 · Cited by 1,379 · see citing works
Intranasal delivery of biologics to the central nervous system
Lochhead, J. J., & Thorne, R. G. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.11.002 · Cited by 1,214 · see citing works
Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome
Kuiken, T., Fouchier, R. A. M., Schutten, M., Rimmelzwaan, G. F., van Amerongen, G., van Riel, D. A. J., Laman, J. D., de Jong, T., van Doornum, G., Lim, W. W. L., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13967-0 · Cited by 1,015 · see citing works
CLINICAL VIRAL INFECTIONS AND MULTIPLE SCLEROSIS
SIBLEY, W. (1985) · The Lancet · doi:10.1016/s0140-6736(85)92801-6 · Cited by 595 · see citing works
Pathology and Pathogenesis of Severe Acute Respiratory Syndrome
Gu, J., & Korteweg, C. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.061088 · Cited by 583 · see citing works
Neuroinvasion by Human Respiratory Coronaviruses
Arbour, N., Day, R. W., Newcombe, J., & Talbot, P. J. (2000) · Journal of Virology · doi:10.1128/jvi.74.19.8913-8921.2000 · Cited by 518 · see citing works
Self-citationPossible Central Nervous System Infection by SARS Coronavirus
Lau, K., Yu, W.-C., Chu, C., Lau, S.-T., Sheng, B., & Yuen, K. (2004) · Emerging infectious diseases · doi:10.3201/eid1002.030638 · Cited by 395 · see citing works
van Riel, D., Verdijk, R., & Kuiken, T. (2015) · The Journal of Pathology · doi:10.1002/path.4461 · Cited by 394 · see citing works
Severe neurologic syndrome associated with Middle East respiratory syndrome corona virus (MERS-CoV)
Arabi, Y. M., Alharthi, A. F., Hussein, J., Bouchama, A., Johani, S. A., Hajeer, A. H., Saeed, B. T., Wahbi, A. M. A., Saedy, A., Aldabbagh, T., et al. (2015) · Infection · doi:10.1007/s15010-015-0720-y · Cited by 385 · see citing works
Vlasak, R., Luytjes, W., Spaan, W. J. M., & Palese, P. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.12.4526 · Cited by 351 · see citing works
Yeh, E. A., Collins, A. R., Cohen, M. E., Duffner, P. K., & Faden, H. S. (2004) · PEDIATRICS · doi:10.1542/peds.113.1.e73 · Cited by 329 · see citing works
Human Coronavirus OC43 Associated with Fatal Encephalitis
Morfopoulou, S., Brown, J. R., Davies, E. G., Anderson, G. W., Virasami, A. K., Qasim, W., Chong, W. K., Hubank, M. J. F., Plagnol, V., Desforges, M., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmc1509458 · Cited by 276 · see citing works
Self-citationKatsetos, C. D., Legido, A., Perentes, E., et al. (2003) · Journal of Child Neurology · doi:10.1177/088307380301801205 · Cited by 250 · see citing works
Neurological manifestations in severe acute respiratory syndrome.
Tsai, L., Hsieh, S., & Chang, Y. (2005) · PubMed · Cited by 235 · see citing works
Frana, M. F., Behnke, J. N., Sturman, L. S., et al. (1985) · Journal of Virology · doi:10.1128/jvi.56.3.912-920.1985 · Cited by 213 · see citing works
Li, Y., Li, H., Fan, R., Wen, B., Zhang, J., Cao, X., Wang, C., Song, Z., Li, S., Li, X., et al. (2016) · Intervirology · doi:10.1159/000453066 · Cited by 203 · see citing works
Mechanism of neuroinvasion of Venezuelan equine encephalitis virus in the mouse.
Charles, P. C., Walters, E., Margolis, F. L., & Johnston, R. E. (1995) · Virology · doi:10.1006/viro.1995.1197 · Cited by 200 · see citing works
Human coronavirus OC43 infection induces chronic encephalitis leading to disabilities in BALB/C mice
Jacomy, H., Fragoso, G., Almazán, G., Mushynski, W. E., & Talbot, P. J. (2006) · Virology · doi:10.1016/j.virol.2006.01.049 · Cited by 197 · see citing works
Self-citationHuman coronavirus gene expression in the brains of multiple sclerosis patients
Stewart, J. N., Mounir, S., & Talbot, P. J. (1992) · Virology · doi:10.1016/0042-6822(92)90220-j · Cited by 194 · see citing works
Self-citationCerebrospinal fluid antibodies to coronavirus in patients with Parkinson's disease
Fazzini, E., Fleming, J. O., & Fahn, S. (1992) · Movement Disorders · doi:10.1002/mds.870070210 · Cited by 193 · see citing works
Structure, function and evolution of the hemagglutinin-esterase proteins of corona- and toroviruses
de Groot, R. J. (2006) · Glycoconjugate Journal · doi:10.1007/s10719-006-5438-8 · Cited by 187 · see citing works
Algahtani, H. A., Subahi, A. M., & Shirah, B. H. (2016) · Case Reports in Neurological Medicine · doi:10.1155/2016/3502683 · Cited by 177 · see citing works
Acute and Persistent Infection of Human Neural Cell Lines by Human Coronavirus OC43
Arbour, N., Côté, G., Lachance, C., Tardieu, M., Cashman, N. R., & Talbot, P. J. (1999) · Journal of Virology · doi:10.1128/jvi.73.4.3338-3350.1999 · Cited by 174 · see citing works
Self-citationHuman Respiratory Coronavirus OC43: Genetic Stability and Neuroinvasion
St-Jean, J. R., Jacomy, H., Desforges, M., Vabret, A., Freymuth, F., & Talbot, P. J. (2004) · Journal of Virology · doi:10.1128/jvi.78.16.8824-8834.2004 · Cited by 166 · see citing works
Self-citationSimple piggyBac transposon-based mammalian cell expression system for inducible protein production
Li, Z.-J., Michael, I., Zhou, D., Nagy, A., & Rini, J. (2013) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1218620110 · Cited by 161 · see citing works
Self-citationThe E3 protein of bovine coronavirus is a receptor-destroying enzyme with acetylesterase activity
Vlasak, R., Luytjes, W., Leider, J. M., Spaan, W. J. M., & Palese, P. (1988) · Journal of Virology · doi:10.1128/jvi.62.12.4686-4690.1988 · Cited by 153 · see citing works
Verheije, M. H., Hagemeijer, M. C., Ulaşlı, M., et al. (2010) · Journal of Virology · doi:10.1128/jvi.00569-10 · Cited by 143 · see citing works
Vijgen, L., Keyaerts, E., Moës, E., Maes, P., Duson, G., & Ranst, M. A. V. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.11.5452-5456.2005 · Cited by 132 · see citing works
Effect of olfactory bulb ablation on spread of a neurotropic coronavirus into the mouse brain.
Perlman, S. M., Evans, G., & Afifi, A. K. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.4.1127 · Cited by 129 · see citing works
Vacuolating encephalitis in mice infected by human coronavirus OC43
Jacomy, H., & Talbot, P. J. (2003) · Virology · doi:10.1016/s0042-6822(03)00323-4 · Cited by 128 · see citing works
Self-citationEffects of Coronavirus Infections in Children
Principi, N., Bosis, S., & Esposito, S. (2010) · Emerging infectious diseases · doi:10.3201/eid1602.090469 · Cited by 109 · see citing works
Barnett, E. M., & Perlman, S. M. (1993) · Virology · doi:10.1006/viro.1993.1248 · Cited by 100 · see citing works
Carmo, S. D., Jacomy, H., Talbot, P. J., & Rassart, É. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2644-08.2008 · Cited by 95 · see citing works
Self-citationSpread of a neurotropic murine coronavirus into the CNS via the trigeminal and olfactory nerves
Perlman, S. M., Jacobsen, G., & Afifi, A. K. (1989) · Virology · doi:10.1016/0042-6822(89)90446-7 · Cited by 91 · see citing works
Saksena, M. M., Wakisaka, H., Tijono, B., Boadle, R. A., Rixon, F., Takahashi, H., & Cunningham, A. L. (2006) · Journal of Virology · doi:10.1128/jvi.80.7.3592-3606.2006 · Cited by 89 · see citing works
Assessment of plaque assay methods for alphaviruses
Juárez, D., Long, K. C., Aguilar, P., et al. (2012) · Journal of Virological Methods · doi:10.1016/j.jviromet.2012.09.026 · Cited by 81 · see citing works
Axonal spread of neuroinvasive viral infections
Taylor, M. P., & Enquist, L. W. (2015) · Trends in Microbiology · doi:10.1016/j.tim.2015.01.002 · Cited by 80 · see citing works
Nidovirus Sialate-O-Acetylesterases
Smits, S. L., Gerwig, G. J., van Vliet, A. L. W., Lissenberg, A., Briza, P., Kamerling, J. P., Vlasak, R., & de Groot, R. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409683200 · Cited by 76 · see citing works
Coupanec, A. L., Desforges, M., Meessen-Pinard, M., Dubé, M., Day, R. W., Seidah, N. G., & Talbot, P. J. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005261 · Cited by 72 · see citing works
Self-citationTransolfactory neuroinvasion by viruses threatens the human brain
MORI, I. (2015) · Acta Virologica · doi:10.4149/av_2015_04_338 · Cited by 72 · see citing works
The direct passage of animal viruses between cells
Sattentau, Q. J. (2011) · Current Opinion in Virology · doi:10.1016/j.coviro.2011.09.004 · Cited by 71 · see citing works
Desforges, M., Desjardins, J., Zhang, C., & Talbot, P. J. (2013) · Journal of Virology · doi:10.1128/jvi.02699-12 · Cited by 71 · see citing works
Self-citationBrison, É., Jacomy, H., Desforges, M., & Talbot, P. J. (2013) · Journal of Virology · doi:10.1128/jvi.02972-13 · Cited by 71 · see citing works
Self-citationParticle-to-PFU Ratio of Ebola Virus Influences Disease Course and Survival in Cynomolgus Macaques
Alfson, K. J., Avena, L. E., Beadles, M. W., Staples, H. M., Nunneley, J. W., Ticer, A. E., Dick, E. J., Owston, M. A., Reed, C. D., Patterson, J. L., et al. (2015) · Journal of Virology · doi:10.1128/jvi.00649-15 · Cited by 69 · see citing works
A rare cause of acute flaccid paralysis: Human coronaviruses
Çokyaman, T., Tekin, E., Köken, Ö. Y., Muhammet, S., & Haydar, A. (2015) · Journal of Pediatric Neurosciences · doi:10.4103/1817-1745.165716 · Cited by 69 · see citing works
Brison, É., Jacomy, H., Desforges, M., & Talbot, P. J. (2011) · Journal of Virology · doi:10.1128/jvi.05576-11 · Cited by 68 · see citing works
Self-citationAnalysis of Cellular Receptors for Human Coronavirus OC43
Krempl, C. D., Schultze, B., & Herrler, G. (1995) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-1899-0_60 · Cited by 65 · see citing works
Severity and Outcome Associated With Human Coronavirus OC43 Infections Among Children
Jean, A., Quach, C., Yung, A., & Semret, M. (2013) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e3182812787 · Cited by 65 · see citing works
Vabret, A., Dina, J., Brison, É., Brouard, J., & Freymuth, F. (2008) · Pathologie Biologie · doi:10.1016/j.patbio.2008.02.018 · Cited by 63 · see citing works
Regge, N. D., Nauwynck, H., Geenen, K., Krummenacher, C., Cohen, G. H., Eisenberg, R. J., Mettenleiter, T. C., & Favoreel, H. W. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200510156 · Cited by 60 · see citing works
Cristallo, A. F., Gambaro, F., Biamonti, G., Ferrante, P., Battaglia, M., & Cereda, P. M. (1997) · PubMed · Cited by 58 · see citing works
Bauer, A., Nolden, T., Schröter, J., et al. (2014) · Journal of Virology · doi:10.1128/jvi.02254-14 · Cited by 57 · see citing works
Healthcare-Associated Atypical Pneumonia
Forgie, S. E. D., & Marrie, T. J. (2009) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0028-1119811 · Cited by 56 · see citing works
Mounir, S., & Talbot, P. J. (1992) · Journal of General Virology · doi:10.1099/0022-1317-73-10-2731 · Cited by 56 · see citing works
Self-citationTaylor, M. P., Kramer, T., Lyman, M. G., Kratchmarov, R., & Enquist, L. W. (2012) · mBio · doi:10.1128/mbio.00063-12 · Cited by 54 · see citing works
Favreau, D. J., Desforges, M., St-Jean, J. R., & Talbot, P. J. (2009) · Virology · doi:10.1016/j.virol.2009.09.026 · Cited by 53 · see citing works
Self-citationPasick, J. M. M., Kalicharran, K., & Dales, S. (1994) · Journal of Virology · doi:10.1128/jvi.68.5.2915-2928.1994 · Cited by 52 · see citing works
Zurbach, K. A., Moghbeli, T., & Snyder, C. M. (2014) · Virology Journal · doi:10.1186/1743-422x-11-71 · Cited by 52 · see citing works
Meessen-Pinard, M., Coupanec, A. L., Desforges, M., & Talbot, P. J. (2016) · Journal of Virology · doi:10.1128/jvi.01513-16 · Cited by 50 · see citing works
Self-citationLee, J., & Storch, G. A. (2014) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000000292 · Cited by 48 · see citing works
Jacomy, H., St-Jean, J. R., Brison, É., Marceau, G., Desforges, M., & Talbot, P. J. (2010) · Journal of NeuroVirology · doi:10.3109/13550284.2010.497806 · Cited by 47 · see citing works
Self-citationHoward, P. W., Wright, C. C., Howard, T. L., & Johnson, D. C. (2014) · Journal of Virology · doi:10.1128/jvi.01627-14 · Cited by 41 · see citing works
Bender, S. J., Phillips, J. M., Scott, E. P., & Weiss, S. R. (2010) · Journal of Virology · doi:10.1128/jvi.02688-09 · Cited by 37 · see citing works
Les virus des bronchiolites aiguës
Freymuth, F., Vabret, A., Dina, J., et al. (2010) · Archives de Pédiatrie · doi:10.1016/j.arcped.2010.05.006 · Cited by 35 · see citing works
Bosch, B., de Haan, C. A. M., & Rottier, P. J. M. (2004) · Journal of Virology · doi:10.1128/jvi.78.14.7369-7378.2004 · Cited by 30 · see citing works
Rochel, S. S., & Margolis, F. L. (1980) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1980.tb07082.x · Cited by 30 · see citing works
Pathogenesis of Human Coronaviruses Other than Severe Acute Respiratory Syndrome Coronavirus
Talbot, P. J., Jacomy, H., & Desforges, M. (2014) · ASM Press eBooks · doi:10.1128/9781555815790.ch20 · Cited by 25 · see citing works
Self-citationHill, D. P., & Robertson, K. A. (1998) · Brain Research Protocols · doi:10.1016/s1385-299x(97)00041-x · Cited by 24 · see citing works
Effects of intranasal ZnSO4 irrigation on olfactory and trigeminal cues
Hansen, L. F., Hammer, M., Petersen, S. H., et al. (1994) · Physiology & Behavior · doi:10.1016/0031-9384(94)90047-7 · Cited by 22 · see citing works
Genetic Evolution of Human Coronavirus OC43 in Neural Cell Culture
St-Jean, J. R., Desforges, M., & Talbot, P. J. (2006) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-33012-9_88 · Cited by 19 · see citing works
Self-citationKünkel, F., & Herrler, G. (1996) · Archives of Virology · doi:10.1007/bf01718615 · Cited by 19 · see citing works
Titration of Human Coronaviruses Using an Immunoperoxidase Assay
Lambert, F., Jacomy, H., Marceau, G., et al. (2008) · Journal of Visualized Experiments · doi:10.3791/751 · Cited by 14 · see citing works
Methylcellulose media for plaque assay of murine leukemia virus
Watanabe, T., Horikawa, Y., Sato, K., et al. (1982) · Journal of Clinical Microbiology · doi:10.1128/jcm.16.3.542-544.1982 · Cited by 12 · see citing works
Coronavirus and Multiple Sclerosis: Results of a Case/Control Longitudinal Serological Study
Johnson-Lussenburg, C. M., & Zheng, Q. (1987) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-1280-2_51 · Cited by 10 · see citing works
Background Paper Coronavirus M and HE: Two Peculiar Glycoproteins
Rottier, P. J. M. (1990) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-5823-7_13 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Holmes, E. A., O'Connor, R. C., Perry, V. H., Tracey, I., Wessely, S., Arseneault, L., Ballard, C., Christensen, H., Cohen Silver, R., Everall, I., et al. (2020) · The Lancet Psychiatry · doi:10.1016/s2215-0366(20)30168-1 · Cited by 5,715 · see citing works
Li, Y., Bai, W., & Hashikawa, T. (2020) · Journal of Medical Virology · doi:10.1002/jmv.25728 · Cited by 2,266 · see citing works
Desforges, M., Le Coupanec, A., Dubeau, P., Bourgouin, A., Lajoie, L., Dubé, M., & Talbot, P. J. (2019) · Viruses · doi:10.3390/v12010014 · Cited by 1,048 · see citing works
Self-citationZubair, A. S., McAlpine, L. S., Gardin, T., Farhadian, S., Kuruvilla, D. E., & Spudich, S. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2020.2065 · Cited by 923 · see citing works
Alterations in Smell or Taste in Mildly Symptomatic Outpatients With SARS-CoV-2 Infection
Spinato, G., Fabbris, C., Polesel, J., Cazzador, D., Borsetto, D., Hopkins, C., & Boscolo-Rizzo, P. (2020) · JAMA · doi:10.1001/jama.2020.6771 · Cited by 698 · see citing works
COVID-19: ICU delirium management during SARS-CoV-2 pandemic
Kotfis, K., Williams Roberson, S., Wilson, J. E., Dabrowski, W., Pun, B. T., & Ely, E. W. (2020) · Critical Care · doi:10.1186/s13054-020-02882-x · Cited by 506 · see citing works
Miskowiak, K., Johnsen, S., Sattler, S., Nielsen, S., Kunalan, K., Rungby, J., Lapperre, T., & Porsberg, C. (2021) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2021.03.019 · Cited by 365 · see citing works
Neuroinfection may contribute to pathophysiology and clinical manifestations of COVID‐19
Steardo, L., Steardo, L., Zorec, R., & Verkhratsky, A. (2020) · Acta Physiologica · doi:10.1111/apha.13473 · Cited by 367 · see citing works
Anosmia in COVID-19: Underlying Mechanisms and Assessment of an Olfactory Route to Brain Infection
Butowt, R., & von Bartheld, C. S. (2021) · The Neuroscientist · doi:10.1177/1073858420956905 · Cited by 345 · see citing works
Spectrum of neuropsychiatric manifestations in COVID-19.
Nalleballe, K., Reddy Onteddu, S., Sharma, R., Dandu, V., Brown, A., Jasti, M., Yadala, S., Veerapaneni, K., Siddamreddy, S., Avula, A., et al. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.06.020 · Cited by 235 · see citing works
Alquisiras-Burgos, I., Peralta-Arrieta, I., Alonso-Palomares, L. A., Zacapala-Gómez, A. E., Salmerón-Bárcenas, E. G., & Aguilera, P. (2021) · Molecular Neurobiology · doi:10.1007/s12035-020-02134-7 · Cited by 115 · see citing works
COVID-19: Review of a 21st Century Pandemic from Etiology to Neuro-psychiatric Implications
Yamamoto, V., Bolanos, J. F., Fiallos, J., Strand, S. E., Morris, K., Shahrokhinia, S., Cushing, T. R., Hopp, L., Tiwari, A., Hariri, R., et al. (2020) · Journal of Alzheimer's Disease · doi:10.3233/jad-200831 · Cited by 100 · see citing works
Damiano, R. F., Guedes, B. F., de Rocca, C. C., de Pádua Serafim, A., Castro, L. H. M., Munhoz, C. D., Nitrini, R., Filho, G. B., Miguel, E. C., Lucchetti, G., et al. (2022) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-021-01286-4 · Cited by 98 · see citing works
Brainstem neuropathology in two cases of COVID-19: SARS-CoV-2 trafficking between brain and lung
Bulfamante, G., Bocci, T., Falleni, M., Campiglio, L., Coppola, S., Tosi, D., Chiumello, D., & Priori, A. (2021) · Journal of Neurology · doi:10.1007/s00415-021-10604-8 · Cited by 83 · see citing works
SARS-CoV-2 Dissemination Through Peripheral Nerves Explains Multiple Organ Injury
Fenrich, M., Mrdenovic, S., Balog, M., Tomic, S., Zjalic, M., Roncevic, A., Mandic, D., Debeljak, Z., & Heffer, M. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00229 · Cited by 95 · see citing works
Imaging Features of Acute Encephalopathy in Patients with COVID-19: A Case Series
Kihira, S., Delman, B. N., Belani, P., Stein, L., Aggarwal, A., Rigney, B., Schefflein, J., Doshi, A. H., & Pawha, P. S. (2020) · American Journal of Neuroradiology · doi:10.3174/ajnr.a6715 · Cited by 38 · see citing works
- Authors
- Dubé, M., Le Coupanec, A., Wong, A. H. M., Rini, J. M., Desforges, M., & Talbot, P. J.
- Affiliations
- Institut National de la Recherche Scientifique (CA)
- Laboratory of Neuroimmunovirology, INRS-Institut Armand-Frappier, Université du Québec, Laval, Québec, Canada
- University of Toronto (CA)
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2018-09
- Volume
- 92
- Issue
- 17
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC6096804
- OpenAlex
- W2808077517
- Cited by
- 452
- References
- 78
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 30 · 2023: 40 · 2022: 75 · 2021: 131 · 2020: 160 · 2019: 2
- FWCI
- 49.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Virology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- EspaceINRS (National Institute for Scientific Research (Canada)) (submittedVersion)
- Funders
- CIHR Institute of infection and immunity (MT-9203)
- Topics
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Keywords
- HCoV-OC43, axonal transport, neuroinvasion, neuropathogenesis, brainstem, spinal cord, host-virus interaction, coronavirus pathogenesis
- MeSH terms
- Animals, Axons, Humans, Nasal Cavity, Olfactory Bulb, Viral Proteins, Coronavirus Infections, Virus Assembly, Coronavirus OC43, Human, Mice, Piriform Cortex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
