Nrf2-dependent persistent oxidative stress results in stress-induced vulnerability to depression

Bouvier, E; Brouillard, F; Molet, J; Claverie, D; Cabungcal, J-H; Cresto, N; Doligez, N; Rivat, C; Do, K Q; Bernard, C; Benoliel, J-J; Becker, C

doi:10.1038/mp.2016.144

Cited by 248Genomics, phytochemicals, and oxidative stressTreatment of Major DepressionRedox biology and oxidative stress

Nrf2-dependent persistent oxidative stress results in stress-induced vulnerability to depression

Open access

Bouvier, E, Brouillard, F, Molet, J, Claverie, D, Cabungcal, J-H, Cresto, N, Doligez, N, Rivat, C +4 more·2017·Molecular Psychiatry

DOI 10.1038/mp.2016.144PMC PMC8127815

Open this paper in CoChat — free account Open PDF

Abstract

Stressful life events produce a state of vulnerability to depression in some individuals. The mechanisms that contribute to vulnerability to depression remain poorly understood. A rat model of intense stress (social defeat (SD), first hit) produced vulnerability to depression in 40% of animals. Only vulnerable animals developed a depression-like phenotype after a second stressful hit (chronic mild stress). We found that this vulnerability to depression resulted from a persistent state of oxidative stress, which was reversed by treatment with antioxidants. This persistent state of oxidative stress was due to low brain-derived neurotrophic factor (BDNF) levels, which characterized the vulnerable animals. We found that BDNF constitutively controlled the nuclear translocation of the master redox-sensitive transcription factor Nrf2, which activates antioxidant defenses. Low BDNF levels in vulnerable animals prevented Nrf2 translocation and consequently prevented the activation of detoxifying/antioxidant enzymes, ultimately resulting in the generation of sustained oxidative stress. Activating Nrf2 translocation restored redox homeostasis and reversed vulnerability to depression. This mechanism was confirmed in Nrf2-null mice. The mice displayed high levels of oxidative stress and were inherently vulnerable to depression, but this phenotype was reversed by treatment with antioxidants. Our data reveal a novel role for BDNF in controlling redox homeostasis and provide a mechanistic explanation for post-stress vulnerability to depression while suggesting ways to reverse it. Because numerous enzymatic reactions produce reactive oxygen species that must then be cleared, the finding that BDNF controls endogenous redox homeostasis opens new avenues for investigation.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/mp.2016.144

Cites

70 of 70 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Redox dysregulation has successfully been targeted to protect PVIs with antioxidants/redox regulators across several animal models.
“As convergent end point, redox dysregulation has successfully been targeted to protect PVIs with antioxidants/redox regulators across several animal models.”
From Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia (2017) · cites this paper as [84]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351 · see citing works
Stress and the brain: from adaptation to disease
de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621 · see citing works
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634 · see citing works
The molecular neurobiology of depression
Krishnan, V., & Nestler, E. J. (2008) · Nature · doi:10.1038/nature07455 · Cited by 2,889 · see citing works
Oxidative stress and neurodegeneration: where are we now?
Halliwell, B. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03907.x · Cited by 2,614 · see citing works
Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions
Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307 · see citing works
H 2 O 2 , a Necessary Evil for Cell Signaling
Rhee, S. G. (2006) · Science · doi:10.1126/science.1130481 · Cited by 2,160 · see citing works
GO::TermFinder–open source software for accessing gene ontology information and finding significantly enriched gene ontology terms associated with a list of genes
Boyle, E. I., Weng, S., Gollub, J., Jin, H., Botstein, D., Cherry, J. M., & Sherlock, G. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth456 · Cited by 2,067 · see citing works
Oxidative stress in Parkinson's disease
Jenner, P. (2003) · Annals of Neurology · doi:10.1002/ana.10483 · Cited by 2,053 · see citing works
Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology
Matés, J. M. (2000) · Toxicology · doi:10.1016/s0300-483x(00)00306-1 · Cited by 1,510 · see citing works
Lasting epigenetic influence of early-life adversity on the BDNF gene
Roth, T. L., Lubin, F. D., Funk, A. J., & Sweatt, J. D. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.028 · Cited by 1,273 · see citing works
Analysis of a form of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis
Kasai, H. (1997) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(97)00035-5 · Cited by 1,140 · see citing works
The cytoprotective role of the Keap1–Nrf2 pathway
Baird, L., & Dinkova‐Kostova, A. T. (2011) · Archives of Toxicology · doi:10.1007/s00204-011-0674-5 · Cited by 1,029 · see citing works
ATP-dependent reduction of cysteine–sulphinic acid by S. cerevisiae sulphiredoxin
Biteau, B., Labarre, J., & Tolédano, M. B. (2003) · Nature · doi:10.1038/nature02075 · Cited by 970 · see citing works
A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone
Jang, S., Liu, X., Yepes, M., Shepherd, K. R., Miller, G. W., Liu, Y., Wilson, W. D., Xiao, G., Blanchi, B., Sun, Y. E., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913572107 · Cited by 689 · see citing works
Oxygen, Reactive Oxygen Species and Tissue Damage
Bergamini, C. M., Gambetti, S., Dondi, A., & Cervellati, C. (2004) · Current Pharmaceutical Design · doi:10.2174/1381612043384664 · Cited by 661 · see citing works
The inactivation of Fe-S cluster containing hydro-lyases by superoxide
Flint, D. H., Tuminello, J. F., & Emptage, M. H. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41538-4 · Cited by 637 · see citing works
Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxides
Rhee, S. G., Woo, H. A., Kil, I. S., & Bae, S. H. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.r111.283432 · Cited by 603 · see citing works
Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase‐related protein 2, α‐enolase and heat shock cognate 71
Castegna, A., Aksenov, M. Y., Thongboonkerd, V., Klein, J. B., Pierce, W. M. J., Booze, R. M., Markesbery, W. R., & Butterfield, D. A. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01103.x · Cited by 581 · see citing works
Effects of tempol and redox-cycling nitroxides in models of oxidative stress
Wilcox, C. S. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.01.003 · Cited by 466 · see citing works
Glutathione is present in high concentrations in cultured astrocytes but not in cultured neurons
Raps, S. P., Lai, J. C. K., Hertz, L., & Cooper, A. J. L. (1989) · Brain Research · doi:10.1016/0006-8993(89)91178-5 · Cited by 417 · see citing works
A Small-Molecule-Inducible Nrf2-Mediated Antioxidant Response Provides Effective Prophylaxis against Cerebral IschemiaIn Vivo
Shih, A. Y., Li, P., & Murphy, T. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4014-05.2005 · Cited by 413 · see citing works
Peripheral BDNF Produces Antidepressant-Like Effects in Cellular and Behavioral Models
Schmidt, H. D., & Duman, R. S. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.114 · Cited by 403 · see citing works
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 396 · see citing works
Brain-derived neurotrophic factor as a state-marker of mood episodes in bipolar disorders: A systematic review and meta-regression analysis
Fernandes, B. S., Gama, C. S., Maria Ceresér, K., Yatham, L. N., Fries, G. R., Colpo, G., de Lucena, D., Kunz, M., Gomes, F. A., & Kapczinski, F. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.03.002 · Cited by 389 · see citing works
Redox dysregulation, neurodevelopment, and schizophrenia
Do, K. Q., Cabungcal, J. H., Frank, A., Steullet, P., & Cuenod, M. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.05.001 · Cited by 384 · see citing works
Self-citation
Chemistry and Antihypertensive Effects of Tempol and Other Nitroxides
Wilcox, C. S., & Pearlman, A. (2008) · Pharmacological Reviews · doi:10.1124/pr.108.000240 · Cited by 377 · see citing works
Oxidative stress in anxiety and comorbid disorders
Hovatta, I., Juhila, J., & Donner, J. (2010) · Neuroscience Research · doi:10.1016/j.neures.2010.08.007 · Cited by 365 · see citing works
Modulation of Oxidant and Antioxidant Enzyme Expression and Function in Vascular Cells
Waßmann, S., Wassmann, K., & Nickenig, G. (2004) · Hypertension · doi:10.1161/01.hyp.0000142232.29764.a7 · Cited by 352 · see citing works
Stress, sex, and neural adaptation to a changing environment: mechanisms of neuronal remodeling
McEwen, B. S. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05568.x · Cited by 335 · see citing works
New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates—Nrf2 activators and GSK-3 inhibitors
Maes, M., Fišar, Z., Medina, M., Scapagnini, G., Nowak, G., & Berk, M. (2012) · Inflammopharmacology · doi:10.1007/s10787-011-0111-7 · Cited by 325 · see citing works
Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression
Golden, S. A., Christoffel, D. J., Heshmati, M., Hodes, G. E., Magida, J., Davis, K., Cahill, M. E., Dias, C., Ribeiro, E., Ables, J. L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3090 · Cited by 322 · see citing works
Depression's multiple comorbidities explained by (neuro)inflammatory and oxidative & nitrosative stress pathways.
Maes, M. H. J., Kubera, M., Obuchowiczwa, E., Goehler, L. E., & Brzeszcz, J. (2011) · PubMed · Cited by 303 · see citing works
Nrf2-ARE stress response mechanism: A control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases
Singh, S., Vrishni, S., Singh, B. K., Rahman, I., & Kakkar, P. (2010) · Free Radical Research · doi:10.3109/10715762.2010.507670 · Cited by 294 · see citing works
Correlations and Discrepancies Between Serum and Brain Tissue Levels of Neurotrophins after Electroconvulsive Treatment in Rats
Sartorius, A., Hellweg, R., Litzke, J., Vogt, M., Dormann, C., Vollmayr, B., Danker-Hopfe, H., & Gass, P. (2009) · Pharmacopsychiatry · doi:10.1055/s-0029-1224162 · Cited by 276 · see citing works
The Brain on Stress: Toward an Integrative Approach to Brain, Body, and Behavior
McEwen, B. S. (2013) · Perspectives on Psychological Science · doi:10.1177/1745691613506907 · Cited by 237 · see citing works
BDNF Serum Concentrations in Healthy Volunteers are Associated with Depression-Related Personality Traits
Lang, U. E., Hellweg, R., & Gallinat, J. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300382 · Cited by 219 · see citing works
Individual Variation in Aggression of Feral Rodent Strains: A Standard for the Genetics of Aggression and Violence?
de Boer, S. F., van der Vegt, B. J., & Koolhaas, J. M. (2003) · Behavior Genetics · doi:10.1023/a:1025766415159 · Cited by 219 · see citing works
Repeated social defeat-induced depression-like behavioral and biological alterations in rats: involvement of cholecystokinin
Becker, C., Zeau, B., Rivat, C., Blugeot, A., Hamon, M., & Benoliel, J. J. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002097 · Cited by 214 · see citing works
Self-citation
What Is the Functional Significance of Chronic Stress-Induced CA3 Dendritic Retraction Within the Hippocampus?
Conrad, C. D. (2006) · Behavioral and Cognitive Neuroscience Reviews · doi:10.1177/1534582306289043 · Cited by 211 · see citing works
Neurodegeneration in amyotrophic lateral sclerosis: the role of oxidative stress and altered homeostasis of metals
Carrı̀, M. T., Ferri, A., Cozzolino, M., Calabrese, L., & Rotilio, G. (2003) · Brain Research Bulletin · doi:10.1016/s0361-9230(03)00179-5 · Cited by 209 · see citing works
The Nrf2-ARE Signalling Pathway: Promising Drug Target to Combat Oxidative Stress in Neurodegenerative Disorders
Muiswinkel, F. L. V., & Kuiperij, H. B. (2005) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007054038238 · Cited by 207 · see citing works
Adverse Stress, Hippocampal Networks, and Alzheimer’s Disease
Rothman, S. M., & Mattson, M. P. (2009) · NeuroMolecular Medicine · doi:10.1007/s12017-009-8107-9 · Cited by 197 · see citing works
The resolution of inflammation: the devil in the flask and in the details
Serhan, C. N. (2011) · The FASEB Journal · doi:10.1096/fj.11-0502ufm · Cited by 195 · see citing works
Vulnerability to Depression: From Brain Neuroplasticity to Identification of Biomarkers
Blugeot, A., Rivat, C., Bouvier, E., Molet, J., Mouchard, A., Zeau, B., Bernard, C., Benoliel, J., & Becker, C. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1309-11.2011 · Cited by 187 · see citing works
Self-citation
Differential proteome analysis of aging in rat skeletal muscle
Piec, I., Listrat, A., Alliot, J., Chambon, C., Taylor, R. G., & Béchet, D. (2005) · The FASEB Journal · doi:10.1096/fj.04-3084fje · Cited by 181 · see citing works
Biomarkers for assessing population and individual health and disease related to stress and adaptation
McEwen, B. S. (2014) · Metabolism · doi:10.1016/j.metabol.2014.10.029 · Cited by 171 · see citing works
Antioxidant activity of 7,8-dihydroxyflavone provides neuroprotection against glutamate-induced toxicity
Chen, J., Chua, K., Chua, C. C., Yu, H., Pei, A., Chua, B. H. L., Hamdy, R. C., Xu, X., & Liu, C.-F. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.05.054 · Cited by 153 · see citing works
Nrf2 participates in depressive disorders through an anti-inflammatory mechanism
Martín-de-Saavedra, M. D., Budni, J., Cunha, M. P., Gómez-Rangel, V., Lorrio, S., del Barrio, L., Lastres-Becker, I., Parada, E., Tordera, R. M., Rodrigues, A. L. S., et al. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.03.020 · Cited by 143 · see citing works
Transcriptional Regulation of the AP-1 and Nrf2 Target Gene Sulfiredoxin
Soriano, F. X., Baxter, P. S., Murray, L. M., Sporn, M. B., Gillingwater, T. H., & Hardingham, G. E. (2009) · Molecules and Cells · doi:10.1007/s10059-009-0050-y · Cited by 142 · see citing works
Oxidation state governs structural transitions in peroxiredoxin II that correlate with cell cycle arrest and recovery
Phalen, T. J., Weirather, K., Deming, P. B., Anathy, V., Howe, A. K., van der Vliet, A., Jönsson, T. J., Poole, L. B., & Heintz, N. H. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200606005 · Cited by 130 · see citing works
Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila
Cochemé, H. M., Logan, A., Prime, T. A., Abakumova, I., Quin, C., McQuaker, S. J., Patel, J. V., Fearnley, I. M., James, A. M., Porteous, C. M., et al. (2012) · Nature Protocols · doi:10.1038/nprot.2012.035 · Cited by 128 · see citing works
Involvement of Cholecystokininergic Systems in Anxiety-Induced Hyperalgesia in Male Rats: Behavioral and Biochemical Studies
André, J., Zeau, B., Pohl, M., Cesselin, F., Benoliel, J. J., & Becker, C. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0743-05.2005 · Cited by 121 · see citing works
Self-citation
Environmental and pharmacological modulations of cellular plasticity: Role in the pathophysiology and treatment of depression
Ota, K. T., & Duman, R. S. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.05.022 · Cited by 94 · see citing works
Protective Effects of 7,8-Dihydroxyflavone on Retinal Ganglion and RGC-5 Cells Against Excitotoxic and Oxidative Stress
Gupta, V., You, Y., Li, J. C., Klistorner, A. I., & Graham, S. L. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9899-x · Cited by 91 · see citing works
Enhanced Cortical Extracellular Levels of Cholecystokinin-Like Material in a Model of Anticipation of Social Defeat in the Rat
Becker, C., Thiébot, M.-H., Touitou, Y., Hamon, M., Cesselin, F., & Benoliel, J. J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-01-00262.2001 · Cited by 84 · see citing works
Self-citation
Neuroticism, Depressive Symptoms, and Serum BDNF
Terracciano, A., Lobina, M., Piras, M. G., Mulas, A., Cannas, A., Meirelles, O., Sutin, A. R., Zonderman, A. B., Uda, M., Crisponi, L., et al. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3182306a4f · Cited by 83 · see citing works
Predicting and treating stress‐Induced vulnerability to epilepsy and depression
Becker, C., Bouvier, E., Ghestem, A., Siyoucef, S. S., Claverie, D., Camus, F., Bartoloméi, F., Benoliel, J. J., & Bernard, C. (2015) · Annals of Neurology · doi:10.1002/ana.24414 · Cited by 81 · see citing works
Self-citation
Nitric oxide activates an Nrf2/sulfiredoxin antioxidant pathway in macrophages
Abbas, K., BRETON, J. L., Planson, A., Bouton, C., Bignon, J. S., Seguin, C., Riquier, S., Tolédano, M. B., & Drapier, J. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.03.039 · Cited by 78 · see citing works
CNS Peroxiredoxins and Their Regulation in Health and Disease
Bell, K. F. S., & Hardingham, G. E. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3567 · Cited by 71 · see citing works
Nrf2: bane or blessing in cancer?
Xiang, M., Namani, A., Wu, S., & Wang, X. (2014) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-014-1627-1 · Cited by 67 · see citing works
BDNF serum levels, but not BDNF Val66Met genotype, are correlated with personality traits in healthy subjects
Minelli, A., Zanardini, R., Bonvicini, C., Sartori, R., Pedrini, L., Gennarelli, M., & Bocchio‐Chiavetto, L. (2011) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-011-0189-3 · Cited by 66 · see citing works
Alterations of brain and cerebellar proteomes linked to Aβ and tau pathology in a female triple-transgenic murine model of Alzheimer's disease
Ciavardelli, D., Silvestri, E., Viscovo, A. D., Bomba, M., Gregorio, D. D., Moreno, M., Ilio, C. D., Goglia, F., Canzoniero, L. M. T., & Sensi, S. L. (2010) · Cell Death and Disease · doi:10.1038/cddis.2010.68 · Cited by 57 · see citing works
Preventive Effect of 7,8-Dihydroxyflavone against Oxidative Stress Induced Genotoxicity
Zhang, R., Kang, K. A., Piao, M. J., Ko, D. O., Wang, Z. H., Chang, W. Y., You, H. J., Lee, I. K., Kim, B., Kang, S. S., et al. (2009) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.32.166 · Cited by 47 · see citing works
Motor Impairments in an Oxidative Stress Model and its Correlation with Cytological Changes on Rat Striatum and Prefrontal Cortex
Ávila-Costa, M. R., Colín-Barenque, L., van der Goes, T. I. F., Machado-Salas, J. P., Espinosa-Villanueva, J., Rugerio-Vargas, C., Borgonio, C., Dorado, C., & Rivas-Arancibia, S. (2001) · International Journal of Neuroscience · doi:10.3109/00207450108986514 · Cited by 39 · see citing works
Gene Expression in Aminergic and Peptidergic Cells During Aggression and Defeat: Relevance to Violence, Depression and Drug Abuse
Miczek, K. A., Nikulina, E. M., Takahashi, A., Covington, H. E., Yap, J. J., Boyson, C. O., Shimamoto, A., & de Almeida, R. M. M. (2011) · Behavior Genetics · doi:10.1007/s10519-011-9462-5 · Cited by 38 · see citing works
Opioid Control of the In Vitro Release of Cholecystokinin‐Like Material from the Rat Substantia Nigra
Benoliel, J. J., Mauborgne, A., Bourgoin, S., Legrand, J. C., Hamon, M., & Cesselin, F. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09344.x · Cited by 36 · see citing works
Self-citation
Phenylarsine Oxide Binding Reveals Redox-Active and Potential Regulatory Vicinal Thiols on the Catalytic Subunit of Protein Phosphatase 2A
Foley, T. D., Melideo, S. L., Healey, A. E., Lucas, E. J., & Koval, J. A. (2010) · Neurochemical Research · doi:10.1007/s11064-010-0310-4 · Cited by 32 · see citing works
Tempol Prevents Altered K + Channel Regulation of Afferent Arteriolar Tone in Diabetic Rat Kidney
Brindeiro, C. M. T., Lane, P. H., & Carmines, P. K. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.184218 · Cited by 29 · see citing works
Peroxiredoxin-2 links Cdk5 to neurodegeneration
Przedborski, S. (2007) · Nature Medicine · doi:10.1038/nm0807-907 · Cited by 15 · see citing works

Flagged first, then by citations

Research works printed but not linked: 1

Rhee SG. Cell signaling. H2O2, a necessary evil for cell signaling. Science 2006; 312: 1882-1883.

Sorted by citations

Chronic stress, neuroinflammation, and depression: an overview of pathophysiological mechanisms and emerging anti-inflammatories
Hassamal, S. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1130989 · Cited by 578 · see citing works
“Reduced BDNF inhibits Nrf2 transcription of antioxidant enzymes and increases susceptibility to depressive behaviors in animal models (109).”
Background
Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway
Dang, R., Wang, M., Li, X., Wang, H., Liu, L., Wu, Q., Zhao, J., Ji, P., Zhong, L., Licinio, J., et al. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02400-6 · Cited by 538 · see citing works
Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway
Arioz, B. I., Tastan, B., Tarakcioglu, E., Tufekci, K. U., Olcum, M., Ersoy, N., Bagriyanik, A., Genc, K., & Genc, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01511 · Cited by 516 · see citing works
Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia
Steullet, P., Cabungcal, J.-H., Coyle, J., Didriksen, M., Gill, K., Grace, A. A., Hensch, T. K., LaMantia, A.-S., Lindemann, L., Maynard, T. M., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.47 · Cited by 360 · see citing works
Self-citation
Hierarchical Status Predicts Behavioral Vulnerability and Nucleus Accumbens Metabolic Profile Following Chronic Social Defeat Stress
Larrieu, T., Cherix, A., Duque, A., Rodrigues, J., Lei, H., Gruetter, R., & Sandi, C. (2017) · Current Biology · doi:10.1016/j.cub.2017.06.027 · Cited by 202 · see citing works
Redox toxicology of environmental chemicals causing oxidative stress
Zheng, F., Gonçalves, F. M., Abiko, Y., Li, H., Kumagai, Y., & Aschner, M. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101475 · Cited by 190 · see citing works
Targeting Akt/CREB/BDNF signaling pathway by ginsenosides in neurodegenerative diseases: A mechanistic approach
Zarneshan, S. N., Fakhri, S., & Khan, H. Z. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106099 · Cited by 175 · see citing works
Effects of Single Cage Housing on Stress, Cognitive, and Seizure Parameters in the Rat and Mouse Pilocarpine Models of Epilepsy
Manouze, H., Ghestem, A., Poillerat, V., Bennis, M., Ba-M’hamed, S., Benoliel, J. J., Becker, C., & Bernard, C. (2019) · eNeuro · doi:10.1523/eneuro.0179-18.2019 · Cited by 141 · see citing works
Self-citation
Nrf2: An all-rounder in depression
Zuo, C., Cao, H., Song, Y., Gu, Z., Huang, Y., Yang, Y., Miao, J., Zhu, L., Chen, J., Jiang, Y., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102522 · Cited by 138 · see citing works
Possible antidepressant mechanisms of omega-3 polyunsaturated fatty acids acting on the central nervous system
Zhou, L., Xiong, J., Chai, Y.-Q., Huang, L., Tang, Z.-Y., Zhang, X., Liu, B., & Zhang, J.-T. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.933704 · Cited by 115 · see citing works
Uric Acid Protects against Focal Cerebral Ischemia/Reperfusion‐Induced Oxidative Stress via Activating Nrf2 and Regulating Neurotrophic Factor Expression
Ya, B., Liu, Q., Li, H., Cheng, H.-J., Yu, T., Chen, L., Wang, Y., Yuan, L., Li, W., Liu, W., et al. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/6069150 · Cited by 110 · see citing works
Role of Nrf2 in Synaptic Plasticity and Memory in Alzheimer’s Disease
Davies, D. A., Adlimoghaddam, A., & Albensi, B. C. (2021) · Cells · doi:10.3390/cells10081884 · Cited by 111 · see citing works
Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents
Yao, W., Lin, S., Su, J. Y., Cao, Q., Chen, Y., Chen, J., Zhang, Z., Hashimoto, K., Qi, Q., & Zhang, J. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01261-6 · Cited by 106 · see citing works
Non-linear association between composite dietary antioxidant index and depression
Zhao, L., Sun, Y., Cao, R., Wu, X., Huang, T., & Peng, W. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.988727 · Cited by 103 · see citing works
Ferroptosis regulation through Nrf2 and implications for neurodegenerative diseases
Xiang, Y., Song, X., & Long, D. (2024) · Archives of Toxicology · doi:10.1007/s00204-023-03660-8 · Cited by 109 · see citing works
Essential Role of Keap1-Nrf2 Signaling in Mood Disorders: Overview and Future Perspective
Hashimoto, K. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01182 · Cited by 98 · see citing works
Focusing on mitochondria in the brain: from biology to therapeutics
Song, N., Mei, S., Wang, X.-X., Hu, G., & Lu, M. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00409-w · Cited by 102 · see citing works
Ischaemic and hypoxic conditioning: potential for protection of vital organs
Sprick, J. D., Mallet, R. T., Przyklenk, K., & Rickards, C. A. (2018) · Experimental Physiology · doi:10.1113/ep087122 · Cited by 97 · see citing works
High frequency repetitive transcranial magnetic stimulation alleviates cognitive deficits in 3xTg-AD mice by modulating the PI3K/Akt/GLT-1 axis
Cao, H., Zuo, C., Gu, Z., Huang, Y., Yang, Y., Zhu, L., Jiang, Y., & Wang, F. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102354 · Cited by 97 · see citing works
Stress and coping in women with breast cancer:unravelling the mechanisms to improve resilience
Borgi, M., Collacchi, B., Ortona, E., & Cirulli, F. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.10.011 · Cited by 90 · see citing works
Intracellular inflammatory and antioxidant pathways in postmortem frontal cortex of subjects with major depression: effect of antidepressants
Martín-Hernández, D., Caso, J. R., Javier Meana, J., Callado, L. F., Madrigal, J. L. M., García-Bueno, B., & Leza, J. C. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1294-2 · Cited by 80 · see citing works
Curculigoside facilitates fear extinction and prevents depression-like behaviors in a mouse learned helplessness model through increasing hippocampal BDNF
Yang, S., Song, Z., Wang, X., Zhang, Z.-R., Wu, S.-B., & Zhu, G. (2019) · Acta Pharmacologica Sinica · doi:10.1038/s41401-019-0238-4 · Cited by 80 · see citing works
Noxious Iron–Calcium Connections in Neurodegeneration
Núñez, M. T., & Hidalgo, C. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00048 · Cited by 80 · see citing works
Escitalopram Targets Oxidative Stress, Caspase-3, BDNF and MeCP2 in the Hippocampus and Frontal Cortex of a Rat Model of Depression Induced by Chronic Unpredictable Mild Stress.
Dionisie, V., Ciobanu, A. M., Toma, V. A., Manea, M. C., Baldea, I., Olteanu, D., Sevastre-Berghian, A., Clichici, S., Manea, M., Riga, S., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147483 · Cited by 78 · see citing works
Targeting Inflammatory-Mitochondrial Response in Major Depression: Current Evidence and Further Challenges
Visentin, A. P. V., Colombo, R., Scotton, E., Fracasso, D. S., Rosa, A. R., Branco, C. S., & Salvador, M. M. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/2972968 · Cited by 77 · see citing works
The Biological Effects of Pharmaceuticals in the Marine Environment
Mezzelani, M., & Regoli, F. (2021) · Annual Review of Marine Science · doi:10.1146/annurev-marine-040821-075606 · Cited by 75 · see citing works
Hydroxytyrosol alleviates oxidative stress and neuroinflammation and enhances hippocampal neurotrophic signaling to improve stress-induced depressive behaviors in mice
Zhao, Y., Zhang, L., Yin, H., Shen, L., Zheng, W., Zhang, K., Zeng, J., Hu, C., & Liu, Y. (2021) · Food & Function · doi:10.1039/d1fo00210d · Cited by 74 · see citing works
Neuroprotective activity of tetramethylpyrazine against 3-nitropropionic acid induced Huntington’s disease-like symptoms in rats
Danduga, R. C. S. R., Dondapati, S. R., Kola, P. K., Grace, L., Tadigiri, R. V. B., & Kanakaraju, V. K. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.06.079 · Cited by 73 · see citing works
The signaling pathways underlying BDNF-induced Nrf2 hippocampal nuclear translocation involve ROS, RyR-Mediated Ca2+ signals, ERK and PI3K
Bruna, B., Lobos, P., Herrera‐Molina, R., Hidalgo, C., Paula-Lima, A. C., & Adasme, T. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.09.080 · Cited by 72 · see citing works
Oxidation-reduction mechanisms in psychiatric disorders: A novel target for pharmacological intervention
Rossetti, A. C., Paladini, M. S., Riva, M. A., & Molteni, R. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107520 · Cited by 70 · see citing works
Potential anxiolytic and antidepressant-like effects of luteolin in a chronic constriction injury rat model of neuropathic pain: Role of oxidative stress, neurotrophins, and inflammatory factors
Mokhtari, T., Lu, M., & El-Kenawy, A. E.-M. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110520 · Cited by 70 · see citing works
Quinolinic Acid and Nuclear Factor Erythroid 2-Related Factor 2 in Depression: Role in Neuroprogression
Bansal, Y., Singh, R., Parhar, I. S., Kuhad, A., & Soga, T. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00452 · Cited by 68 · see citing works
Nrf2 regulates iron-dependent hippocampal synapses and functional connectivity damage in depression
Zeng, T., Li, J., Xie, L., Dong, Z., Chen, Q., Huang, S., Xie, S., Lai, Y., Li, J., Yan, W., et al. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02875-x · Cited by 71 · see citing works
Keap1-Nrf2 signaling pathway confers resilience versus susceptibility to inescapable electric stress
Zhang, J.-C., Yao, W., Dong, C., Han, M., Shirayama, Y., & Hashimoto, K. (2018) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-017-0848-0 · Cited by 66 · see citing works
Importance of oxidative stress in the pathogenesis, diagnosis, and monitoring of patients with neuropsychiatric disorders, a review
Cecerska-Heryć, E., Polikowska, A., Serwin, N., Roszak, M., Grygorcewicz, B., Heryć, R., Michalczyk, A., & Dołęgowska, B. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2021.105269 · Cited by 68 · see citing works
Therapeutic potential of glutathione-enhancers in stress-related psychopathologies
Zalachoras, I., Hollis, F., Ramos‐Fernández, E., Trovò, L., Sonnay, S., Geiser, E., Preitner, N., Steiner, P., Sandi, C., & Morató, L. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.03.015 · Cited by 67 · see citing works
Polysaccharides from Polygonatum cyrtonema Hua Reduce Depression‐Like Behavior in Mice by Inhibiting Oxidative Stress‐Calpain‐1‐NLRP3 Signaling Axis
Shen, F., Xie, P., Li, C., Bian, Z., Wang, X., Peng, D., & Zhu, G. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2566917 · Cited by 63 · see citing works
Astrocyte truncated tropomyosin receptor kinase B mediates brain‐derived neurotrophic factor anti‐apoptotic effect leading to neuroprotection
Saba, J., Turati, J., Ramírez, D., Carniglia, L., Durand, D., Lasaga, M., & Caruso, C. M. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14476 · Cited by 63 · see citing works
Association of Postpartum Depression with Maternal Suicide: A Nationwide Population-Based Study
Lee, Y.-L., Tien, Y., Bai, Y.-S., Lin, C.-K., Yin, C.-S., Chung, C.-H., Sun, C.-A., Huang, S.-H., Huang, Y.-C., Chien, W.-C., et al. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19095118 · Cited by 61 · see citing works
The Exposome and Toxicology: A Win–Win Collaboration
Barouki, R., Audouze, K., Becker, C., Bláha, L., Coumoul, X., Karakitsios, S., Klánová, J., Miller, G. W., Price, E. J., & Sarigiannis, D. (2021) · Toxicological Sciences · doi:10.1093/toxsci/kfab149 · Cited by 60 · see citing works
Self-citation
Priming of microglia with dysfunctional gut microbiota impairs hippocampal neurogenesis and fosters stress vulnerability of mice
He, H., He, H., Mo, L., You, Z., & Zhang, J. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.10.031 · Cited by 61 · see citing works
Antioxidant Biomolecules and Their Potential for the Treatment of Difficult-to-Treat Depression and Conventional Treatment-Resistant Depression
Riveros, M. E., Ávila, A., Schruers, K. R. J., & Ezquer, F. E. (2022) · Antioxidants · doi:10.3390/antiox11030540 · Cited by 59 · see citing works
Quercetin reverses chronic unpredictable mild stress-induced depression-like behavior in vivo by involving nuclear factor-E2-related factor 2
Guan, Y., Wang, J., Wu, X., Song, L., Wang, Y., Gong, M., & Li, B. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147661 · Cited by 57 · see citing works
Predictable chronic mild stress promotes recovery from LPS-induced depression
Dang, R., Guo, Y., Zhang, K., Jiang, P., & Zhao, M. (2019) · Molecular Brain · doi:10.1186/s13041-019-0463-2 · Cited by 58 · see citing works
The SIRT-1/Nrf2/HO-1 axis: Guardians of neuronal health in neurological disorders
Sethi, P., Mehan, S., Khan, Z., Maurya, P. K., Kumar, B., Kumar, A., Tiwari, A., Sharma, T., Gupta, G. D., Narula, A. S., et al. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115280 · Cited by 57 · see citing works
Recent advances in understanding the mechanisms of PM2.5-mediated neurodegenerative diseases
Zhu, X., Ji, X., Shou, Y., Huang, Y., Hu, Y., & Wang, H. (2020) · Toxicology Letters · doi:10.1016/j.toxlet.2020.04.017 · Cited by 54 · see citing works
Epilepsy as a Network Disorder (1): What can we learn from other network disorders such as autistic spectrum disorder and mood disorders?
Kanner, A. M., Scharfman, H. E., Jetté, N., Anagnostou, E. A., Bernard, C., Camfield, C., CAMFIELD, P. R., Legg, K. T., Dinstein, I., Giacobbe, P., et al. (2017) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2017.09.014 · Cited by 53 · see citing works
Self-citation
Chronic Stress Exposure Reduces Parvalbumin Expression in the Rat Hippocampus through an Imbalance of Redox Mechanisms: Restorative Effect of the Antipsychotic Lurasidone
Rossetti, A. C., Paladini, M. S., Colombo, M., Gruca, P., Łasoń, M., Tota-Glowczyk, K., Papp, M., Riva, M. A., & Molteni, R. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy046 · Cited by 53 · see citing works
Understanding the Role of Oxidative Stress, Neuroinflammation and Abnormal Myelination in Excessive Aggression Associated with Depression: Recent Input from Mechanistic Studies
Вячеславовна, Г. А., Svirin, E. P., Pavlov, D., Cespuglio, R., Proshin, A. T., Schroeter, C. A., Lesch, K., & Strekalova, T. V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24020915 · Cited by 54 · see citing works
Neurobiological Links between Stress, Brain Injury, and Disease
Guo, H., Zheng, L., Xu, H., Pang, Q., Ren, Z., Gao, Y. Z., & Wang, T. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/8111022 · Cited by 53 · see citing works
Integrated Analysis Reveals Altered Lipid and Glucose Metabolism and Identifies NOTCH2 as a Biomarker for Parkinson's Disease Related Depression
Dong, M.-X., Feng, X., Xu, X., Hu, L., Liu, Y., Jia, S., Li, B., Chen, W., & Wei, Y. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00257 · Cited by 51 · see citing works
Naringin Confers Protection against Psychosocial Defeat Stress-Induced Neurobehavioral Deficits in Mice: Involvement of Glutamic Acid Decarboxylase Isoform-67, Oxido-Nitrergic Stress, and Neuroinflammatory Mechanisms
Oladapo, O. M., Ben‐Azu, B., Ajayi, A. M., Emokpae, O., Eneni, A.-E. O., Omogbiya, I. A., & Iwalewa, E. O. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01664-y · Cited by 50 · see citing works
Diapocynin neuroprotective effects in 3-nitropropionic acid Huntington’s disease model in rats: emphasis on Sirt1/Nrf2 signaling pathway
Ibrahim, W. W., & Rasheed, N. O. A. (2022) · Inflammopharmacology · doi:10.1007/s10787-022-01004-z · Cited by 49 · see citing works
The treatment of depression — searching for new ideas
Stachowicz, K., & Sowa-Kućma, M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.988648 · Cited by 50 · see citing works
Hidrox® and Endometriosis: Biochemical Evaluation of Oxidative Stress and Pain
Cordaro, M., Salinaro, A. T., Siracusa, R., D’Amico, R., Impellizzeri, D., Scuto, M. C., Ontario, M. L., Interdonato, L., Crea, R., Fusco, R., et al. (2021) · Antioxidants · doi:10.3390/antiox10050720 · Cited by 48 · see citing works
Dl-3-n-Butylphthalide improves lipopolysaccharide-induced depressive-like behavior in rats: involvement of Nrf2 and NF-κB pathways
Yang, M., Dang, R., Xu, P., Guo, Y., Han, W., Liao, D., & Jiang, P. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4949-x · Cited by 48 · see citing works
Regulation of BDNF transcription by Nrf2 and MeCP2 ameliorates MPTP-induced neurotoxicity
Cao, Q., Zou, Q., Zhao, X. Y., Zhang, Y., Qu, Y., Wang, N., Murayama, S., Qi, Q., Hashimoto, K., Lin, S., et al. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01063-9 · Cited by 47 · see citing works
Stress and Epilepsy: Towards Understanding of Neurobiological Mechanisms for Better Management
Jhaveri, D. J., McGonigal, A., Becker, C., Benoliel, J. J., Nandam, L. S., Soncin, L., Kotwas, I., Bernard, C., & Bartoloméi, F. (2023) · eNeuro · doi:10.1523/eneuro.0200-23.2023 · Cited by 47 · see citing works
Self-citation
Berberine exerts antidepressant effects in vivo and in vitro through the PI3K/AKT/CREB/BDNF signaling pathway
Tang, Y., Su, H., Nie, K., Wang, H., Gao, Y., Shen, C., Lu, F., & Dong, H. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.116012 · Cited by 49 · see citing works
Social isolation after chronic unpredictable mild stress perpetuates depressive-like behaviors, memory deficits and social withdrawal via inhibiting ERK/KEAP1/NRF2 signaling
Si, L., Xiao, L., Xie, Y., Xu, H., Yuan, G., Xu, W., & Wang, G. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.12.092 · Cited by 44 · see citing works
Electroacupuncture Pretreatment Ameliorates PTSD-Like Behaviors in Rats by Enhancing Hippocampal Neurogenesis via the Keap1/Nrf2 Antioxidant Signaling Pathway
Zhou, C.-H., Xue, F., Xue, S.-S., Sang, H., Liu, L., Wang, Y., Cai, M., Zhang, Z.-J., Tan, Q.-R., Wang, H.-N., et al. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00275 · Cited by 41 · see citing works
Sulforaphane activates anti-inflammatory microglia, modulating stress resilience associated with BDNF transcription
Tang, R., Cao, Q., Hu, S.-W., He, L., Du, P., Chen, G., Fu, R., Xiao, F., Sun, Y., Zhang, J., et al. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00727-z · Cited by 42 · see citing works
Inflammation-induced behavioral changes is driven by alterations in Nrf2-dependent apoptosis and autophagy in mouse hippocampus: Role of fluoxetine
Ghosh, S., Choudhury, S., Chowdhury, O., Mukherjee, S., Das, A., Sain, A., Gupta, P., Adhikary, A., & Chattopadhyay, S. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2019.109521 · Cited by 43 · see citing works
The Chinese herbal formula Free and Easy Wanderer ameliorates oxidative stress through KEAP1-NRF2/HO-1 pathway
Hong, C., Cao, J., Wu, C., Kadioglu, O., Schüffler, A., Kauhl, U., Klauck, S. M., Opatz, T., Thines, E., Paul, N. W., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10443-6 · Cited by 41 · see citing works
Age and oxidative stress regulate Nrf2 homeostasis in human articular chondrocytes
Taylor, E. L., Collins, J. A., Gopalakrishnan, P. P., Chubinskaya, S., & Loeser, R. F. (2023) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2023.05.004 · Cited by 41 · see citing works
The role of ROS/p38 MAPK/NLRP3 inflammasome cascade in arsenic-induced depression-/anxiety-like behaviors of mice
Liu, X., Zhang, R., Fan, J., Chen, Y., Wang, H., Ge, Y., Liang, H., Li, W., Liu, H., Lv, Z., et al. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115111 · Cited by 40 · see citing works
Inflammatory and antioxidant pathway dysfunction in borderline personality disorder
MacDowell, K. S., Díaz‐Marsá, M., Buenache, E., López‐Villatoro, J. M., Moreno, B., Leza, J. C., & Carrasco, J. L. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2020.112782 · Cited by 38 · see citing works
Interplay between oxidative damage, the redox status, and metabolic biomarkers during long-term fasting
Grundler, F., Mesnage, R., Goutzourelas, N., Tekos, F., Makri, S., Brack, M., Kouretas, D., & de Toledo, F. W. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111701 · Cited by 40 · see citing works
The Nrf2 Pathway in Depressive Disorders: A Systematic Review of Animal and Human Studies
Sani, G., Margoni, S., Brugnami, A., Ferrara, O. M., Bernardi, E., Simonetti, A., Monti, L., Mazza, M., Janiri, D., Moccia, L., et al. (2023) · Antioxidants · doi:10.3390/antiox12040817 · Cited by 40 · see citing works
Diminished stress resistance and defective adaptive homeostasis in age-related diseases
Lomeli, N., Bota, D. A., & Davies, K. J. A. (2017) · Clinical Science · doi:10.1042/cs20160982 · Cited by 39 · see citing works
Xiaoyao Pills Ameliorate Depression-like Behaviors and Oxidative Stress Induced by Olfactory Bulbectomy in Rats via the Activation of the PIK3CA-AKT1-NFE2L2/BDNF Signaling Pathway
Ji, Y., Luo, J., Zeng, J., Fang, Y., Liu, R., Luan, F., & Zeng, N. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.643456 · Cited by 38 · see citing works
Are Resistance Training-Induced BDNF in Hemodialysis Patients Associated with Depressive Symptoms, Quality of Life, Antioxidant Capacity, and Muscle Strength? An Insight for the Muscle–Brain–Renal Axis
Deus, L. A., Corrêa, H. D. L., Neves, R. V. P., Reis, A. L., Honorato, F. S., Silva, V. L., Souza, M. K., de Araújo, T. B., Alves, L. S. D. G., Sousa, C. V., et al. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182111299 · Cited by 38 · see citing works
The impact of resistance training on brain-derived neurotrophic factor and depression among older adults aged 60 years or older: A systematic review and meta-analysis of randomized controlled trials
Setayesh, S., & Rahimi, G. R. M. (2023) · Geriatric Nursing · doi:10.1016/j.gerinurse.2023.08.022 · Cited by 37 · see citing works
7,8-Dihydroxyflavone alleviated the high-fat diet and alcohol-induced memory impairment: behavioral, biochemical and molecular evidence
Pandey, S. N., Kwatra, M., Dwivedi, D. K., Choubey, P., Lahkar, M., & Jangra, A. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05502-2 · Cited by 37 · see citing works
Food-derived cyanidin-3- O -glucoside alleviates oxidative stress: evidence from the islet cell line and diabetic db/db mice
Ye, X., Chen, W. L., Tu, P., Jia, R., Liu, Y., Li, Y., Tang, Q., Zheng, X., & Chu, Q. (2021) · Food & Function · doi:10.1039/d1fo02385c · Cited by 35 · see citing works
The ‘Yin’ and the ‘Yang’ of the kynurenine pathway: excitotoxicity and neuroprotection imbalance in stress-induced disorders
Barone, P. R. (2019) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000477 · Cited by 33 · see citing works
Individual differences in inflammatory and oxidative mechanisms of stress-related mood disorders
Kalinichenko, L. S., Kornhuber, J., & Müller, C. P. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100783 · Cited by 34 · see citing works
RETRACTED ARTICLE: Xanthohumol Attenuates Lipopolysaccharide-Induced Depressive Like Behavior in Mice: Involvement of NF-κB/Nrf2 Signaling Pathways
Rahman, S. U., Ali, T., Hao, Q., He, K., Li, W., Ullah, N., Zhang, Z., Jiang, Y., & Li, S. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03396-w · Cited by 33 · see citing works
Retracted
Ferulic acid as a therapeutic agent in depression: Evidence from preclinical studies
Dong, X., & Zhao, D. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14265 · Cited by 31 · see citing works
The Nrf2 pathway in psychiatric disorders: pathophysiological role and potential targeting
Bhandari, R., Kaur, J., Kaur, S., & Kuhad, A. (2021) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.1887141 · Cited by 32 · see citing works
Elevating the level of hypoxia inducible factor may be a new potential target for the treatment of depression
Kang, I., Kondo, D. G., Kim, J., Lyoo, I. K., Yurgelun-Todd, D. A., Hwang, J., & Renshaw, P. F. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.110398 · Cited by 31 · see citing works
Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr’InsideTM) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders
Wauquier, F., Boutin-Wittrant, L., Pourtau, L., Gaudout, D., Moras, B., Vignault, A., de Oliveira, C. M., Gabaston, J., Vaysse, C., Bertrand, K., et al. (2022) · Nutrients · doi:10.3390/nu14071511 · Cited by 31 · see citing works
Is burning mouth syndrome associated with stress? A meta‐analysis
Porporatti, A. L., Schröder, Â. G. D., Lebel, A., Moreau, N., Misery, L., Alajbeg, I., Braud, A., & Boucher, Y. (2023) · Journal of Oral Rehabilitation · doi:10.1111/joor.13536 · Cited by 30 · see citing works
Study on Lactiplantibacillus plantarum R6-3 from Sayram Ketteki to prevent chronic unpredictable mild stress-induced depression in mice through the microbiota–gut–brain axis
Zhao, L., Li, D., Chitrakar, B., Li, C., Zhang, N., Zhang, S., Wang, X., Wang, M., Tian, H., & Luo, Y. (2023) · Food & Function · doi:10.1039/d2fo03708d · Cited by 30 · see citing works
The Gut–Brain Axis as a Therapeutic Target in Multiple Sclerosis
Bugă, A. M., Pădureanu, V., Riza, A., Oancea, C. N., Albu, C. V., & Nica, A. D. (2023) · Cells · doi:10.3390/cells12141872 · Cited by 32 · see citing works
Methylphenidate Attenuates the Cognitive and Mood Alterations Observed inMbnl2Knockout Mice and Reduces Microglia Overexpression
Ramon‐Duaso, C., Gener, T., Consegal, M., Fernández-Avilés, C., Gallego, J., Castarlenas, L., Swanson, M. S., de la Torre, R., Maldonado, R. J., Puig, M. V., et al. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy164 · Cited by 29 · see citing works
Insights into serotonergic and antioxidant mechanisms involved in antidepressant-like action of 2-phenyl-3-(phenylselanyl)benzofuran in mice
Gall, J. I., Alves, A. G., Júnior, L. R. C., Rech, T. D. S. T., Neto, J. S. S., Alves, D. A. C., Soares, M. S. P., Spohr, L., Spanevello, R. M., Brüning, C. A., et al. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109956 · Cited by 29 · see citing works
Catalpol Weakens Depressive-like Behavior in Mice with Streptozotocin-induced Hyperglycemia via PI3K/AKT/Nrf2/HO-1 Signaling Pathway
Wu, X., Wang, J., Song, L., Guan, Y., Cao, C., Cui, Y., Zhang, Y., & Liu, C. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.07.029 · Cited by 28 · see citing works
Soy isoflavones alleviate lipopolysaccharide-induced depressive-like behavior by suppressing neuroinflammation, mediating tryptophan metabolism and promoting synaptic plasticity
Lü, C., Wei, Z., Wang, Y., Li, S., Tong, L., Liu, X., Fan, B., & Wang, F. (2022) · Food & Function · doi:10.1039/d2fo01437h · Cited by 29 · see citing works
Holothuria leucospilota polysaccharides alleviate liver injury via AMPK and NF-κB signaling pathways in type 2 diabetic rats
Zhao, F., Zhu, K., Zhao, Q., Liu, Q., Cao, J., Xia, G., Liu, Z., & Li, C. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104657 · Cited by 28 · see citing works
Mitochondria and the Repurposing of Diabetes Drugs for Off-Label Health Benefits
Yip, J., Chiang, G. S. H., Lee, I. C. J., Lehming-Teo, R., Dai, K., Dongol, L., Wang, L. Y.-T., Teo, D. W. X., Seah, G. T., & Lehming, N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26010364 · Cited by 28 · see citing works
Preventive effect of quercetin-Loaded nanophytosome against autistic-like damage in maternal separation model: The possible role of Caspase-3, Bax/Bcl-2 and Nrf2
Moghaddam, A. H., Eslami, A., Jelodar, S. K., Ranjbar, M., & Hasantabar, V. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114300 · Cited by 27 · see citing works
Bdnf-Nrf-2 crosstalk and emotional behavior are disrupted in a sex-dependent fashion in adolescent mice exposed to maternal stress or maternal obesity
Musillo, C., Creutzberg, K. C., Collacchi, B., Ajmone‐Cat, M. A., Simone, R. D., Lepre, M., Amrein, I., Riva, M. A., Berry, A., & Cirulli, F. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02701-1 · Cited by 27 · see citing works
Effect of Epigallocatechin-3-gallate on Stress-Induced Depression in a Mouse Model: Role of Interleukin-1β and Brain-Derived Neurotrophic Factor
Abdelmeguid, N. E., Hammad, T. M., Abdel-Moneim, A. M., & Salam, S. A. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03707-9 · Cited by 26 · see citing works
Evaluation of the Effect of Hypericum triquetrifolium Turra on Memory Impairment Induced by Chronic Psychosocial Stress in Rats: Role of BDNF
Alzoubi, K. H., Abdel‐Hafiz, L., Khabour, O. F., El‐Elimat, T., Alzubi, M. A., & Alali, F. Q. (2020) · Drug Design Development and Therapy · doi:10.2147/dddt.s278153 · Cited by 26 · see citing works
The triterpenoid ursolic acid ameliorates stress in Caenorhabditis elegans by affecting the depression-associated genes skn-1 and prdx2
Naß, J., Abdelfatah, S., & Efferth, T. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153598 · Cited by 26 · see citing works
In vitro and in vivo immunoregulatory activity of sulfated fucan from the sea cucumber A. leucoprocta
Feng, G., Su, L., Chen, S., Wang, T., Zhou, D., Yin, C., & Shoudong, G. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.08.008 · Cited by 26 · see citing works
Targeting NRF2 in Type 2 diabetes mellitus and depression: Efficacy of natural and synthetic compounds
Subba, R., Ahmad, M. H., Ghosh, B., & Mondal, A. C. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.174993 · Cited by 25 · see citing works
Low protein-induced intrauterine growth restriction as a risk factor for schizophrenia phenotype in a rat model: assessing the role of oxidative stress and neuroinflammation interaction
Allgäuer, L., Cabungcal, J.-H., Yzydorczyk, C., Kim, Q., & Dwir, D. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02322-8 · Cited by 26 · see citing works
Self-citation
A review of the pharmacological action and mechanism of natural plant polysaccharides in depression
Yang, Y., Li, C.-X., Zhang, R., Shen, Y. H., Xu, X., & Yu, Q. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1348019 · Cited by 27 · see citing works

BDNF and oxidative stress (key role in the vulnerability to depression)
Bouvier, E., & Benoliel, J. J. (2012) · OpenGrey (Institut de l'Information Scientifique et Technique)
Self-citation
BDNF et stress oxydant : deux acteurs majeurs de la vulnérabilité à la dépression
Bouvier, E. (2012)
Self-citation
Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents
Yao, W., Lin, S., Su, J. Y., Cao, Q., Chen, Y., Chen, J., Zhang, Z., Hashimoto, K., Qi, Q., & Zhang, J. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01261-6 · Cited by 106 · see citing works
Nrf2: An all-rounder in depression
Zuo, C., Cao, H., Song, Y., Gu, Z., Huang, Y., Yang, Y., Miao, J., Zhu, L., Chen, J., Jiang, Y., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102522 · Cited by 138 · see citing works
NADPH Oxidase Mediates Depressive Behavior Induced by Chronic Stress in Mice
Seo, J., Park, J., Choi, J., Kim, T.-K., Shin, J., Lee, J.-K., & Han, P. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0794-12.2012 · Cited by 184 · see citing works

Authors: Bouvier, E., Brouillard, F., Molet, J., Claverie, D., Cabungcal, J.-H., Cresto, N., Doligez, N., Rivat, C., Do, K. Q., Bernard, C., Benoliel, J.-J., & Becker, C.
Affiliations: Centre National de la Recherche Scientifique (FR)
Centre Hospitalier Universitaire Vaudois (CH)
Inserm (FR)
Corresponding author: Becker, C
ORCID: Molet, J
Claverie, D
Cresto, N
Rivat, C
Bernard, C
Becker, C
Venue: Molecular Psychiatry
Publisher: Springer Science and Business Media LLC
Published: 2016-09-20
Volume: 22
Issue: 12
Pages: 1701-1713
ISSN: 1359-4184 (ISSN-L)
1476-5578
DOI: 10.1038/mp.2016.144
PMC: PMC8127815
OpenAlex: W2522819450
Cited by: 248
References: 70
Citations by year: 2026: 15 · 2025: 25 · 2024: 24 · 2023: 47 · 2022: 42 · 2021: 28 · 2020: 24 · 2019: 17 · 2018: 15 · 2017: 9 · 2016: 1 · 2014: 1
FWCI: 7.28
Type: journal article
Language: en
Update notices: erratum (2016-11-01)
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
creativecommons.org/licenses/by-nc-nd/4.0 (tdm)
creativecommons.org/licenses/by-nc-nd/4.0 (vor)
Locations: Molecular Psychiatry (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
SERVAL (Université de Lausanne) (publishedVersion, other-oa)
IRIS (submittedVersion)
HAL (submittedVersion)
Funders: Institut National de la Santé et de la Recherche Médicale
Rijksuniversiteit Groningen
Université Pierre et Marie Curie
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: depression vulnerability, oxidative stress, Nrf2, brain-derived neurotrophic factor, redox homeostasis, social defeat stress, chronic mild stress, antioxidants, Nrf2 nuclear translocation, reactive oxygen species, antidepressant mechanism
MeSH terms: Animals, Antioxidants, Depressive Disorder, Disease Models, Animal, Disease Susceptibility, Dominance-Subordination, Hippocampus, Male, Mice, Inbred C57BL, Random Allocation, Rats, Sprague-Dawley, Mice, Knockout, Oxidative Stress, Brain-Derived Neurotrophic Factor, Proteome, Active Transport, Cell Nucleus, NF-E2-Related Factor 2

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Nrf2-dependent persistent oxidative stress results in stress-induced vulnerability to depression

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks