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LncRNA 4344 promotes NLRP3-related neuroinflammation and cognitive impairment by targeting miR‐138-5p

Feng, Xiaojin, Zhan, Fenfang, Luo, Deqiang, Hu, Jialing, Wei, Gen, Hua, Fuzhou, Xu, Guohai·2021·Brain, Behavior, and Immunity
DOI 10.1016/j.bbi.2021.08.230
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Abstract

Objective Cognitive impairment is a common neurological disease of which NLRP3-related neuroinflammation has been demonstrated to be an essential mediator. Previous studies have indicated that long non-coding RNAs (lncRNAs) are critical for the development of neurological disorders. However, the roles and functions of lncRNA 4344 in neuroinflammation during cognitive impairment are unknown and need to be further elucidated. Methods Lipopolysaccharide (LPS)-induced rat cognitive impairment and rat microglia (RM) cell inflammation models were established in vitro and in vivo. The Morris water maze test was used to evaluate the cognitive behavior of the rats. Gene expression was assessed using real-time quantitative polymerase chain reaction, and protein levels using enzyme-linked immunosorbent assay, or western blot analysis. The targeting relationship between lncRNA 4344, miR-138-5p, and NLRP3 was identified using bioinformatics analysis and a dual-luciferase reporter gene assay. Hematoxylin-Eosin and Nissl stainings, terminal deoxynucleotidyl transferase dUTP nick end labeling, or immunofluorescence staining assays were performed to detect pathological changes, neuronal apoptosis, or positive cells in hippocampal tissues, respectively. Results The expression levels of lncRNA 4344 and NLRP3 were upregulated in the hippocampal tissues of LPS-treated rats and RM cells, and showed a strong positive correlation between each other. LncRNA 4344 overexpression further enhanced the ex…

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Metadata

Authors
Feng, X., Zhan, F., Luo, D., Hu, J., Wei, G., Hua, F., & Xu, G.
Venue
Brain, Behavior, and Immunity
Publisher
Elsevier BV
Published
2021-11
Volume
98
Pages
283-298
ISSN
0889-1591
DOI
10.1016/j.bbi.2021.08.230
Cited by
66
References
7
Language
en
Licence
Funders
  • National Natural Science Foundation of China (81760208, 81760261)
  • Jiangsu Province Key Laboratory of Anesthesiology (20164BCD40093)

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