The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Social behavior deficits in the Fmr1 mutant mouse
Abstract
Mice exhibiting deficits in social behavior may provide valuable models for autistic-like behavioral problems. We tested social interactions in male mice from three inbred strains: C57BL/6J (B6), BALB/cJ (C) and DBA/2J (D2). All three strains showed gradual habituation of the number of social interactions with an ovariectomized female over four subsequent 2min sessions, returning to initial levels when presented with another stimulus mouse. Next, we studied males with a knockout mutation in the Fmr1 gene on a B6 background. KO animals showed strongly reduced levels of social interaction, which were about similar as those of habituated controls. This social behavior deficit suggests that Fmr1 KO mice could possibly be used as models for autistic behaviors.
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“Fmr1 KO, in comparison to the wild-type (WT) strain, are described as having lower than normal levels of initial social interactions (Mineur et al., 2006), fail to show a preference for social novelty, and display inappropriate social responses (Pietropaolo et al., 2011).”
From Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders (2014) · cites this paper as Mineur et al., 2006
In the citing paper
“Fmr1 KO also exhibit abnormal social interactions, including a general reduction in social contact and a failure to show social recognition (Bernardet and Crusio, 2006; Mineur et al., 2006; Spencer et al., 2005; Yan et al., 2004).”
From Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders (2014) · cites this paper as Mineur et al., 2006
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Cites
Model of autism: increased ratio of excitation/inhibition in key neural systems
Rubenstein, J. L. R., & Merzenich, M. M. (2003) · Genes, Brain and Behavior · doi:10.1034/j.1601-183x.2003.00037.x · Cited by 2,768
Social amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130
Abnormal dendritic spines in fragile X knockout mice: Maturation and pruning deficits
Comery, T. A., Harris, J. B., Willems, P. J., Oostra, B. A., Irwin, S. A., Weiler, I. J., & Greenough, W. T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5401 · Cited by 1,046
Fragile X Syndrome: Diagnosis, Treatment, And Research
Silverman, & Cronister, A. (1991) · Johns Hopkins University Press eBooks · Cited by 481
Autism: not an extremely rare disorder
Gillberg, C., & Wing, L. (1999) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1999.tb00984.x · Cited by 381
Rousseau, F., Rouillard, P., Morel, M. L., Khandjian, E. W., & Morgan, K. (1995) · Europe PMC (PubMed Central) · Cited by 361
Altered anxiety‐related and social behaviors in the Fmr1 knockout mouse model of fragile X syndrome
Spencer, C. M., Alekseyenko, O., Serysheva, E., Yuva‐Paylor, L. A., & Paylor, R. (2005) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2005.00123.x · Cited by 349
Behavioral and neuroanatomical characterization of the Fmr1 knockout mouse
Mineur, Y. S., Sluyter, F., de Wit, S., Oostra, B. A., & Crusio, W. E. (2002) · Hippocampus · doi:10.1002/hipo.10005 · Cited by 216
Self-citationMolecular-clinical correlations in males with an expanded FMR1 mutation
Merenstein, S. A., Sobesky, W. E., Taylor, A. K., Riddle, J. E., Tran, H. X., & Hagerman, R. J. (1996) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19960809)64:2 · Cited by 213
A phenotypic and molecular characterization of the fmr1‐tm1Cgr Fragile X mouse
Yan, Q. J., Asafo‐Adjei, P. K., Arnold, H. M., Brown, R. E., & Bauchwitz, R. P. (2004) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2004.00087.x · Cited by 213
Mildly impaired water maze performance in maleFmr1 knockout mice
D'Hooge, R., Nagels, G., Franck, F., Bakker, C. E., Reyniers, E., Storm, K., Kooy, R. F., Oostra, B. A., Willems, P. J., & De Deyn, P. P. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00224-2 · Cited by 208
Hessl, D., Dyer-Friedman, J., Glaser, B., Wisbeck, J., Barajas, R. G., Taylor, A., & Reiss, A. L. (2001) · Pediatrics · doi:10.1542/peds.108.5.e88 · Cited by 201
Fmr1 knockout mouse has a distinctive strain-specific learning impairment
Dobkin, C., Rabe, A., Dumas, R., El Idrissi, A., Haubenstock, H., & Ted Brown, W. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00292-x · Cited by 179
Dam, D. V., D’Hooge, R., Hauben, E., Reyniers, E., Gantois, I., Bakker, C. E., Oostra, B. A., Kooy, R. F., & Deyn, P. P. D. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00296-5 · Cited by 145
Flanking gene and genetic background problems in genetically manipulated mice
Crusio, W. E. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.12.026 · Cited by 133
Self-citationFragile X Syndrome: Diagnosis, Treatment, and Research
Schmidt, M. A. (1997) · JAMA · doi:10.1001/jama.1997.03540380083039 · Cited by 95
Mouse models for psychiatric disorders
Seong, E., Seasholtz, A. F., & Burmeister, M. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(02)02807-x · Cited by 86
Molecular dissection of the amygdala and its relevance to autism
Zirlinger, M., & Anderson, D. J. (2003) · Genes Brain & Behavior · doi:10.1034/j.1601-183x.2003.00039.x · Cited by 37
Shrimpton, A. E., Daly, K. M., & Hoo, J. J. (1999) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19990528)84:3 · Cited by 20
Opponent strain effect on eliciting attacks in NZB mice: Physiological correlates
Francois, M.-H., Nosten‐Bertrand, M., Roubertoux, P. L., Kottler, M., & Degrelle, H. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90370-j · Cited by 20
A proposed primate animal model of autism
Teitelbaum, P. (2003) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-003-0306-6 · Cited by 11
Orsmond, G. I., Seltzer, M. M., Krauss, M. W., & Hong, J. (2003) · American Journal on Mental Retardation · doi:10.1352/0895-8017(2003)108
Research works printed but not linked: 1
- Spencer, 2003, Social behaviors in the Fmr1 knockout mouse model of Fragile X Syndrome, Soc Neurosci Abstr, 33, 646.6
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Silverman, J. L., Yang, M., Lord, C., & Crawley, J. N. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2851 · Cited by 1,462
Autism‐like behavioral phenotypes in BTBR T+tf/J mice
McFarlane, H. G., Kusek, G. K., Yang, M., Phoenix, J. L., Bolivar, V. J., & Crawley, J. N. (2008) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2007.00330.x · Cited by 812
Mouse behavioral tasks relevant to autism: Phenotypes of 10 inbred strains
MOY, S., NADLER, J., YOUNG, N., PEREZ, A., HOLLOWAY, L., BARBARO, R., BARBARO, J., WILSON, L., THREADGILL, D., & LAUDER, J. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.07.030 · Cited by 776
Jamain, S., Radyushkin, K., Hammerschmidt, K., Granon, S., Boretius, S., Varoqueaux, F., Ramanantsoa, N., Gallego, J., Ronnenberg, A., Winter, D., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711555105 · Cited by 556
Panksepp, J. B., Jochman, K. A., Kim, J. U., Koy, J. J., Wilson, E. D., Chen, Q., Wilson, C. R., & Lahvis, G. P. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000351 · Cited by 295
Metadata
- Authors
- Mineur, Y. S., Huynh, L. X., & Crusio, W. E.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Corresponding author
- Crusio, Wim E.
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2006-03
- Volume
- 168
- Issue
- 1
- Pages
- 172-175
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2032131334
- Cited by
- 177
- References
- 22
- Citations by year
- 2026: 3 · 2025: 12 · 2024: 8 · 2023: 7 · 2022: 5 · 2021: 4 · 2020: 7 · 2019: 6 · 2018: 3 · 2017: 8 · 2016: 10 · 2015: 8 · 2014: 10 · 2013: 8 · 2012: 20
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- March of Dimes Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- Fmr1 knockout mice, social interaction deficits, autism model, inbred mouse strains, habituation, ovariectomized females, FMR1 gene, social behavior
- MeSH terms
- Animals, Autistic Disorder, Female, Habituation, Psychophysiologic, Interpersonal Relations, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred DBA, Mutation, Ovariectomy, Pilot Projects, Social Behavior, Social Environment, Species Specificity, Mice, Fragile X Mental Retardation Protein, Fragile X Messenger Ribonucleoprotein 1
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